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Background: The four-dimensional (‘4-D’) model has been proposed as a theoretical framework to understand and delineate trauma-related dissociative experiences, categorizing symptoms into trauma-related altered states of consciousness (TRASC) and normal waking consciousness (NWC), which occur along four dimensions: time, thought, body and emotion. Objective: The main aim of the present study was to evaluate the validity of this model in patients with post-traumatic stress disorder (PTSD), with and without comorbid dissociative disorders. Method: The predictions of the 4-D model were tested in 142 patients with PTSD, with (N = 46) and without (N = 96) comorbid dissociative disorders. Results: As predicted by the 4-D model, experiences of TRASC were less frequent and more specifically related to other measures of dissociation, dissociative disorder comorbidity and a history of childhood sexual abuse compared to experiences of NWC. The predicted lower intercorrelation of TRASC was not supported. Conclusion: The 4-D model represents a promising framework for understanding dissociation across trauma-related disorders.

Objective: The aim of this study was to assess the results of all meta-analyses on anomalous cognition conducted between 1989 and 2021 in order to find moderators associated with greater effect sizes. Method: We included all meta-analyses of studies related to anomalous cognition published up to 2021. Results: Our dataset, accumulated over more than 80 years of investigation, refers to 11 meta-analyses related to six different states of consciousness. The evidence clearly shows that anomalous cognition seems possible and its effects can be enhanced by using a combination of some non-ordinary or altered states of consciousness (e.g., dreaming, ganzfeld, etc.), coupled with free-response procedures, or neurophysiological dependent variables. These conditions facilitate an alternative form of cognition seemingly unconstrained by the known biological characteristics of the sense organs and the brain. Conclusion: The accumulated evidence expands our understanding of the mind-brain relation and the nature of the human mind.

A typical occurrence in emergency rooms is traumatic brain injury (TBI) resulting from head trauma which is normally responsible for far more than 1 million visits per year. The magnitude of TBIs varies from mild, intermittent symptoms to longer periods of altered states of consciousness. The precise mechanism of concussion is indefinite. In serious brain trauma, Axon tearing is expected, but there is no evidence for this concussion process. Most concussion patients improve rapidly and entirely. Concussion management is usually supportive and some cases may need hospital admissions and ICU care according to severity of injury and related symptoms.

The article is devoted to the problem of studying and applying the phenomena of suggestion, auto-suggestion and altered states of consciousness in modern sports psychology. A brief excursion into the history of the use of altered states of consciousness in elite sports is given. The advantages, disadvantages, limitations and specificity of different methods using suggestion and auto-suggestion in the framework of psychological support for athletes of various sports are discussed. The article also raises questions about the methods of assessing the effectiveness of psychological and pedagogical interventions with athletes using hypnosis and self-hypnosis, as well as verification of suggestive influences at the psychophysiological level. Finally, the article discusses the ethical aspects of using altered states of consciousness in the framework of psychological support for athletes and the prospects for popularizing sports hypnosis.

[Image: see text] Classic psychedelics produce altered states of consciousness that individuals often interpret as meaningful experiences. Across a number of human studies, when the participant-rated intensity of the overall drug effects are statistically controlled for, certain subjective effects predict therapeutic and other desirable outcomes. Underlying neurobiological mechanisms are likely necessary but not sufficient to confer full and enduring beneficial effects. We propose that the subjective effects of psychedelics are necessary for their enduring beneficial effects and that these subjective effects account for the majority of their benefit.

As more local, state, and national governments change laws regarding the legality of cannabis use, it is essential for organizations to understand how the workplace may be influenced by these changes. The current study begins to answer this question by examining the relationship between three temporal-based cannabis measures and five forms of workplace performance. Using data from 281 employees and their direct supervisors, our results indicate that cannabis use before and during work negatively relate to task performance, organization-aimed citizenship behaviors, and two forms of counterproductive work behaviors. At the same time, after-work cannabis use was not related (positively or negatively) to any form of performance as rated by the user’s direct supervisor. We discuss methodological, theoretical, and practical implications for researchers, organizations, and governmental agencies concerned with cannabis use.

Case Presentation A 50-year-old woman presented to the ED with a 3-day history of increasing confusion. Prior to her presentation, the patient had been in her usual state of health as reported by her family. She had a history of bipolar disorder and attention-deficit/hyperactivity disorder but had stopped her psychiatric medications for the past 4 days secondary to loss of insurance coverage. History was limited due to the patient's altered state and confusion, and was obtained from family. There was no history of headache, loss of consciousness, weakness of extremities, seizures, fever, or recent trauma. The patient's medical history also included cocaine abuse. The patient's family believed she had been abstinent from cocaine use for several years.

This study investigates eight case reports of spontaneously emerging, brief episodes of vivid altered states of Selfhood (ASoSs) that occurred during mental exercise in six long-term meditators by using a neurophenomenological electroencephalography (EEG) approach. In agreement with the neurophenomenological methodology, first-person reports were used to identify such spontaneous ASoSs and to guide the neural analysis, which involved the estimation of three operational modules of the brain self-referential network (measured by EEG operational synchrony). The result of such analysis demonstrated that the documented ASoSs had unique neurophenomenological profiles, where several aspects or components of Selfhood (measured neurophysiologically and phenomenologically) are affected and expressed differently, but still in agreement with the neurophysiological three-dimensional construct model of the complex experiential Selfhood proposed in our earlier work (Fingelkurts et al. in Conscious Cogn 86:103031. https://doi.org/10.1016/j.concog.2020.103031 , 2020).

When performing willed actions, we have the unified and coherent experience of owning and controlling our body. Body ownership is believed to emerge from the integration of coherent multisensory signals, while agency is believed to emerge from the coherence between predicted and perceived outcomes of actions. As a consequence, body ownership and agency can both be modulated by multisensory conflicts. The contribution of active movement generation to ownership and agency has not been parametrically explored. Here, we investigated the contribution of interaction force between the agent and the environment to the sense of hand ownership (SO) and the sense of hand agency (SA). By combining robotics and virtual reality, we manipulated the sensorimotor and visual information during immersive scenarios to induce and quantify altered states of SO and SA. First, we demonstrated that SO and SA could be successfully manipulated by our experimental paradigms. Second, we showed that interaction force strongly contributes to SA, but to a lesser extent to SO. Finally, we showed that SO and SA interact beyond their common multisensory basis. Our results, based on two independent studies, provide a direct link between sensorimotor interactions and subjective body experience and demonstrate a new dissociation between SO and SA., Scientific Reports, 11 (1), ISSN:2045-2322

Psychoactive drugs can transiently perturb brain physiology while preserving brain structure. The role of physiological state in shaping neural function can therefore be investigated through neuroimaging of pharmacologically induced effects. Previously, using pharmacological neuroimaging, we found that neural and experiential effects of lysergic acid diethylamide (LSD) are attributable to agonism of the serotonin-2A receptor (Preller et al., 2018). Here, we integrate brain-wide transcriptomics with biophysically based circuit modeling to simulate acute neuromodulatory effects of LSD on human cortical large-scale spatiotemporal dynamics. Our model captures the inter-areal topography of LSD-induced changes in cortical blood oxygen level-dependent (BOLD) functional connectivity. These findings suggest that serotonin-2A-mediated modulation of pyramidal-neuronal gain is a circuit mechanism through which LSD alters cortical functional topography. Individual-subject model fitting captures patterns of individual neural differences in pharmacological response related to altered states of consciousness. This work establishes a framework for linking molecular-level manipulations to systems-level functional alterations, with implications for precision medicine.

The Museum of Consciousness contains exhibits by a multitude of artists, mavericks and consciousness explorers who are here to transmit their most treasured work: For the first exhibition we decided to use short, audio-based samples that are designed to cultivate and manufacture expansive states of consciousness. The range of samples encompassed by the current iteration of the museum includes mindfulness meditations, “placebo highs,” sound journeys, novel modes of introspection, and more. The structure of the museum is centered around recipes for consciousness augmentation. The museum also has an interactive component: visitors will rate the samples according to Raph Milliere’s 6D model of self-consciousness, which was inspired by the effects of psychedelics and meditation on subjective experience. Additionally, visitors will play a game in which they try to figure out the ratings that the curators had pre-assigned to the samples. Finally, visitors will have the opportunity to provide feedback to the artists, as part of the cyclically regenerative system at the heart of the museum.

The past decade has seen a renaissance of research interest into the psychotherapeutic potential of psychedelic compounds. In 2019, Oakland and Denver became the first two jurisdictions in the United States to decriminalize the possession of psychedelic-containing organisms. As research and public policy continue to evolve, it becomes increasingly plausible that psychedelics will become viable treatment options for psychiatric conditions. Psychiatrists should be integral to models of psychedelic prescription and patient management. The risk for adverse psychological and medical effects from psychedelic sessions necessitates psychiatric supervision. The literature on psychedelic-assisted psychotherapy may provide wisdom regarding practical aspects of managing patients' treatment sessions.

Biologicals are a rapidly evolving group of drugs derived from biological agents which target specific immune mediators. The use of biologicals in dermatology is on the rise, especially for inflammatory and immunological conditions. As pregnancy and lactation are associated with exacerbation of various inflammatory conditions necessitating administration of biologicals in certain cases, their use in these physiologically altered states has to be evaluated. This article aims at reviewing the common biologicals used in dermatology and their feasibility in pregnancy and lactation. Tumor necrosis factor-alpha inhibitors are the most experienced group of biologicals in pregnancy and lactation, the newer biologicals have only animal studies and isolated case reports to back up their use. The commonly used biologicals are tabulated and discussed herewith. The guidelines and recommendations are derived from the data of use in other conditions such as inflammatory bowel disease and rheumatoid arthritis as there is no sufficient literature evidence for the use of biologicals in pregnancy for dermatological conditions. It was extrapolated that biologicals, being large molecular weight immunoglobulins or recombinant proteins, may be used with judicious care in the first two trimesters of pregnancy and after the 1stweek of lactation, if benefits to the mother outweigh the theoretical risk to the infant.

Introduction: Altered states of consciousness have traditionally been associated with poor prognosis. At present, clinical differences between these entities are beginning to be established. Method: Our study included 37 patients diagnosed with vegetative state/unresponsive wakefulness syndrome (UWS) and 43 in a minimally conscious state (MCS) according to the Coma Recovery Scale–Revised (CRS-R). All patients were followed up each month for at least 6 months using the CRS-R. We recorded the time points when vegetative state progressed from ‘persistent’ to ‘permanent’ based on the cut-off points established by the Multi-Society-Task-Force: 12 months in patients with traumatic injury and 3 months in those with non-traumatic injury. A logistic regression model was used to determine the factors potentially predicting which patients will emerge from MCS. Results: In the UWS group, 23 patients emerged from UWS but only 9 emerged from MCS. Of the 43 patients in the MCS group, 26 patients emerged from that state during follow-up. Eight of the 23 patients (34.7%) who emerged from UWS and 17 of the 35 (48.6%) who emerged from MCS recovered after the time points proposed by the Multi-Society-Task-Force. According to the multivariate regression analysis, aetiology (P

What is called “time travel” cinema is but one aspect in a tripartite series of interweaving modes of disjunctive narration which is also – simultaneously – a cinema of “many worlds” and “altered states”. Exploiting Gilles Deleuze's three syntheses of time, space, and consciousness from Difference and Repetition (1968) allows a conceptual development of these cinematic series through three popular Hollywood film cycles beginning with Planet of the Apes (Franklin J. Schaffner, 1968), The Terminator (James Cameron, 1984), and Back to the Future (Robert Zemeckis, 1985). In so doing, film and philosophy are deployed as two series which together create inexhaustible atemporal, aspatial, and ahuman disjunctions, ungrounding everyday spatio-temporal identities, and affirming productive images of cinematic thought.

This paper continues the cycle of interdisciplinary studies that feature a new technology of audiovisual induction of altered states of consciousness. The technology is based on a combination of models, methods, and approaches of psychology, mathematics, and computer science. The research objective was to prove that the technology can induce relaxation states. The authors conducted two experiments with a specific configuration of synchronized fractal and musical sequences. The study involved 47 people, who were presented with audiovisual stimulation. Before and after the procedure, the panelists were presented with two sets of questionnaires to define their mental and emotional state. The results demonstrated significant negative changes on the demobilizing components: mental anxiety or resentment (N), mental depression and exhaustion (D) and depressed mood (S). The data analysis confirmed the hypothesis: the method can induce states of relaxation. The data obtained are can be used in further experiments, e.g. to reveal creative potential by means of audiovisual stimulation.

O presente artigo analisa os padrões de manifestação dos ‘desafios da internet’, manifestação viral da qual participam principalmente pré-adolescentes e adolescentes, e que estimulam teleparticipação mundial em desafios geradores de estados alterados de consciência que carregam um risco de morte em potencial. Objetivou-se traçar os padrões de incidência da ferramenta Google Trends para mapear padrões de manifestação que são analisados do ponto de vista dos contágios psíquicos das massas próprios das sociedades tomadas pelas redes de comunicação. À análise dos padrões de incidência segue-se uma reflexão teórica sobre o fenômeno e os seus desdobramentos a partir das teorias da comunicação, da mídia e da psicologia junguiana, especialmente acerca dos fenômenos das massas. Para a discussão, utilizaram-se como referências básicas Dietmar Kamper, Jean Baudrillard, Norval Baitello Junior e Malena Segura Contrera.

Stroboscopic stimulation has been previously shown to induce visual hallucinations and altered states of consciousness, state by entraining the brain to the driving frequency, similar to those reported during the psychedelics although little systematic research exists on the effect of specific stimulation frequency on experience. The present study investigated the effects of different stroboscopic stimulation frequencies on neural dynamics, such as signal diversity (Lempel-Ziv complexity) and spectral power and attempted to relate these changes to self-reported changes in experiential content. The results indicated that the stimulation frequencies near the alpha band (8 – 12 Hz) caused the greatest increase across all neural measures, with 8 Hz consistently displaying the most pronounced results, relative to baseline. All tested frequencies led to an increase in all experiential dimensions, relative to baseline.

This article discusses the psychophysical processes of the actor from a laboratory practice developed with the Arkhétypos Group. The exposition presented is the result of the meeting of two researchers, one from the Performing Arts area and the other from Physiology, generating an interdisciplinary discussion about the Ritual Theater. This article analyzes two creative processes experienced by the authors and proposes an approximation with the theory of transient hypofrontality. The methodological approach is based on the anecdotal evidence and a rigorous bibliographic study. The partial results of the research help us understand what happens to the cerebral physiology of the actor who enters the ritual play. RÉSUMÉ Cet article discute les processus psychophysiques de l'acteur à partir d'une pratique de laboratoire développée avec le Groupe Arkhétypos. La réflexion présentée est le résultat de la rencontre de deux chercheurs, l'un du domaine des arts de la scène et l'autre de la physiologie, générant une discussion interdisciplinaire sur le Théâtre Rituel. L'article analyse deux processus créatifs vécus par les auteurs et propose une approximation avec la théorie de l'hypofrontalité transitoire. L'approche méthodologique est basée sur les preuves anecdotiques et une étude bibliographique rigoureuse. Les résultats partiels de la recherche nous aident à comprendre ce qui arrive à la physiologie cérébrale de l'acteur qui entre dans le jeu rituel. RESUMO Este artigo discute os processos psicofísicos do ator a partir de uma prática laboratorial desenvolvida junto ao Grupo Arkhétypos. A reflexão apresentada é fruto do encontro de dois pesquisadores, um da área de Artes Cênicas e outro da Fisiologia, gerando uma discussão de caráter interdisciplinar sobre o Teatro Ritual. O artigo analisa dois processos de criação vividos pelos autores e propõe uma aproximação com a teoria da hipofrontalidade transitória. O recorte metodológico se estrutura a partir da evidência anedótica e de um rigoroso estudo bibliográfico. Os resultados parciais da pesquisa ajudam a compreender o que acontece com a fisiologia cerebral do ator que adentra ao jogo ritual.

This article is based on a five-year qualitative ethnographic study of bondage and discipline/dominance and submission/sadism and masochism (BDSM) in Sweden. In-depth interviews were completed with 29 self-defined BDSM practitioners. In the article, I investigate spirituality in two different contexts, namely within BDSM practice and in the charismatic Christianity. With a focus on power dynamics, pain rituals, and altered states of consciousness, I discuss the questions: What meaning is given to the concept of spirituality in a BDSM context, and how does this spirituality resemble spirituality in Christianity? Which common denominators between BDSM practice and Christian belief can be found, and how should we interpret the parallels that the informants emphasize between practicing BDSM and having a Christian affiliation? The article aims to broaden our understanding for spirituality in different contexts, and thus contribute to both the research field of BDSM as well as to religion studies. And as such, I hope this study can bring some clarity to the different spiritual experiences individuals may encounter, whether it happens in a BDSM context or in a religious context.

ObjectiveTo understand women's experiences of undisturbed physiological birth by exploring the narratives of women who have freebirthed their babies in the United Kingdom (intentionally giving birth without midwives or doctors present).DesignUnstructured narrative face-to-face interviews were carried out and data were analysed using the Voice Centred Relational Method (VCRM).ParticipantsSixteen women who had freebirthed their babies.FindingsWomen discussed a range of phenomena including birth positions, the fetus ejection reflex, pain, altered states of consciousness, physiological third stages and postnatal experiences that were physically and emotionally positive.Key conclusionsThere is a paucity of literature on physiological birth and limited opportunity for practitioners to witness it. Further research is required on phenomena related to physiological birth so as to better understand how to promote it within the maternity setting and when intervention is justified.Implications for practiceStandard maternity settings and practice may not be conducive to or reflective of physiological birth. Better understanding of physiological birth is required so that pregnant women and people can be appropriately supported during labour and birth.

Chanting is a form of rhythmic, repetitive vocalization practiced in a wide range of cultures. It is used in spiritual practice to strengthen community, heal illness, and overcome psychological and emotional difficulties. In many traditions, chanting is used to induce mystical states, an altered state of consciousness characterised by a profound sense of peace. Despite the global prevalence of chanting, its psychological effects are poorly understood. This investigation examined the psychological and contextual factors associated with mystical states during chanting. Data were analyzed from 464 participants across 33 countries who regularly engaged in chanting. Results showed that 60% of participants experienced mystical states during chanting. Absorption, altruism, and religiosity were higher among people who reported mystical states while chanting compared to those who did not report mystical states. There was no difference in mystical experience scores between vocal, silent, group or individual chanting and no difference in the prevalence of mystical states across chanting traditions. However, an analysis of subscales suggested that mystical experiences were especially characterised by positive mood and feelings of ineffability. The research sheds new light on factors that impact upon chanting experiences. A framework for understanding mystical states during chanting is proposed.

The scope of human consciousness includes states departing from what most of us experience as ordinary wakefulness. These altered states of consciousness constitute a prime opportunity to study how global changes in brain activity relate to different varieties of subjective experience. We consider the problem of explaining how global signatures of altered consciousness arise from the interplay between large-scale connectivity and local dynamical rules that can be traced to known properties of neural tissue. For this purpose, we advocate a research program aimed at bridging the gap between bottom-up generative models of whole-brain activity and the top-down signatures proposed by theories of consciousness. Throughout this paper, we define altered states of consciousness, discuss relevant signatures of consciousness observed in brain activity, and introduce whole-brain models to explore the biophysics of altered consciousness from the bottom-up. We discuss the potential of our proposal in view of the current state of the art, give specific examples of how this research agenda might play out, and emphasize how a systematic investigation of altered states of consciousness via bottom-up modeling may help us better understand the biophysical, informational, and dynamical underpinnings of consciousness. Fil: Cofré, Rodrigo. Universidad de Valparaíso; Chile Fil: Herzog, Rubén. Universidad de Valparaíso; Chile Fil: Mediano, Pedro A.M.. University of Cambridge; Estados Unidos Fil: Piccinini, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina Fil: Rosas, Fernando E.. Imperial College London; Reino Unido Fil: Sanz Perl Hernandez, Yonatan. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina

Eukaryotic cells are exposed to many internal and external stimuli that affect their fate. In particular, the exposure to some of these stimuli induces stress triggering a variety of stress responses aimed to re-establish cellular homeostasis. It is now established that the deregulation of stress response pathways plays a central role in cancer initiation and progression, allowing the adaptation of cells to an altered state in the new environment. Autophagy is a tightly regulated pathway which exerts “housekeeping” role in physiological processes. Recently, a growing amount of evidence highlighted the crucial role of autophagy in the regulation of integrated stress responses, including nucleolar and endoplasmic reticulum. In this review, we attempt to afford an overview of the complex role of nucleolar and endoplasmic reticulum stress-response mechanisms in the regulation of autophagy in cancer and cancer treatment.

Psilocybin is the active component of magic mushrooms and is well known for its psychoactive properties. Different questionnaires have been developed to systematically quantify altered states of consciousness induced by psychoactive drugs. The aim of this study was to obtain the dose-response relationships of the subjective experiences induced by psilocybin in healthy study participants. For this purpose, we applied a linear meta-regression approach on questionnaire ratings after oral administration of psilocybin in a controlled setting. Data was obtained from The Altered States Database, which contains psychometric data extracted from peer-reviewed articles published in MEDLINE-listed journals that used standardized and validated questionnaires. Our meta-analysis included data of the Altered States of Consciousness Rating Scale, the Mystical Experience Questionnaire (MEQ30), and the Hallucinogen Rating Scale (HRS). We used the Robust Variance Estimation Framework to obtain linear dose-response relationship estimates for each dimension of the given questionnaires. Ratings on most dimensions and subscales of the included questionnaires correlated positively with dose. Since subjective experiences are not only determined by dose, but also by individual differences and environmental factors, our results do not necessarily generalize to recreational use, as our analyses are based on data from controlled laboratory experiments. The paper at hand could serve as a general literature citation for the use of psilocybin in experimental and clinical research, especially for the comparison of expected and observed subjective drug experiences.

A growing number of studies have demonstrated that BDSM (Bondage/Discipline-Domination/Submission-Sadism/Masochism) practices are not signs of mental illness. However, the reasons for engaging in such behaviors are not well understood, especially for sexual masochism or submission (m/s). A thorough review of the literature was conducted, as well as a search in Internet forums and an online survey to obtain testimonies that provide information on the origins of interest in m/s and the reasons for engaging in it. A qualitative content analysis was performed on narratives from 227 m/s practitioners. Sixteen themes emerged from this analysis, eight related to the origins of interest in m/s and eight to the reasons for engaging in m/s. The origins described were seen as either intrinsic or extrinsic. Reasons to engage in m/s were related to one of three main types of activities: use of interpersonal power; experiencing physical pain; and altering one's state of mind. These results concord with accounts found in non-academic books and small-scale studies suggesting that m/s interests are often present early in life and usually practiced to reach an altered state of mind associated with sexual arousal. Possible reasons for choosing m/s over more common means of mind alteration are discussed.

Ayahuasca is described as a hallucinogenic substance whose property is to alter the subjective experience of time and impair the perception of the passage of time during stimuli of more than two to three seconds. The dose-dependent effects of two concentrations of ayahuasca in the ritualistic context were investigated employing temporal reproduction tasks in participants experienced in shamanistic ayahuasca rituals. The study was conducted on nine healthy volunteers who ingested two doses of ayahuasca at two times during a ritual session. The doses of each session, consumed in amounts ranging from 20 to 60 mL, were either of low concentration or of experimental ayahuasca according to a double-blind procedure. Participants performed the task of immediately listening and reproducing, with a laptop, 20-s musical stimuli during the session. The results showed that significant temporal distortion was triggered by the musical stimulus presented without the ingestion of ayahuasca, with means of 16.33 to 16.52 s. There were minor temporal distortions after ingestion of ayahuasca: a mean of 17.91 s for control ayahuasca and of 18.38 s for experimental ayahuasca. These results with less temporal distortion among participants with ayahuasca intake disagree with other studies of hallucinogens involving temporal reproduction.

Time Expansion Experiences (TEEs) occur when a person’s normal experience of time slows down or expands significantly. Previous research has associated them mainly with accidents but also with altered states of consciousness such as mystical experiences, psychedelic experiences, and near-death experiences. This article describes a qualitative study of 74 reports of “Time Expansion Experiences” (also a pilot study of 22 reports), which investigated the phenomenology of such experiences, using thematic analysis to highlight the main themes. The most common triggers of TEEs in the study were accidents (40 of 74), followed by spiritual states (12), and, then, psychedelic experiences and sports and games (both 7). Many participants commented on the dramatic nature of their TEEs, with themes of positive affective states (most notably calmness), alertness, the opportunity to take preventative action (related to very rapid cognition), and quietness. Interpretations of TEEs are discussed, arguing against the theory that they are an illusion created by recollection. TEEs are seen as a characteristic of altered states of consciousness, which occur when the normal self-system dissolves in exceptional circumstances. Human beings’ normal experience of time is a psychological construct, produced by the psychological structures and processes of the normal self-system.

Dynamically assessing the level of consciousness is still challenging during anesthesia. With the help of Electroencephalography (EEG), the human brain electric activity can be noninvasively measured at high temporal resolution. Several typical quasi-stable states are introduced to represent the oscillation of the global scalp electric field. These so-called microstates reflect spatiotemporal dynamics of coherent neural activities and capture the switch of brain states within the millisecond range. In this study, the microstates of high-density EEG were extracted and investigated during propofol-induced transition of consciousness. To analyze microstates on the frequency domain, a novel microstate-wise spectral analysis was proposed by the means of multivariate empirical mode decomposition and Hilbert–Huang transform. During the transition of consciousness, a map with a posterior central maximum denoted as microstate F appeared and became salient. The current results indicated that the coverage, occurrence, and power of microstate F significantly increased in moderate sedation. The results also demonstrated that the transition of brain state from rest to sedation was accompanied by significant increase in mean energy of all frequency bands in microstate F. Combined with studies on the possible cortical sources of microstates, the findings reveal that non-canonical microstate F is highly associated with propofol-induced altered states of consciousness. The results may also support the inference that this distinct topography can be derived from canonical microstate C (anterior-posterior orientation). Finally, this study further develops pertinent methodology and extends possible applications of the EEG microstate during propofol-induced anesthesia.

In ‘REBUS and the Anarchic Brain: Towards a Unified Model of the Brain Action of Psychedelics’, Carhart-Harris and Friston offer an important analysis of what the predictive processing framework has to offer our understanding of psychedelic experiences, providing an invaluable ground for psychedelic psychiatry. While applauding this, we encourage paying greater attention to contextual factors shaping extreme experiences and their sequalae, and suggest that the authors’ comparisons with certain non-psychedelic altered states may overlook more informative parallels that can be drawn elsewhere. Addressing both points will prove fruitful, ultimately, in identifying the mechanisms of action of greatest interest in psychedelic experiences.

Charisma is an unstable basis upon which to build authority. Charismatic leaders need their followers to perceive them as being endowed with extraordinary, even supernatural, gifts. Detractors can in turn question whether the leader actually possesses these unique qualities. Using Judith von Halle and her conflicts with the Anthroposophical Society as a case study, we address the question of how charismatic authority can be constructed and deconstructed in polemical texts. At various points throughout her career, Von Halle has made extraordinary claims. She presents herself as being clairvoyant and as having received stigmata. Anthroposophists who believe these claims cite them as their reasons for regarding her doctrinal statements as being trustworthy. Skeptical Anthroposophists, on the other hand, question her experiences and motives. Using a theoretical framework inspired by Foucault and Bourdieu, we discuss how both camps discuss von Halle’s charismatic status in terms that are opaque to outsiders unfamiliar with Anthroposophical discourse.

Patterns of functional interactions across distributed brain regions are suggested to provide a scaffold for the conscious processing of information, with marked topological alterations observed in loss of consciousness. However, establishing a firm link between macro-scale brain network organisation and conscious cognition requires direct investigations into neuropsychologically-relevant architectural modifications across systematic reductions in consciousness. Here we assessed both global and regional disturbances to brain graphs in a group of healthy participants across baseline resting state fMRI as well as two distinct levels of propofol-induced sedation. We found a persistent modular architecture, yet significant reorganisation of brain hubs that formed parts of a wider rich-club collective. Furthermore, the reduction in the strength of rich-club connectivity was significantly associated with the participants' performance in a semantic judgment task, indicating the importance of this higher-order topological feature for conscious cognition. These results highlight a remarkable interplay between global and regional properties of brain functional interactions in supporting conscious cognition that is relevant to our understanding of clinical disorders of consciousness., Scientific Reports, 10 (1), ISSN:2045-2322

Sexual intercourse alters normal waking consciousness. Altered states of consciousness (ASC) refer to marked deviations from usual waking consciousness, and include alterations in the sense of self, attention, thought processes, time awareness and sensory perception. Sex can induce ASC, as indicated by states of attentional absorption in bodily sensations concomitant with loss of time awareness. The present study aimed at testing if, during sexual relations, higher sexual responsiveness relates to higher intensity of dimensions of ASC that can occur in other contexts, such as meditation or use of psychoactive substances. The personality trait of absorption appears to reflect individual differences in the proclivity to experience ASC; thus, a second aim was to examine if trait absorption relates to intensity of ASC during sex. The international sample consisted of 448 participants (303 women, 145 men). Sex-induced ASC were measured with four sub-scales of The Altered States of Consciousness Rating Scale (OAV): Experience of Unity, Spiritual Experience, Blissful State and Insightfulness. Trait absorption was measured by the Modified Tellegen Absorption Scale (MODTAS). Sexual responsiveness during the last intercourse was assessed by the sum of measures of arousal, desire, and satisfaction, as well as by questions on the occurrence of orgasm from different sexual activities. Trait absorption and sexual responsiveness predicted independently all dimensions of ASC among women and men. In women, vaginal orgasm (during vaginal intercourse without concomitant clitoral masturbation) was an additional independent predictor of ASC. Male orgasm related to ASC, but not independently from other aspects of sexual responsiveness. As relações sexuais alteram a consciência vígil usual. Estados alterados de consciência (EAC) referem-se a desvios marcados da consciência vígil usual. Investigação confirma que EAC podem ocorrer no sexo em termos de estados de absorção atencional nas sensações corporais concomitantes à perda de consciência do tempo. O presente estudo testou se, durante as relações sexuais, maior responsividade sexual está relacionada com maior intensidade em dimensões de EAC que podem ocorrer com desencadeantes não sexuais, como meditação ou substâncias psicoactivas. Adicionalmente, o traço de personalidade “absorção” parece reflectir diferenças individuas na propensão para EAC. Assim, um segundo objetivo foi examinar se a absorção traço se relaciona com a intensidade de EAC durante o sexo. A amostra internacional contou com 448 participantes (303 mulheres, 145 homens). Os EAC foram medidos com quatro sub-escalas da Altered States of Consciousness Rating Scale (OAV): Experiência de Unidade, Experiência Espiritual, Estado de Beatitude e Momentos de Insight. A absorção-traço foi medida pela Modified Tellegen Absorption Scale (MODTAS). A responsividade durante a última relação sexual foi medida através da soma de medidas de excitação, desejo, satisfação, assim como com questões sobre a ocorrência do orgasmo através de diversas actividades sexuais. Absorção-traço e responsividade sexual foram preditores independentes da intensidade de todas as dimensões dos EAC em mulheres e homens. Nas mulheres, o orgasmo vaginal feminino (durante o coito vaginal sem masturbação clitoriana concomitante) foi um preditor independente adicional dos EAC. O orgasmo masculino relacionou-se com os EAC, mas não independentemente dos outros aspectos da responsividade sexual. info:eu-repo/semantics/publishedVersion

Astrocytes exhibit dynamic and complex reactions to various insults. Recently, investigations into the transitions that occur during cellular specification, differentiation, maturation, and disease responses have provided insights into understanding the mechanisms that underlie these altered states of reactivity and function. Here we summarize current concepts in how astrocyte state transitions, termed astroplasticity, are regulated, as well as how this affects neural circuit function through extracellular signaling. We postulate that a promising future approach toward enhancing functional repair after injury and disease would be to steer astrocytes away from an inhibitory response and toward one that is beneficial to neuroplasticity and neuroregeneration. Toward this goal, we discuss emerging biotechnological advancements, with a focus on human pluripotent stem cell bioengineering, which has high potential for effective manipulation and control of astroplasticity. Highlights include innovations in cellular transdifferentiation techniques, nanomedicine, organoid and three-dimensional (3D) spheroid microcircuit development, and the use of biomaterials to influence the extracellular environment. Current barriers and future applications are also summarized in order to augment the design of future preclinical trials aimed toward astrocyte-targeted neuroregeneration with a concept termed astrocellular therapeutics. Developmental Dynamics 248:21-33, 2019. © 2018 Wiley Periodicals, Inc.

"Este artículo vincula la frontera, como frontera de un Estado, con la idea de un Estado alterado, y sitúa lo político en el corazón de lo psicológico y lo psicológico en el corazón de lo político. Un Estado alterado produce condiciones alteradas en los ciudadanos que tienen un aire de familia con la crisis psicótica, en especial cuando el delirio es sobre el poder y su violencia. La diferencia entre las experiencias de un Estado alterado y la crisis psicótica se juega al menos en dos aspectos fundamentales: la relación de estas fronteras con los discursos y la relación de las fronteras con el secreto."

Environmental events are processed on multiple timescales via hierarchical organization of temporal receptive windows (TRWs) in the brain. The dependence of neural timescales and TRWs on altered states of consciousness is unclear. States of reduced consciousness are marked by a shift toward slowing of neural dynamics (n= 23; male/female 14/9) during graded sedation with propofol. We further examined the relationship between the intrinsic timescales (local/voxel level) and its regional connectivity (across neighboring voxels; regional homogeneity, ReHo), global (whole-brain level) functional connectivity (GFC), and topographical similarity (Topo). Additional results were obtained from patients undergoing deep general anesthesia (n= 12; male/female: 5/7) and in patients with disorders of consciousness (DOC) (n= 21; male/female: 14/7). We found that MF, AC, and ReHo increased, whereas GFC and Topo decreased, during propofol sedation. The local alterations occur before changes of distant connectivity. Conversely, all of these parameters decreased in deep anesthesia and in patients with DOC. We conclude that propofol synchronizes local neuronal interactions and prolongs the timescales of intrinsic BOLD signals. These effects may impede communication among distant brain regions. Furthermore, the intrinsic timescales exhibit distinct dynamic signatures in sedation, deep anesthesia, and DOC. These results improve our understanding of the neural mechanisms of unconsciousness in pharmacologic and neuropathologic states.SIGNIFICANCE STATEMENTInformation processing in the brain occurs through a hierarchy of temporal receptive windows (TRWs) in multiple timescales. Anesthetic drugs induce a reversible suppression of consciousness and thus offer a unique opportunity to investigate the state dependence of neural timescales. Here, we demonstrate for the first time that sedation with propofol is accompanied by the prolongation of the timescales of intrinsic BOLD signals presumably reflecting enlarged TRWs. We show that this is accomplished by an increase of local and regional signal synchronization, effects that may disrupt information exchange among distant brain regions. Furthermore, we show that the timescales of intrinsic BOLD signals exhibit distinct dynamic signatures in sedation, deep anesthesia, and disorders of consciousness.

In modern game culture, religion and mythology often act as the main backbone basis of a plot, gameplay, and personalities of game characters. In a multiplatform game “Hellblade: Senua’s Sacrifice” released in 2017, the subject line, images of the characters, and internal game mechanics are based on Scandinavian and Celtic mythology. The authors distinguish the main components of mythological and religious traditions of the peoples, which were used to create the game. An important part of archaic religions of many peoples were altered states of consciousness (ASC). According to the plot, the main character experiences an altered state of consciousness that creates specific audiovisual perception of the game. The authors of the article try to consider specific features of creation of the computer game on religious and mythological basis bringing in the last achievements in the field of computer technologies. The authors claim that computer games are not only a demonstration of the growing power of digital technologies, but also “a mold of modern culture”, a reflection of the moods dominating in the society, ethical installations, and worldview criteria. Popular game “Hellblade: Senua’s Sacrifice” not only reflects these aspects of modern Western culture, but also forms mentality of those people who are fond of the game.

Hubble Space Telescope photometry of $\eta$ Carinae spans 23 years, including five spectroscopic events. The rapid brightening rate decreased after 2010, and the spectroscopic events in 2014 and 2020 had light curves different from their predecessors. Together with other indicators, these developments probably foretell the conclusion of $\eta$ Car's change of state., Comment: 8 pages, 1 figure, 1 table

Precise rare-cell technologies require the blood to be processed immediately or be stabilized with fixatives. Such restrictions limit the translation of circulating tumor cell (CTC)-based liquid biopsy assays that provide accurate molecular data in guiding clinical decisions. Here we describe a method to preserve whole blood in its minimally altered state by combining hypothermic preservation with targeted strategies that counter cooling-induced platelet activation. Using this method, whole blood preserved for up to 72 h can be readily processed for microfluidic sorting without compromising CTC yield and viability. The tumor cells retain high-quality intact RNA suitable for single-cell RT-qPCR as well as RNA-Seq, enabling the reliable detection of cancer-specific transcripts including the androgen-receptor splice variant 7 in a cohort of prostate cancer patients with an overall concordance of 92% between fresh and preserved blood. This work will serve as a springboard for the dissemination of diverse blood-based diagnostics., The current FDA-approved whole blood stabilization method for circulating tumor cell (CTC) isolation suffers from RNA degradation. Here the authors combine hypothermic preservation and antiplatelet strategies to stabilize whole blood up to 72 h without compromising CTC yield and RNA integrity.

Self-forgetfulness is a facet of self-transcendence characterized by tendency to experience altered states of consciousness. We examined associations of self-forgetfulness with sexual desire and frequency. Two hundred sixty-one Portuguese men and women completed the self-forgetfulness subscale of the Temperament and Character Inventory-Revised, a measure of openness to experience, and a questionnaire on desired and actual frequency of vaginal intercourse, noncoital sex, and masturbation in the past month. In simple and partial correlations controlling for openness to experience and relationship status, women's self-forgetfulness correlated with desired frequency of intercourse and noncoital sex. For men, self-forgetfulness correlated with actual frequency of intercourse and noncoital sex. Fundação para a Ciência e a Tecnologia (FCT) info:eu-repo/semantics/publishedVersion

How might a book review—or a book itself for that matter—change in scope or meaning if its readers are under quarantine? For those of us living in an altered state due to the COVID-19 public health crisis, nothing is as it was. So why should reading and reviewing a book like Archival Values: Essays in Honor of Mark A. Greene be any different? When libraries, archives, historical societies, and college classrooms closed to the public to slow the spread of a deadly disease, many archivists and librarians went into exile. Our reading rooms and our researchers, our collections and our facilities, were off limits. For some of us, our very livelihoods are at risk (or worse, were laid waste) by these closures. What would Mark Greene have said? What would he have done? And for those who don’t yet know who Mark Greene was, why do his archival values matter? And why now?