6 results on '"Alp BF"'
Search Results
2. Medical ozone therapy reduces shock wave therapy-induced renal injury.
- Author
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Uğuz S, Demirer Z, Uysal B, Alp BF, Malkoc E, Guragac A, Turker T, Ateş F, Karademir K, Ozcan A, Yildirim I, Korkmaz A, and Guven A
- Subjects
- Acute Kidney Injury etiology, Animals, Glutathione Peroxidase metabolism, Kidney Calculi surgery, Lipid Peroxidation drug effects, Male, Malondialdehyde blood, Random Allocation, Rats, Rats, Sprague-Dawley, Superoxide Dismutase metabolism, Acute Kidney Injury prevention & control, Kidney pathology, Lithotripsy adverse effects, Neopterin blood, Oxidative Stress drug effects, Ozone pharmacology
- Abstract
Objectives: Extracorporeal shock wave (ESW) lithotripsy is the preferred treatment modality for uncomplicated kidney stones. More recently free oxygen radical production following ESW application has been considered to be crucial in shock wave-induced renal damage. It has been shown that ozone therapy (OT) has ameliorative and preventive effects against various pathological conditions due to increased nitro-oxidative stress. In current study, we aimed to evaluate the efficacy of OT against ESW-induced renal injury., Methods: Twenty-four male Sprague-Dawley rats were divided into three groups: sham-operated, ESW, and ESW + OT groups. All groups except sham-operated group were subjected to ESW procedure. ESW + OT group received 1 mg/kg/day of oxygen/ozone mixture intraperitoneally at 2 h before ESW, and OT was continued once a day for consecutive three days. The animals were killed at the 4th day, and kidney tissue and blood samples were harvested for biochemical and histopathologic analysis., Results: Serum ALT and AST levels, serum neopterin, tissue nitrite/nitrate levels, and tissue oxidative stress parameters were increased in the ESW group and almost came close to control values in the treatment group (p < 0.05, ESW vs. ESW + OT). Histopathological injury scores were significantly lower in treatment group than the ESW group (p < 0.05, ESW vs. ESW + OT). Immunohistochemical iNOS staining scores in ESW group were higher than those of sham-operated group (p < 0.05, ESW vs. sham-operated), iNOS staining scores in OT group were significantly lower than the ESW group (p < 0.05, ESW + OT vs. ESW)., Conclusion: OT ameliorates nitro-oxidative stress and reduces the severity of pathological changes in the experimental ESW-induced renal injury of rat model.
- Published
- 2016
- Full Text
- View/download PDF
3. Does hypericin boost the efficacy of high-power laser? A preliminary experimental study on rats.
- Author
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Zor M, Goktas S, Yildirim I, Zorba UO, Basal S, Alp BF, Kaya E, and Erogul O
- Subjects
- Animals, Anthracenes, Male, Models, Animal, Muscle, Skeletal pathology, Muscle, Skeletal radiation effects, Perylene pharmacology, Random Allocation, Rats, Wistar, Thigh pathology, Thigh radiation effects, Time Factors, Lasers, Solid-State, Muscle, Skeletal drug effects, Perylene analogs & derivatives, Radiation-Sensitizing Agents pharmacology
- Abstract
Context and Objective: Lasers are widely used in treating symptomatic benign prostatic hyperplasia. In current practice, potassium titanyl phosphate (KTP) lasers are the most common type of laser systems used. The aim here was to evaluate the rapid effect of high-power laser systems after application of hypericin., Design and Setting: Experimental animal study conducted in the Department of Urology, Gülhane Military Medical Academy, Ankara, Turkey, in 2012., Methods: Sixteen rats were randomized into four groups: 120 W KTP laser + hypericin; 120 W KTP laser alone; 80 W KTP laser + hypericin; and 80 W KTP laser alone. Hypericin was given intraperitoneally two hours prior to laser applications. The laser incisions were made through the quadriceps muscle of the rats. The depth and the width of the laser incisions were evaluated histologically and recorded., Results: To standardize the effects of the laser, we used the ratio of depth to width. These new values showed us the depth of the laser application per unit width. The new values acquired were evaluated statistically. Mean depth/width values were 231.6, 173.6, 214.1 and 178.9 in groups 1, 2, 3 and 4, respectively. The most notable result was that higher degrees of tissue penetration were achieved in the groups with hypericin (P < 0.05)., Conclusions: The encouraging results from our preliminary study demonstrated that hypericin may improve the effects of KTP laser applications.
- Published
- 2014
4. Does circumcision have a relationship with ejaculation time? Premature ejaculation evaluated using new diagnostic tools.
- Author
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Alp BF, Uguz S, Malkoc E, Ates F, Dursun F, Okcelik S, Kocoglu H, and Karademir AK
- Subjects
- Age Factors, Humans, Male, Premature Ejaculation diagnosis, Prospective Studies, Time Factors, Young Adult, Circumcision, Male adverse effects, Ejaculation physiology
- Abstract
The aim of the study is to investigate whether there is an effect of adult circumcision on ejaculation parameters and to research the relationship between intravaginal ejaculation latency time (IELT) and premature ejaculation diagnostic tool (PEDT). Adults who underwent voluntary circumcision between September 2010 and November 2011 were enrolled in this prospective study. The IELT before and 3 months following circumcision was recorded. Also, PEDT was filled out before and 3 months after circumcision. During statistical evaluation, the comparison of situations before and after circumcision was made using IELT averages and PEDT total scores. Furthermore, the correlation between changes in IELT and PEDT has also been evaluated. A total of 30 volunteers (mean age 21.25±0.44) were enrolled in the study. The volunteers' mean and median IELT before were 104.36±66.21 and 88 (26-307) seconds, whereas mean and median IELT after circumcision were 123.56±54.44 and 107.5 (67-300) seconds, respectively. The increase after circumcision was statistically significant (P=0.001). The mean and median PEDT score were 4.26±2.91 and 3 (1-12) before, and 2.63±1.82 and 2 (0-7) after circumcision. Improvement was statistically significant (P<0.0001). No correlation could be found between ejaculation time and PEDT scores. Circumcision during adulthood does not adversely affect ejaculatory function; it may slightly improve. However, it could not be interpreted as a justification for circumcision in men with premature ejaculation (PE).
- Published
- 2014
- Full Text
- View/download PDF
5. Comparison of the inguinal and scrotal approaches for the treatment of communicating hydrocele in children.
- Author
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Alp BF, Irkilata HC, Kibar Y, Zorba U, Sancaktutar AA, Kaya E, and Dayanc M
- Subjects
- Child, Child, Preschool, Demography, Humans, Infant, Inguinal Canal pathology, Male, Postoperative Care, Postoperative Complications etiology, Preoperative Care, Scrotum pathology, Testicular Hydrocele pathology, Inguinal Canal surgery, Scrotum surgery, Testicular Hydrocele surgery
- Abstract
The inguinal approach is used for the treatment of hydrocele in the pediatric population. Although studies on scrotal orchiopexy have mentioned hernia or hydrocele repair through the same scrotal incision as a part of an orchiopexy procedure, there are a few studies reporting the treatment of isolated communicating hydrocele through a scrotal incision. We retrospectively evaluated and compared the outcomes of inguinal and scrotal approaches for the treatment of communicating hydrocele in boys. The classical inguinal and scrotal approaches to the treatment of communicating hydrocele were performed on 46 and 30 testicular units (in 43 boys and 27 boys, respectively). The patients' charts were reviewed to assess the operative times as well as the immediate and long-term complications during follow-up periods. The patients' ages ranged from 1 year to 8 years (3.6 ± 2.0 years) in the inguinal group and from 1 year to 10 years (mean 4.6 ± 2.8 years) in the scrotal group. Operative time was significantly lower in the scrotal group (p < 0.0001). The early minor complication rate did not differ between the two groups. Furthermore, there were no major complications noted. None of the patients had hydrocele recurrence after a mean follow-up of 6 months. The advantages of the scrotal approach for the treatment of communicating hydrocele are as follows: it is well tolerated, simple, and cosmetically appealing, and it has a short operative time in comparison with the standard inguinal approach. The scrotal incision technique is an effective alternative in communicating hydrocele treatment., (Copyright © 2013. Published by Elsevier B.V.)
- Published
- 2014
- Full Text
- View/download PDF
6. Adult type granulosa cell tumor of the testis: case report and review of the literature.
- Author
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Kucukodaci Z, Keles M, Yapanoglu T, Alp BF, Aksoy Y, and Ozbey I
- Abstract
Testicular granulosa cell tumors are extremely rare in adults. We report a case of a testicular germ cell tumor (GCT) in a 21-year-old man. The tumor was treated successfully with radical orchiectomy, and follow-up computed tomography revealed no evidence of recurrence or metastasis 10 months postoperatively. The clinical and histopathological features, treatment, and prognosis of testicular GCT are reviewed in this manuscript.
- Published
- 2008
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