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6. Overlapping Community Detection on a Graph of Chemicals, Diseases and Genes for Drug Repositioning and Adverse Reactions Prediction

Author

García-Ochagavía, María Elena, Almeida-Cruz, Yudivián, Estévez-Velarde, Suilán, Alonso-Reina, Aimée, and Ochagavía-Roque, María Elena

Subjects
biological network, lcsh:Management. Industrial management, lcsh:HD28-70, Biological network, Overlapping community detection, Drug repositioning, Management. Industrial management, adverse reactions, overlapping community detection, HD28-70, Adverse reactions
Abstract

URL del artículo en la web de la Revista: https://www.upo.es/revistas/index.php/gecontec/article/view/4081, Developing a drug from scratch is a very long and expensive process that has a small probability of success. For this reason, pharmaceutical companies are devoting their efforts to find drugs that could be repositioned. When using a drug to treat a disease is necessary to consider what adverse reactions it may cause, this is why the prediction of adverse reactions is highly related to drug repositioning. We propose the detection of overlapping communities over a biological network of chemicals, diseases and genes in order to find drug-disease pairs that could be used as basis for later drug repositioning and adverse reactions prediction analysis. Of the evaluated overlapping community detection algorithms, OSLOM got the best results, producing 724 communities from which was possible to extract 215944 drug-disease pairs not present in the analyzed graph. We illustrate the usefulness of this set through examples of associations between pairs found in the scientific literature., Universidad Pablo de Olavide

Published
2019
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7. EVALUACIÓN DE ALGORITMOS DE CLASIFICACION SUPERVISADA PARA EL MINADO DE OPINIÓN EN TWITTER.

Author

Estévez-Velarde, Suilan and Almeida Cruz, Yudivián

Subjects
*CLASSIFICATION algorithms, *MACHINE learning, *ARTIFICIAL intelligence, *MACHINE theory, *SENTIMENT analysis
Abstract

This paper proposes a comprehensive evaluation of supervised classification algorithms without semantic information for opinion mining on Twitter. The evaluation will assess the potential of this approach to tackle the given problem. Also, as result of evaluating, the impact of different variants of the text preprocessing is assessed, as well as different alternatives of dimension reduction techniques in the problem solution. Finally, the results obtained in the experiments offer evidence to direct the use of supervised classification to classify opinions and its valence in a domain of short messages such as Twitter. [ABSTRACT FROM AUTHOR]

Published
2015

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