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4. Understanding the gut-kidney axis in nephrolithiasis: An analysis of the gut microbiota composition and functionality of stone formers

Author

Ticinesi, A., Milani, C., Guerra, A., Allegri, F., Lauretani, F., Nouvenne, A., Mancabelli, L., Lugli, G. A., Turroni, F., Duranti, S., Mangifesta, M., Viappiani, A., Ferrario, C., Dodi, R., Dall'Asta, Margherita, Del Rio, D., Ventura, M., Meschi, T., Dall'Asta M. (ORCID:0000-0002-0558-0337), Ticinesi, A., Milani, C., Guerra, A., Allegri, F., Lauretani, F., Nouvenne, A., Mancabelli, L., Lugli, G. A., Turroni, F., Duranti, S., Mangifesta, M., Viappiani, A., Ferrario, C., Dodi, R., Dall'Asta, Margherita, Del Rio, D., Ventura, M., Meschi, T., and Dall'Asta M. (ORCID:0000-0002-0558-0337)

Abstract

Objectives: The involvement of the gut microbiota in the pathogenesis of calcium nephrolithiasis has been hypothesised since the discovery of the oxalate-degrading activity of Oxalobacter formigenes, but never comprehensively studied with metagenomics. The aim of this case-control study was to compare the faecal microbiota composition and functionality between recurrent idiopathic calcium stone formers (SFs) and controls. Design: Faecal samples were collected from 52 SFs and 48 controls (mean age 48±11). The microbiota composition was analysed through 16S rRNA microbial profiling approach. Ten samples (five SFs, five controls) were also analysed with deep shotgun metagenomics sequencing, with focus on oxalate-degrading microbial metabolic pathways. Dietary habits, assessed through a food-frequency questionnaire, and 24-hour urinary excretion of prolithogenic and antilithogenic factors, including calcium and oxalate, were compared between SFs and controls, and considered as covariates in the comparison of microbiota profiles. Results: SFs exhibited lower faecal microbial diversity than controls (Chao1 index 1460±363vs 1658±297, fully adjusted p=0.02 with stepwise backward regression analysis). At multivariate analyses, three taxa (Faecalibacterium, Enterobacter, Dorea) were significantly less represented in faecal samples of SFs. The Oxalobacter abundance was not different between groups. Faecal samples from SFs exhibited a significantly lower bacterial representation of genes involved in oxalate degradation, with inverse correlation with 24-hour oxalate excretion (r= '0.87, p=0.002). The oxalate-degrading genes were represented in several bacterial species, whose cumulative abundance was inversely correlated with oxaluria (r= '0.85, p=0.02). Conclusions: Idiopathic calcium SFs exhibited altered gut microbiota composition and functionality that could contribute to nephrolithiasis physiopathology.

Published
2018

6. Decreased transcriptional activity of Calcium-sensing receptor gene promoter 1 is associated with calcium nephrolithiasis

Author

Vezzoli G, Terranegra A, Aloia A, Arcidiacono T, Milanesi L, Mosca E, Mingione A, Spotti D, Cusi D, Hou J, Hendy GN, Soldati L, Paloschi V, Dogliotti E, Brasacchio C, Dell'Antonio G, Montorsi F, Bertini R, Bellinzoni P, Guazzoni G, Borghi L, Guerra A, Allegri F, Ticinesi A, Meschi T, Nouvenne A, Lupo A, Fabris A, Gambaro G, Rendina D, De Filippo G, Brandi ML, Croppi E, Cianferotti L, Trinchieri A, Caudarella R, Cupisti A, Anglani F, Del Prete D, GENIAL network, STRAZZULLO, PASQUALE, Vezzoli, G, Terranegra, A, Aloia, A, Arcidiacono, T, Milanesi, L, Mosca, E, Mingione, A, Spotti, D, Cusi, D, Hou, J, Hendy, Gn, Soldati, L, Paloschi, V, Dogliotti, E, Brasacchio, C, Dell'Antonio, G, Montorsi, F, Bertini, R, Bellinzoni, P, Guazzoni, G, Borghi, L, Guerra, A, Allegri, F, Ticinesi, A, Meschi, T, Nouvenne, A, Lupo, A, Fabris, A, Gambaro, G, Strazzullo, Pasquale, Rendina, D, De Filippo, G, Brandi, Ml, Croppi, E, Cianferotti, L, Trinchieri, A, Caudarella, R, Cupisti, A, Anglani, F, Del Prete, D, and Genial, Network

Subjects
Male, Transcription, Genetic, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Kidney, Biochemistry, Endocrinology, Receptors, Site-Directed, Settore MED/14 - NEFROLOGIA, Hypercalciuria, strontium, Promoter Regions, Genetic, transcription factor, messenger RNA, Single Nucleotide, Middle Aged, unclassified drug, Calcium-Sensing, Female, Calcium-sensing receptor, Transcription, Adult, medicine.medical_specialty, Calcium Nephrolithiasis, Genotype, chemistry.chemical_element, Single-nucleotide polymorphism, Calcium, Biology, Nephrolithiasis, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Internal medicine, medicine, claudin, CaSR, Humans, Endocrine Research, Polymorphism, Gene, Transcription factor, Alleles, Calcium sensing receptor, Biochemistry (medical), HEK 293 cells, Promoter, claudin 14, CaSR, Calcium Nephrolithiasis, kidney, medicine.disease, Molecular biology, HEK293 Cells, chemistry, Mutagenesis, Case-Control Studies, Mutagenesis, Site-Directed, Receptors, Calcium-Sensing
Abstract

BACKGROUND: CaSR gene is a candidate for calcium nephrolithiasis. Single-nucleotide polymorphisms (SNPs) encompassing its regulatory region were associated with calcium nephrolithiasis. AIMS: We tested SNPs in the CaSR gene regulatory region associated with calcium nephrolithiasis and their effects in kidney. SUBJECTS AND METHODS: One hundred sixty-seven idiopathic calcium stone formers and 214 healthy controls were genotyped for four CaSR gene SNPs identified by bioinformatics analysis as modifying transcription factor binding sites. Strontium excretion after an oral load was tested in 55 stone formers. Transcriptional activity induced by variant alleles at CaSR gene promoters was compared by luciferase reporter gene assay in HEK-293 and HKC-8 cells. CaSR and claudin-14 mRNA levels were measured by real-time PCR in 107 normal kidney medulla samples and compared in patients with different CaSR genotype. RESULTS: Only rs6776158 (A>G), located in the promoter 1, was associated with nephrolithiasis. Its minor G allele was more frequent in stone formers than controls (37.8% vs 26.4%, P = .001). A reduced strontium excretion was observed in GG homozygous stone formers. Luciferase fluorescent activity was lower in cells transfected with the promoter 1 including G allele at rs6776158 than cells transfected with the A allele. CaSR mRNA levels were lower in kidney medulla samples from homozygous carriers for the G allele at rs6776158 than carriers for the A allele. Claudin-14 mRNA levels were also lower in GG homozygous subjects. CONCLUSIONS: Minor allele at rs6776158 may predispose to calcium stones by decreasing transcriptional activity of the CaSR gene promoter 1 and CaSR expression in kidney tubules.

Published
2013
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7. La clinica della dermatite allergica da contatto con diagnostica differenziale

Author

Palminteri, G, Allegri, F, Caminita, ML, Ferruzza, A, PICCIOTTO, Diego, Giueppe Palminteri, Raffaele Scerrato, Antonino Coppola, Palminteri, G, Allegri, F, Caminita, ML, Ferruzza, A, and Picciotto, D

Subjects
eczema da contatto, eczema fotoallergico da contatto, Settore MED/44 - Medicina Del Lavoro
Published
2012

8. Sulla dermatite da contatto sistemica nella patologia generale e professionale

Author

Palminteri, G, Allegri, F, Coppola, A, Scerrato, R, PICCIOTTO, Diego, VERSO, Maria Gabriella, Giuseppe Palminteri, Raffaele Scerrato, Antonino Coppola, Palminteri, G, Allegri, F, Coppola, A, Scerrato, R, Picciotto, D, and Verso, MG

Subjects
Settore MED/44 - Medicina Del Lavoro, dermatite da contatto irritativa, dermatite allegica da contatto, dermatite da agenti biotici
Published
2012

9. Sulla propedeutica dermatologica nella Medicina del Lavoro

Author

Palminteri, G, Coppola, A, Allegri, F, Ferruzza, A, PICCIOTTO, Diego, VERSO, Maria Gabriella, Giuseppe Palminteri, Raffaele Scerrato, Antonino Coppola, Palminteri, G, Coppola, A, Allegri, F, Ferruzza, A, Picciotto, D, and Verso, MG

Subjects
Settore MED/44 - Medicina Del Lavoro, esposizione lavorativa, dermopatie professionali, dermatite da contatto
Published
2012

10. Sulla predisposizione individuale e prevenzione in dermatologia professionale

Author

Palminteri, G, Allegri, F, Coppola, A, Allegri, D, Ferruzza, A, Lo Cascio, G, Lo Cascio, N, PICCIOTTO, Diego, VERSO, Maria Gabriella, Giuseppe Palminteri, Raffaele Scerrato, Antonino Coppola, Palminteri, G, Allegri, F, Coppola, A, Allegri, D, Ferruzza, A, Lo Cascio, G, Lo Cascio, N, Picciotto, D, and Verso, MG

Subjects
Settore MED/44 - Medicina Del Lavoro, xerosi cutanea, cheloidi, ittiosi
Published
2012

11. Polymorphisms at the regulatory regions of the calcium-sensing receptor gene influence stone risk in primary hyperparathyroidism

Author

Vezzoli G, Scillitani A, Corbetta S, Terranegra A, Dogliotti E, Guarnieri V, Arcidiacono T, Paloschi V, Rainone F, Eller-Vainicher C, Borghi L, Nouvenne A, Guerra A, Meschi T, Allegri F, Cusi D, Spada A, Cole DEC, Hendy GN, Spotti D, Soldati L, Vezzoli, G, Scillitani, A, Corbetta, S, Terranegra, A, Dogliotti, E, Guarnieri, V, Arcidiacono, T, Paloschi, V, Rainone, F, Eller-Vainicher, C, Borghi, L, Nouvenne, A, Guerra, A, Meschi, T, Allegri, F, Cusi, D, Spada, A, Cole, Dec, Hendy, Gn, Spotti, D, and Soldati, L

Published
2011

12. Adherence issues related to sublingual immunotherapy as perceived by allergists

Author

Scurati, S., Frati, F., Passalacqua, G., Puccinelli, P., Hilaire, C., Incorvaia, C., D Avino, G., Comi, R., Lo Schiavo, M., Pezzuto, F., Montera, C., Pio, A., Teresa Ielpo, M., Cellini, F., Vicentini, L., Pecorari, R., Aresu, T., Capra, L., Benedictis, E., Bombi, C., Zauli, D., Vanzi, A., Alberto Paltrinieri, C., Bondioli, A., Paletta, I., Ventura, D., Mei, F., Paolini, F., Colangelo, C., Cavallucci, E., Cucinelli, F., Tinari, R., Ermini, G., Beltrami, V., Novembre, E., Begliomini, C., Marchese, E., Solito, E., Ammannati, V., Molino, G., Galli, E., Baldassini, M., Di Michele, L., Calvani, M., Gidaro, M., Venuti, A., Li Bianchi, E., Benassi, F., Pocobelli, D., Zangari, P., Rocco, M. G., Lo Vecchio, A., Pingitore, G., Grimaldi, O., Schiavino, D., Perrone, N., Antonietta Frieri, M., Di Rienzo, V., Tripodi, S., Scarpa, A., Tomsic, M., Bonaguro, R., Enrico Senna, G., Sirena, A., Turatello, F., Crescioli, S., Favero, E., Billeri, L., Chieco Bianchi, F., Gemignani, C., Zanforlin, M., Angiola Crivellaro, M., Hendrick, B., Maltauro, A., Masieri, S., Elisabetta Conte, M., Fama, M., Pozzan, M., Bonadonna, P., Casanova, S., Vallerani, E., Schiappoli, M., Borghesan, F., Giro, G., Casotto, S., Berardino, L., Zanoni, G., Ariano, R., Aquilina, R., Pellegrino, R., Marsico, P., Del Giudice, A., Narzisi, G., Tomaselli, V., Fornaca, G., Favro, M., Loperfido, B., Gallo, C., Buffoni, S., Gani, F., Raviolo, P., Faggionato, S., Truffelli, T., Vivalda, L., Albano, M., Enzo Rossi, R., Lattuada, G., Bona, F., Quaglio, L., Chiesa, A., Trapani, M., Seminara, R., Cucchi, B., Oderda, S., Borio, G., Galeasso, G., Garbaccio, P., Marco, A., Marengo, F., Cadario, G., Manzoni, S., Vinay, C., Curcio, A., Silvestri, A., Peduto, A., Riario-Sforza, G. G., Maria Forgnone, A., Barocelli, P., Tartaglia, N., Feyles, G., Giacone, A., Ricca, V., Guida, G., Nebiolo, F., Bommarito, L., Heffler, E., Vietti, F., Galimberti, M., Savi, E., Pappacoda, A., Bottero, P., Porcu, S., Felice, G., Berra, D., Francesca Spina, M., Pravettoni, V., Calamari, A. M., Varin, E., Iemoli, E., Lietti, D., Ghiglioni, D., Alessandro Fiocchi, Tosi, A., Poppa, M., Caviglia, A., Restuccia, M., Russello, M., Alciato, P., Manzotti, G., Ranghino, E., Luraschi, G., Rapetti, A., Rivolta, F., Allegri, F., Terracciano, L., Agostinis, F., Paolo Piras, P., Ronchi, G., Gaspardini, G., Caria, V., Tolu, F., Fantasia, D., Carta, P., Moraschini, A., Quilleri, R., Santelli, A., Prandini, P., Del Giudice, G., Apollonio, A., Bonazza, L., Teresa Franzini, M., Branchi, S., Zanca, M., Rinaldi, S., Catelli, L., Zanoletti, T., Cosentino, C., Della Torre, F., Cremonte, L., Musazzi, D., Suli, C., Rivolta, L., Ottolenghi, A., Marino, G., Sterza, G., Sambugaro, R., Orlandini, A., Minale, P., Voltolini, S., Bignardi, D., Omodeo, P., Tiri, A., Milani, S., Ronchi, B., Licardi, G., Bruni, P., Scibilia, J., Schroeder, J., Crosti, F., Maltagliati, A., Alesina, M. R., Mosca, M., Leone, G., Napolitano, G., Di Gruttola, G., Scala, G., Mascio, S., Valente, A., Marchetiello, I., Catello, R., Gazulli, A., Del Prete, A., Varricchio, A. M., Carbone, A., Forestieri, A., Stillitano, M., Leonetti, L., Tirroni, E., Castellano, F., Abbagnara, F., Romano, F., Levanti, C., Cilia, M., Longo, R., Ferrari, A., Merenda, R., Di Ponti, A., Guercio, E., Surace, L., Ammendola, G., Tansella, F., Peccarisi, L., Stragapede, L., Minenna, M., Granato, M., Fuiano, N., Pannofino, A., Ciuffreda, S., Giannotta, A., Morero, G., D Oronzio, L., Taddeo, G., Nettis, E., Cinquepalmi, G., Lamanna, C., Mastrandrea, F., Minelli, M., Salamino, F., Muratore, L., Latorre, F., Quarta, C., Ventura, M., D Ippolito, G., Giannoccaro, F., Dambra, P., Pinto, L., Triggiani, M., Munno, G., Manfredi, G., Lonero, G., Damiano, V., Errico, G., Di Leo, E., Manzari, F., Spagna, V., Arsieni, A., Matarrese, A., Mazzarella, G., Scarcia, G., Scarano, R., Ferrannini, A., Pastore, A., Maionchi, P., Filannino, L., Tria, M., Giuliano, G., Damiani, E., Scichilone, N., Marchese, M., Lucania, A., Marino, M., Strazzeri, L., Tumminello, S., Vitale, G. I., Gulotta, S., Gragotto, G., Zambito, M., Greco, D., Valenti, G., Licitra, G., Cannata, E., Filpi, R., Contraffatto, M., Sichili, S., Randazzo, S., Scarantino, G., Lo Porto, B., Pavone, F., Di Bartolo, C., Paternò, A., Rapisarda, F., Laudani, E., Leonardi, S., Padua, V., Cabibbo, G., Marino Guzzardi, G., Deluca, F., Agozzino, C., Pettinato, R., Ghini, M., Scurati S., Frati F., Passalacqua G., Puccinelli P., Hilaire C., Incorvaia C., D'Avino G., Comi R., Lo Schiavo M., Pezzuto F., Montera C., Pio A., Teresa Ielpo M., Cellini F., Vicentini L., Pecorari R., Aresu T., Capra L., De Benedictis E., Bombi C., Zauli D., Vanzi A., Alberto Paltrinieri C., Bondioli A., Paletta I., Ventura D., Mei F., Paolini F., Colangelo C., Cavallucci E., Cucinelli F., Tinari R., Ermini G., Beltrami V., Novembre E., Begliomini C., Marchese E., Solito E., Ammannati V., Molino G., Galli E., Baldassini M., Di Michele L., Calvani M., Gidaro M., Venuti A., Li Bianchi E., Benassi F., Pocobelli D., Zangari P., De Rocco M.G., Lo Vecchio A., Pingitore G., Grimaldi O., Schiavino D., Perrone N., Antonietta Frieri M., Di Rienzo V., Tripodi S., Scarpa A., Tomsic M., Bonaguro R., Enrico Senna G., Sirena A., Turatello F., Crescioli S., Favero E., Billeri L., Chieco Bianchi F., Gemignani C., Zanforlin M., Angiola Crivellaro M., Hendrick B., Maltauro A., Masieri S., Elisabetta Conte M., Fama M., Pozzan M., Bonadonna P., Casanova S., Vallerani E., Schiappoli M., Borghesan F., Giro G., Casotto S., Berardino L., Zanoni G., Ariano R., Aquilina R., Pellegrino R., Marsico P., Del Giudice A., Narzisi G., Tomaselli V., Fornaca G., Favro M., Loperfido B., Gallo C., Buffoni S., Gani F., Raviolo P., Faggionato S., Truffelli T., Vivalda L., Albano M., Enzo Rossi R., Lattuada G., Bona F., Quaglio L., Chiesa A., Trapani M., Seminara R., Cucchi B., Oderda S., Borio G., Galeasso G., Garbaccio P., De Marco A., Marengo F., Cadario G., Manzoni S., Vinay C., Curcio A., Silvestri A., Peduto A., Riario-Sforza G.G., Maria Forgnone A., Barocelli P., Tartaglia N., Feyles G., Giacone A., Ricca V., Guida G., Nebiolo F., Bommarito L., Heffler E., Vietti F., Galimberti M., Savi E., Pappacoda A., Bottero P., Porcu S., Felice G., Berra D., Francesca Spina M., Pravettoni V., Calamari A.M., Varin E., Iemoli E., Lietti D., Ghiglioni D., Fiocchi A., Tosi A., Poppa M., Caviglia A., Restuccia M., Russello M., Alciato P., Manzotti G., Ranghino E., Luraschi G., Rapetti A., Rivolta F., Allegri F., Terracciano L., Agostinis F., Paolo Piras P., Ronchi G., Gaspardini G., Caria V., Tolu F., Fantasia D., Carta P., Moraschini A., Quilleri R., Santelli A., Prandini P., Del Giudice G., Apollonio A., Bonazza L., Teresa Franzini M., Branchi S., Zanca M., Rinaldi S., Catelli L., Zanoletti T., Cosentino C., Della Torre F., Cremonte L., Musazzi D., Suli C., Rivolta L., Ottolenghi A., Marino G., Sterza G., Sambugaro R., Orlandini A., Minale P., Voltolini S., Bignardi D., Omodeo P., Tiri A., Milani S., Ronchi B., Licardi G., Bruni P., Scibilia J., Schroeder J., Crosti F., Maltagliati A., Alesina M.R., Mosca M., Leone G., Napolitano G., Di Gruttola G., Scala G., Mascio S., Valente A., Marchetiello I., Catello R., Gazulli A., Del Prete A., Varricchio A.M., Carbone A., Forestieri A., Stillitano M., Leonetti L., Tirroni E., Castellano F., Abbagnara F., Romano F., Levanti C., Cilia M., Longo R., Ferrari A., Merenda R., Di Ponti A., Guercio E., Surace L., Ammendola G., Tansella F., Peccarisi L., Stragapede L., Minenna M., Granato M., Fuiano N., Pannofino A., Ciuffreda S., Giannotta A., Morero G., D'Oronzio L., Taddeo G., Nettis E., Cinquepalmi G., Lamanna C., Mastrandrea F., Minelli M., Salamino F., Muratore L., Latorre F., Quarta C., Ventura M., D'Ippolito G., Giannoccaro F., Dambra P., Pinto L., Triggiani M., Munno G., Manfredi G., Lonero G., Damiano V., Errico G., Di Leo E., Manzari F., Spagna V., Arsieni A., Matarrese A., Mazzarella G., Scarcia G., Scarano R., Ferrannini A., Pastore A., Maionchi P., Filannino L., Tria M., Giuliano G., Damiani E., Scichilone N., Marchese M., Lucania A., Marino M., Strazzeri L., Tumminello S., Vitale G.I., Gulotta S., Gragotto G., Zambito M., Greco D., Valenti G., Licitra G., Cannata E., Filpi R., Contraffatto M., Sichili S., Randazzo S., Scarantino G., Lo Porto B., Pavone F., Di Bartolo C., Paterno A., Rapisarda F., Laudani E., Leonardi S., Padua V., Cabibbo G., Marino Guzzardi G., Deluca F., Agozzino C., Pettinato R., Ghini M., Scurati S, Frati F, Passalacqua G, Puccinelli P, Hilaire C, Incorvaia I, D'Avino G, Comi R, Lo Schiavio M, Pezzuto F, Montera C, Pio A, Ielpo MT, Cellini F, Vicentini L, Pecorari R, Aresu T, Capra L, De Benedictis E, Bombi C, Zauli D, and et al

Subjects
medicine.medical_specialty, Pathology, genetic structures, efficacy, Alternative medicine, Medicine (miscellaneous), Adherence, Cost, Efficacy, Side effects, Sublingual immunotherapy, Settore MED/10 - Malattie Dell'Apparato Respiratorio, sublingual immunotherapy, ALLERGEN, cost, medicine, Subcutaneous immunotherapy, Sublingual immunotherapy, adherence, Clinical efficacy, Intensive care medicine, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), sublingual immunoterapy, Original Research, Asthma, AEROALLERGENS, side effects, business.industry, Health Policy, medicine.disease, Slit, eye diseases, Clinical trial, Patient Preference and Adherence, immunotherapy, sense organs, Allergists, ADHERENCE TO TREATMENT, business, Social Sciences (miscellaneous)
Abstract

Silvia Scurati1, Franco Frati1, Gianni Passalacqua2, Paola Puccinelli1, Cecile Hilaire1, Cristoforo Incorvaia3, Italian Study Group on SLIT Compliance 1Scientific and Medical Department, Stallergenes, Milan, Italy; 2Allergy and Respiratory Diseases, Department of Internal Medicine, Genoa; 3Allergy/Pulmonary Rehabilitation, ICP Hospital, Milan, ItalyObjectives: Sublingual immunotherapy (SLIT) is a viable alternative to subcutaneous immunotherapy to treat allergic rhinitis and asthma, and is widely used in clinical practice in many European countries. The clinical efficacy of SLIT has been established in a number of clinical trials and meta-analyses. However, because SLIT is self-administered by patients without medical supervision, the degree of patient adherence with treatment is still a concern. The objective of this study was to evaluate the perception by allergists of issues related to SLIT adherence.Methods: We performed a questionnaire-based survey of 296 Italian allergists, based on the adherence issues known from previous studies. The perception of importance of each item was assessed by a VAS scale ranging from 0 to 10.Results: Patient perception of clinical efficacy was considered the most important factor (ranked 1 by 54% of allergists), followed by the possibility of reimbursement (ranked 1 by 34%), and by the absence of side effects (ranked 1 by 21%). Patient education, regular follow-up, and ease of use of SLIT were ranked first by less than 20% of allergists.Conclusion: These findings indicate that clinical efficacy, cost, and side effects are perceived as the major issues influencing patient adherence to SLIT, and that further improvement of adherence is likely to be achieved by improving the patient information provided by prescribers.Keywords: adherence, sublingual immunotherapy, efficacy, cost, side effects

Published
2010

15. Polymorphisms of the calcium-sensing receptor gene and stones in primary hyperparathyroidism

Author

Arcidiacono T, Rainone F, Paloschi V, Scillitani A, Terranegra A, Dogliotti E, Guarnieri V, Aloia A, Borghi L, Guerra A, Nouvenne A, Prati B, Allegri F, Meschi T, Eller-Vainicher C, Corbetta S, Spada A, Soldati L, Vezzoli G, Arcidiacono, T, Rainone, F, Paloschi, V, Scillitani, A, Terranegra, A, Dogliotti, E, Guarnieri, V, Aloia, A, Borghi, L, Guerra, A, Nouvenne, A, Prati, B, Allegri, F, Meschi, T, Eller-Vainicher, C, Corbetta, S, Spada, A, Soldati, L, and Vezzoli, G

Published
2009

16. Systemic lupus erythematosus in Europe at the change of the millennium: lessons from the 'Euro-Lupus Project'

Author

Cervera, R, ABARCA-COSTALAGO, M, Abramovicz, D, Allegri, F, Annunziata, P, Aydintug, Ao, Bacarelli, Mr, Bellisai, F, Bernardino, I, BIERNAT-KALUZA, E, Blockmans, D, Boki, K, Bracci, L, Campanella, V, Camps, Mt, Carcassi, C, Cattaneo, R, Cauli, A, CHWALINSKA-SADOWSKA, H, Contu, L, Cosyns, Jp, Danieli, Mg, Dcruz, D, Depresseux, G, Direskeneli, H, Domenech, I, Espinosa, G, FERNANDEZ-NEBRO, A, Ferrara, Gb, Font, J, Frutos, Ma, Galeazzi, M., GARCIA-CARRASCO, M, GARCIA IGLESIAS MF, GARCIA-TOBARUELA, A, George, J, Gil, A, GONZALEZ-SANTOS, P, Grana, M, Gul, A, Haga, Hj, DE HARO-LIGER, M, Houssiau, F, Hughes, Gr, Ingelmo, M, JEDRYKA-GORAL, A, Khamashta, Ma, Lavilla, P, Levi, Y, LOPEZ-DULPA, M, LOPEZ-SOTO, A, Maldykowa, H, Marcolongo, R, Mathieu, A, Morozzi, G, Nicolopoulou, N, Papasteriades, C, Passiu, G, Perello, I, Petera, P, Petrovic, R, Piette, Jc, Pintado, V, DE PITA, O, Popovic, R, Pucci, G, Puddu, P, DE RAMON, E, RAMOS-CASALS, M, RODRIGUEZ-ANDREU, J, RUIZ-IRASTORZA, G, SANCHEZ-LORA, J, Sanna, G, Scorza, R, Sebastiani, Gd, Sherer, Y, Shoenfeld, Y, Simpatico, A, Sinico, Ra, Smolen, J, Tincani, A, Tokgoz, G, URBANO-MARQUEZ, A, Vasconcelos, C, Vazquez, Jj, Veronesi, J, Vianna, J, Vivancos, J, UCL - MD/MINT - Département de médecine interne, UCL - (SLuc) Service de rhumatologie, UCL - MD/MNOP - Département de morphologie normale et pathologique, UCL - (SLuc) Service d'anatomie pathologique, Cervera, R, Abarca Costalago, M, Abramovicz, D, Allegri, F, Annunziata, P, Aydintug, A, Bacarelli, M, Bellisai, F, Bernardino, I, Biernat Kaluza, E, Blockmans, D, Boki, K, Bracci, L, Campanella, V, Camps, M, Carcassi, C, Cattaneo, R, Cauli, A, Chwalinska Sadowska, H, Contu, L, Cosyns, J, Danieli, M, D́cruz, D, Depresseux, G, Direskeneli, H, Domènech, I, Espinosa, G, Fernández Nebro, A, Ferrara, G, Font, J, Frutos, M, Galeazzi, M, García Carrasco, M, García Iglesias, M, García Tobaruela, A, George, J, Gil, A, González Santos, P, Grana, M, Gül, A, Haga, H, de Haro Liger, M, Houssiau, F, Hughes, G, Ingelmo, M, Jedryka Góral, A, Khamashta, M, Lavilla, P, Levi, Y, López Dupla, M, López Soto, A, Maldykowa, H, Marcolongo, R, Mathieu, A, Morozzi, G, Nicolopoulou, N, Papasteriades, C, Passiu, G, Perelló, I, Petera, P, Petrovic, R, Piette, J, Pintado, V, de Pita, O, Popovic, R, Pucci, G, Puddu, P, de Ramón, E, Ramos Casals, M, Rodríguez Andreu, J, Ruiz Irastorza, G, Sánchez Lora, J, Sanna, G, Scorza, R, Sebastiani, G, Sherer, Y, Shoenfeld, Y, Simpatico, A, Sinico, R, Smolen, J, Tincani, A, Tokgöz, G, Urbano Márquez, A, Vasconcelos, C, Vázquez, J, Veronesi, M, Vianna, J, and Vivancos, J

Subjects
Male, medicine.medical_specialty, Prognosi, Epidemiology, Immunology, Systemic lupus erythematosu, Disease, Prognostic factors, Autoimmune Disease, Follow-Up Studie, Autoimmune Diseases, Cohort Studies, Systemic lupus erythematosus, immune system diseases, medicine, Immunology and Allergy, Humans, Lupus Erythematosus, Systemic, Prospective Studies, Age of Onset, Mortality, Prospective cohort study, skin and connective tissue diseases, Survival rate, Prognostic factor, business.industry, medicine.disease, Prognosis, Europe, Survival Rate, Prospective Studie, Family medicine, Antibodies, Antinuclear, Cohort, Female, Cohort Studie, Age of onset, Morbidity, business, Human, Cohort study, Follow-Up Studies
Abstract

The "Euro-Lupus Cohort" is composed by 1000 patients with systemic lupus erythematosus (SLE) that have been followed prospectively since 1991. These patients have been gathered by a European consortium-the "Euro-Lupus Project Group". This consortium was originated as part of the network promoted by the "European Working Party on SLE", a working group created in 1990 in order to promote research in Europe on the different problems related to this disease. The "Euro-Lupus Cohort" provides an updated information on the SLE morbidity and mortality characteristics in the present decade as well as defines several clinical and immunological prognostic factors. © 2005 Elsevier B.V. All rights reserved.

Published
2006

17. Idiopathic Calcium Nephrolithiasis and Hypovitaminosis D: A Case-control Study

Author

Ticinesi, A, Nouvenne, A, Ferraro, Pietro Manuel, Folesani, G, Lauretani, F, Allegri, F, Guerra, A, Cerundolo, N, Aloe, R, Lippi, G, Maggio, M, Gambaro, Giovanni, Borghi, L, Meschi, T., Ferraro, Pietro Manuel (ORCID:0000-0002-1379-022X), Gambaro, Giovanni (ORCID:0000-0001-5733-2370), Ticinesi, A, Nouvenne, A, Ferraro, Pietro Manuel, Folesani, G, Lauretani, F, Allegri, F, Guerra, A, Cerundolo, N, Aloe, R, Lippi, G, Maggio, M, Gambaro, Giovanni, Borghi, L, Meschi, T., Ferraro, Pietro Manuel (ORCID:0000-0002-1379-022X), and Gambaro, Giovanni (ORCID:0000-0001-5733-2370)

Abstract

To investigate the association between vitamin D deficiency (25-hydroxyvitamin D <20 ng/mL) and idiopathic calcium nephrolithiasis (ICN).

Published
2016

18. Inhibiting insulin resistance mechanisms by DTS phytocompound: an experimental study on metabolic syndrome-prone adipocytes

Author

Catanzaro, R., Lorenzett, A., Allegri, F., Hariom Yadav, Solimene, U., Kumaraju, A. K., Minelli, E., Tomella, C., Polimeni, A., and Marotta, F.

Subjects
Metabolic Syndrome, Oxidative Stress, Sulfonamides, Thiadiazoles, Adipocytes, NF-kappa B, Humans, Nitric Oxide Synthase Type II, Insulin Resistance, Nitric Oxide, Cells, Cultured
Abstract

The present study was designed to determine whether DTS a phytocompound endowed with antioxidant properties, could beneficially modulate nitric oxide (NO) production stimulated by lipopolysaccharide (LPS) and tumor necrosis factor-alpha (TNF-alpha) in adipocytes. Combined stimulation (CS-treatment) exerted by using 5 microg/ml of LPS together with 100 ng/ml of TNF-alpha significantly enhanced NO production in 3T3-L1 adipocytes. Preincubation of the adipocytes with DTS (10-30 mM) inhibited such phenomenon in a dose-dependent fashion. The production of NO was decreased by 52% at the concentration of 30mM of DTS. The decrease in NO production by DTS was associated also with a decrease in inducible nitric oxide synthase (iNOS) protein and iNOS mRNA expression. Nuclear factor-kappa B (NF-kappaB) was significantly enhanced by CS-treatment, while the pretreatment with 30 mM of DTS prevented the activity by 27%. IL-6 production in 3T3-L1 adipocytes was markedly increased by CS stimulus, and the enhanced secretion of IL-6 was suppressed in a dose-dependent manner by DTS. These results suggest that DTS regulates iNOS expression and NO production in adipocytes through the modulating activation of NF-kappaB and may have a potential clinical application within protocols designed for treating metabolic syndrome. (www.actabiomedica.it).

Published
2013

19. Lessons from the 'Euro-Lupus Cohort'

Author

Cervera, R., Abarca Costalago, M., Abramovicz, D., Allegri, F., PASQUALE ANNUNZIATA, Aydintug, Ao, Bacarelli, Mr, Bellisai, F., Bernardino, I., Biernat Kaluza, E., Blockmans, D., Boki, K., LUISA BRACCI, Campanella, V., Camps, Mt, Carcassi, C., Cattaneo, R., Cauli, A., Chwalinska Sadowska, H., Contu, L., Cosyns, Jp, Danieli, Mg, D Cruz, D., Depresseux, G., Direskeneli, H., Domènech, I., Espinosa, G., Fernández Nebro, A., Ferrara, Gb, Font, J., Frutos, Ma, MAURO GALEAZZI, García Carrasco, M., GARCÍA IGLESIAS MF, García Tobaruela, A., George, J., Gil, A., González Santos, P., Grana, M., Gül, A., Haga, Hj, Haro Liger, M., Houssiau, F., Hughes, Gr, Ingelmo, M., Jedryka Góral, A., Khamashta, Ma, Lavilla, P., Levi, Y., López Dupla, M., López Soto, A., Maldykowa, H., Marcolongo, R., Mathieu, A., GABRIELLA MOROZZI, Nicolopoulou, N., Papasteriades, C., Passiu, G., Perelló, I., Petera, P., Petrovic, R., Piette, Jc, Pintado, V., Pita, O., Popovic, R., Pucci, G., Puddu, P., Ramón, E., Ramos Casals, M., Rodríguez Andreu, J., Ruiz Irastroza, G., Sánchez Lora, J., Sanna, G., Scorza, R., Sebastini, Gd, Sherer, Y., Shoenfeld, Y., Simpatico, A., Sinico, Ra, Smolen, J., Tincani, A., Tokgöz, G., Urbano Márquez, A., Vasconcelos, C., Vázquez, Jj, Veronesi, M., Vianni, J., Vivancos, J., EUROPEAN WORKING PARTY ON SYSTEMIC LUPUS ERYTHEMATOSUS, Cervera, R, Abarca Costalago, M, Abramovicz, D, Allegri, F, Annunziata, P, Aydintug, A, Bacarelli, M, Bellisai, F, Bernardino, I, Biernat Kaluza, E, Blockmans, D, Boki, K, Bracci, L, Campanella, V, Camps, M, Carcassi, C, Cattaneo, R, Cauli, A, Chwalinska Sadowska, H, Contu, L, Cosyns, J, Danieli, M, D'Cruz, D, Depresseux, G, Direskeneli, H, Domènech, I, Espinosa, G, Fernández Nebro, A, Ferrara, G, Font, J, Frutos, M, Galeazzi, M, García Carrasco, M, García Iglesias, M, García Tobaruela, A, George, J, Gil, A, González Santos, P, Grana, M, Gül, A, Haga, H, de Haro Liger, M, Houssiau, F, Hughes, G, Ingelmo, M, Jedryka Góral, A, Khamashta, M, Lavilla, P, Levi, Y, López Dupla, M, López Soto, A, Maldykowa, H, Marcolongo, R, Mathieu, A, Morozzi, G, Nicolopoulou, N, Papasteriades, C, Passiu, G, Perelló, I, Petera, P, Petrovic, R, Piette, J, Pintado, V, de Pita, O, Popovic, R, Pucci, G, Puddu, P, de Ramón, E, Ramos Casals, M, Rodríguez Andreu, J, Ruiz Irastroza, G, Sánchez Lora, J, Sanna, G, Scorza, R, Sebastini, G, Sherer, Y, Shoenfeld, Y, Simpatico, A, Sinico, R, Smolen, J, Tincani, A, Tokgöz, G, Urbano Márquez, A, Vasconcelos, C, Vázquez, J, Veronesi, M, Vianni, J, and Vivancos, J

Subjects
Adult, Male, Adolescent, Prognosi, Middle Aged, Prognosis, Cohort Studies, Europe, Survival Rate, Prospective Studie, Antibodies, Antinuclear, Humans, Lupus Erythematosus, Systemic, Female, Prospective Studies, Cohort Studie, Age of Onset, Human
Abstract

The "Euro-Lupus Cohort" is composed by 1,000 patients with systemic lupus erythematosus (SLE) that have been followed prospectively since 1991. These patients have been gathered by a European consortium - the "Euro-Lupus Project Group". This consortium was originated as part of the network promoted by the "European Working Party on SLE", a working group created in 1990 in order to promote research in Europe on the different problems related to this disease. The "Euro-Lupus Cohort" provides an updated information on the SLE morbidity and mortality characteristics in the present decade as well as defines several clinical and immunological prognostic factors.

Published
2002

20. Beneficial effect of a sturgeon-based bioactive compound on gene expression of tumor necrosis factor-alpha, matrix metalloproteinases and type-10 collagen in human chondrocytes

Author

Roberto CATANZARO, Marotta F, Jain S, Rastmanesh R, Allegri F, Celep G, Lorenzetti A, Polimeni A, and Yadav H

Subjects
Fish Proteins, Male, Tumor Necrosis Factor-alpha, Interleukin-1beta, Fishes, NF-kappa B, Complex Mixtures, Middle Aged, Chondrocytes, Gene Expression Regulation, Matrix Metalloproteinase 13, Animals, Humans, Female, Matrix Metalloproteinase 1, Cells, Cultured, Aged, Collagen Type X
Abstract

In the present study, we examined the effect of a marine bioactive compound containing high-purity caviar-derived DNA, collagen elastin and protein extracts from sturgeon (LD-1227, Caviarlieri, Laboratoires Dom, Switzerland) on IL-1beta-induced activation and production of TNFalpha and MMP-13 in human osteo-arthritis (OA) chondrocytes and intracellular signaling factors. Human chondrocytes were derived from OA cartilage and stimulated with IL-1beta. Gene expression of TNFalpha, MMP-13, MMP-1 and Col10A1 was measured by quantitative RT-PCR. TNFalpha protein in culture medium was determined using cytokine-specific ELISA. Western immunoblotting was used to analyze the MMP-13 production in the culture medium and the activation of NF-kB. DNA binding activity of NF-kB p65 was determined using a highly sensitive and specific ELISA. MMP-13 activity in the culture medium was assayed by gelatine zymography. LD-1227 significantly decreased IL-1beta-stimulated gene expression and production of TNFalpha, MMP-1, MMP-13 and Col10A1 in human chondrocytes. The inhibitory effect of LD-1227 on the IL-1beta-induced expression of these genes was mediated at least in part via suppression of NF-kB p65. These data show that LD-1227 can inhibit IL-1beta-induced proliferation and inflammatory reactions via inhibited activation of the transcription factor NF-kB pathway in human chondrocytes derived from OA patients. These novel pharmacological actions of LD-1227 on IL-1beta-stimulated human OA chondrocytes provide suggestions that this marine biology compound may inhibit cartilage degradation by suppressing IL-1beta-mediated activation and the catabolic response in human chondrocytes.

Published
2012

21. Diagnostic value of anti-mutated citrullinated vimentin in comparison to anti-cyclic citrullinated peptide and anti-viral citrullinated peptide 2 antibodies in rheumatoid arthritis: An Italian multicentric study and review of the literature

Author

Bartoloni, E., Alunno, A., Bistoni, O., Bizzaro, N., PAOLA MIGLIORINI, Morozzi, G., Doria, A., Mathieu, A., Lotzniker, M., Allegri, F., Riccieri, V., Alpini, C., Gabrielli, A., Tampoia, M., Gerli, R., and FEDERICO PRATESI

Subjects
musculoskeletal diseases, rheumatoid arthritis, Immunology, Arthritis, Enzyme-Linked Immunosorbent Assay, Vimentin, Peptides, Cyclic, Epitope, Arthritis, Rheumatoid, diagnostics, Humans, Immunology and Allergy, Rheumatoid factor, Medicine, anti-mutated citrullinated vimentin antibodies, Autoantibodies, biology, business.industry, Reproducibility of Results, medicine.disease, ROC Curve, anti-viral citrullinated peptide 2 antibodies, Rheumatoid arthritis, Anti-mutated citrullinated vimentin antibodies, Anti-viral citrullinated peptide 2 antibodies, Diagnostics, biology.protein, Biomarker (medicine), Antibody, Mutated citrullinated vimentin, business
Abstract

In the last years, the detection of antibodies (Abs) against citrullinated peptides (ACPA) has largely replaced rheumatoid factor (RF) as the most helpful biomarker in the diagnosis of rheumatoid arthritis (RA). Current assays detect ACPA reactivity with epitopes on various different citrullinated proteins. Among these, anti-cyclic citrullinated peptide (CCP) Abs have been widely demonstrated to be an important diagnostic and prognostic tool because of their high specificity. Recently, citrullinated vimentin, a protein highly released in synovial microenvironment, has been identified as potential autoantigen in the pathophysiology of RA and an enzyme-linked immunosorbent assay (ELISA) for the detection of Abs directed against a mutated citrullinated vimentin (anti-MCV) was developed. Several recent studies evaluating the characteristics of anti-MCV in comparison to anti-CCP Abs, have given conflicting results. Anti-MCV have been demonstrated to perform better than anti-CCP as predictor of radiographic damage. Conversely, its additional diagnostic and prognostic role in comparison to anti-CCP in both early and established RA is controversial. Aim of this study was to evaluate the diagnostic performance of anti-MCV in RA and to compare it to anti-CCP and the recently developed assay targeting viral citrullinated peptide 2 (VCP2) in a large cohort of RA patients (n=285), healthy subjects and other disease controls (n=227). Anti-MCV resulted to have a sensitivity of 59% and a specificity of 92%. In comparison, anti-CCP and anti-VCP2 displayed a sensitivity of 77% and 61% and a specificity of 96% and 95%, respectively. Of interest, at the manufacturer recommended cutoff value of 20U/mL, a high percentage of healthy subjects as well as Epstein Barr (EBV) and hepatitis C (HCV) virus infected patients resulted anti-MCV positive. In our large cohort of RA patients, anti-MCV demonstrated lower sensitivity than anti-CCP and VCP2 test, thus not allowing to confirm previously published data. Moreover, the high rate of detection in infectious diseases limits its diagnostic value in undifferentiated arthritis.

Published
2012

22. Antiprothrombin antibodies: a comparative analysis of home made and commercial methods. A collaborative study of the 'Forum Interdisciplinare per la Ricerca nelle Malattie Autoimmuni (FIRMA)'

Author

Tincani, A, Morozzi, G, Afeltra, A, Alessandri, Cristiano, Allegri, F, Bistoni, O, Bizzaro, N, Caccavo, D, Galeazzi, M, Gerli, R, Giovannelli, L, Longobardo, G, Lotzniker, M, Malacarne, F, Migliorini, P, Parodi, A, Pregnolato, F, Radice, A, Riccieri, Valeria, Ruffelli, M, Sinico, Ra, Tozzoli, R, Villalta, D, Marcolongo, R, and Meroni, P.

Published
2007

23. Decreased transcriptional activity of calcium-sensing receptor gene promoter 1 is associated with calcium nephrolithiasis

Author

Vezzoli, G, Terranegra, A, Aloia, A, Arcidiacono, T, Milanesi, L, Mosca, E, Mingione, A, Spotti, D, Cusi, D, Hou, J, Hendy, Gn, Soldati, L, Paloschi, V, Dogliotti, E, Brasacchio, C, Dell'Antonio, G, Montorsi, F, Bertini, R, Bellinzoni, P, Guazzoni, G, Borghi, L, Guerra, A, Allegri, F, Ticinesi, A, Meschi, T, Nouvenne, A, Lupo, A, Fabris, A, Gambaro, Giovanni, Strazzullo, P, Rendina, D, De Filippo, G, Brandi, Ml, Croppi, E, Cianferotti, L, Trinchieri, A, Caudarella, R, Cupisti, A, Anglani, F, Del Prete, D., Gambaro, Giovanni (ORCID:0000-0001-5733-2370), Vezzoli, G, Terranegra, A, Aloia, A, Arcidiacono, T, Milanesi, L, Mosca, E, Mingione, A, Spotti, D, Cusi, D, Hou, J, Hendy, Gn, Soldati, L, Paloschi, V, Dogliotti, E, Brasacchio, C, Dell'Antonio, G, Montorsi, F, Bertini, R, Bellinzoni, P, Guazzoni, G, Borghi, L, Guerra, A, Allegri, F, Ticinesi, A, Meschi, T, Nouvenne, A, Lupo, A, Fabris, A, Gambaro, Giovanni, Strazzullo, P, Rendina, D, De Filippo, G, Brandi, Ml, Croppi, E, Cianferotti, L, Trinchieri, A, Caudarella, R, Cupisti, A, Anglani, F, Del Prete, D., and Gambaro, Giovanni (ORCID:0000-0001-5733-2370)

Abstract

CaSR gene is a candidate for calcium nephrolithiasis. Single-nucleotide polymorphisms (SNPs) encompassing its regulatory region were associated with calcium nephrolithiasis.

Published
2013

24. Dietary habits in women with recurrent idiopathic calcium nephrolithiasis

Author

Meschi, T, Nouvenne, A, Ticinesi, A, Prati, B, Guerra, A, Allegri, F, Pigna, F, Soldati, L, Vezzoli, G, Gambaro, Giovanni, Lauretani, F, Maggio, M, Borghi, L., Gambaro, Giovanni (ORCID:0000-0001-5733-2370), Meschi, T, Nouvenne, A, Ticinesi, A, Prati, B, Guerra, A, Allegri, F, Pigna, F, Soldati, L, Vezzoli, G, Gambaro, Giovanni, Lauretani, F, Maggio, M, Borghi, L., and Gambaro, Giovanni (ORCID:0000-0001-5733-2370)

Abstract

Nutrition has been widely recognized to influence the risk of kidney stone formation. Therefore the aim of our study was to assess: a) whether usual diet of women with idiopathic calcium nephrolithiasis (ICN) living in Parma (Northern-Italy) is different compared to healthy controls, b) how their diet differs from Italian National guidelines and c) whether it is related to nephrolithiasis clinical course.

Published
2012

27. Effects of a low-salt diet on idiopathic hypercalciuria in calcium-oxalate stone formers: a 3-mo randomized controlled trial.

Author

Nouvenne, A, Meschi, T, Prati, B, Guerra, A, Allegri, F, Vezzoli, G, Soldati, L, Gambaro, Giovanni, Maggiore, U, Borghi, L., Gambaro, Giovanni (ORCID:0000-0001-5733-2370), Nouvenne, A, Meschi, T, Prati, B, Guerra, A, Allegri, F, Vezzoli, G, Soldati, L, Gambaro, Giovanni, Maggiore, U, Borghi, L., and Gambaro, Giovanni (ORCID:0000-0001-5733-2370)

Abstract

BACKGROUND: A direct relation exists between sodium and calcium excretion, but randomized studies evaluating the sustained effect of a low-salt diet on idiopathic hypercalciuria, one of the main risk factors for calcium-oxalate stone formation, are still lacking. OBJECTIVE: Our goal was to evaluate the effect of a low-salt diet on urinary calcium excretion in patients affected by idiopathic calcium nephrolithiasis. DESIGN: Patients affected by idiopathic calcium stone disease and hypercalciuria (>300 mg Ca/d in men and >250 mg Ca/d in women) were randomly assigned to receive either water therapy alone (control diet) or water therapy and a low-salt diet (low-sodium diet) for 3 mo. Twenty-four-hour urine samples were obtained twice from all patients: one sample at baseline on a free diet and one sample after 3 mo of treatment. RESULTS: A total of 210 patients were randomly assigned to receive a control diet (n = 102) or a low-sodium diet (n = 108); 13 patients (2 on the control diet, 11 on the low-sodium diet) withdrew from the trial. At the follow-up visit, patients on the low-sodium diet had lower urinary sodium (mean +/- SD: 68 +/- 43 mmol/d at 3 mo compared with 228 +/- 57 mmol/d at baseline; P < 0.001). Concomitant with this change, they showed lower urinary calcium (271 +/- 86 mg/d at 3 mo compared with 361 +/- 129 mg/d on the control diet, P < 0.001) and lower oxalate excretion (28 +/- 8 mg/d at 3 mo compared with 32 +/- 10 mg/d on the control diet, P = 0.001). Urinary calcium was within the normal range in 61.9% of the patients on the low-salt diet and in 34.0% of those on the control diet (difference: +27.9%; 95% CI: +14.4%, +41.3%; P < 0.001). CONCLUSION: A low-salt diet can reduce calcium excretion in hypercalciuric stone formers. This trial was registered at clinicaltrials.gov as NCT01005082.

Published
2010

28. Laboratory criteria of the obstetrical antiphospholipid syndrome. Data from a multicentric prospective European women cohort.

Author

Boffa, Marie Claire, Boinot, C, De Carolis, Sara, Roveri Querini, P, Aurousseau, Mh, Allegri, F, Nicaise Roland, P, Barra, A, Botta, Angela, Ambrozic, A, Avcin, T, Tincani, A., Boffa , Marie Claire, De Carolis, Sara (ORCID:0000-0002-5160-7609), Boffa, Marie Claire, Boinot, C, De Carolis, Sara, Roveri Querini, P, Aurousseau, Mh, Allegri, F, Nicaise Roland, P, Barra, A, Botta, Angela, Ambrozic, A, Avcin, T, Tincani, A., Boffa , Marie Claire, and De Carolis, Sara (ORCID:0000-0002-5160-7609)

Abstract

A debate on updating the laboratory criteria of antiphospholipid syndrome (APS) was recently opened in view to lower the risk of over diagnosis of the syndrome. Based on data related to thrombotic APS, it proposes the exclusion of anticardiolipin antibodies (aCL) and anti-beta2-glycoprotein 1 (a-beta2-GPI) IgM detection. Here, we examine this possibility in a study which focuses on obstetrical APS (OAPS). We report new data on a prospective multicenter European cohort of 109 pregnant women having APS. Among them, 73 had purely obstetrical APS, not associated to autoimmune diseases or thrombosis. Isolated antibodies and isolated aCL positivity were present in 50/109 (46%) and in 34/109 (31%) of the women, respectively. An isolated a-beta2-GPI IgM was present in three women. These results suggest that aCL and a-beta2-GPI IgM cannot be dropped for the diagnosis and classification of OAPS. The low level of some antibodies associated with severe obstetrical complications raise the issue of keeping or not the same laboratory criteria for OAPS and for thrombotic APS and whether additional criteria after large prospective studies could further improve diagnosis.

Published
2009

29. Antinucleosome antibodies in primary antiphospholipid syndrome: A hint at systemic autoimmunity?

Author

Andreoli, L, Pregnolato, F, Burlingame, R, Allegri, F, Rizzini, S, Fanelli, V, Radice, A, Corace, C, Sinico, R, Meroni, P, Tincani, A, Tincani, A., SINICO, RENATO ALBERTO, Andreoli, L, Pregnolato, F, Burlingame, R, Allegri, F, Rizzini, S, Fanelli, V, Radice, A, Corace, C, Sinico, R, Meroni, P, Tincani, A, Tincani, A., and SINICO, RENATO ALBERTO

Abstract

Background: Antinucleosome antibodies (anti-NCS) are reported to be highly sensitive and specific for systemic lupus erythematosus (SLE) and to correlate with disease activity. They may appear in early stages of the disease, in particular before anti-dsDNA antibodies, being a potential marker for identifying patients susceptible to SLE. Patients with primary antiphospholipid syndrome (PAPS) may develop full-blown SLE but there is no evidence for markers predictive for that. Aim: To evaluate whether anti-NCS may be predictors for full-blown or lupus like disease (LL) in a cohort of PAPS patients. Methods: A multicentric cohort of 105 PAPS patients was tested for IgG/IgM anti-NCS by using a home made assay with H1-stripped chromatin as antigen. Results: Eighty-one out of 105 (77%) of the patients were positive for anti-NCS; medium-high titre results were present only in 49/105 (46%). Anti-NCS were more frequently detected in PAPS + LL, but no relationship with clinical/serological features was found, except for a weak correlation with anti-dsDNA antibodies. Two PAPS patients evolved into full-blown SLE during the follow-up and displayed high titre anti-NCS many years before. Conclusions: Our findings suggest that anti-NCS might be added to the mosaic of autoimmune phenomena characterizing PAPS patients and in particular those with more chance to evolve to SLE. © 2007 Elsevier Ltd. All rights reserved.

Published
2008

30. [Primary antiphospholipid syndrome evolving into systemic lupus erythematosus: may antinucleosome antibodies be predictive?]

Author

Andreoli, L, Pregnolato, F, Burlingame, R, Fanelli, V, Allegri, F, Radice, A, Corace, C, Sinico, R, Tincani, A, Meroni, P, Meroni, P., SINICO, RENATO ALBERTO, Andreoli, L, Pregnolato, F, Burlingame, R, Fanelli, V, Allegri, F, Radice, A, Corace, C, Sinico, R, Tincani, A, Meroni, P, Meroni, P., and SINICO, RENATO ALBERTO

Abstract

It was reported by several groups that patients diagnosed as primary antiphospholipid syndrome (PAPS) had developed a full-blown systemic lupus erythematosus (SLE) even after many years of follow-up. Little is known about clinical and/or serological factors that may help predict such evolution. Antinucleosome antibodies (anti-NCS) were described to appear in early stages of SLE, in particular before anti-dsDNA antibodies. The aim of the study is to evaluate the prevalence of anti-NCS in a large cohort of PAPS patients

Published
2008

31. Daily Use, Especially of High-Potency Cannabis, Drives the Earlier Onset of Psychosis in Cannabis Users

Author

Di Forti, M., primary, Sallis, H., additional, Allegri, F., additional, Trotta, A., additional, Ferraro, L., additional, Stilo, S. A., additional, Marconi, A., additional, La Cascia, C., additional, Reis Marques, T., additional, Pariante, C., additional, Dazzan, P., additional, Mondelli, V., additional, Paparelli, A., additional, Kolliakou, A., additional, Prata, D., additional, Gaughran, F., additional, David, A. S., additional, Morgan, C., additional, Stahl, D., additional, Khondoker, M., additional, MacCabe, J. H., additional, and Murray, R. M., additional

Published
2013
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32. Antinucleosome antibodies in primary antiphospholipid syndrome

Author

Andreoli, L, Pregnolato, F, Burlingame, R, Fanelli, V, Allegri, F, Radice, A, Sinico, R, Tincani, A, Meroni, P, Meroni, P., SINICO, RENATO ALBERTO, Andreoli, L, Pregnolato, F, Burlingame, R, Fanelli, V, Allegri, F, Radice, A, Sinico, R, Tincani, A, Meroni, P, Meroni, P., and SINICO, RENATO ALBERTO

Published
2007

33. Antiprothrombin antibodies: a comparative analysis of homemade and commercial methods. A collaborative study by the Forum Interdisciplinare per la Ricerca nelle Malattie Autoimmuni (FIRMA)

Author

Tincani, A, Morozzi, G, Afeltra, A, Alessandri, C, Allegri, F, Bistoni, O, Bizzaro, N, Caccavo, D, Galeazzi, M, Gerli, R, Giovannelli, L, Longobardo, G, Lotzniker, M, Malacarne, F, Migliorini, P, Parodi, A, Pregnolato, F, Radice, A, Riccieri, V, Ruffelli, M, Sinico, R, Tozzoli, R, Villalta, D, Marcolongo, R, Meroni, P, Meroni, P., SINICO, RENATO ALBERTO, Tincani, A, Morozzi, G, Afeltra, A, Alessandri, C, Allegri, F, Bistoni, O, Bizzaro, N, Caccavo, D, Galeazzi, M, Gerli, R, Giovannelli, L, Longobardo, G, Lotzniker, M, Malacarne, F, Migliorini, P, Parodi, A, Pregnolato, F, Radice, A, Riccieri, V, Ruffelli, M, Sinico, R, Tozzoli, R, Villalta, D, Marcolongo, R, Meroni, P, Meroni, P., and SINICO, RENATO ALBERTO

Abstract

Objective: Prothrombin (PT) is a target for antibodies with lupus anticoagulant (LA) activity, suggesting the possible application of anti-prothrombin antibody (aPT) assays in patients with antiphospholipid syndrome (APS). Different methods - both homemade and commercial - for the detection of aPT are available, but they seem to produce conflicting results. The purpose of this study was to compare the performance of different assays on a set of well-characterized serum samples. Patients and methods: Sera were gathered from 4 FIRMA institutions, and distributed to 15 participating centres. Forty-five samples were from patients positive for LA and/or anticardiolipin antibodies (aCL) with or without APS, and 15 were from rheumatoid arthritis (RA) patients negative for antiphospholipid antibodies. The samples were evaluated for IgG and IgM antibodies using a homemade direct aPT assay (method 1), a homemade phosphatidylserine-dependent aPT assay (aPS/PT, method 2), and two different commercial kits (methods 3 and 4). In addition, a commercial kit for the detection of IgG-A-M aPT (method 5) was used. Results: Inter-laboratory results for the 5 methods were not always comparable when different methods were used. Good inter-assay concordance was found for IgG antibodies evaluated using methods 1, 3, and 4 (Cohen k > 0.4), while the IgM results were discordant between assays. In patients with thrombosis and pregnancy losses, method 5 performed better than the others. Conclusion: While aPT and aPS/PT assays could be of interest from a clinical perspective, their routine performance cannot yet be recommended because of problems connected with the reproducibility and interpretation of the results

Published
2007

34. Anti-DNA antibodies: A diagnostic and prognostic tool for systemic lupus erythematosus?

Author

Riboldi, P, Gerosa, M, Moroni, G, Radice, A, Allegri, F, Sinico, R, Tincani, A, Meroni, P, Meroni, P., SINICO, RENATO ALBERTO, Riboldi, P, Gerosa, M, Moroni, G, Radice, A, Allegri, F, Sinico, R, Tincani, A, Meroni, P, Meroni, P., and SINICO, RENATO ALBERTO

Abstract

The clinical impact of anti-DNA antibodies lies on their diagnostic power for systemic lupus erythematosus (SLE), being a formal classification criterion. In spite of such a disease association, low-avidity anti-DNA antibodies might also be part of the natural autoantibody repertoire.Their switch to pathogenic high-avidity autoantibodies is the result of the autoimmune process leading to SLE. Anti-DNA antibodies were shown to play a role in SLE pathogenesis and particularly in kidney damage. Accordingly, antibody titres might fluctuate in relation to disease activity, but their prognostic value for flares is still debated. Several methods for anti-DNA detection were described and there is evidence that the assays identify different antibodies with different prognostic value. The results of a multicenter study on four different routine tests for anti-dsDNA antibody detection showed that: (i) Farr assay displays the best diagnostic specificity/sensitivity for SLE, followed by Crithidia luciliae method (CLIFT), (ii) the new generation of solid phase assay (EliA) shows an increased sensibility versus the classical enzyme linked immune assay (ELISA) but a decreased specificity. Antibody titre detected by EliA and Farr assay correlated with disease activity. These findings would suggest that more than one assay should be useful for SLE diagnosis and monitoring. © 2005 Taylor & Francis Ltd

Published
2005

39. Lessons from the 'Euro-Lupus Cohort'

Author

Cervera, R, Abarca Costalago, M, Abramovicz, D, Allegri, F, Annunziata, P, Aydintug, A, Bacarelli, M, Bellisai, F, Bernardino, I, Biernat Kaluza, E, Blockmans, D, Boki, K, Bracci, L, Campanella, V, Camps, M, Carcassi, C, Cattaneo, R, Cauli, A, Chwalinska Sadowska, H, Contu, L, Cosyns, J, Danieli, M, D'Cruz, D, Depresseux, G, Direskeneli, H, Domènech, I, Espinosa, G, Fernández Nebro, A, Ferrara, G, Font, J, Frutos, M, Galeazzi, M, García Carrasco, M, García Iglesias, M, García Tobaruela, A, George, J, Gil, A, González Santos, P, Grana, M, Gül, A, Haga, H, de Haro Liger, M, Houssiau, F, Hughes, G, Ingelmo, M, Jedryka Góral, A, Khamashta, M, Lavilla, P, Levi, Y, López Dupla, M, López Soto, A, Maldykowa, H, Marcolongo, R, Mathieu, A, Morozzi, G, Nicolopoulou, N, Papasteriades, C, Passiu, G, Perelló, I, Petera, P, Petrovic, R, Piette, J, Pintado, V, de Pita, O, Popovic, R, Pucci, G, Puddu, P, de Ramón, E, Ramos Casals, M, Rodríguez Andreu, J, Ruiz Irastroza, G, Sánchez Lora, J, Sanna, G, Scorza, R, Sebastini, G, Sherer, Y, Shoenfeld, Y, Simpatico, A, Sinico, R, Smolen, J, Tincani, A, Tokgöz, G, Urbano Márquez, A, Vasconcelos, C, Vázquez, J, Veronesi, M, Vianni, J, Vivancos, J, SINICO, RENATO ALBERTO, Vivancos, J., Cervera, R, Abarca Costalago, M, Abramovicz, D, Allegri, F, Annunziata, P, Aydintug, A, Bacarelli, M, Bellisai, F, Bernardino, I, Biernat Kaluza, E, Blockmans, D, Boki, K, Bracci, L, Campanella, V, Camps, M, Carcassi, C, Cattaneo, R, Cauli, A, Chwalinska Sadowska, H, Contu, L, Cosyns, J, Danieli, M, D'Cruz, D, Depresseux, G, Direskeneli, H, Domènech, I, Espinosa, G, Fernández Nebro, A, Ferrara, G, Font, J, Frutos, M, Galeazzi, M, García Carrasco, M, García Iglesias, M, García Tobaruela, A, George, J, Gil, A, González Santos, P, Grana, M, Gül, A, Haga, H, de Haro Liger, M, Houssiau, F, Hughes, G, Ingelmo, M, Jedryka Góral, A, Khamashta, M, Lavilla, P, Levi, Y, López Dupla, M, López Soto, A, Maldykowa, H, Marcolongo, R, Mathieu, A, Morozzi, G, Nicolopoulou, N, Papasteriades, C, Passiu, G, Perelló, I, Petera, P, Petrovic, R, Piette, J, Pintado, V, de Pita, O, Popovic, R, Pucci, G, Puddu, P, de Ramón, E, Ramos Casals, M, Rodríguez Andreu, J, Ruiz Irastroza, G, Sánchez Lora, J, Sanna, G, Scorza, R, Sebastini, G, Sherer, Y, Shoenfeld, Y, Simpatico, A, Sinico, R, Smolen, J, Tincani, A, Tokgöz, G, Urbano Márquez, A, Vasconcelos, C, Vázquez, J, Veronesi, M, Vianni, J, Vivancos, J, SINICO, RENATO ALBERTO, and Vivancos, J.

Abstract

The "Euro-Lupus Cohort" is composed by 1,000 patients with systemic lupus erythematosus (SLE) that have been followed prospectively since 1991. These patients have been gathered by a European consortium - the "Euro-Lupus Project Group". This consortium was originated as part of the network promoted by the "European Working Party on SLE", a working group created in 1990 in order to promote research in Europe on the different problems related to this disease. The "Euro-Lupus Cohort" provides an updated information on the SLE morbidity and mortality characteristics in the present decade as well as defines several clinical and immunological prognostic factors

Published
2002

42. Induction of experimental SLE in naive mice by immunization with human polyclonal anti-DNA antibody carrying the 16/6 idiotype

Author

Tincani, A, Balestrieri, G, Allegri, F, Cattaneo, R, Fornasieri, A, Li, M, Sinico, R, D'Amico, G, D'Amico, G., SINICO, RENATO ALBERTO, Tincani, A, Balestrieri, G, Allegri, F, Cattaneo, R, Fornasieri, A, Li, M, Sinico, R, D'Amico, G, D'Amico, G., and SINICO, RENATO ALBERTO

Abstract

Recently, the induction of SLE in naive mice employing monoclonal anti-DNA antibodies (anti-DNA Ab) carrying the pathogenic idiotype 16/6 (16/6 Id) has been reported. In the current study we report on the induction of experimental SLE by polyclonal IgG anti-DNA Ab derived from a patient with active SLE and carrying the 16/6 Id. Two different experiments were conducted in which BALB/c mice were immunized in the footpads with 1 microgram/ml or 5 micrograms/ml of anti-DNA Ab. The first experiment showed the appearance in the immunized mice of high titre anti-DNA Ab together with antinuclear antibodies, alopecia and proteinuria. In the second experiment we compared, as immunizing agents, 16/6 positive anti-DNA Ab and 16/6 negative anti-tetanus toxoid antibodies (anti-TT Ab) obtained from the serum of the same patients. Our results show that only mice immunized with 16/6 positive antibodies produced anti-DNA Ab, while mice immunized with anti-TT Ab did not show any DNA-binding activity but, surprisingly, developed high titre anti-cardiolipin antibodies

Published
1993

43. The plasma cofactor and anticardiolipin antibodies

Author

Allegri, F, Balestrieri, G, Cattaneo, R, Martinelli, M, Tincani, A, Barcellini, W, Del Papa, N, Meroni, P, Falco, M, Luan, F, Valesini, G, Sinico, R, SINICO, RENATO ALBERTO, Allegri, F, Balestrieri, G, Cattaneo, R, Martinelli, M, Tincani, A, Barcellini, W, Del Papa, N, Meroni, P, Falco, M, Luan, F, Valesini, G, Sinico, R, and SINICO, RENATO ALBERTO

Published
1990

45. First-episode psychosis and migration in Italy (PEP-Ita migration): A study in the Italian mental health services

Author

Orlando Todarello, Silvia Ferrari, Maria Antonietta Furio, Mario Luciano, Marcello Nardini, Patrizia Zeppegno, Ilaria Tarricone, Mauro Braca, Domenico Berardi, Elena Turella, Corinna Reggianini, Francesca Podavini, Caterina La Cascia, Marco Conforti Donati, Vanna Berlincioni, D. Primavera, Corrado De Rosa, Samuele Defilippi, Giuseppe Barrasso, Alice Mulè, Alessio Ceregato, Fabio Allegri, Valeria Del Vecchio, Antonello Bellomo, Antonio Ventriglio, Andrea Fiorillo, Bernardo Carpiniello, Marco Rigatelli, Carla Gramaglia, Luigi Ferrannini, Ilaria, Tarricone, Mauro, Braca, Fabio, Allegri, Giuseppe, Barrasso, Antonello, Bellomo, Vanna, Berlincioni, Bernardo, Carpiniello, Alessio, Ceregato, Marco, Conforti Donati, Samuele, Defilippi, Valeria Del, Vecchio, Corrado, De Rosa, Luigi, Ferrannini, Silvia, Ferrari, Maria, Furio, Carla, Gramaglia, Caterina La, Cascia, Mario, Luciano, Alice, Mulè, Marcello, Nardini, Francesca, Podavini, Diego, Primavera, Corinna, Reggianini, Marco, Rigatelli, Orlando, Todarello, Elena, Turella, Antonio, Ventriglio, Patrizia, Zeppegno, Andrea, Fiorillo, Domenico, Berardi, Tarricone, I, Braca, M, Allegri, F, Barrasso, G, Bellomo, A, Berlincioni, V, Carpiniello, B, Ceregato, A, Conforti Donati, M, Defilippi, S, Del Vecchio, V, De Rosa, C, Ferrannini, L, Ferrari, S, Furio, Ma, Gramaglia, C, La Cascia, C, Luciano, Mario, Mulè, A, Nardini, M, Podavini, F, Primavera, D, Reggianini, C, Rigatelli, M, Todarello, O, Turella, E, Ventriglio, A, Zeppegno, P, Fiorillo, Andrea, Berardi, D., Tarricone, I., Braca, M., Allegri, F., Barrasso, G., Bellomo, A., Berlincioni, V., Carpiniello, B., Ceregato, A., Conforti Donati, M., Defilippi, S., Del Vecchio, V., De Rosa, C., Ferrannini, L., Ferrari, S., Furio, M., Fiorillo, A., Gramaglia, C., LA CASCIA, C., Luciano, M., Mulè, A., Nardini, M., Podavini, F., Primavera, D., Reggianini, C., Rigatelli, M., Todarello, O., Turella, E., Ventriglio, A., and Zeppegno, P.

Subjects
Male, Immigration, Ethnic group, Study Protocol, Ethnicity, Settore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat, Prospective Studies, 10. No inequality, media_common, First-episode psychosis, Italy, Migrants, Protective factors, Risk factors, Transients and Migrants, education.field_of_study, Protective factor, Incidence, Middle Aged, Psychiatry and Mental health, Mental Health, 8. Economic growth, Female, Psychopathology, Adult, Mental Health Services, medicine.medical_specialty, Psychosis, Adolescent, media_common.quotation_subject, Population, Emigrants and Immigrants, Migrants, First-episode psychosis, Italy, Risk factors, Protective factors, Young Adult, First-episode psychosi, Intervention (counseling), medicine, Humans, Psychiatry, education, Settore MED/25 - Psichiatria, business.industry, Migrant, medicine.disease, Mental health, Psychotic Disorders, Observational study, business
Abstract

Background It has been frequently reported a higher incidence of psychotic disorders in immigrants than in native populations. There is, however, a lack of knowledge about risk factors which may explain this phenomenon. A better understanding of the causes of psychosis among first-generation migrants is highly needed, particularly in Italy, a country with a recent massive migration. Methods/Design The “Italian study on first-episode psychosis and migration (PEP-Ita)” is a prospective observational study over a two-year period (1 January 2012–31 December 2013) which will be carried out in 11 Italian mental health centres. All participating centres will collect data about all new cases of migrants with first-episode psychosis. The general purpose (“core”) of the PEP-Ita study is to explore the socio-demographic and clinical characteristics, and the pathways to care of a population of first-episode psychosis migrants in Italy. Secondary aims of the study will be: 1) to understand risk and protective factors for the development of psychotic disorders in migrants; 2) to evaluate the correlations between psychopathology of psychotic disorders in migrants and socio-demographic characteristics, migration history, life experiences; 3) to evaluate the clinical and social outcomes of first-episode psychoses in migrants. Discussion The results of the PEP-Ita study will allow a better understanding of risk factors for psychosis in first-generation migrants in Italy. Moreover, our results will contribute to the development of prevention programmes for psychosis and to the improvement of early intervention treatments for the migrant population in Italy.

Published
2014

46. Daily use, especially of high-potency cannabis, drives the earlier onset of psychosis in cannabis users

Author

James H. MacCabe, Mizanur Khondoker, Fabio Allegri, Tiago Reis Marques, Marta Di Forti, Craig Morgan, Anna Kolliakou, Paola Dazzan, Robin M. Murray, Fiona Gaughran, Daniel Stahl, Antonella Trotta, Hannah M Sallis, Carmine M. Pariante, Anthony S. David, Valeria Mondelli, Alessandra Paparelli, Caterina La Cascia, Laura Ferraro, Arianna Marconi, Diana Prata, Simona A. Stilo, Di Forti, M., Sallis, H., Allegri, F., Trotta, A., Ferraro, L., Stilo, S., Marconi, A., LA CASCIA, C., Reis Marques, T., Pariante, C., Dazzan, P., Mondelli, V., Paparelli, A., Kolliakou, A., Prata, D., Gaugrhan, F., David, A., Morgan, C., Sthal, D., Khondoker, M., Maccabe, J., and Murray, R.

Subjects
Adult, Affective Disorders, Psychotic, Male, Risk, age of onset, cannabis, drug use, gender, high-potency cannabis, psychotic disorders, survival plots, Psychosis, Pediatrics, medicine.medical_specialty, Sex Factors, Delta-9-tetrahydrocannabinol, Settore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat, medicine, Humans, Age of Onset, Psychiatry, Settore MED/25 - Psichiatria, Cannabis, First episode, biology, Proportional hazards model, Hazard ratio, Regular Article, medicine.disease, biology.organism_classification, Psychiatry and Mental health, Psychotic Disorders, Schizophrenia, Female, Age of onset, Psychology
Abstract

UNLABELLED: Cannabis use is associated with an earlier age of onset of psychosis (AOP). However, the reasons for this remain debated. METHODS: We applied a Cox proportional hazards model to 410 first-episode psychosis patients to investigate the association between gender, patterns of cannabis use, and AOP. RESULTS: Patients with a history of cannabis use presented with their first episode of psychosis at a younger age (mean years = 28.2, SD = 8.0; median years = 27.1) than those who never used cannabis (mean years = 31.4, SD = 9.9; median years = 30.0; hazard ratio [HR] = 1.42; 95% CI: 1.16-1.74; P < .001). This association remained significant after controlling for gender (HR = 1.39; 95% CI: 1.11-1.68; P < .001). Those who had started cannabis at age 15 or younger had an earlier onset of psychosis (mean years = 27.0, SD = 6.2; median years = 26.9) than those who had started after 15 years (mean years = 29.1, SD = 8.5; median years = 27.8; HR = 1.40; 95% CI: 1.06-1.84; P = .050). Importantly, subjects who had been using high-potency cannabis (skunk-type) every day had the earliest onset (mean years = 25.2, SD = 6.3; median years = 24.6) compared to never users among all the groups tested (HR = 1.99; 95% CI: 1.50- 2.65; P < .0001); these daily users of high-potency cannabis had an onset an average of 6 years earlier than that of non-cannabis users. CONCLUSIONS: Daily use, especially of high-potency cannabis, drives the earlier onset of psychosis in cannabis users.

Published
2013

47. European registry of babies born to mothers with antiphospholipid syndrome

Author

Sara De Carolis, Ales Ambrozic, Amélie Benbara, Eric Vicaut, Marie Claire Boffa, Tadej Avcin, Chiara Biasini-Rebaioli, Patrizia Rovere-Querini, Lionel Carbillon, Jérôme Stirnemann, Sylvie Chollet-Martin, Fabrice Pierre, M. H. Aurousseau, Olivier Fain, Pascale Nicaise-Roland, Angela Tincani, F. Allegri, Andrea Lojacono, Olivier Pourrat, Philippe Letoumelin, Rosanna Rovelli, A. Botta, C. Boinot, E. Lachassinne, Arsène Mekinian, Sophie Derenne, Pierre Yves Hatron, Mario Motta, Monica Nuzzo, Marc Lambert, Mekinian, A, Lachassinne, E, Nicaise Roland, P, Carbillon, L, Motta, M, Vicaut, E, Boinot, C, Avcin, T, Letoumelin, P, De Carolis, S, ROVERE QUERINI, Patrizia, Lambert, M, Derenne, S, Pourrat, O, Stirnemann, J, Chollet Martin, S, Biasini Rebaioli, C, Rovelli, R, Lojacono, A, Ambrozic, A, Botta, A, Benbara, A, Pierre, F, Allegri, F, Nuzzo, M, Hatron, Py, Tincani, A, Fain, O, Aurousseau, Mh, and Boffa, Mc

Subjects
Male, medicine.medical_specialty, Pediatrics, Settore MED/16 - REUMATOLOGIA, Developmental Disabilities, Birth weight, Immunology, Physical examination, Antiphospholipid Syndrome/complications, General Biochemistry, Genetics and Molecular Biology, Rheumatology, Pregnancy, Antiphospholipid syndrome, antipospholipid syndrome, Epidemiology, Humans, Immunology and Allergy, Medicine, Registries, new born, medicine.diagnostic_test, business.industry, Infant, Clinical and Epidemiological Research, medicine.disease, Connective tissue disease, Thrombosis, Europe, Pregnancy Complications, Settore MED/40 - GINECOLOGIA E OSTETRICIA, Developmental Disabilities/epidemiology/etiology, Child, Preschool, ddc:618.97, Cohort, Female, business, antiphospholipid syndrome
Abstract

Objectives This study aimed to describe the long-term outcome and immunological status of children born to mothers with antiphospholipid syndrome, to determine the factors responsible for childhood abnormalities, and to correlate the child's immunological profile with their mothers. Methods A prospective follow-up of a European multicentre cohort was conducted. The follow-up consisted of clinical examination, growth data, neurodevelopmental milestones and antiphospholipid antibodies (APL) screening. Children were examined at 3, 9, 24 months and 5 years. Results 134 children were analysed (female sex in 65 cases, birth weight 3000±500 g, height 48±3 cm). Sixteen per cent had a preterm birth (

Published
2013

48. Effects of a low-salt diet on idiopathic hypercalciuria in calcium-oxalate stone formers: a 3-mo randomized controlled trial

Author

Antonio Nouvenne, Angela Guerra, Loris Borghi, Tiziana Meschi, Umberto Maggiore, Laura Soldati, Giuseppe Vezzoli, Franca Allegri, Giovanni Gambaro, Beatrice Prati, Nouvenne, A, Meschi, T, Prati, B, Guerra, A, Allegri, F, Vezzoli, G, Soldati, L, Gambaro, G, Maggiore, U, and Borghi, L

Subjects
Adult, Male, medicine.medical_specialty, food.diet, Urinary system, Hypercalciuria, Calcium oxalate, Medicine (miscellaneous), chemistry.chemical_element, Urine, Low sodium diet, Calcium, Gastroenterology, nutrition, renal stones, hypercalciuria, low sodium diet, Excretion, chemistry.chemical_compound, Kidney Calculi, food, Internal medicine, medicine, Settore MED/14 - NEFROLOGIA, Humans, Sodium Chloride, Dietary, Nutrition and Dietetics, Calcium Oxalate, business.industry, Sodium, Water, Diet, Sodium-Restricted, Middle Aged, medicine.disease, Urinary calcium, Endocrinology, chemistry, Female, business
Abstract

Background: A direct relation exists between sodium and calcium excretion, but randomized studies evaluating the sustained effect of a low-salt diet on idiopathic hypercalciuria, one of the main risk factors for calcium-oxalate stone formation, are still lacking. Objective: Our goal was to evaluate the effect of a low-salt diet on urinary calcium excretion in patients affected by idiopathic calcium nephrolithiasis. Design: Patients affected by idiopathic calcium stone disease and hypercalciuria (.300 mg Ca/d in men and .250 mg Ca/d in women) were randomly assigned to receive either water therapy alone (control diet) or water therapy and a low-salt diet (low-sodium diet) for 3 mo. Twenty-four-hour urine samples were obtained twice from all patients: one sample at baseline on a free diet and one sample after 3 mo of treatment. Results: A total of 210 patients were randomly assigned to receive a control diet (n = 102) or a low-sodium diet (n = 108); 13 patients (2 on the control diet, 11 on the low-sodium diet) withdrew from the trial. At the follow-up visit, patients on the low-sodium diet had lower urinary sodium (mean 6 SD: 68 6 43 mmol L 21 d 21 at 3 mo compared with 228 6 57 mmol L 21 d 21 at baseline; P , 0.001). Concomitant with this change, they showed lower urinary calcium (271 6 86 mg/d at 3 mo compared with 361 6 129 mg/d at baseline, P , 0.001) and lower oxalate excretion (28 6 8 mg/d at 3 mo compared with 32 6 10 mg/d at baseline, P = 0.001). Urinary calcium was within the normal range in 61.9% of the patients on the low-salt diet and in 34.0% of those on the control diet (difference: +27.9%; 95% CI: +14.4%, +41.3%; P , 0.001). Conclusion: A low-salt diet can reduce calcium excretion in hypercalciuric stone formers. This trial was registered at clinicaltrials.gov as NCT01005082. Am J Clin Nutr doi: 10.3945/ajcn.2009.28614.

Published
2010

49. Laboratory criteria of the obstetrical antiphospholipid syndrome Data from a multicentric prospective European women cohort

Author

Tadej Avcin, Anne Barra, Marie Claire Boffa, Patrizia Rovere-Querini, Angela Tincani, F. Allegri, A. Botta, Ales Ambrozic, Sara De Carolis, M. H. Aurousseau, Pascale Nicaise-Roland, C. Boinot, Boffa, Mc, Boinot, C, De Carolis, S, ROVERE QUERINI, Patrizia, Aurousseau, Mh, Allegri, F, Nicaise Roland, P, Barra, A, Botta, A, Ambrozic, A, Avcin, T, and Tincani, A.

Subjects
medicine.medical_specialty, Pediatrics, Cohort Studies, Pregnancy, Risk Factors, Seroepidemiologic Studies, Antiphospholipid syndrome, Immunopathology, medicine, Humans, Longitudinal Studies, Prospective Studies, Prospective cohort study, Vascular disease, business.industry, Pregnancy Complications, Hematologic, Thrombosis, Hematology, medicine.disease, Surgery, Europe, Settore MED/40 - GINECOLOGIA E OSTETRICIA, Immunoglobulin M, beta 2-Glycoprotein I, Antibodies, Anticardiolipin, Immunoglobulin G, Cohort, Laboratory criteria, Female, business, antiphospholipid syndrome, Cohort study
Abstract

SummaryA debate on updating the laboratory criteria of antiphospholipid syndrome (APS) was recently opened in view to lower the risk of over diagnosis of the syndrome. Based on data related to thrombotic APS, it proposes the exclusion of anticardiolipin antibodies (aCL) and anti-beta2-glycoprotein 1 (a-β2-GPI) IgM detection. Here, we examine this possibility in a study which focuses on obstetrical APS (OAPS).We report new data on a prospective multicenter European cohort of 109 pregnant women having APS.Among them, 73 had purely obstetrical APS, not associated to autoimmune diseases or thrombosis. Isolated antibodies and isolated aCL positivity were present in 50/109 (46%) and in 34/109 (31%) of the women, respectively. An isolated a-β2-GPI IgM was present in three women.These results suggest that aCL and a-β2-GPI IgM cannot be dropped for the diagnosis and classification of OAPS.The low level of some antibodies associated with severe obstetrical complications raise the issue of keeping or not the same laboratory criteria for OAPS and for thrombotic APS and whether additional criteria after large prospective studies could further improve diagnosis.

Published
2009

50. Mothers' antiphospholipid antibodies during pregnancy and the relation to offspring outcome

Author

Mekinian, A., Carbillon, L., Nicaise-Roland, P., Rousseau, H., Lachassinne, E., Motta, M., Vicaut, E., Boinot, C., Avcin, T., Carolis, S., Rovere-Querini, P., marc lambert, Derenne, S., Pourrat, O., Chollet-Martin, S., Biasini-Rebaioli, R., Rovelli, R., Lojacono, A., Ambrozic, A., Benbara, A., Pierre, E., Allegri, E., Nuzzo, M., Hatron, P. Y., Tincani, A., Aurousseau, M. H., Boffa, M. C., Fain, O., Mekinian, A, Carbillon, L, Nicaise Roland, P, Rousseau, H, Lachassinne, E, Motta, M, Vicaut, E, Boinot, C, Avcin, T, De Carolis, S, ROVERE QUERINI, Patrizia, Lambert, M, Derenne, S, Pourrat, O, Chollet Martin, S, Biasini Rebaioli, R, Rovelli, R, Lojacono, A, Ambrozic, A, Benbara, A, Pierre, F, Allegri, F, Nuzzo, M, Hatron, Py, Tincani, A, Aurousseau, Mh, Boffa, Mc, and Fain, O.

Subjects
Pregnancy Complications, Pregnancy, Risk Factors, Antibodies, Antiphospholipid, Infant, Newborn, Pregnancy Outcome, Humans, Premature Birth, Female, Antiphospholipid Syndrome

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