1. Is asthma associated with COVID-19 infection? A UK Biobank analysis
- Author
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Caroline J. Lodge, Alice Doherty, Dinh S. Bui, Raisa Cassim, Adrian J. Lowe, Alvar Agusti, Melissa A. Russell, and Shyamali C. Dharmage
- Subjects
Medicine - Abstract
Background The relationship between asthma and coronavirus disease 2019 (COVID-19) risk is not clear and may be influenced by level of airway obstruction, asthma medication and known COVID-19 risk factors. We aimed to investigate COVID-19 risk in people with asthma. Methods We used UK Biobank data from all participants tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (n=107 412; 17 979 test positive). Questions at baseline defined ever asthma and asthma medications. Baseline forced expiratory volume in 1 s (FEV1) was categorised into quartiles. Logistic regression modelled relationships between asthma, and asthma categories (age at onset, medications, FEV1 quartiles), and risk of SARS-CoV-2 positive test. We investigated modification by sex, ethnic group, smoking and body mass index. Results There was a reduced risk of a positive test associated with early-onset asthma (
- Published
- 2021
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