271 results on '"Alhayek A"'
Search Results
2. Translation and Validation of the Sinus and Nasal Quality of Life Surgery Survey in Serbian
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Nevena Jovicic, Masa Petrovic, Bojana Salovic, Aleksandar Matejic, Ana Tomic, Nina Milanovic, Teja Scepanovic, Nabil Alhayek, and Ivan Soldatovic
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allergy ,quality of life ,rhinitis ,translation ,validation ,Otorhinolaryngology ,RF1-547 ,Surgery ,RD1-811 - Abstract
Abstract Objective The aim of this study was to translate the Sinus and Nasal Quality of Life Surgery Survey into the Serbian language to evaluate the test‐retest reliability and validity. Study Design The study included 49 consecutive patients between 12 and 18 years old with rhinologic symptoms. Patients were given a paper survey to complete along with a link to complete the online survey within the same day. Setting The study was conducted at the University Children's Hospital Clinic for Pulmonology and Allergology between January 2023 and March 2023. Methods Responses between the paper and online survey were compared and regression analysis was performed to evaluate the relationship. Internal reliability and test‐retest reliability were assessed using Cronbach's α coefficient and intraclass correlation coefficient. All data were collected and analyzed using SPSS 29.0. Results Pearson correlation coefficient between the paper and online survey was very high and statistically significant (r = 0.999; P
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- 2024
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3. Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections
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Jelena Konstantinović, Andreas M. Kany, Alaa Alhayek, Ahmed S. Abdelsamie, Asfandyar Sikandar, Katrin Voos, Yiwen Yao, Anastasia Andreas, Roya Shafiei, Brigitta Loretz, Esther Schönauer, Robert Bals, Hans Brandstetter, Rolf W. Hartmann, Christian Ducho, Claus-Michael Lehr, Christoph Beisswenger, Rolf Müller, Katharina Rox, Jörg Haupenthal, and Anna K.H. Hirsch
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Chemistry ,QD1-999 - Published
- 2023
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4. Spray drying of a zinc complexing agent for inhalation therapy of pulmonary fibrosis
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Stella, Justin, Abdelaal, Maryam Ayman Mohamed Ezzat, Kamal, Mohamed Ashraf Mostafa, Shehu, Kristela, Alhayek, Alaa, Haupenthal, Jörg, Hirsch, Anna K., and Schneider, Marc
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- 2024
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5. The HAPSTR2 retrogene buffers stress signaling and resilience in mammals
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Amici, David R., Cingoz, Harun, Alasady, Milad J., Alhayek, Sammy, Phoumyvong, Claire M., Sahni, Nidhi, Yi, S. Stephen, and Mendillo, Marc L.
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- 2023
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6. Thermochromic Polymer Nanocomposites for the Heat Detection System: Recent Progress on Properties, Applications, and Challenges
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A. B. M. Supian, M. R. M. Asyraf, Agusril Syamsir, M. I. Najeeb, Abdulrahman Alhayek, Rayeh Nasr Al-Dala’ien, Gunasilan Manar, and A. Atiqah
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reversible thermochromic ,thermochromism ,polymer nanocomposites ,heat detection sensing ,colour-changing materials ,Organic chemistry ,QD241-441 - Abstract
Reversible thermochromic polymers have emerged as compelling candidates in recent years, captivating attention for their application in heat detection systems. This comprehensive review navigates through the multifaceted landscape, intricately exploring both the virtues and hurdles inherent in their integration within these systems. Their innate capacity to change colour in response to temperature fluctuations renders reversible thermochromic nanocomposites promising assets for heat detection technologies. However, despite their inherent potential, certain barriers hinder their widespread adoption. Factors such as a restricted colour spectrum, reliance on external triggers, and cost considerations have restrained their pervasive use. For instance, these polymer-based materials exhibit utility in the domain of building insulation, where their colour-changing ability serves as a beacon, flagging areas of heat loss or inadequate insulation, thus alerting building managers and homeowners to potential energy inefficiencies. Nevertheless, the limited range of discernible colours may impede precise temperature differentiation. Additionally, dependency on external stimuli, such as electricity or UV light, can complicate implementation and inflate costs. Realising the full potential of these polymer-based materials in heat detection systems necessitates addressing these challenges head-on. Continuous research endeavours aimed at augmenting colour diversity and diminishing reliance on external stimuli offer promising avenues to enhance their efficacy. Hence, this review aims to delve into the intricate nuances surrounding reversible thermochromic nanocomposites, highlighting their transformative potential in heat detection and sensing. By exploring their mechanisms, properties, and current applications, this manuscript endeavours to shed light on their significance, providing insights crucial for further research and potential applications.
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- 2024
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7. Host cell sensing and restoration of mitochondrial function and metabolism within Helicobacter pylori VacA intoxicated cells
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Ami Y. Seeger, Faisal Zaidi, Sammy Alhayek, Rachel M. Jones, Huzaifa Zohair, Robin L. Holland, Ik-Jung Kim, and Steven R. Blanke
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Helicobacter pylori ,vacuolating cytotoxin ,VacA ,mitochondrial dysfunction ,mitochondrial dynamics ,proton motive force ,Microbiology ,QR1-502 - Abstract
ABSTRACT Helicobacter pylori vacuolating cytotoxin A (VacA) is an intracellular-acting protein exotoxin that induces mitochondrial dysfunction and energy depletion within host cells. Although exposure to VacA results in mitochondrial dysfunction, one recent study revealed that, following limited exposure to VacA, mitochondrial function and cellular ATP levels were restored in a time-dependent manner. Studies performed to address the mechanism by which host cells detect and respond to intracellular VacA identified the adenosine monophosphate (AMP)-activated protein kinase (AMPK) as a sensor of toxin-dependent alterations in cellular energy status. Activation of AMPK in response to VacA was demonstrated to orchestrate alterations in mitochondrial dynamics which resulted in restoration of mitochondrial function. Specifically, upregulation of dynamin-related protein 1 (Drp-1)-dependent mitochondrial fission resulted in reversible fragmentation of filamentous mitochondria and time-dependent reduction in mitochondrial-associated VacA, suggesting that fragmentation is important for removal of VacA from mitochondria. Cells with reduced levels of Drp-1 were more susceptible to VacA-dependent cell death, suggesting that mitochondrial dynamics is important for maintaining cell viability through the reduction in mitochondrial-associated toxin. Collectively, these studies support a model that cellular recovery and survival in response to VacA-dependent mitochondrial dysfunction is linked to host cell modulation of mitochondrial dynamics. This study provides new insights into cellular recognition and responses to intracellular-acting toxin modulation of host cell function, which could be relevant for the growing list of pathogenic microbes and viruses identified that target mitochondria as part of their virulence strategies. IMPORTANCE Persistent human gastric infection with Helicobacter pylori is the single most important risk factor for development of gastric malignancy, which is one of the leading causes of cancer-related deaths worldwide. An important virulence factor for Hp colonization and severity of gastric disease is the protein exotoxin VacA, which is secreted by the bacterium and modulates functional properties of gastric cells. VacA acts by damaging mitochondria, which impairs host cell metabolism through impairment of energy production. Here, we demonstrate that intoxicated cells have the capacity to detect VacA-mediated damage, and orchestrate the repair of mitochondrial function, thereby restoring cellular health and vitality. This study provides new insights into cellular recognition and responses to intracellular-acting toxin modulation of host cell function, which could be relevant for the growing list of pathogenic microbes and viruses identified that target mitochondria as part of their virulence strategies.
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- 2023
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8. The HAPSTR2 retrogene buffers stress signaling and resilience in mammals
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David R. Amici, Harun Cingoz, Milad J. Alasady, Sammy Alhayek, Claire M. Phoumyvong, Nidhi Sahni, S. Stephen Yi, and Marc L. Mendillo
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Science - Abstract
The recently described protein HAPSTR1 governs cellular stress resilience. Here, the authors discover a mammalian HAPSTR1 paralog, called HAPSTR2, which formed via retro-transposition and operates to augment and buffer cellular stress signaling.
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- 2023
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9. Atypical distal tracheal fibrous bridge and bronchial stenosis in an adult patient with bronchopulmonary dysplasia
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Ishaq J. Wadiwala, Alejandra Yu Lee‐Mateus, Bakr Alhayek, David Abia‐Trujillo, Ryan Chadha, Britney N. Hazelett, and Sebastian Fernandez‐Bussy
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bronchial stenosis ,bronchoscopy ,electrocautery knife ,fibrotic bridge ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Tracheobronchial stenosis (TBS) in adults derives from congenital and acquired conditions, including prolonged mechanical intubation, expiratory central airway collapse, infectious or inflammatory disease, and malignancy. The most common clinical presentation is shortness of breath, recurrent infections, and chronic cough. TBS is usually diagnosed via computed tomography or bronchoscopy, with the latter doubling as a therapeutic tool. We present a case of an atypical fibrotic bridge connecting the walls of the distal trachea and fibrotic bronchial stenosis treated with electrocautery knife and balloon dilation, in an adult patient with bronchopulmonary dysplasia.
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- 2023
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10. Renal BCGosis managed conservatively with antituberculous medications
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Amr Elmekresh, Yazan Al Shaikh, Rafe Alhayek, and Yaser Saeedi
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antitubercular therapy ,bacillus calmette–guérin ,nonmuscle-invasive bladder cancer ,renal tuberculosis ,transurethral resection ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Intravesical Bacillus Calmette–Guérin (BCG) therapy for nonmuscle-invasive bladder cancer rarely leads to the development of granulomatous renal masses (renal BCGosis). The management includes nephroureterectomy, antitubercular therapy (ATT), or both. Here, we present a case of a 62-year-old male who was treated with ATT alone for renal masses. Six months after intravesical BCG therapy for transitional cell carcinoma, he developed high-grade fever and night sweat and had multiple renal parenchymal hypodensities on computed tomography (CT) scan. Repeat CT scan 6 months after ATT revealed full resolution of renal hypodensities. This case report highlights the importance of follow-up for early detection of adverse effects of BCG treatment.
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- 2023
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11. A Review of Non-wood Lignocellulose Waste Material Reinforced Concrete for Light-weight Construction Applications
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Salem Saeed, Hossam Saleh, primary, Syamsir, Agusril, additional, Abu Bakar, Mohd Supian, additional, Najeeb, Muhammad Imran, additional, Alhayek, Abdulrahman, additional, Itam, Zarina, additional, Muhammad Asyraf, Muhammad Rizal, additional, and Ali, Mohd Radzi, additional
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- 2024
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12. Translation and Validation of the Sinus and Nasal Quality of Life Surgery Survey in Serbian
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Jovicic, Nevena, primary, Petrovic, Masa, additional, Salovic, Bojana, additional, Matejic, Aleksandar, additional, Tomic, Ana, additional, Milanovic, Nina, additional, Scepanovic, Teja, additional, Alhayek, Nabil, additional, and Soldatovic, Ivan, additional
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- 2024
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13. First crystal structures of 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization
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Robin M. Gierse, Rick Oerlemans, Eswar R. Reddem, Victor O. Gawriljuk, Alaa Alhayek, Dominik Baitinger, Harald Jakobi, Bernd Laber, Gudrun Lange, Anna K. H. Hirsch, and Matthew R. Groves
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Medicine ,Science - Abstract
Abstract The development of drug resistance by Mycobacterium tuberculosis and other pathogenic bacteria emphasizes the need for new antibiotics. Unlike animals, most bacteria synthesize isoprenoid precursors through the MEP pathway. 1-Deoxy-d-xylulose 5-phosphate synthase (DXPS) catalyzes the first reaction of the MEP pathway and is an attractive target for the development of new antibiotics. We report here the successful use of a loop truncation to crystallize and solve the first DXPS structures of a pathogen, namely M. tuberculosis (MtDXPS). The main difference found to other DXPS structures is in the active site where a highly coordinated water was found, showing a new mechanism for the enamine-intermediate stabilization. Unlike other DXPS structures, a “fork-like” motif could be identified in the enamine structure, using a different residue for the interaction with the cofactor, potentially leading to a decrease in the stability of the intermediate. In addition, electron density suggesting a phosphate group could be found close to the active site, provides new evidence for the D-GAP binding site. These results provide the opportunity to improve or develop new inhibitors specific for MtDXPS through structure-based drug design.
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- 2022
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14. Abstract Number ‐ 278: Transient Ischemic Attack Evaluation Pathways: Inpatient Versus Expedited Outpatient Comparative Analysis
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Parth P Parikh, Hira Chaudhary, Nour Alhayek, Juli Kelly, Brandi Butterfield, Andrej Urumov, Bart Demaerschalk, and Oana Dumitrascu
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Neurology. Diseases of the nervous system ,RC346-429 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Introduction Transient Ischemic Attack (TIA) evaluation requires urgent etiology identification and targeted stroke prevention, traditionally performed via hospital admission. The literature suggests that outpatient evaluation may be safe and cost‐effective. Hence, we implemented an expedited outpatient pathway (OP) for patients presenting to our institution’s Emergency Department (ED) with TIA. To further guide future practice, we compared clinical features and outcomes between expedited OP and our well‐established inpatient pathway (IP). Methods We implemented an algorithm of direct communication between ED providers and Vascular Neurologists for all TIA patients. Certain screening studies (head CT, CT angiogram, basic laboratories) and acute therapies were implemented in the ED, whereas others (brain MRI, echocardiogram, etc) and Vascular Neurology consultations were expedited outpatient within 48–72 hours.We included all patients that underwent OP evaluation from May 2021‐May 2022. Further, we extracted patients with a final diagnosis of TIA and compared them with IP TIA patients hospitalized (2017‐2021), matched by age, gender, and clinical severity (ABCD2). Descriptive statistics were used to summarize patient demographics, clinical data, treatments, and 3‐month outcomes. Continuous variables were summarized with mean and standard deviations while categorical variables were shown as counts and percentages. Chi‐square test was used for categorical variables and Mann‐Whitney U test was used to compare continuous variables. P‐values < 0.05 were considered statistically significant and all tests were two‐sided. Statistical Analysis was completed in R 4.0.3. Results Of 43 patients who underwent expedited OP TIA workup, TIA or minor stroke was diagnosed in 21/43 (48.9%). 18 TIAs underwent comparative analyses. Mean symptom duration was longer in the IP (2.06 hours) than OP (0.99 hours), p = 0.370%. TIA was more likely to be diagnosed in the OP 14/18 (78%) versus IP 12/18 (67%), (p = 0.423). OP had more transesophageal echocardiograms (17% vs 5%, p = 0.630) and longer duration of ambulatory cardiac monitoring (mean 574.3 vs 381.7 hours, p = 0.100). IP patients were more likely to get started on anticoagulation compared to OP (38% vs 11%, p = 0.258) and high‐intensity statin (38% vs 17%, p = 0.260). All laboratories, echocardiograms and brain MR imaging were performed significantly sooner for the IP (p< 0.05 for all). IP had higher rate of return ED visits (22%) and readmissions at 3 months (11%), whereas OP had none. OP had no deaths or recurrent strokes, whereas 11% and 5.6% respectively were noted in the IP at 3 months (p = 0.310, p = 0.310). Conclusions Our study shows that routine IP evaluation for patients presenting with TIA in the ED may not offer diagnostic superiority nor lead to improvement of short‐term clinical outcomes, as compared to the expedited OP evaluation. Careful evaluation of TIA patients in the ED followed by expedited OP evaluation might be a plausible approach to help lower costs and avoid hospitalization without compromising the safety of these patients.
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- 2023
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15. First crystal structures of 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization
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Gierse, Robin M., Oerlemans, Rick, Reddem, Eswar R., Gawriljuk, Victor O., Alhayek, Alaa, Baitinger, Dominik, Jakobi, Harald, Laber, Bernd, Lange, Gudrun, Hirsch, Anna K. H., and Groves, Matthew R.
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- 2022
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16. Dual inhibitors of Pseudomonas aeruginosa virulence factors LecA and LasB.
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Metelkina, Olga, Konstantinović, Jelena, Klein, Andreas, Shafiei, Roya, Fares, Mario, Alhayek, Alaa, Yahiaoui, Samir, Elgaher, Walid A. M., Haupenthal, Jörg, Titz, Alexander, and Hirsch, Anna K. H.
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- 2024
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17. Finite Element Analysis of a Portable Bamboo Girder Used in Emergency Responses.
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Musthaffa, Azrul Affandhi, Nor, Norazman Mohamad, Alhayek, Abdulrahman, Yusof, Mohammed Alias, and Yaakob, Mohd Yuhazri
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STEEL girders ,STRAINS & stresses (Mechanics) ,FINITE element method ,MODULUS of elasticity ,HUMANITARIAN assistance - Abstract
This study uses numerical simulation to explore the performance of a portable bamboo girder designed for emergency scenarios and compares it to its steel counterpart. It underscores bamboo's appeal, offering a lightweight, quickly deployable, and eco-friendly alternative to steel. The research aims to assess bamboo's viability in emergency bridge construction, utilising SOLIDWORKS and ANSYS to create and simulate bamboo and steel girders. A bamboo girder aimed at humanitarian assistance and disaster relief (HADR) operations was analysed through ANSYS software under a Toyota Hilux truck's weight. Material properties, loads, and boundary conditions were defined for an accurate simulation. Three individual bamboo culms were tested in four-point flexural experiments, and the results revealed a modulus of elasticity of 14583 MPa and a local failure due to crushing and splitting with an ultimate strength of 263 MPa. Finite element analysis results indicated that the bamboo girder had a stress of 85.56 MPa and a deflection of 84.68 mm. Although the steel girder showed lower deflection, it had significantly higher stresses and weighed 180% more than the bamboo version. The bamboo girder's deflection surpassed the recommended limit under a fully loaded truck, indicating room for improvement. However, stress analysis revealed that the bamboo's structural integrity remained below its design strength. Conversely, the steel girder exhibited higher stresses and considerably greater weight. Despite deflection concerns, the bamboo girder demonstrated structural soundness and lower weight compared to steel. This positions it as a viable solution for swift emergency deployment, warranting further refinement for enhanced performance. [ABSTRACT FROM AUTHOR]
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- 2024
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18. The Reduction Factor of Pultrude Glass Fibre-Reinforced Polyester Composite Cross-Arm: A Comparative Study on Mathematical Modelling for Life-Span Prediction
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Mohd Supian Abu Bakar, Agusril Syamsir, Abdulrahman Alhayek, Muhammad Rizal Muhammad Asyraf, Zarina Itam, Shaikh Muhammad Mubin Shaik, Nurhanani Abd Aziz, Tarique Jamal, and Siti Aminah Mohd Mansor
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reduction factor ,pultrude glass fibre-reinforced polyester composite ,mathematical model ,life-span prediction ,energy ,Technology ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Microscopy ,QH201-278.5 ,Descriptive and experimental mechanics ,QC120-168.85 - Abstract
This paper presents an experimental and numerical investigation of pultruded composite glass fibre-reinforced polymer (pGFRP) cross-arms subjected to flexural creep behaviour to assess their performance and sustainability in composite cross-arm structure applications. The primary objective of this study was to investigate the failure creep behaviour of pGFRP cross-arms with different stacking sequences. Specifically, the study aimed to understand the variations in strain rate exhibited during different stages of the creep process. Therefore, this study emphasizes a simplified approach within the experiment, numerical analysis, and mathematical modelling of three different pGFRP composites to estimate the stiffness reduction factors that determine the prediction of failure. The findings show that Findley’s power law and the Burger model projected very different strains and diverged noticeably outside the testing period. Findley’s model estimated a minimal increase in total strain over 50 years, while the Burger model anticipated PS-1 and PS-2 composites would fail within about 11 and 33 years, respectively. The Burger model’s forecasts might be more reasonable due to the harsh environment the cross-arms are expected to withstand. The endurance and long-term performance of composite materials used in overhead power transmission lines may be predicted mathematically, and this insight into material property factors can help with design and maintenance.
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- 2023
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19. Person-Centered-Care Climate in a Tertiary Hospital: Staff Perspective
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Al-Surimi K, Alhayek Z, Edvardsson D, Al-Khateeb B, and Shaheen N
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health care providers’ perception ,person-centered care ,psychosocial climate ,tertiary care facility ,work climate ,Public aspects of medicine ,RA1-1270 - Abstract
Khaled Al-Surimi,1– 3 Zahra Alhayek,1,2 David Edvardsson,4 Badr Al-Khateeb,1,2 Naila Shaheen1,5 1King Saud bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi Arabia; 2King Abdullah International Medical Research Center, Riyadh, Kingdom of Saudi Arabia; 3Faculty of Medicine and Health Sciences, Thamar University, Dhamar, Yemen; 4Department of Nursing, Umea University, Umea, Sweden; 5Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center, Riyadh, Kingdom of Saudi ArabiaCorrespondence: Naila Shaheen Email drnaila@hotmail.comIntroduction: Most health care systems strive to improve the quality, safety and value of healthcare, with an emphasis on moving towards patient-centered care/person-centered care (PCC) approach. The aim of the current study was to assess health care providers’ perspectives on PCC climate in hospital setting and to identify the role of providers in determining the perception of the PCC climate.Methods: A survey, using person-centered climate questionnaire-staff version, was employed in health care providers of a tertiary care hospital. Data included variables age, gender, education level, occupation, and years of experience and three PCC dimensions. PCC overall and subscale scores were reported as mean and standard deviation. Factors associated with PCC climate perception were analyzed using a Poisson model.Results: Out of 1216 respondents; the majority 47% aged between 18 and 34 years; 79% women, 68% were nurses. The overall mean score was 45.96± 15.36 (range 0– 70). Subscale scores were Safety 20.15± 5.0 (range 0– 30), Everydayness 12.02± 3.52 (range 0– 20) and Community 13.79± 3.34 (range 0– 20). Increasing age was a significant factor associated with PCC scores for the overall, safety, everydayness, and community scales, with a positive association. Lower scores were reported more by women compared with men, for overall (p=0.0005), and everydayness (p=0.006) scales. Higher safety scores were reported by health care providers with a diploma compared to master’s degree (p=0.009), Ph.D. (p=0.007), for technicians compared with nurses (p=0.007), and for day shift compared with day/night shift workers (p=0.025). PCC scores were not significantly different across health care providers’ years of experience.Conclusion: There is a room for PCC climate improvement based on the low scores compared to the literature. The study findings indicated that the main factors associated with HCPs’ perception of PCC were higher age and female gender, and these factors would benefit from further research.Keywords: health care providers’ perception, person-centered care, psychosocial climate, tertiary care facility, work climate
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- 2021
20. Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life
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Amici, David R, primary, Alhayek, Sammy, additional, Klein, Austin T, additional, Wang, Yi-Zhi, additional, Wilen, Anika P, additional, Song, Weimin, additional, Zhu, Pei, additional, Thakkar, Abhishek, additional, King, McKenzi A, additional, Steffeck, Adam WT, additional, Alasady, Milad J, additional, Peek, Clara, additional, Savas, Jeffrey N, additional, and Mendillo, Marc L, additional
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- 2024
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21. Green nanotechnology synthesized silver nanoparticles: Characterization and testing its antibacterial activity
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AlMasoud Najla, Alhaik Hajar, Almutairi Malak, Houjak Asmaa, Hazazi Khlood, Alhayek Fatema, Aljanoubi Sarah, Alkhaibari Ahad, Alghamdi Asma, Soliman Dina A., Alomar Taghrid S., and Awad Manal A.
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green synthesis ,agnps ,ficus carica ,salvia rosmarinus ,antimicrobial activities ,Chemistry ,QD1-999 - Abstract
The green plant-mediated synthesis of silver (GPS-Ag) nanoparticles (NPs) has been increasingly popular due to its eco-friendliness, availability, cost-effectiveness, and the fact that it can be safely handled and possesses a broad variability of metabolites, such as antioxidant and antimicrobial activities. In this current study, the synthesis of AgNPs has been demonstrated using aqueous extracts of fresh leaves of Ficus carica and Salvia rosmarinus (rosemary) that reduced aqueous silver nitrate. This procedure made the synthesis of NPs possible, which was characterized by numerous analytical techniques such as ultraviolet-visible (UV-Vis) spectrophotometry, Fourier transform infrared spectroscopy, transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy, and dynamic light scattering studies. The visual observation indicated that the colour of aqueous silver nitrate turned brownish yellow after treatment with the fresh leaf extracts and was confirmed by UV-Vis spectra. In addition, the TEM analysis showed that the synthesized NPs well dispersed with average sizes less than 22 nm. Furthermore, AgNPs and aqueous leaf extracts of F. carica and rosemary were examined for their antimicrobial activities against different Gram-positive and Gram-negative bacteria strains. The results indicated that the AgNPs, derived from F. carica, have more antibacterial activities than others and inhibited bacterial growth.
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- 2021
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22. Milk intake enhances cerebral antioxidant (glutathione) concentration in older adults: A randomized controlled intervention study
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In-Young Choi, Matthew K. Taylor, Phil Lee, Sibelle Alwatchi Alhayek, Misty Bechtel, Jill Hamilton-Reeves, Kendra Spaeth, Peter Adany, and Debra K. Sullivan
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brain glutathione (GSH) ,milk intervention ,older adults ,randomized controlled clinical trial (RCT) ,aging ,magnetic resonance spectroscopy (MRS) ,Nutrition. Foods and food supply ,TX341-641 - Abstract
BackgroundA major antioxidant, glutathione (GSH), is a key factor in the antioxidant defense mechanism against oxidative stress and aging-related functional declines. Our previous observational study showed positive correlations between brain GSH concentrations and dairy food consumption, particularly milk (p < 0.001), in older adults.ObjectiveTo investigate whether a recommended amount of milk intake (3 cups/day) in low dairy consumers enhances brain GSH concentrations through an intervention trial.MethodsSeventy-three older adults (60–89 years) with a low dairy intake (≤1.5 servings/day) were randomized (5:2 ratio) in this 3-month randomized clinical trial. The intervention group was provided 1% milk weekly and instructed to consume 3 cups of milk/day for 3 months while the control group continued their habitual intake of total dairy ≤ 1.5 servings/day (
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- 2022
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23. Diagnosis and management of testicular compartment syndrome caused by tension hydrocele
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Irene Chen, Sohrab Arora, Kenan Alhayek, David Leavitt, and Ali Dabaja
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Hydrocele ,Hydrocelectomy ,Tension hydrocele ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
A hydrocele is an abnormal collection of fluid within the tunica vaginalis which may either be congenital or acquired. Hydroceles are usually painless and don't require immediate intervention unless they impact activities of daily living. This case demonstrates a rare complication of hydroceles termed tension hydrocele which presented with scrotal swelling and acute pain. Unlike the classic presentation of hydroceles with minimal pain or discomfort, it is important to recognize tension hydroceles as an extremely rare but possible cause of acute scrotum, which needs to be emergently diagnosed and treated.
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- 2022
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24. The psychological impact of the COVID‐19 pandemic on otolaryngologists: Should we be concerned?
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Mona Mohammedsaleh Ashoor, Noorah Jamal Almulhem, Zaid Abdulrahman AlMubarak, Ahmed Abdulrahman Alrahim, Saad Mohammed Alshammari, Fahad Saleh Alzahrani, Ali Radi Alhayek, and Abdullah Alardhi
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COVID‐19 ,mental wellness ,otolaryngologist ,pandemic ,psychiatric distress ,SARS‐CoV‐2 ,Otorhinolaryngology ,RF1-547 ,Surgery ,RD1-811 - Abstract
Abstract Objective Physicians on the frontline of the COVID‐19 pandemic are at increased risk of contracting the disease. Otolaryngologists are amongst the high‐risk practitioners, as they are in close proximity to patient's upper airway, which may induce their psychological stress. Methods A cross‐sectional survey study, conducted among otolaryngologists in Saudi Arabia from June 11 to June 22. Survey consisted of sociodemographic questionnaire, Coronavirus Anxiety Scale (CAS), Obsession with COVID‐19 Scale (OCS) and Patient Health Questionnaire‐9 (PHQ‐9). Available otolaryngologists with no history of mental health problems were included. A P‐value lower than .05 was considered statistically significant. Results The study included 129 participants; 63.6% men and 36.4% women. 81.4% of participants were living with family, 57.4% living with either a child or an elderly family member. Nearly 7.8% of participants had dysfunctional COVID‐19 anxiety and 75.2% had COVID‐19‐related depression symptoms ranging from minimal to severe. Obsession and dysfunctional thinking regarding COVID‐19 were found in 26.4% of participants. Single otolaryngologists had significantly higher CAS (P = .025), OCS (P = .048), and PHQ‐9 (P
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- 2021
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25. Thermochromic Polymer Nanocomposites for the Heat Detection System: Recent Progress on Properties, Applications, and Challenges.
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Supian, A. B. M., Asyraf, M. R. M., Syamsir, Agusril, Najeeb, M. I., Alhayek, Abdulrahman, Al-Dala'ien, Rayeh Nasr, Manar, Gunasilan, and Atiqah, A.
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POLYMERIC nanocomposites ,HEATING ,HEAT losses ,POTENTIAL energy ,NANOCOMPOSITE materials - Abstract
Reversible thermochromic polymers have emerged as compelling candidates in recent years, captivating attention for their application in heat detection systems. This comprehensive review navigates through the multifaceted landscape, intricately exploring both the virtues and hurdles inherent in their integration within these systems. Their innate capacity to change colour in response to temperature fluctuations renders reversible thermochromic nanocomposites promising assets for heat detection technologies. However, despite their inherent potential, certain barriers hinder their widespread adoption. Factors such as a restricted colour spectrum, reliance on external triggers, and cost considerations have restrained their pervasive use. For instance, these polymer-based materials exhibit utility in the domain of building insulation, where their colour-changing ability serves as a beacon, flagging areas of heat loss or inadequate insulation, thus alerting building managers and homeowners to potential energy inefficiencies. Nevertheless, the limited range of discernible colours may impede precise temperature differentiation. Additionally, dependency on external stimuli, such as electricity or UV light, can complicate implementation and inflate costs. Realising the full potential of these polymer-based materials in heat detection systems necessitates addressing these challenges head-on. Continuous research endeavours aimed at augmenting colour diversity and diminishing reliance on external stimuli offer promising avenues to enhance their efficacy. Hence, this review aims to delve into the intricate nuances surrounding reversible thermochromic nanocomposites, highlighting their transformative potential in heat detection and sensing. By exploring their mechanisms, properties, and current applications, this manuscript endeavours to shed light on their significance, providing insights crucial for further research and potential applications. [ABSTRACT FROM AUTHOR]
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- 2024
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26. A Review of Non-wood Lignocellulose Waste Material Reinforced Concrete for Light-weight Construction Applications.
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Saeed, Hossam Saleh Salem, Syamsir, Agusril, Abu Bakar, Mohd Supian, Najeeb, Muhammad Imran, Alhayek, Abdulrahman, Itam, Zarina, Muhammad Asyraf, Muhammad Rizal, and Ali, Mohd Radzi
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REINFORCED concrete construction ,AGRICULTURAL waste recycling ,LIGNOCELLULOSE ,CONCRETE construction ,SUSTAINABLE construction ,NATURAL fibers - Abstract
In recent decades, non-wood lignocellulosic materials have gained significant attention, particularly in concrete applications for construction purposes. This study delves into utilising non-wood lignocellulosic materials for reinforcing concrete in construction applications. Lignocellulosic material emerges as a promising option for formulating new fibre cement compositions, thereby enhancing the sustainability, affordability, and performance of construction materials. Moreover, this research broadens the horizons of recycling agricultural waste by facilitating rational disposal and optimal utilisation. Through a comprehensive review, the study reveals that flax fibres, coir pith, prickly pear fibres, and rice husk ash waste exhibit superior workability compared to their counterparts. Furthermore, the strength of non-wood lignocellulosic reinforced concrete, incorporating bagasse ash, rice husk ash, and nutshell ash, peaked when fine aggregate replacement reached 15%, surpassing other types of non-wood lignocellulosic reinforced concrete. Adding a small quantity of prickly pear fibre to cement enhances the thermal conductivity of concrete, consequently improving compressive strength, flexural strength, tensile strength, and elastic modulus. This research is relevant to international research as it advances sustainable construction materials with desirable properties, benefiting society and various industries. [ABSTRACT FROM AUTHOR]
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- 2024
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27. Bilateral Macular Hole Related to Tamoxifen Low-Dose Toxicity
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Nuria Torrell Belzach, José Ignacio Vela Segarra, Jaume Crespí Vilimelis, and Mohammed Alhayek
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macular hole ,vitrectomy ,tamoxifen ,retinal toxicity ,Ophthalmology ,RE1-994 - Abstract
Bilateral macular hole is a rare secondary effect of tamoxifen, a condition which is probably underdiagnosed. We describe the case of a 63-year-old woman who had received low-dose treatment with tamoxifen for 10 years. She presented with a best-corrected visual acuity of 20/40 in both eyes and bilateral macular hole with posterior hyaloid attachment. No reflective deposits were observed. A 23-gauge pars plana vitrectomy with internal limiting membrane peeling and gas tamponade was performed in the right eye with no anatomical or functional improvement. The most accepted mechanism of macular hole related to tamoxifen is Müller cell toxicity with retinal tissue loss. Therefore, it seems that the standard procedure used in idiopathic macular hole is not the optimal choice, due to a different pathogenic mechanism.
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- 2020
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28. Assessment of the relationship between COVID-19 risk perception and vaccine acceptance: a cross-sectional study in Jordan
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Mohammad B. Nusair, Rasha Arabyat, Rawand Khasawneh, Sayer Al-azzam, Amal T. Nusir, and Mohammad Y. Alhayek
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covid-19 ,vaccine acceptance ,vaccine hesitancy ,risk perception ,jordan ,Immunologic diseases. Allergy ,RC581-607 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Background In the absence of definitive treatment, vaccination against COVID-19 emerged as an effective solution to the spread of the pandemic. This study aimed to investigate the factors impacting the rates of COVID-19 vaccine acceptance in Jordan, in addition to examining the relationship between COVID-19 risk perception and vaccine acceptance among the Jordanian population. Methods This cross-sectional study was conducted among a sample of adults (aged ≥18) residing in Jordan. Data were collected using an online questionnaire disseminated using social media platforms between December 2nd and December 29th, 2020. Results A total of 2,268 (72.3%) participants demonstrated willingness to receive the COVID-19 vaccine. The mean COVID-19 risk perception score among the participants was 4.65 out of 10 (median 5; IQR 3–6). Higher risk perception scores were significantly associated with being female (p = .001), young (p
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- 2022
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29. Assessing the Knowledge and Attitude towards Osteoporosis among Syrian Women: A Cross-Sectional Study
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Ahmad Alhouri, Hanaa Zahrawi, Saja Alasaad, Shahd mofid Alhayek, Hasan Nabil Al Houri, Sami Jomaa, André Torbey, Sarya Swed, Douaa Alamash, Aous Zawda, Shahad Alhattab Alhasan, Naram Khalayli, and Maysoun Kudsi
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Diseases of the musculoskeletal system ,RC925-935 - Abstract
Background. Osteoporosis is a progressive decline in the bone mass, which occurs with no alterations to the bone’s composition. It is associated with increased bone fragility that may eventually lead to fractures. In this study, we aim to assess the level of awareness that Syrian women possess regarding osteoporosis and spread the knowledge about its prevention measures. Methods. This study was approved by the Institutional Review Board of the Syrian Private University. A validated questionnaire was asked to be filled in by women aged 18 and above, who were presented to clinics at Damascus, Al Helal, and Al Zahrawi hospitals between 28 November 2021 and 5 March 2022. Results. 6082 women were included, of which 63.9% (n=3884) were under 30 years old and 89.3% (n=5429) were in their reproductive age. The average knowledge score of osteoporosis was 69.2±7.7 (28-100); 88.1% correctly defined osteoporosis while the majority (93.4%) has heard of it. The majority of our participants were living in rural areas (77.2%; n=4698) while only 22.8% (n=1384) were living in urban areas. The respondents from urban areas reported the highest knowledge scores (OR=1.472; 95% CI: 1.258-1.723; P
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- 2022
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30. Comparison of Renal Stones and Nephrocalcinosis in Children: Findings From Two Tertiary Centers in Saudi Arabia
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Khalid A. Alhasan, Mohamed A. Shalaby, Amr S. Albanna, Mohamad-Hani Temsah, Zainab Alhayek, Mohammed S. Abdalla, Najlaa G. Alotaibi, Nada M. Kalakattawi, Zaher Faisal Zaher, and Jameela A. Kari
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children ,nephrolithiasis ,urolithiasis ,outcomes ,renal stones ,Pediatrics ,RJ1-570 - Abstract
Background: Renal stones (nephrolithiasis and urolithiasis) and nephrocalcinosis are uncommon in children; however, their incidences in pediatric populations have been increasing.Patients and Methods: This multicenter retrospective study compared the clinical presentation, etiology, and outcomes of childhood nephrolithiasis or urolithiasis with those of nephrocalcinosis.Results: The study included 144 children: 93 with renal stones and 51 with nephrocalcinosis. The mean age at presentation was 72 months and 54 months for children with renal stones and nephrocalcinosis, respectively. A history of consanguinity was found in 65% and 76% of the cases of renal stones and nephrocalcinosis, respectively. Congenital anomalies of the kidneys and urinary tract (CAKUT) were present in 28 and 9.8% of the patients with renal stones and nephrocalcinosis, respectively. The most common symptoms of renal stones were flank pain (29%), hematuria (15%), and dysuria (11%). Urinary tract infection was the primary presentation in the nephrocalcinosis group (18%), followed by failure to thrive (16%), polyuria (12%), and dehydration (12%). The majority of renal stone cases were caused by metabolic disorders, including hyperoxaluria (18%), cystinuria (18%), hypercalciuria (12%), and hyperuricosuria (2%). In contrast, the most common underlying disorders in cases of nephrocalcinosis were familial hypomagnesemia, hypercalciuria, nephrocalcinosis (35%), distal renal tubular acidosis (23%), and Bartter syndrome (6%). Clinical outcomes were significantly better in children with nephrolithiasis/urolithiasis than in those with nephrocalcinosis, who showed radiological evidence of worsening/persistent calcinosis and progressed more frequently to chronic kidney disease (stage II-IV) and end-stage kidney disease.Conclusion: The average age at presentation for children with renal stones was greater than that for those presenting with nephrocalcinosis. More than 25% of the children with renal stones were found to have CAKUT. Nephrocalcinosis was associated with worse clinical outcomes related to kidney function and disease resolution than nephrolithiasis.
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- 2022
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31. PalAST: A Cross-Platform Mobile Application for Automated Disk Diffusion Antimicrobial Susceptibility Testing
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AlAgha, Iyad, primary, ElShawa, Ayah, additional, Alhayek, Ghadeer, additional, Ghabayen, Malak, additional, and Alkhattib, Raghad, additional
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- 2023
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32. Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections
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Konstantinović, Jelena, primary, Kany, Andreas M., additional, Alhayek, Alaa, additional, Abdelsamie, Ahmed S., additional, Sikandar, Asfandyar, additional, Voos, Katrin, additional, Yao, Yiwen, additional, Andreas, Anastasia, additional, Shafiei, Roya, additional, Loretz, Brigitta, additional, Schönauer, Esther, additional, Bals, Robert, additional, Brandstetter, Hans, additional, Hartmann, Rolf W., additional, Ducho, Christian, additional, Lehr, Claus-Michael, additional, Beisswenger, Christoph, additional, Müller, Rolf, additional, Rox, Katharina, additional, Haupenthal, Jörg, additional, and Hirsch, Anna K.H., additional
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- 2023
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33. Host cell sensing and restoration of mitochondrial function and metabolism within Helicobacter pylori VacA intoxicated cells
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Seeger, Ami Y., primary, Zaidi, Faisal, additional, Alhayek, Sammy, additional, Jones, Rachel M., additional, Zohair, Huzaifa, additional, Holland, Robin L., additional, Kim, Ik-Jung, additional, and Blanke, Steven R., additional
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- 2023
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34. Fibrous Meningioma in a Patient with Encephalocraniocutaneous Lipomatosis: A Rare Case with Unique Features
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Al Qawasmeh M, Aldabbour B, Alhayek K, and El-Salem K
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neurocutaneous syndromes ,neurocutaneous disorders ,encephalocraniocutaneous lipomatosis ,haberland syndrome ,Medicine (General) ,R5-920 - Abstract
Majdi Al Qawasmeh, Belal Aldabbour, Kefah Alhayek, Khalid El-Salem Department of Neurology, King Abdullah University Hospital (KAUH), Jordan University of Science and Technology (JUST), Irbid, JordanCorrespondence: Majdi Al QawasmehNeurology Department of KAUH, King Abdullah University Hospital, P.O. Box 630001, Irbid 22110, JordanTel +962 797477731Email m0alqawasmeh@just.edu.joAbstract: Encephalocraniocutaneous lipomatosis “ECCL” is a rare, sporadic neurocutaneous disorder that results from a lethal autosomal mutation surviving by somatic mosaicism. It is characterized by unilateral involvement of skin, eyes and central nervous system in addition to a propensity for mesenchymal tumors. A 30-year-old male with previously controlled epilepsy presented with recurrent seizures. Brain imaging revealed a left parietal parasagittal enhancing tumor, in addition to left sided gyriform calcifications, and bilateral cerebral atrophy and ventricular dilatation more prominent on the left side. He also presented multiple left sided sebaceous nevi and abundant subcutaneous lipomas in addition to left mandibular condylar cysts. The brain tumor was excised, and cytopathology revealed a WHO grade I fibrous meningioma. After a thorough evaluation and exclusion of alternative diagnoses, the patient was diagnosed with definite encephalocraniocutaneous lipomatosis as per Moog’s criteria. Several cases of ECCL recently presented with different intracranial neoplasms. Here we report the first case of ECCL in association with meningioma.Keywords: neurocutaneous syndromes, neurocutaneous disorders, encephalocraniocutaneous lipomatosis, Haberland syndrome
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- 2020
35. Finite element method for the static and dynamic analysis of FRP guyed tower
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Alshurafa, Sami, Alhayek, Hanan, and Polyzois, Dimos
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- 2019
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36. Atypical distal tracheal fibrous bridge and bronchial stenosis in an adult patient with bronchopulmonary dysplasia
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Wadiwala, Ishaq J., primary, Yu Lee‐Mateus, Alejandra, additional, Alhayek, Bakr, additional, Abia‐Trujillo, David, additional, Chadha, Ryan, additional, Hazelett, Britney N., additional, and Fernandez‐Bussy, Sebastian, additional
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- 2023
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37. The Reduction Factor of Pultrude Glass Fibre-Reinforced Polyester Composite Cross-Arm: A Comparative Study on Mathematical Modelling for Life-Span Prediction
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Abu Bakar, Mohd, primary, Syamsir, Agusril, additional, Alhayek, Abdulrahman, additional, Asyraf, Muhammad, additional, Itam, Zarina, additional, Shaik, Shaikh, additional, Abd Aziz, Nurhanani, additional, Jamal, Tarique, additional, and Mohd Mansor, Siti, additional
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- 2023
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38. Evaluation of facial appearance in patients with repaired cleft lip and palate: comparing the assessment of laypeople and healthcare professionals
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Samar Alhayek, Mohammed Alsalem, Yazeed Alotaibi, and Aamir Omair
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Assessment ,Cleft lip palate ,Facial appearance ,Laypeople ,Dentistry ,RK1-715 ,Surgery ,RD1-811 - Abstract
Abstract Background The present study aimed to determine whether laypeople and professionals rate the facial appearance of individuals with repaired complete unilateral or bilateral cleft lip and palate (UCLP, BCLP) similarly based on viewing full facial images. Methods The study followed a cross-sectional analytical design where five young patients aged 10 to 14 years, who had completed all stages of their unilateral or bilateral cleft lip and palate treatment (bilateral: three, unilateral: two), were evaluated by two groups. The assessment was done by laypeople and 97 qualified professionals (33 orthodontists, 32 plastic surgeons, and 32 oral and maxillofacial surgeons). Professionals were not involved in any stage of the patients’ treatment. Results The facial appearance assessment of the professional groups on different facial aesthetics was significantly lower than that of laypeople, and they had higher perceived need for further treatment. On the other hand, laypeople had higher aesthetic ratings and lower perceived need for further treatment. Differences were also observed between the assessments of the professional groups. Participants who had lower aesthetic assessments of the repair tended to report a higher influence of cleft lip and palate on social activities and professional life. Conclusion Differences in perception exist between healthcare professionals and laypeople. The discrepancies between the professional groups could be attributed to different treatment modalities and protocols.
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- 2019
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39. Changing trends of prosthetic rehabilitation of partially edentulous patients visiting a tertiary care dental hospital
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Marwa E. I. Elagra, Abdulhadi I. A. Alhayek, Bashayir F. M. Al-Mutairi, Noora A Aljohar, and Reem A Aladwani
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Fixed partial denture ,implant ,removable partial denture ,tooth replacement ,Medicine - Abstract
Introduction: The choice of prosthetic replacement is largely determined by the patient's choice and economic status, available technology and expertise, as well as the number of missing teeth. The aim of this study was to identify the trend in prosthetic replacement, in partially edentulous patients treated at Riyadh Elm University (REU) hospitals, as well as to investigate the factors that might influence the prosthetic choice. Methods: The records from Dentoplus digital system of all partially edentulous patients who had a prosthetic replacement at REU 2013, until June 2018, were screened and analyzed using Statistical software SPSS version 25. Chi-square and Fisher exact tests were performed. Alpha level was set at ≤0.05. Results: 6,340 patients received implants, removable or fixed prosthesis. Majority of the patients were females (60%). RPDs were the highest placed restorations (69%). Students (73%) placed most RPDs. Implants significantly increased through the years by almost (30%) (P-value = 0.00). Among FPDs, metal-ceramics were the highest restorations (74%), with a significant increase of all-ceramic restorations through years (P-value = 0.00). Moreover, FPDs were significantly the highest restorations among young-adult and middle-aged patients (P-value = 0.00). Conclusion: There was a clear change in prosthetic rehabilitation trends over the past few years. Although removable partial dentures continued to play a major role in prosthetic teeth replacement, the use of dental implants showed a steady increase every year. Students' requirements and level of experience, along with the patient age, had an influence in the prosthetic choice.
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- 2019
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40. Elevated Transaminases as Predictors of COVID-19 Pneumonia Severity
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Tijana Radonjić, Ognjen Milićević, Igor Jovanović, Marija Zdravković, Marija Dukić, Olga Milorad Mandić, Jelica Bjekić-Macut, Olivera Borko Marković, Zoran Todorović, Milica Brajković, Novica Nikolić, Slobodan Klašnja, Višeslav Popadić, Anica Divac, Milica Marinković, Nabil Alhayek, and Marija Svetislav Branković
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liver ,transaminases ,COVID-19 ,SARS-CoV-2 ,Medicine (General) ,R5-920 - Abstract
Background: This study aimed to calculate the frequency of elevated liver enzymes in hospitalized patients with coronavirus disease 2019 (COVID-19) infection and to test if liver enzyme biochemistry levels on admission could predict the computed tomography (CT) scan severity score of bilateral interstitial pneumonia. Methods: This single-center study comprised of 323 patients including their demographic data, laboratory analyses, and radiological findings. All the information was taken from electronic health records, followed by statistical analysis. Results: Out of 323 patients, 115 of them (35.60%) had aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) over 40 U/L on admission. AST was the best predictor of CT scan severity score of bilateral interstitial pneumonia (R2 = 0.313, Adjusted R2 = 0.299). CT scan severity score in the peak of the infection could be predicted with the value of AST, neutrophils, platelets, and monocytes count (R2 = 0.535, Adjusted R2 = 0.495). Conclusion: AST, neutrophils, platelets, and monocytes count on admission can account for almost half (49.5%) of the variability in CT scan severity score at peak of the disease, predicting the extensiveness of interstitial pneumonia related to COVID-19 infection. Liver enzymes should be closely monitored in order to stratify COVID-19 patients with a higher risk of developing severe forms of the disease and to plan the beforehand step-up treatment.
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- 2022
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41. دراسة تأثير التضخم على المركز المالي للمصارف التقليدية السورية باستخدام نموذج VECM
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Bassel Alhayek, Yomn Mansour, and Talal Suleiman
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Law ,Economics as a science ,HB71-74 - Abstract
يعتبر التضخم من أهم المقاييس التي تعبر عن الوضع الاقتصادي في بلد معين من حيث الرخاء الاجتماعي والاقتصادي والمالي حيث أن التذبذب الشديد في هذا المقياس يؤدي إلى ضعف ثقة المواطنين بالعملة المحلية وانخفاض القيمة الحقيقية للمدخرات والودائع، كما يؤدي إلى تخبط حركة السوق المحلي، وذلك بسبب مخاوف المصدرين والمستوردين من عقد الصفقات التجارية نتيجة هامش المخاطرة العالية الناتج عن هذا التقلب هدف هذا البحث إلى دراسة معدل التضخم خلال الفترة الواقعة بين 1/1/2009م ولغاية 31-12-2018م، وآلية تأثيره على المركز المالي للمصارف التقليدية السورية. بينت الدراسة أن معدل التضخم خلال الفترة المدروسة يؤثر على المركز المالي للمصارف التقليدية وهذا التأثير يتجه باتجاه واحد فقط وهو طردي ومعنوي حيث أن زيادة التضخم بمقدار ليرة واحدة يؤدي إلى زيادة المركز المالي بمقدار 12178860 ل.س. إن أي تغير قصير الأجل في معدل التضخم لابد وأن يؤثر بالنموذج ويدفعه نحو التوازن في الأجل الطويل وذلك بسرعة تعديل تبلغ95.3% خلال الفترة الزمنية الواحدة (أي شهر)، أي أن النموذج يعاود الاستقرار خلال فترة مقدارها شهر ويومان.
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- 2020
42. Flexural Creep Behaviour of Pultruded GFRP Composites Cross-Arm: A Comparative Study on the Effects of Stacking Sequence
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Abdulrahman Alhayek, Agusril Syamsir, Abu Bakar Mohd Supian, Fathoni Usman, Muhammad Rizal Muhammad Asyraf, and Mohd Afdzaluddin Atiqah
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stacking sequence ,pultrusion ,creep ,glass fibres-reinforced polymer ,flexural ,cross arm ,Organic chemistry ,QD241-441 - Abstract
Pultruded glass fibre reinforced polymer (pGFRP) composites provide outstanding properties for composite polymer cross arms in power transmission line applications. This study has investigated the effects of various stacking sequences of fibres directions of pGFRP on flexural strength and creep behaviour. The use of static four-point bending flexural tests revealed that Stacking Sequence 2 (±45/0/90/0/90/0) had a significant flexural strength of 399.9 MPa while Stacking Sequence 1 (±45/90/0/±45) had a flexural strength of 242.5 MPa. Furthermore, the four-point bending creep experiments were performed at three distinct stress levels, notably 12%, 24%, and 37% of the ultimate flexural strength, to characterise the creep behaviour of distinct stacking sequences. Moreover, Findley’s power law equation for bending creep behaviour has revealed that the time-dependent reduction factor of Stacking Sequence 1 and Stacking Sequence 2 estimates a drop in flexural modulus of 23% and 10% respectively.
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- 2022
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43. Overview on Congestive Heart Failure Imaging
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Hossam A. El-Kenawy, null Abdulrahman Kareem Ibrahim Altuwayhir, null Daniyah Abdul qader Fatani, null Nujud Adel Barayan, null Mohammed Shari Alshahrani, null Aminah Abdulghany Sabbagh, null Mahdi Abdulmohsen M Alnemer, null Zahraa Ahmad AlAhmad, null Abdullah Abdulaziz Albakri, null Lama Kamal Kabrah, null Khalid Hassan Al Mughram, null Hussain Jassim Alhayek, and null Ahmed Mohammed Alkathim
- Abstract
Background: Heart failure is a complex clinical syndrome that results from a functional or structural heart disorder. Acute heart failure is one of the main diagnostic and therapeutic challenges in clinical practice due to a non-specific clinical manifestation and the urgent need for timely and tailored management at the same time. During the first hours of admission the point-of-care focused on cardiac and lung ultrasound examination that are invaluable tool for rapid differential diagnosis of acute dyspnoea, which are highly feasible and relatively easy to learn. Objective: The study aimed to investigate the role of several portable and stationary imaging modalities, which are being increasingly used for the evaluation of cardiac structure and function, haemodynamic and volume status, precipitating myocardial ischaemia or valvular abnormalities, and systemic and pulmonary congestion. Methods: For article selection, the PubMed database and EBSCO Information Services were used. All articles relevant with our topic and other articles were used in our review. Other articles that were not related to this field were excluded. The data was extracted in a specific format that was reviewed by the group members. Conclusion: Heart failure is a main cause of mortality and morbidity worldwide. Assessment of the case is essential to determine the etiology and the best treatment strategy. For the assessment of HF patients, a variety of imaging techniques are used, each with advantages and disadvantages. For its accessibility, affordability, and utility, echocardiography remains the preferred method. It offers the majority of the data necessary it has been improved with the addition of 3DE and strain for the management and follow-up of patients with HF. In particular cases like ischemic heart disease, other methods may be helpful. It should be noted that the right imaging choice can assist in the management of the patient with HF.
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- 2022
44. فعالية المبيدين فلوبندياميد flubendiamide و كلورانترانيليبرول chlorantraniliprole وجزيئات النانوسيليكا في مكافحة حافرة أنفاق أوراق البندورة Tuta absoluta (Meyrick ) في ظروف البيت البلاستيكي
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Samir Tabbache, Ahmad Kara Ali, Mohammed Ahmad, and Ritta Alhayek
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Biology (General) ,QH301-705.5 - Abstract
تمَّ اختبار فعالية المبيدين فلوبندياميدflubendiamide ، وكلورانترانيليبرول chlorantraniliprole وجزيئات النانوسيليكا ضد حافرة أنفاق أوراق البندورة absoluta Tuta تحت ظروف البيت البلاستيكي، حيث استخدم المبيدان بالتراكيز المنصوح بها ( 0.4 غ/ ل و 0.31 مل/ ل ) والنانوسيليكا بالتركيز 500 ppm. أظهرت النتائج وجود فروق معنوية بين جميع المعاملات والشاهد ، من حيث عدد اليرقات الحية / النبات ، حيث بلغت فعالية المبيدينflubendiamide ، chlorantraniliprole 51.37 و 63.85 % بعد 7 أيام من الرشة الأولى ، ووصلت إلى52.33 و 69.95 بعد 7 أيام من الرشة الثانية على التوالي ، أما جزيئات النانوسيليكا فقد بلغت فعاليتها 36.14 و 55.15 على التوالي. خفضت جميع المعاملات عدد الثمار المصابة بفرق معنوي بالمقارنة مع الشاهد، حيث بلغت نسبة التخفيض 63.83% في معاملة flubendiamide و 64.62% في معاملة chlorantraniliprole و37.11% في المعاملة بجزيئات النانوسيليكا ، و ذلك في اليوم العاشر بعد الرشة الأولى ، ووصلت إلى 37.5، 58.7 ،34.81 % على التوالي بعد 9 أيام من الرشة الثانية. بينت النتائج فعالية كل من المبيد flubendiamide و chlorantraniliprole و جزيئات النانوسيليكا في تخفيض شدة الإصابة بالحافرة على الثمار، وقد بلغت 40 ، 26.3 و 23.2 % على التوالي بعد 10 أيام من الرشة الأولى بالمقارنة مع الشاهد ، ووصلت إلى 51.8، 76.8و 42.4 % بعد 9 أيام من الرشة الثانية بالمقارنة مع الشاهد أيضاً مع تفوق معاملة المبيد كلورانترانيليبرول chlorantraniliprole على بقية المعاملات.
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- 2020
45. Epidemiology, Risk Factors, and Predictors of Disability in a Cohort of Jordanian Patients with the First Ischemic Stroke
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Majdi Al Qawasmeh, Belal Aldabbour, Aiman Momani, Deema Obiedat, Kefah Alhayek, Raid Kofahi, Ahmed Yassin, and Khalid El-Salem
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Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Objective. To identify the risk factors, etiologies, length of stay, severity, and predictors of disability among patients with the first ischemic stroke in Jordan. Methods. A retrospective cohort study of 142 patients who were admitted to the Neurology Department at King Abdullah University Hospital between July/2017 and March/2018 with a first ischemic stroke. Etiology was classified according to the TOAST criteria. Severity was represented by NIHSS score, disability by mRS score, and prolonged length of stay as hospitalizations more than 75th percentile of the cohort’s median length of stay. Analysis of the sample demographics and descriptive statistics were done, including frequencies of prevalence of independent variables (risk factors) and frequencies of stroke and etiology work-up. Chi-square and univariate analysis of variance “ANOVA” were used to investigate the relationship between risk factors and type of stroke. Finally, logistic regression analysis was used to measure the contribution of each of the independent variables. IRB approval was obtained as necessary. Results. The mean age for the cohort was 66.5 years. The most common risk factors were hypertension (78.8%), diabetes mellitus (60.5%), and ischemic heart disease (29.4%). The most common stroke etiology was small-vessel occlusion (54.2%). Median length of stay was 4 days. Prolonged length of stay was observed in 23.23% of patients, which was associated with several factors, the most common of which were persistent dysphagia (57.5%), nosocomial infection (39.3%), and combined dysphagia and nosocomial infection (21.2%). The mean admission NIHSS score was 7.94, and on discharge was 5.76. In-hospital mortality was 2.81%, while 50% of patients had a favorable outcome on discharge (mRS score between 0-2). The mean discharge mRS score for the cohort was 2.47 (SD±1.79). Large artery atherosclerosis was associated with the highest residual disability with a mean score of 3.67 (SD±1.88), while the stroke of undetermined etiology was associated with the lowest residual disability with a mean score of 1.60 (SD±1.78). Significant predictors of mRS score were smoking (t 3.24, P
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- 2020
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46. Prevalence of mental illness, and the demographic and socio-economic conditions that are associated with the self-rated mental health in an adult population in Sweden : A cross-sectional study
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Naji Alhayek, Mhd Nizar and Naji Alhayek, Mhd Nizar
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Bakgrund: Andelen av den svenska befolkningen som rapporterade psykiska problem har ökat under de senaste decennierna och särskilt de senaste åren, vilket bekräftar betydelsen av att monitorera den psykiska hälsan i befolkningen. Syfte: Att undersöka förekomsten av psykiska problem i en population av svenska vuxna, och att analysera de oberoende sambanden mellan de demografiska och socioekonomiska förhållandena och mellan självskattat psykiskt välbefinnande och psykisk påfrestning. Metod: Studien baseras på den senaste undersökningen Liv och Hälsa (2022) som hade 35 169 deltagare av båda könen och från 55 kommuner i Mellansverige. Deskriptiv statistik användes för att besvara den första forskningsfrågan. Binära logistiska regressionsanalyser gjordes för att besvara den andra forskningsfrågan. Resultat: Kvinnor rapporterade sämre resultat för alla mentala variabler. Unga deltagare (18–29) inom varje kön rapporterade de högsta andelarna för de diagnostiserade problemen, för att ha psykisk påfrestning och inte ha bra psykiskt välbefinnande och för de allvarliga symtomen av nästan alla psykiska problem. Faktorer som var starkt och oberoende associerade med psykisk påfrestning och psykiskt välbefinnande var: Att ha blivit förringad under de senaste tre månaderna, att sakna socialt stöd och att sakna ett förvärvsarbete. Slutsats: Intressenter bör ägna mer uppmärksamhet åt kvinnors och ungas psykiska hälsa och åt de demografiska och socioekonomiska förhållandena som potentiella områden för intervention och förebyggande insatser. Mer forskning rekommenderas för att förbättra kvinnors och ungas psykiska hälsa och för att få en bättre förståelse av faktorerna som associeras med psykisk hälsa., Background: The proportion of the Swedish population that reported mental problems has increased during the last decades and especially the last few years, which confirms the importance of keeping track of mental health in the population. Aim: To investigate the prevalence of mental problems in a population of Swedish adults, and to disentangle the independent associations between the demographic and socio-economic conditions and self-rated mental wellbeing and psychological distress. Method: The study is based on the most recent Life and Health survey (2022) which had 35 169 responders from both genders and from 55 municipalities in central Sweden. Descriptive statistics was used to answer the first research question. Binary logistic regression analyses were done to answer the second research question. Results: Women reported worse results for all of the mental variables. Young participants (18-29) within each gender reported the highest proportions for the diagnosed problems, for having psychological distress and not having good mental wellbeing and for the severe symptoms of almost all of the mental problems. Factors that were strongly and independently associated with psychological distress and with mental wellbeing were: Being belittled in the last three months, lacking social support and lacking a paid job. Conclusion: Stake-holders should pay more attention to women's and youth's mental health, and to the demographic and socio-economic conditions as potential areas for intervention and prevention. Further research is recommended to enhance the mental health of women and youths, and to get a better understanding of the factors that are associated with mental health.
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- 2023
47. Optimization of Rhombus Opening Area of Shear Walls On Tall Buildings
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Syamsir, Agusril, Iskandar, Isdaryanto, Malekzadah, Abdul Rahman, Alhayek, Abdulrahman, Syamsir, Agusril, Iskandar, Isdaryanto, Malekzadah, Abdul Rahman, and Alhayek, Abdulrahman
- Abstract
This research was designed to determine the optimum percentage and configuration of rhombus opening on shear wall of tall building. A residential tall building of 12-storeys having base size of 20m × 10m with height of floor of 3m was analysed. In this paper, percentages of 12%, 24%, 36%, 42%, and 54% concentric rhombus opening in a shear wall in tall buildings were modeled. The effect of the opening size on the lateral displacement, base shear, and stress at the opening was determined. It was found that the opening of 12% has less lateral displacement, base shear, and stress at the opening. This indicates that this opening delivers the best performance among the other percentages. Five models with the same percentage of rhombus opening of 12% at different configuration on the shear wall in tall buildings were modeled to determine the optimum configuration of opening on shear walls. It was found that Model-1 is the optimum configuration since this model has the lowest lateral displacement and stress at the opening. It can be concluded that Model-1 with 12% opening area is the optimum size and configuration to resist lateral force on tall buildings.
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- 2023
48. Evaluation of facial appearance in patients with repaired cleft lip and palate: comparing the assessment of laypeople and healthcare professionals
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Alhayek, Samar, Alsalem, Mohammed, Alotaibi, Yazeed, and Omair, Aamir
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- 2019
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49. Not Every Hit-Identification Technique Works on 1-Deoxy-D-Xylulose 5-Phosphate Synthase (DXPS)
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Sandra Johannsen, Robin M. Gierse, Aleksandra Olshanova, Ellie Smerznak, Christian Laggner, Lea Eschweiler, Zahra Adeli, Rawia Hamid, Alaa Alhayek, Norbert Reiling, Jörg Haupenthal, Anna K. H. Hirsch, and Chemical Biology 2
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Pharmacology ,Drug discovery ,2-C-methyl-D-erythritol 4-phosphate pathway ,Organic Chemistry ,inhibitors ,Molecular Medicine ,General Pharmacology, Toxicology and Pharmaceutics ,1-deoxy-D-xylulose 5-phosphate synthase ,neural networks ,Biochemistry - Abstract
In this work, we demonstrate how important it is to investigate not only on-target activity but to keep antibiotic activity against critical pathogens in mind. Since antimicrobial resistance is spreading in bacteria such as Mycobacterium tuberculosis, investigations into new targets are urgently needed. One promising new target is 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) of the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. We have recently solved the crystal structure of truncated M. tuberculosis DXPS and used it to perform a virtual screening in collaboration with Atomwise Inc. using their deep convolutional neural network-based AtomNet® platform. Of 94 virtual hit compounds only one showed interesting results in binding and activity studies. We synthesized 30 close derivatives using a straightforward synthetic route that allowed for easy derivatization. However, no improvement in activity was observed for any of the derivatives. Therefore, we tested them against a variety of pathogens and found them to be good inhibitors against Escherichia coli.
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- 2023
50. Watching television while forcibly displaced: Syrian refugees as participant audiences
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Katty Alhayek
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In this article, I explore how Syrian refugees and internally displaced people are using social media to reshape interpretations of their own status through their engagement with quality TV texts that tackle the refugee crisis. I focus on the discourse surrounding the Syrian Television Drama series Ghadan Naltaqi (GN) [We’ll Meet Tomorrow] which is particularly interesting because of the dialogue that has developed between the forcibly displaced segment of its audience and the writer/creator of the show, Iyad Abou Chamat. Methodologically, this research is based on 26 semi-structured interviews conducted in Arabic language: one interview with Chamat, and 25 interviews with members of his audience who friended Chamat on Facebook after GN aired. I demonstrate that Facebook serves as an outlet for interactivity between displaced drama producers and audiences in a way that imitates the dynamics of live theater. While such interactivity is facilitated by technology, the emergence of this interactive relationship is owned to the desires for (re- )connection of both drama creators and audiences stemming from the alienation of war, violence and displacement. The particularity of the Syrian war-related topic in GN and its applicability to both the creator of the series as well as to audiences’ lived experiences evoked a significant level of online participation with Chamat. I use the term ‘participant audiences’ to describe the interactive, emotional responses of displaced audiences and their online engagement with TV content that address the disconnections they experience because of conflict and displacement while offering them possibilities for coping with violence, marginalization, and suffering. I show how the entertainment interventions of drama creators help displaced people both to mitigate the traumatic effects of a highly polarizing conflict, and to find a healing space from violent and alienating dominant media discourses
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- 2023
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