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Background: Single nucleotide polymorphisms (SNPs) interfere with the function of certain genes and thus may influence the probability of skin cancer. The correlation between SNPs and skin cancer (SC) lacks statistical power, however. Therefore, the purpose of this study was to identify the gene polymorphisms involved in skin cancer susceptibility using network meta-analysis and to determine the relationship between SNPs and SC risk. Methods: PubMed, Embase, andWeb of Science were searched for articles including "SNP" and different types of SC as keywords between January 2005 and May 2022. The Newcastle-Ottawa Scale was used to assess bias judgments. The odds ratio (ORs) and their 95% confidence intervals (CIs) were determined to estimate heterogeneity within and between studies. Meta-analysis and network meta-analysis were carried out to identify the SNPs associated with SC. The P-score of each SNP was compared to obtain the rank of probability. Subgroup analyses were performed by cancer type. Results: A total of 275 SNPs from 59 studies were included in the study. Two subgroup SNP networks using the allele model and dominant model were analyzed. The alternative alleles of rs2228570 (FokI) and rs13181 (ERCC2) were the first-ranking SNPs in both subgroups one and two of the allele model, respectively. The homozygous dominant genotype and heterozygous genotype of rs475007 in subgroup one and the homozygous recessive genotype of rs238406 in subgroup twoweremost likely to be associatedwith skin cancer based on the dominantmodel. Conclusions: According to the allele model, SNPs FokI rs2228570 and ERCC2 rs13181 and, according to the dominant model, SNPs MMP1 rs475007 and ERCC2 rs238406 are closely linked to SC risk. [ABSTRACT FROM AUTHOR]

Introduction: Knee osteoarthritis (OA) is a chronic musculoskeletal disease that is associated with mortality, disability, and low quality of life. In Hungary, the number of patients diagnosed with severe knee osteoarthritis is dramatically increasing yearly. Objective: This study aims to assess the quality of life among patients with severe knee osteoarthritis who undergo knee replacement surgery after one month to assess their quality of life (QoL). Material and Method: Ten patients (6 female, 4 male, 70±4 years, 30.7±3.4 kg/m2) with severe knee osteoarthritis were included from an orthopedic clinic in Pécs, Hungary. The SF-36 questionnaire (Hungarian version) was used to assess QoL of the patients one month prior to knee replacement surgery. Results: The participants with severe knee OA reported allow overall average of pain (40.95%), role limitations due to physical health (42.5%), and role limitations due to emotional problems (46.7%) that reduced their QoL. In addition, there are significant differences between women and men in some domains. Women had significantly lower physical functioning and role limitations due to emotional problems than men, by 42.8% (p=0.03) and 73.3% (P=0.005), respectively. Moreover, women had a higher feeling of pain than men; however, the differences was insignificant. Conclusions: Patients with severe knee osteoarthritis have low quality of life and severe pain during daily activities. Furthermore, women with severe knee OA had significantly higher pain and lower quality of life than men due to their emotional status. Further studies with large sample sizes are needed. [ABSTRACT FROM AUTHOR]