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1. Identifying plasma proteomic signatures from health to heart failure, across the ejection fraction spectrum

Author

Andrzejczyk, Karolina, Abou Kamar, Sabrina, van Ommen, Anne-Mar, Canto, Elisa Dal, Petersen, Teun B., Valstar, Gideon, Akkerhuis, K. Martijn, Cramer, Maarten Jan, Umans, Victor, Rutten, Frans H., Teske, Arco, Boersma, Eric, Menken, Roxana, van Dalen, Bas M., Hofstra, Leonard, Verhaar, Marianne, Brugts, Jasper, Asselbergs, Folkert, den Ruijter, Hester, and Kardys, Isabella

Published
2024
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5. Abstract 12012: Subphenotypes of Heart Failure With Reduced Ejection Fraction Based on Repeated Measurements of 4210 Circulating Proteins Are Driven by Protein Subsets Reflecting Different Biological Mechanisms

Author

Petersen, Teun B, de Bakker, Marie, Asselbergs, Folkert W, Akkerhuis, K. Martijn, Brugts, Jasper J, van Ramshorst, Jan, Lumbers, Tom, Ostroff, Rachel, Katsikis, Peter D, van der Spek, Peter J, Umans, Victor A, Boersma, Eric, Rizopoulos, Dimitris, and Kardys, Isabella

Published
2022
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8. Machine learning–based biomarker profile derived from 4210 serially measured proteins predicts clinical outcome of patients with heart failure

Author

de Bakker, Marie, primary, Petersen, Teun B, additional, Rueten-Budde, Anja J, additional, Akkerhuis, K Martijn, additional, Umans, Victor A, additional, Brugts, Jasper J, additional, Germans, Tjeerd, additional, Reinders, Marcel J T, additional, Katsikis, Peter D, additional, van der Spek, Peter J, additional, Ostroff, Rachel, additional, She, Ruicong, additional, Lanfear, David, additional, Asselbergs, Folkert W, additional, Boersma, Eric, additional, Rizopoulos, Dimitris, additional, and Kardys, Isabella, additional

Published
2023
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11. Sex‐specific cardiovascular protein levels and their link with clinical outcome in heart failure.

Author

de Bakker, Marie, Loncq de Jong, Mylène, Petersen, Teun, de Lange, Iris, Akkerhuis, K. Martijn, Umans, Victor A., Rizopoulos, Dimitris, Boersma, Eric, Brugts, Jasper J., and Kardys, Isabella

Subjects
HEART assist devices, FATTY acid-binding proteins, HEART failure, MATRIX metalloproteinases, TREFOIL factors, HEART transplantation
Abstract

Aims: This study aims to provide insight into sex‐specific cardiovascular protein profiles and their associations with adverse outcomes, which may contribute to a better understanding of heart failure (HF) pathophysiology and the optimal use of circulating proteins for prognostication in women and men. Methods and results: In 250 stable patients with HF with reduced ejection fraction (HFrEF), we performed trimonthly blood sampling (median follow‐up: 26 [17–30] months). We selected all baseline samples and two samples closest to the primary endpoint (PEP; composite of cardiovascular death, heart transplantation, left ventricular assist device implantation, and HF hospitalization) or one sample closest to censoring and applied the Olink Cardiovascular III panel. We used linear regression to study sex‐based differences in baseline levels and joint models to study differences in the prognostic value of serially measured proteins. In 66 women and 184 men (mean age of 66 and 67 years, respectively), 21% and 28% reached the PEP, respectively. Mean baseline levels of fatty acid‐binding protein 4, secretoglobin family 3A member 2, paraoxonase 3, and trefoil factor 3 were higher in women (Pinteraction: 0.001, 0.007, 0.018, and 0.049, respectively), while matrix metalloproteinase‐3, interleukin 1 receptor‐like 1, and myoglobin were higher in men (Pinteraction: <0.001, 0.001, and 0.049, respectively), independent of clinical characteristics. No significant differences between sexes were observed in the longitudinal associations of proteins with the PEP. Only peptidoglycan recognition protein 1 showed a suggestive interaction with sex for the primary outcome (Pinteraction = 0.028), without multiple testing correction, and was more strongly associated with adverse outcome in women {hazard ratio [HR] 3.03 [95% confidence interval (CI), 1.42 to 6.68], P = 0.008} compared with men [HR 1.18 (95% CI, 0.84 to 1.66), P = 0.347]. Conclusions: Although multiple cardiovascular‐related proteins show sex differences at baseline, temporal associations with the adverse outcome do not differ between women and men with HFrEF. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Circulating biomarkers of cardiovascular disease are related to aneurysm volume in abdominal aortic aneurysm

Author

Bouwens, Elke, primary, Vanmaele, Alexander, additional, Hoeks, Sanne E, additional, Verhagen, Hence JM, additional, Fioole, Bram, additional, Moelker, Adriaan, additional, ten Raa, Sander, additional, Hussain, Burhan, additional, Oliveira-Pinto, José, additional, Bastos Gonçalves, Frederico, additional, Ijpma, Arne S, additional, Hoefer, Imo E, additional, van Lier, Felix, additional, Akkerhuis, K Martijn, additional, Majoor-Krakauer, Danielle F, additional, Boersma, Eric, additional, and Kardys, Isabella, additional

Published
2023
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13. Effects of Ticagrelor, Prasugrel, or Clopidogrel on Endothelial Function and Other Vascular Biomarkers: A Randomized Crossover Study

Author

Frigoli, Enrico, Monti, Monia, Ciociano, Nestor, Karagiannis, Alexios, Heg, Dik, Valgimigli, Marco, Leonardi, Sergio, Brugaletta, Salvatore, Rizzotti, Diego, Mandurino Mirizzi, Alessandro, Van Royen, Niels, van Leeuwen, Maarten, Janssens, Gladys, Räber, Lorenz, Ariotti, Sara, Windecker, Stephan, Rimoldi, Stefano F., Rexhaj, Emrush, Sabaté, Manel, Ortega-Paz, Luis, Akkerhuis, K. Martijn, van den Berge, Jan C., and Gianni, Umberto

Published
2018
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14. Circulating biomarkers of cardiovascular disease are related to aneurysm volume in abdominal aortic aneurysm

Author

Bouwens, Elke, Vanmaele, Alexander, Hoeks, Sanne E., Verhagen, Hence J.M., Fioole, Bram, Moelker, Adriaan, ten Raa, Sander, Hussain, Burhan, Oliveira-Pinto, José, Bastos Gonçalves, Frederico, Ijpma, Arne S., Hoefer, Imo E., van Lier, Felix, Akkerhuis, K. Martijn, Majoor-Krakauer, Danielle F., Boersma, Eric, Kardys, Isabella, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
endovascular aneurysm repair, SDG 3 - Good Health and Well-being, biomarkers, Cardiology and Cardiovascular Medicine, abdominal aortic aneurysm (AAA), cardiovascular diseases
Abstract

Funding Information: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work is supported by Stichting Lijf en Leven. The sponsor had no role in study design, methods, subject recruitment, data collection or analysis, or preparation of the manuscript. Publisher Copyright: © The Author(s) 2023. Background: Surveillance programs in abdominal aortic aneurysms (AAA) are mainly based on imaging and leave room for improvement to timely identify patients at risk for AAA growth. Many biomarkers are dysregulated in patients with AAA, which fuels interest in biomarkers as indicators of disease progression. We examined associations of 92 cardiovascular disease (CVD)-related circulating biomarkers with AAA and sac volume. Methods: In a cross-sectional analysis, we separately investigated (1) 110 watchful waiting (WW) patients (undergoing periodic surveillance imaging without planned intervention) and (2) 203 patients after endovascular aneurysm repair (EVAR). The Cardiovascular Panel III (Olink Proteomics AB, Sweden) was used to measure 92 CVD-related circulating biomarkers. We used cluster analyses to investigate protein-based subphenotypes, and linear regression to examine associations of biomarkers with AAA and sac volume on CT scans. Results: Cluster analyses revealed two biomarker-based subgroups in both WW and EVAR patients, with higher levels of 76 and 74 proteins, respectively, in one subgroup versus the other. In WW patients, uPA showed a borderline significant association with AAA volume. Adjusting for clinical characteristics, there was a difference of −0.092 (−0.148, −0.036) loge mL in AAA volume per SD uPA. In EVAR patients, after multivariable adjustment, four biomarkers remained significantly associated with sac volume. The mean effects on sac volume per SD difference were: LDLR: −0.128 (−0.212, −0.044), TFPI: 0.139 (0.049, 0.229), TIMP4: 0.110 (0.023, 0.197), IGFBP-2: 0.103 (0.012, 0.194). Conclusion: LDLR, TFPI, TIMP4, and IGFBP-2 were independently associated with sac volume after EVAR. Subgroups of patients with high levels of the majority of CVD-related biomarkers emphasize the intertwined relationship between AAA and CVD. ClinicalTrials.gov Identifier: NCT03703947. publishersversion epub_ahead_of_print

Published
2023

15. Prognostic value of temporal patterns of global longitudinal strain in patients with chronic heart failure

Author

Abou Kamar, Sabrina, primary, Aga, Yaar S., additional, de Bakker, Marie, additional, van den Berg, Victor J., additional, Strachinaru, Mihai, additional, Bowen, Dan, additional, Frowijn, René, additional, Akkerhuis, K. Martijn, additional, Brugts, Jasper, additional, Manintveld, Olivier, additional, Umans, Victor, additional, Geleijnse, Marcel L., additional, Boersma, Eric, additional, van Dalen, Bas M., additional, and Kardys, Isabella, additional

Published
2023
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16. Multimarker Analysis of Serially Measured GDF-15, NT-proBNP, ST2, GAL-3, cTnI, Creatinine, and Prognosis in Acute Heart Failure

Author

Gürgöze, Muhammed T., primary, van Vark, Laura C., additional, Baart, Sara J., additional, Kardys, Isabella, additional, Akkerhuis, K. Martijn, additional, Manintveld, Olivier C., additional, Postmus, Douwe, additional, Hillege, Hans L., additional, Lesman-Leegte, Ivonne, additional, Asselbergs, Folkert W., additional, Brunner-la-Rocca, Hans-Peter, additional, van den Bos, Ewout J., additional, Orsel, Joke G., additional, de Ridder, Stijn P.J., additional, Pinto, Yigal M., additional, and Boersma, Eric, additional

Published
2023
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17. sj-pdf-3-vmj-10.1177_1358863X231181159 – Supplemental material for Circulating biomarkers of cardiovascular disease are related to aneurysm volume in abdominal aortic aneurysm

Author

Bouwens, Elke, Vanmaele, Alexander, Hoeks, Sanne E, Verhagen, Hence JM, Fioole, Bram, Moelker, Adriaan, ten Raa, Sander, Hussain, Burhan, Oliveira-Pinto, José, Bastos Gonçalves, Frederico, Ijpma, Arne S, Hoefer, Imo E, van Lier, Felix, Akkerhuis, K Martijn, Majoor-Krakauer, Danielle F, Boersma, Eric, and Kardys, Isabella

Subjects
Cardiology, Surgery
Abstract

Supplemental material, sj-pdf-3-vmj-10.1177_1358863X231181159 for Circulating biomarkers of cardiovascular disease are related to aneurysm volume in abdominal aortic aneurysm by Elke Bouwens, Alexander Vanmaele, Sanne E Hoeks, Hence JM Verhagen, Bram Fioole, Adriaan Moelker, Sander ten Raa, Burhan Hussain, José Oliveira-Pinto, Frederico Bastos Gonçalves, Arne S Ijpma, Imo E Hoefer, Felix van Lier, K Martijn Akkerhuis, Danielle F Majoor-Krakauer, Eric Boersma and Isabella Kardys in Vascular Medicine

Published
2023
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18. sj-pdf-2-vmj-10.1177_1358863X231181159 – Supplemental material for Circulating biomarkers of cardiovascular disease are related to aneurysm volume in abdominal aortic aneurysm

Author

Bouwens, Elke, Vanmaele, Alexander, Hoeks, Sanne E, Verhagen, Hence JM, Fioole, Bram, Moelker, Adriaan, ten Raa, Sander, Hussain, Burhan, Oliveira-Pinto, José, Bastos Gonçalves, Frederico, Ijpma, Arne S, Hoefer, Imo E, van Lier, Felix, Akkerhuis, K Martijn, Majoor-Krakauer, Danielle F, Boersma, Eric, and Kardys, Isabella

Subjects
Cardiology, Surgery
Abstract

Supplemental material, sj-pdf-2-vmj-10.1177_1358863X231181159 for Circulating biomarkers of cardiovascular disease are related to aneurysm volume in abdominal aortic aneurysm by Elke Bouwens, Alexander Vanmaele, Sanne E Hoeks, Hence JM Verhagen, Bram Fioole, Adriaan Moelker, Sander ten Raa, Burhan Hussain, José Oliveira-Pinto, Frederico Bastos Gonçalves, Arne S Ijpma, Imo E Hoefer, Felix van Lier, K Martijn Akkerhuis, Danielle F Majoor-Krakauer, Eric Boersma and Isabella Kardys in Vascular Medicine

Published
2023
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19. sj-pdf-1-vmj-10.1177_1358863X231181159 – Supplemental material for Circulating biomarkers of cardiovascular disease are related to aneurysm volume in abdominal aortic aneurysm

Author

Bouwens, Elke, Vanmaele, Alexander, Hoeks, Sanne E, Verhagen, Hence JM, Fioole, Bram, Moelker, Adriaan, ten Raa, Sander, Hussain, Burhan, Oliveira-Pinto, José, Bastos Gonçalves, Frederico, Ijpma, Arne S, Hoefer, Imo E, van Lier, Felix, Akkerhuis, K Martijn, Majoor-Krakauer, Danielle F, Boersma, Eric, and Kardys, Isabella

Subjects
Cardiology, Surgery
Abstract

Supplemental material, sj-pdf-1-vmj-10.1177_1358863X231181159 for Circulating biomarkers of cardiovascular disease are related to aneurysm volume in abdominal aortic aneurysm by Elke Bouwens, Alexander Vanmaele, Sanne E Hoeks, Hence JM Verhagen, Bram Fioole, Adriaan Moelker, Sander ten Raa, Burhan Hussain, José Oliveira-Pinto, Frederico Bastos Gonçalves, Arne S Ijpma, Imo E Hoefer, Felix van Lier, K Martijn Akkerhuis, Danielle F Majoor-Krakauer, Eric Boersma and Isabella Kardys in Vascular Medicine

Published
2023
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20. Additional file 1 of Sex-based differences in cardiovascular proteomic profiles and their associations with adverse outcomes in patients with chronic heart failure

Author

de Bakker, Marie, Petersen, Teun B., Akkerhuis, K. Martijn, Harakalova, Magdalena, Umans, Victor A., Germans, Tjeerd, Caliskan, Kadir, Katsikis, Peter D., van der Spek, Peter J., Suthahar, Navin, de Boer, Rudolf A., Rizopoulos, Dimitris, Asselbergs, Folkert W., Boersma, Eric, and Kardys, Isabella

Abstract

Additional file 1. Supplemental materials.

Published
2023
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21. High-Frequency Biomarker Measurements of Troponin, NT-proBNP, and C-Reactive Protein for Prediction of New Coronary Events After Acute Coronary Syndrome: BIOMArCS Study

Author

Oemrawsingh, Rohit M., Akkerhuis, K. Martijn, de Mulder, Maarten, Umans, Victor A., Kietselaer, Bas, Schotborgh, Carl, Ronner, Eelko, Lenderink, Timo, Liem, Anho, Haitsma, David, van der Harst, Pim, Asselbergs, Folkert W., Maas, Arthur, Oude Ophuis, Anton J., Ilmer, Ben, Dijkgraaf, Rene, de Winter, Robbert J., Kie The, S. Hong, Wardeh, Alexander J., Hermans, Walter, Cramer, Etienne, van Schaik, Ron H., Hoefer, Imo E., Doevendans, Pieter A., Simoons, Maarten L., and Boersma, Eric

Published
2019
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22. Prognostic value of syntax score, intravascular ultrasound and near-infrared spectroscopy to identify low-risk patients with coronary artery disease 5-year results from the ATHEROREMO and IBIS-3 cohorts

Author

Vlieger, Selina, primary, Oemrawsingh, Rohit M., additional, Cheng, Jin M., additional, Schuurman, Anne-Sophie, additional, Vroegindewey, Maxime, additional, Kardys, Isabella, additional, Van Geuns, Robert-Jan, additional, Daemen, Joost, additional, Van Mieghem, Nicolaas M., additional, Akkerhuis, K. Martijn, additional, and Boersma, Eric, additional

Published
2022
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26. Persistently elevated levels of sST2 after acute coronary syndrome are associated with recurrent cardiac events

Author

van den Berg, Victor. J., Vroegindewey, Maxime M., Umans, Victor A., van der Harst, Pim, Asselbergs, Folkert W., Akkerhuis, K. Martijn, Kardys, Isabella, Boersma, Eric, Cardiovascular Centre (CVC), and Cardiology

Subjects
Male, sST2, RISK, NT-PROBNP, Health, Toxicology and Mutagenesis, Clinical Biochemistry, Middle Aged, Prognosis, Interleukin-1 Receptor-Like 1 Protein, Biochemistry, C-REACTIVE PROTEIN, acute coronary syndrome, SDG 3 - Good Health and Well-being, MYOCARDIAL-INFARCTION, MANAGEMENT, IL-33, Humans, atherosclerosis, repeated measurements, SOLUBLE ST2, Biomarkers, secondary prevention, Proportional Hazards Models
Abstract

Purpose: Higher soluble ST2 (sST2) levels at admission are associated with adverse outcome in acute coronary syndrome (ACS) patients. We studied the dynamics of sST2 over time in post-ACS patients prior to a recurrent ACS or cardiac death. Methods: We used the BIOMArCS case cohort, consisting of 187 patients who underwent serial blood sampling during one-year follow-up post-ACS. sST2 was batch-wise quantified after completion of follow-up in a median of 8 (IQR: 5–11) samples per patient. Joint modelling was used to investigate the association between longitudinally measured sST2 and the endpoint, adjusted for gender, GRACE risk score and history of cardiovascular diseases. Results: Median age was 64 years and 79% were men. The 36 endpoint patients had systematically higher sST2 levels than those that remained endpoint free (mean value 29.6 ng/ml versus 33.7 ng/ml, p-value 0.052). The adjusted hazard ratio for the endpoint per standard deviation increase of sST2 was 1.64 (95% confidence interval: 1.09–2.34; p = 0.019) at any time point. We could not identify a steady or sudden increase of sST2 in the run-up to the combined endpoint. Conclusion: Asymptomatic post-ACS patients with persistently higher sST2 levels are at higher risk of recurrent ACS or cardiac death during one-year follow-up.

Published
2022

27. IGF-1 is not related to long-term outcome in hyperglycemic acute coronary syndrome patients

Author

Iswandi, Cindya P, primary, van den Berg, Victor J, additional, Simsek, Suat, additional, Velzen, Daan van, additional, Boekel, Edwin Ten, additional, Cornel, Jan-Hein, additional, Boer, Sanneke de, additional, Mulder, Maarten de, additional, Akkerhuis, K Martijn, additional, Boersma, Eric, additional, Umans, Victor A, additional, and Kardys, Isabella, additional

Published
2021
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28. Left ventricular remodelling and prognosis after discharge in new‐onset acute heart failure with reduced ejection fraction

Author

van den Berge, Jan C., primary, Vroegindewey, Maxime M., additional, Veenis, Jesse F., additional, Brugts, Jasper J., additional, Caliskan, Kadir, additional, Manintveld, Olivier C., additional, Akkerhuis, K. Martijn, additional, Boersma, Eric, additional, Deckers, Jaap W., additional, and Constantinescu, Alina A., additional

Published
2021
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31. Temporal Evolution of Serum Concentrations of High‐Sensitivity Cardiac Troponin During 1 Year After Acute Coronary Syndrome Admission

Author

van den Berg, Victor J., primary, Oemrawsingh, Rohit M., additional, Umans, Victor A. W. M., additional, Kardys, Isabella, additional, Asselbergs, Folkert W., additional, van der Harst, Pim, additional, Hoefer, Imo E., additional, Kietselaer, Bas, additional, Lenderink, Timo, additional, Oude Ophuis, Anton J., additional, van Schaik, Ron H., additional, de Winter, Robbert J., additional, Akkerhuis, K. Martijn, additional, Boersma, Eric, additional, Mulder, Maarten, additional, Schotborgh, Carl, additional, Ronner, Eelko, additional, Liem, Anho, additional, Haitsma, David, additional, Maas, Arthur, additional, Ilmer,, Ben, additional, Dijkgraaf, Rene, additional, Kie, S. Hong, additional, Wardeh, Alexander J, additional, Hermans, Walther, additional, Cramer, Etienne, additional, Doevendans, Pieter A, additional, and Simoons, Maarten L, additional

Published
2021
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35. Renal tubular damage and worsening renal function in chronic heart failure: Clinical determinants and relation to prognosis (Bio‐SHiFT study)

Author

Brankovic, Milos, primary, Akkerhuis, K. Martijn, additional, Hoorn, Ewout J., additional, Boven, Nick, additional, Berge, Jan C., additional, Constantinescu, Alina, additional, Brugts, Jasper, additional, Ramshorst, Jan, additional, Germans, Tjeerd, additional, Hillege, Hans, additional, Boersma, Eric, additional, Umans, Victor, additional, and Kardys, Isabella, additional

Published
2020
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36. Temporal patterns of macrophage‐ and neutrophil‐related markers are associated with clinical outcome in heart failure patients

Author

Klimczak‐Tomaniak, Dominika, primary, Bouwens, Elke, additional, Schuurman, Anne‐Sophie, additional, Akkerhuis, K. Martijn, additional, Constantinescu, Alina, additional, Brugts, Jasper, additional, Westenbrink, B. Daan, additional, van Ramshorst, Jan, additional, Germans, Tjeerd, additional, Pączek, Leszek, additional, Umans, Victor, additional, Boersma, Eric, additional, and Kardys, Isabella, additional

Published
2020
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37. Circulating Biomarkers of Cell Adhesion Predict Clinical Outcome in Patients with Chronic Heart Failure

Author

Bouwens, Elke, primary, van den Berg, Victor J., additional, Akkerhuis, K. Martijn, additional, Baart, Sara J., additional, Caliskan, Kadir, additional, Brugts, Jasper J., additional, Mouthaan, Henk, additional, van Ramshorst, Jan, additional, Germans, Tjeerd, additional, Umans, Victor A. W. M., additional, Boersma, Eric, additional, and Kardys, Isabella, additional

Published
2020
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38. Details on high frequency blood collection, data analysis, available material and patient characteristics in BIOMArCS

Author

Boersma, Eric, primary, Vroegindewey, Maxime M., additional, van den Berg, Victor J., additional, Asselbergs, Folkert W., additional, van der Harst, Pim, additional, Kietselaer, Bas, additional, Lenderink, Timo, additional, Oude Ophuis, Anton J., additional, Umans, Victor A.W.M., additional, de Winter, Robbert J., additional, Oemrawsingh, Rohit M., additional, and Akkerhuis, K. Martijn, additional

Published
2019
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39. Longitudinal patterns of N-terminal pro B-type natriuretic peptide, troponin T, and C-reactive protein in relation to the dynamics of echocardiographic parameters in heart failure patients

Author

Klimczak-Tomaniak, Dominika, primary, van den Berg, Victor J, additional, Strachinaru, Mihai, additional, Akkerhuis, K Martijn, additional, Baart, Sara, additional, Caliskan, Kadir, additional, Manintveld, Olivier C, additional, Umans, Victor, additional, Geleijnse, Marcel, additional, Boersma, Eric, additional, van Dalen, Bas M, additional, and Kardys, Isabella, additional

Published
2019
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40. Left ventricular remodelling and prognosis after discharge in new‐onset acute heart failure with reduced ejection fraction.

Author

Berge, Jan C., Vroegindewey, Maxime M., Veenis, Jesse F., Brugts, Jasper J., Caliskan, Kadir, Manintveld, Olivier C., Akkerhuis, K. Martijn, Boersma, Eric, Deckers, Jaap W., and Constantinescu, Alina A.

Subjects
HEART failure treatment, VENTRICULAR ejection fraction, HEART disease diagnosis
Abstract

Aims: This study aimed to investigate the left ventricular (LV) remodelling and long‐term prognosis of patients with new‐onset acute heart failure (HF) with reduced ejection fraction who were pharmacologically managed and survived until hospital discharge. We compared patients with ischaemic and non‐ischaemic aetiology. Methods and results: This cohort study consisted of 111 patients admitted with new‐onset acute HF in the period 2008–2016 [62% non‐ischaemic aetiology, 48% supported by inotropes, vasopressors, or short‐term mechanical circulatory devices, and left ventricular ejection fraction (LVEF) at discharge 28% (interquartile range 22–34)]. LV dimensions, LVEF, and mitral valve regurgitation were used as markers for LV remodelling during up to 3 years of follow‐up. Both patients with non‐ischaemic and ischaemic HF had significant improvement in LVEF (P < 0.001 and P = 0.004, respectively) with significant higher improvement in those with non‐ischaemic HF (17% vs. 6%, P < 0.001). Patients with non‐ischaemic HF had reduction in LV end‐diastolic and end‐systolic diameters (6 and 10 mm, both P < 0.001), but this was not found in those with ischaemic HF [+3 mm (P = 0.09) and +2 mm (P = 0.07), respectively]. During a median follow‐up of 4.6 years, 98 patients (88%) did not reach the composite endpoint of LV assist device implantation, heart transplantation, or all‐cause mortality, with no difference between with ischaemic and non‐ischaemic HF [hazard ratio 0.69 (95% confidence interval 0.19–2.45)]. Conclusions: Patients with new‐onset acute HF with reduced ejection fraction discharged on optimal medical treatment have a good prognosis. We observed a considerable LV remodelling with improvement in LV function and dimensions, starting already at 6 months in patients with non‐ischaemic HF but not in their ischaemic counterparts. [ABSTRACT FROM AUTHOR]

Published
2021
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42. Temporal Patterns of 14 Blood Biomarker candidates of Cardiac Remodeling in Relation to Prognosis of Patients With Chronic Heart Failure—The Bio‐SHiFT Study

Author

Bouwens, Elke, primary, Brankovic, Milos, additional, Mouthaan, Henk, additional, Baart, Sara, additional, Rizopoulos, Dimitris, additional, van Boven, Nick, additional, Caliskan, Kadir, additional, Manintveld, Olivier, additional, Germans, Tjeerd, additional, van Ramshorst, Jan, additional, Umans, Victor, additional, Akkerhuis, K. Martijn, additional, and Kardys, Isabella, additional

Published
2019
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43. Prognostic Value of Serial Galectin-3 Measurements in Patients With Acute Heart Failure

Author

van Vark, Laura C, Lesman-Leegte, Ivonne, Baart, Sara J, Postmus, Douwe, Pinto, Yigal M, de Boer, Rudolf A., Asselbergs, Folkert W, Wajon, Elly M C J, Orsel, Joke G, Boersma, Eric, Hillege, Hans L., Akkerhuis, K Martijn, and TRIUMPH (Translational Initiative on Unique and Novel Strategies for Management of Patients with Heart Failure) Investigators

Subjects
galectin-3, biomarker, heart failure, repeated measurements
Abstract

BACKGROUND: Several clinical studies have evaluated the association between galectin-3 levels and outcome in patients with heart failure (HF). However, little is known about the predictive value of repeated galectin-3 measurements. This study evaluates the prognostic value of repeated time-dependent galectin-3 measurements in acute HF patients. METHODS AND RESULTS: In the TRIUMPH (Translational Initiative on Unique and Novel Strategies for Management of Patients with Heart Failure) clinical cohort study, 496 acute HF patients were enrolled in 14 hospitals in The Netherlands, between 2009 and 2014. Repeated blood samples (7) were drawn during 1-year follow-up. Associations between repeated biomarker measurements and the primary end point were assessed using a joint model. Median age was 74 years and 37% were women. The primary end point, composite of all-cause mortality and HF rehospitalization, was reached in 188 patients (40%), during a median follow-up of 325 days (interquartile range 85-401). The median baseline galectin-3 level was 24 ng/mL (interquartile range 18-34). The mean number of galectin-3 measurements available per patient was 4.3. After adjustment for clinical factors and N-terminal pro-brain natriuretic peptide, there was a weak association between baseline galectin-3 and risk of the primary end point. When repeated measurements were taken into account, the adjusted hazard ratio per 1 SD increase of the galectin-3 level (on the log2 scale) at any time point increased to 1.67 (95% confidence interval, 1.24-2.23, P

Published
2017

45. IgM anti-malondialdehyde low density lipoprotein antibody levels indicate coronary heart disease and necrotic core characteristics in the Nordic Diltiazem (NORDIL) study and the Integrated Imaging and Biomarker Study 3 (IBIS-3)

Author

van den Berg, Victor J., primary, Haskard, Dorian O., additional, Fedorowski, Artur, additional, Hartley, Adam, additional, Kardys, Isabella, additional, Caga-Anan, Mikhail, additional, Akkerhuis, K. Martijn, additional, Oemrawsingh, Rohit M., additional, van Geuns, Robert Jan, additional, de Jaegere, Peter, additional, van Mieghem, Nicolas, additional, Regar, Evelyn, additional, Ligthart, Jurgen M.R., additional, Umans, Victor A.W.M., additional, Serruys, Patrick W., additional, Melander, Olle, additional, Boersma, Eric, additional, and Khamis, Ramzi Y., additional

Published
2018
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46. Plasma concentrations of molecular lipid species predict long-term clinical outcome in coronary artery disease patients

Author

Anroedh, Sharda, primary, Hilvo, Mika, additional, Akkerhuis, K. Martijn, additional, Kauhanen, Dimple, additional, Koistinen, Kaisa, additional, Oemrawsingh, Rohit, additional, Serruys, Patrick, additional, van Geuns, Robert-Jan, additional, Boersma, Eric, additional, Laaksonen, Reijo, additional, and Kardys, Isabella, additional

Published
2018
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49. Effects of Ticagrelor, Prasugrel, or Clopidogrel on Endothelial Function and Other Vascular Biomarkers

Author

Ariotti, Sara, primary, Ortega-Paz, Luis, additional, van Leeuwen, Maarten, additional, Brugaletta, Salvatore, additional, Leonardi, Sergio, additional, Akkerhuis, K. Martijn, additional, Rimoldi, Stefano F., additional, Janssens, Gladys, additional, Gianni, Umberto, additional, van den Berge, Jan C., additional, Karagiannis, Alexios, additional, Windecker, Stephan, additional, Valgimigli, Marco, additional, Frigoli, Enrico, additional, Monti, Monia, additional, Ciociano, Nestor, additional, Heg, Dik, additional, Rizzotti, Diego, additional, Mandurino Mirizzi, Alessandro, additional, Van Royen, Niels, additional, Räber, Lorenz, additional, Ariotti, Sara, additional, Rexhaj, Emrush, additional, and Sabaté, Manel, additional

Published
2018
Full Text
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