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25 results on '"Akiyama, Nobu"'

2. MO34-3 Evaluation for penetration and usage of Japanese guidelines on febrile neutropenia among hematology-oncology physicians

Author

Akiyama, Nobu, primary, Okamura, Takuho, additional, Kimura, Shun-ichi, additional, Yano, Shingo, additional, Yoshida, Isao, additional, Kusaba, Hitoshi, additional, Fujita, Hiroyuki, additional, Takahashi, Kosuke, additional, Fukushima, Keitaro, additional, Iwasaki, Hiromichi, additional, Yoshida, Minoru, additional, Saeki, Toshiaki, additional, Tamura, Kazuo, additional, and Zenda, Sadamoto, additional

Published
2021
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5. 1018. Prevalence of Bacteremia/Fungemia and Pneumonia in Remission Induction Chemotherapy for Adult Acute Myeloid Leukemia From 1987 to 2005: Japan Adult Leukemia Study Group (JALSG)

Author

Kato, Hideaki, primary, Fujita, Hiroyuki, additional, Akiyama, Nobu, additional, Kimura, Shun-Ichi, additional, Hiramoto, Nobuhiro, additional, Hosono, Naoko, additional, Takahashi, Tsutomu, additional, Shigeno, Kazuyuki, additional, Minamiguchi, Hitoshi, additional, Miyatake, Junichi, additional, Handa, Hiroshi, additional, Kanda, Yoshinobu, additional, Yoshida, Minoru, additional, Miyawaki, Shuichi, additional, Ohtake, Shigeki, additional, Naoe, Tomoki, additional, Kiyoi, Hitoshi, additional, Matsumura, Itaru, additional, and Miyazaki, Yasushi, additional

Published
2018
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6. Colonic EBV-Associated Lymphoproliferative Disorder in a Patient Treated with Rabbit Antithymocyte Globulin for Aplastic Anemia

Author

Sugimoto-Sekiguchi, Hiroko, Tashiro, Haruko, Shirasaki, Ryosuke, Arai, Tomio, Yamamoto, Tadashi, Oka, Yoko, Akiyama, Nobu, Kawasugi, Kazuo, and Shirafuji, Naoki

Subjects
Article Subject, hemic and lymphatic diseases
Abstract

Epstein-Barr-virus- (EBV-) associated lymphoproliferative disorder (LPD) after immunosuppressive therapy for aplastic anemia (AA), in a nontransplant setting, has not been well described. We report one case of colonic EBV-LPD after a single course of immunosuppressive therapy for AA. The patient developed multiple colonic tumors 3 months after receiving immunosuppressive therapy, which consisted of rabbit antithymocyte globulin (ATG), cyclosporine, and methyl-predonisolone. The histological findings of biopsy specimens revealed that atypical lymphocytes had infiltrated colonic glands. Immunohistochemical staining for CD20 was positive, and in situ hybridization for EBV-encoded small RNAs was also positive. The EBV viral load in peripheral blood was slightly increased to 140/106 white blood cells. After the cessation of immunosuppressant, the colonic tumors spontaneously regressed, and the EBV viral load decreased to undetectable levels. This is the first report of the single use of rabbit ATG inducing colonic EBV-LPD. Because a single use of immunosuppressive therapy containing rabbit ATG can cause EBV-LPD, we should carefully observe patients receiving rabbit ATG for AA.

Published
2012
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7. Cefozoplan, Meropenem, or Imipenem-Cilastatin Versus Cefepime As an Empirical Therapy in High Risk Febrile Neutropenic Adult Patients: A Multicenter Prospective Randomized Trial

Author

Nakane, Takahiko, primary, Tamaki, Toshiharu, additional, Tamura, Kazuo, additional, Yoshida, Isao, additional, Fukushima, Toshihiro, additional, Tatsumi, Yoichi, additional, Nakagawa, Yasunori, additional, Hatanaka, Kazuo, additional, Takahashi, Tsutomu, additional, Akiyama, Nobu, additional, Tanimoto, Mitsune, additional, Ohyashiki, Kazuma, additional, Urabe, Akio, additional, Masaoka, Tohru, additional, and Kanamaru, Akihisa, additional

Published
2012
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12. Efficacy of Gemtuzumab Ozogamicin (GO) Monotherapy on Relapsed/Refractory Acute Promyelocytic Leukemia (APL)

Author

Takeshita, Akihiro, primary, Ono, Takaaki, additional, Kojima, Yumi, additional, Kyo, Taiichi, additional, Asou, Norio, additional, Suzushima, Hitoshi, additional, Yagasaki, Fumiharu, additional, Maeda, Tomoya, additional, Okada, Masaya, additional, Nakaseko, Chiaki, additional, Kanbayashi, Hiroyuki, additional, Yamaguchi, Masaki, additional, Kurosawa, Mitsutoshi, additional, Tsuboi, Kosuke, additional, Yujiri, Toshiaki, additional, Nannya, Yasuhito, additional, Uike, Naokuni, additional, Akiyama, Nobu, additional, Fukuda, Tetsuya, additional, Karimata, Kaori, additional, Okumura, Hirokazu, additional, Eto, Tetsuya, additional, Izumiyama, Koh, additional, Watanabe, Akihiro, additional, Aotsuka, Nobuyuki, additional, Ito, Katsuro, additional, Ozaki, Keiji, additional, and Naoe, Tomoki, additional

Published
2011
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19. Natural History of 33 Patients with Upshaw-Schulman Syndrome Has Revealed That All the Gravida Develop Thrombocytopenia, Often Followed by Thrombotic Microangiopathy with Stillbirth.

Author

Fujimura, Yoshihiro, primary, Matsumoto, Masanori, additional, Kokame, Koichi, additional, Yagi, Hideo, additional, Isonishi, Ayami, additional, Matsuyama, Tomomi, additional, Kato, Seiji, additional, Ishizashi, Hiromichi, additional, Shida, Yasuaki, additional, Kenji, Nishio, additional, Akiyama, Nobu, additional, Tomiyama, Junji, additional, Natori, Kazuhiro, additional, Kuraishi, Yasunobu, additional, Imamura, Yutaka, additional, Inoue, Nobumasa, additional, Higasa, Satoshi, additional, Seike, Masako, additional, Kozuka, Teruhiko, additional, Hara, Masamichi, additional, Sugimoto, Mitsuhiko, additional, Wada, Hideo, additional, Murata, Mitsuru, additional, Miyata, Toshiyuki, additional, and Ikeda, Yasuo, additional

Published
2007
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21. Upshaw-Schulman Syndrome: A Masqueraded Thrombocytopenia during Pregnancy.

Author

Matsuyama, Tomomi, primary, Matsumoto, Masanori, additional, Kato, Seiji, additional, Akiyama, Nobu, additional, Tomiyama, Junji, additional, Natori, Kazuhiko, additional, Kuraishi, Yasunobu, additional, Imamura, Yutaka, additional, Inoue, Nobumasa, additional, Kokame, Koichi, additional, Miyata, Toshiyuki, additional, and Fujimura, Yoshihiro, additional

Published
2005
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25. Chronic Myelogenous Leukemia Cells Contribute to the Stromal Myofibroblasts in Leukemic NOD/SCID Mouse In Vivo.

Author

Shirasaki R, Tashiro H, Oka Y, Matsuo T, Yamamoto T, Sugao T, Akiyama N, Kawasugi K, and Shirafuji N

Abstract

We recently reported that chronic myelogenous leukemia (CML) cells converted into myofibroblasts to create a microenvironment for proliferation of CML cells in vitro. To analyze a biological contribution of CML-derived myofibroblasts in vivo, we observed the characters of leukemic nonobese diabetes/severe combined immunodeficiency (NOD/SCID) mouse. Bone marrow nonadherent mononuclear cells as well as human CD45-positive cells obtained from CML patients were injected to the irradiated NOD/SCID mice. When the chimeric BCR-ABL transcript was demonstrated in blood, human CML cells were detected in NOD/SCID murine bone marrow. And CML-derived myofibroblasts composed with the bone marrow-stroma, which produced significant amounts of human vascular endothelial growth factor A. When the parental CML cells were cultured with myofibroblasts separated from CML cell-engrafted NOD/SCID murine bone marrow, CML cells proliferated significantly. These observations indicate that CML cells make an adequate microenvironment for their own proliferation in vivo.

Published
2012
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