1. Association between PaO2/FiO2 ratio and thrombotic events in COVID-19 patients
- Author
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Loffredo, Lorenzo, Pignatelli, Pasquale, Pirro, Matteo, Ceccarelli, Giancarlo, Oliva, Alessandra, Maggio, Enrico, Cancelli, Francesca, D'Ardes, Damiano, Amitrano, Maria, Zicari, Anna Maria, Cinicola, Bianca Laura, Taliani, Gloria, Cangemi, Roberto, Lichtner, Miriam, Falcone, Marco, Orlando, Federica, Pugliese, Francesco, Venditti, Mario, Mastroianni, Claudio Maria, Violi, Francesco, COVID-Group: Fausto D'Agostino, Felice Eugenio Agrò, Alessia, Mattei, Loredana, Tibullo, Maria Grazia Nunziata, Iorio, Valeria, Natalia, Iuliano, Sara, Mangiacapra, Mariangela, Raimondo, Mariangela, Atteno, Ferri, Claudio, Grassi, Davide, Desideri, Giovambattista, Abballe, Stefano, Serena, Dell'Isola, Monica, Rocco, Daniela, Alampi, Cosmo Del Borgo, Vanessa, Bianconi, Massimo Raffaele Mannarino, Filippo, Figorilli, Alessia, Fallarino, Ilaria Maria Palumbo, Arianna, Pannunzio, Arianna, Magna, Chiara, Bagnato, and Alba Rosa Alfano
- Subjects
Albumin ,Emergency Medicine ,Internal Medicine ,COVID-19 ,P/F ratio ,Thrombosis - Abstract
PaO2/FiO2 (P/F ratio) is considered a marker of hypoxia/hypoxemia and mortality. Several prothrombotic changes are associated with the decrease of P/F ratio. The role of P/F ratio in patients with arterial and venous thrombosis remains unclear. The aim of this study was to assess in patients with coronavirus disease 2019 (COVID-19), the association between P/F ratio and arterial/venous thrombosis. One thousand and four hundred and six COVID-19 patients were recruited; 289 (21%) patients had P/F ratio β: 0.156; SE: 0.001; p = 0.0001) and D–dimer (standardized coefficient β: -0.135; SE: 0.0001; p = 0.0001) were associated with P/F ratio. During the hospitalization 159 patients were transferred in intensive care unit (ICU), 253 patients died, 156 patients had arterial or venous thrombotic events. A bivariate logistic analysis was performed to analyze the predictors of thrombosis in COVID-19 patients; P/F ratio p = 0.021), albumin (OR 1.693, 95% CI 1.055–2.716, p = 0.029), D-dimer (OR 3.469, 95% CI 2.110–5.703, p p = 0.023) and heart failure (OR 2.410 95% CI 1.385–4.193, p = 0.002) independently predicted thrombotic events in this population. This study suggests that the P/F ratio is associated with thrombotic events by promoting a hypercoagulation state in patients hospitalized for COVID-19.
- Published
- 2023