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Indium-111-labeled donor leukocytes were used for the detection of foci of suppuration in eight severely leukopenic patients with marrow suppression, either idiopathic or associated with chemotherapeutic regimens for leukemia. In three patients good correlation was found between the results of imaging and clinical signs or subsequent proof of inflammation. In the other five patients, in whom no evidence of localized suppuration occurred, no abnormal accumulations of radioactivity were demonstrable. Labeled donor leukocytes provide a method for locating suppurative foci in severely leukopenic patients in whom autologous leukocyte labeling is impractical.

A new method of starch-gel electrophoresis using a technique of staining dependent on enzyme activity has been employed to demonstrate the isozymes of aldolase from a variety of human, rat, and frog tissues. Five of these isozymes were detected in man, seven in the rat, and at least four in the frog. The abilities of these isozymes to cleave fructose-1 ,6-diphosphate and fructose-1-phosphate were compared.

Distinctly different electrophoretic patterns of red cell glucose-6-phosphate dehydrogenase were resolved from the hemolyzates of horse and donkey erythrocytes. Examination of their reciprocal hybrids, mules and hinnies, showed that the red cells of female mules and female hinnies contain both horse and donkey G-6-PD; the male mule with an X chromosome from its horse mother contained pure horse G-6-PD, whereas the male hinny with the donkey X chromosome contained pure donkey G-6-PD. These findings on the male reciprocal hybrids suggest X-linkage.