1. N -(diisopropylphosphanyl)benzamide.
- Author
-
Alcaide, María M., Garrido, Daniel García, Álvarez, Eleuterio, and Peloso, Riccardo
- Subjects
- *
BENZAMIDE , *MOLECULAR structure , *NUCLEAR magnetic resonance spectroscopy , *X-ray spectroscopy , *X-ray diffraction , *PROTON transfer reactions - Abstract
N-(diisopropylphosphanyl)benzamide, PhC(O)NHPiPr2, has been synthesized in good yield following two alternative procedures that employ benzamide as the starting material. The first one is a two-step preparation, in which N-(trimetilsilyl)benzamide is reacted with PiPr2Cl to give the title compound in good yield, whereas the second one is a straightforward synthesis which converts benzamide into N-(diisopropylphosphanyl)benzamide by reaction with PiPr2Cl in the presence of N,N-dimethylpyridin-4-amine (DMAP) and triethylamine. NMR spectroscopy and X-ray diffraction analyses have been performed to characterize the new compound and elucidate its molecular structure in the solid state. N-(diisopropylphosphanyl)benzamide adds to the limited family of amido-substituted phosphines, RC(O)NHPR'2, which can be classified as bidentate hybrid P,O-ligands, both in their neutral and anionic forms, the latter achievable by deprotonation of the NH group. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF