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The paper presents an algorithm for defects screening in a continuous dynamic system with a depth of up to dynamic block based on the structure sensitivity function and the sign analysis of integral esti-mates of the output signals deviations.

The authors developed dedicated computational techniques and combined those with numerical simulation of heat transfer processes in ground complex tanks equipped with heat exchange jackets to discover the specifics of how rocket fuel may be cooled with liquid nitrogen used to sparge antifreeze in the cavities of the heat exchange jackets. The paper provides estimation data for rocket fuel cooling efficiency as a function of mass flow rate of liquid nitrogen for various options of setting up fuel mixing in the storage tank during cooling.

The purpose of this research is to represent the results of the development of the design algorithm for the logistics system for the distribution of products of a mechanical engineering enterprise, which would determine the characteristics of the production distribution channel, the optimal arrangement of the elements of the logistics system of product distribution in the environment, and also to optimize the resources flow with regard to the limitations. The main content of this research is the analysis of publications of Russian and foreign scientists and specialists in the field of production management, modeling and optimization of organizational structures and production processes, design of logistics systems. The practical significance of the research is the possibility of the appliance of the presented algorithm by the management team of a mechanical engineering enterprise in a market environment. It would permit to improve the efficiency of using the existing resources of the enterprise. This article is addressed to specialists in the field of theory and practice of production organization

The paper presents numerical simulation results concerning fluid flow in the annular channel of a hydrodynamic filter comprising a perforated protective screen located between another perforated protective screen and a filtering screen, both cylindrical. We investigated the effects of the following two parameters on the flow structure: the perforated area of the protective screen and the width of the annular channel between the protective and filtering cylindrical screens. We established that increasing the annular channel width and the perforation area of the protective screen leads to secondary vortex structures forming in the channel. We obtained circumferential velocity distribution in the channel formed by the protective and filtering screens of the hydrodynamic filter. We show that, in the bracket of modal and design parameters under consideration, a power curve with an exponent in the 2.4--3.3 range may be used to approximate the circumferential velocity profile. We discovered that the structural and modal parameters of the channel between the rotating permeable cylindrical surfaces control the intensity of the deterministic separation process components. Channel width and perforation area are structural parameters; angular velocity is a modal parameter. Arranging the flow in a hydrodynamic filter in the way proposed makes it possible to decrease the intensity of random separation process components in multi-phase media.

In this paper, based on the solution of the Boltzmann kinetic equation, we determine the energy distribution function describing the steady-state deceleration of the cascade of moving atoms taking into account their multiplication at the power interaction potential U∼1/rn.A new approach to the solution of the kinetic equation based on the extended concept of primary knocked-on atoms (PKA) is used for its calculation. One of the advantages of using the power interaction potential is that in this case it is possible to obtain simple analytical formulas for the distribution function of the cascade of slowing-down atoms taking into account their multiplication and demonstrate the simplicity and convenience of the proposed new approach to the solution of the kinetic equation. On the other hand, based on the obtained results it is possible to estimate the accuracy of various approximate solutions. It is shown that this approach will be applicable to other interatomic interaction potentials, if the average PKA energy loss in individual collisions decreases monotonically with decreasing energy, and the relative PKA energy loss in individual collisions will be small.

The paper describes the fuel cooling system which uses liquid nitrogen in the tanks of ground complexes equipped with integrated heat exchangers. We analyzed the characteristics of cooling liquid fuel in tanks with integrated heat exchangers filled with antifreeze, when sparging antifreeze with liquid nitrogen. As a result of the analysis, we introduced the indicators to assess the efficiency of the considered technical solutions in comparison with the existing options for constructing these systems. Furthermore, we developed a mathematical model of the cooling process in the form of a system of equations for temporary changes in the temperature of antifreeze and fuel, including the changes at various modes of fuel mixing. The paper gives the results of studies carried out in order to increase the efficiency of fuel cooling processes at various flow rates of liquid nitrogen by organizing the processes of its heat exchange with the surfaces of the integrated heat exchanger and the use of various types of antifreeze.

The paper describes the propellant cooling system using liquid nitrogen and a combination of recuperative heat exchangers, including sections of the double pipe heat exchanger and a twisted heat exchanger located in a tank with antifreeze, cooled by nitrogen gas coming out of the sections of the double pipe heat exchanger. Mathematical models of cooling processes for two variants of movement of propellant and liquid nitrogen in the channels of the double pipe heat exchanger sections are considered. Their using makes it possible to analyze the efficiency of propellant cooling operations depending on its mass, design parameters of the system tanks and heat exchangers, consumption characteristics of nitrogen and propellant, as well as to predict the required mass of liquid nitrogen and the time of propellant cooling during the operation of launching complex propellant-feed systems. Calculated dependences and simulation results of propellant and antifreeze cooling in a tank with a twisted heat exchanger are presented. The influence of variants of arranging propellant cooling processes and liquid nitrogen consumption on the efficiency of the cooling system is analyzed. Comparing to the available systems the capability of reducing the cost of liquid nitrogen are identified as well as reducing time of the propellant cooling operations by means of equipping launch complexes.

Background Oilfield preparation of hydrocarbons is one of the most urgent tasks in the development of oil fields. The depth of dehydration and desalination of oil significantly depends on the temperature of the emulsion, the process of interaction of the demulsifier and the result of their mixing. Aims and Objectives The aim of the work is to conduct experiments on the selection of demulsifiers for oils of Eastern Siberia. The research involved oils from the Danilovskoye and Ichedinskoye fields and demulsifiers: SNPKh 4802, DIN 4E. Metods Using sedimentation in cylinders (Bottle test), the indicators of the dehydration process of oil-water emulsions were analyzed. To maintain the temperature regime, the obtained oil-water emulsions were poured into cylinders with a volume of 100 ml and placed in a thermostat. Every 15 min, readings were recorded for the amount of settled water. The investigated physical and chemical parameters of demulsifiers contributed to the identification of the most effective for each field. The experiments were continued on the Lumifuge instrument, where the results were confirmed. The obtained graphs of the Danilovskaya and Ichyodinskaya emulsions with the addition of demulsifiers indicate that the separation of water has occurred and two phases have formed: oil - water. Results An analysis of the effect of demulsifiers on dehydration processes using the example of oils from Eastern Siberia showed that with the addition of a demulsifier, the completion time of the process is reduced by 2 times, and almost complete separation of water is observed. The choice of the optimal parameters of the demulsification process of the studied oils is substantiated: the consumption of the demulsifier, the temperature, the intensity of mixing.

The article explains the importance of developing methods and tools in order to provide information support when selection decisions on academic programs are made by individuals. We have developed a model for integrated evaluation of academic programs in view of aims students want to attain and competencies to acquire when entering the profession and building individual careers. The proposed information system provides information interaction among stakeholders and main actors involved in the education market: individuals (prospective students) and educational institutions. Keywords—individuals, educational institution, academic program, integrated evaluation, fuzzy set, alternatives, information system.

CFTR possesses a large cluster of strict dibasic consensus sites for phosphorylation by protein kinase A (PKA) in the R-domain and an obligatory dependence on phosphorylation is a hallmark of CFTR Cl(-) channel function. Removal of as many as 11 of these sites reduces the conformational change in the R-domain and the degree of channel activation in response to PKA. However, until recently a completely PKA-unresponsive CFTR variant has not been reported, leaving open the possibility that the residual response may be mediated by associating ancillary phosphoproteins. We traced the residual PKA-catalyzed (32)P-labelling of the variant with 11 sites mutagenized (11SA) to distinct CNBr phosphopeptides within the R-domain. Mutagenesis of 4 additional monobasic sites in these segments produced a 15SA variant in which Cl(-) channel response to PKA was abolished. Therefore, it can be concluded that ancillary phosphoproteins do not contribute to CFTR activation by PKA. Notably, however, the 15SA protein did exhibit a low level of constitutive channel activity not dependent on PKA, which might have reflected a down-regulating effect of phosphorylation of one or two of the 15 sites as suggested by others. However, this did not prove to be the case.Since immature CFTR has been claimed to be active in the endoplasmic reticulum (ER), we also examined whether it can be phosphorylated in cells and what influence if any this might have on its susceptibility to degradation. Teleologically, activation by phosphorylation of CFTR Cl(-) channels in the ER might be undesirable to the cell. Using various phosphorylation site mutants and kinase and phosphatase inhibitors in pulse-chase experiments, we have found that although nascent CFTR can be phosphorylated at the ER, this is without effect on its ability to mature and avoid proteolysis. Furthermore, we found that microsomes from cells expressing CFTR processing mutants such as DeltaF508 do not generate Cl(-) active channels when fused with planar bilayers unless maturation is promoted, e.g. by growth of cells at reduced temperature or other means. We conclude that the ER-retained mutant nascent chains which are incapable of maturation may be phosphorylated but do not form active channels. Stimulation by PKA of the insertion of CFTR containing vesicles into the plasma membrane as part of the mechanism of stimulation of chloride secretion has been reported, as has an influence of CFTR on the balance between endocytosis and exocytosis but these findings have not been universally confirmed.