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4,611 results on '"A Linhart"'

1. sbi reloaded: a toolkit for simulation-based inference workflows

Author

Boelts, Jan, Deistler, Michael, Gloeckler, Manuel, Tejero-Cantero, Álvaro, Lueckmann, Jan-Matthis, Moss, Guy, Steinbach, Peter, Moreau, Thomas, Muratore, Fabio, Linhart, Julia, Durkan, Conor, Vetter, Julius, Miller, Benjamin Kurt, Herold, Maternus, Ziaeemehr, Abolfazl, Pals, Matthijs, Gruner, Theo, Bischoff, Sebastian, Krouglova, Nastya, Gao, Richard, Lappalainen, Janne K., Mucsányi, Bálint, Pei, Felix, Schulz, Auguste, Stefanidi, Zinovia, Rodrigues, Pedro, Schröder, Cornelius, Zaid, Faried Abu, Beck, Jonas, Kapoor, Jaivardhan, Greenberg, David S., Gonçalves, Pedro J., and Macke, Jakob H.

Subjects
Computer Science - Machine Learning
Abstract

Scientists and engineers use simulators to model empirically observed phenomena. However, tuning the parameters of a simulator to ensure its outputs match observed data presents a significant challenge. Simulation-based inference (SBI) addresses this by enabling Bayesian inference for simulators, identifying parameters that match observed data and align with prior knowledge. Unlike traditional Bayesian inference, SBI only needs access to simulations from the model and does not require evaluations of the likelihood-function. In addition, SBI algorithms do not require gradients through the simulator, allow for massive parallelization of simulations, and can perform inference for different observations without further simulations or training, thereby amortizing inference. Over the past years, we have developed, maintained, and extended $\texttt{sbi}$, a PyTorch-based package that implements Bayesian SBI algorithms based on neural networks. The $\texttt{sbi}$ toolkit implements a wide range of inference methods, neural network architectures, sampling methods, and diagnostic tools. In addition, it provides well-tested default settings but also offers flexibility to fully customize every step of the simulation-based inference workflow. Taken together, the $\texttt{sbi}$ toolkit enables scientists and engineers to apply state-of-the-art SBI methods to black-box simulators, opening up new possibilities for aligning simulations with empirically observed data.

Published
2024

2. When Knockoffs fail: diagnosing and fixing non-exchangeability of Knockoffs

Author

Blain, Alexandre, Thirion, Bertrand, Linhart, Julia, and Neuvial, Pierre

Subjects
Statistics - Methodology
Abstract

Knockoffs are a popular statistical framework that addresses the challenging problem of conditional variable selection in high-dimensional settings with statistical control. Such statistical control is essential for the reliability of inference. However, knockoff guarantees rely on an exchangeability assumption that is difficult to test in practice, and there is little discussion in the literature on how to deal with unfulfilled hypotheses. This assumption is related to the ability to generate data similar to the observed data. To maintain reliable inference, we introduce a diagnostic tool based on Classifier Two-Sample Tests. Using simulations and real data, we show that violations of this assumption occur in common settings for classical Knockoffs generators, especially when the data have a strong dependence structure. We show that the diagnostic tool correctly detects such behavior. To fix knockoff generation, we propose a nonparametric, computationally-efficient alternative knockoff construction, which is based on constructing a predictor of each variable based on all others. We show that this approach achieves asymptotic exchangeability with the original variables under standard assumptions on the predictive model. We show empirically that the proposed approach restores error control on simulated data.

Published
2024

4. Diffusion posterior sampling for simulation-based inference in tall data settings

Author

Linhart, Julia, Cardoso, Gabriel Victorino, Gramfort, Alexandre, Corff, Sylvain Le, and Rodrigues, Pedro L. C.

Subjects
Statistics - Machine Learning, Computer Science - Machine Learning, Statistics - Methodology
Abstract

Determining which parameters of a non-linear model best describe a set of experimental data is a fundamental problem in science and it has gained much traction lately with the rise of complex large-scale simulators. The likelihood of such models is typically intractable, which is why classical MCMC methods can not be used. Simulation-based inference (SBI) stands out in this context by only requiring a dataset of simulations to train deep generative models capable of approximating the posterior distribution that relates input parameters to a given observation. In this work, we consider a tall data extension in which multiple observations are available to better infer the parameters of the model. The proposed method is built upon recent developments from the flourishing score-based diffusion literature and allows to estimate the tall data posterior distribution, while simply using information from a score network trained for a single context observation. We compare our method to recently proposed competing approaches on various numerical experiments and demonstrate its superiority in terms of numerical stability and computational cost., Comment: 49 pages, 24 figures, 3 tables, 2 algorithms, 12 appendices, in proceedings

Published
2024

5. Head-to-head trial of pegunigalsidase alfa versus agalsidase beta in patients with Fabry disease and deteriorating renal function: results from the 2-year randomised phase III BALANCE study.

Author

Wallace, Eric, Goker-Alpan, Ozlem, Wilcox, William, Holida, Myrl, Bernat, John, Longo, Nicola, Linhart, Aleš, Hughes, Derralynn, Hopkin, Robert, Tøndel, Camilla, Langeveld, Mirjam, Giraldo, Pilar, Pisani, Antonio, Germain, Dominique, Mehta, Ankit, Deegan, Patrick, Molnar, Maria, Ortiz, Damara, Jovanovic, Ana, Muriello, Michael, Barshop, Bruce, Kimonis, Virginia, Vujkovac, Bojan, Nowak, Albina, Geberhiwot, Tarekegn, Kantola, Ilkka, Knoll, Jasmine, Waldek, Stephen, Nedd, Khan, Karaa, Amel, Brill-Almon, Einat, Alon, Sari, Chertkoff, Raul, Rocco, Rossana, Sakov, Anat, and Warnock, David

Subjects
Drug-Related Side Effects and Adverse Reactions, Fabry Disease, Genetic Diseases, Inborn, Genetic Diseases, X-Linked, alpha-Galactosidase, Humans, Fabry Disease, Male, alpha-Galactosidase, Adult, Female, Middle Aged, Glomerular Filtration Rate, Enzyme Replacement Therapy, Isoenzymes, Recombinant Proteins, Adolescent, Young Adult, Treatment Outcome
Abstract

BACKGROUND: Pegunigalsidase alfa is a PEGylated α-galactosidase A enzyme replacement therapy. BALANCE (NCT02795676) assessed non-inferiority of pegunigalsidase alfa versus agalsidase beta in adults with Fabry disease with an annualised estimated glomerular filtration rate (eGFR) slope more negative than -2 mL/min/1.73 m2/year who had received agalsidase beta for ≥1 year. METHODS: Patients were randomly assigned 2:1 to receive 1 mg/kg pegunigalsidase alfa or agalsidase beta every 2 weeks for 2 years. The primary efficacy analysis assessed non-inferiority based on median annualised eGFR slope differences between treatment arms. RESULTS: Seventy-seven patients received either pegunigalsidase alfa (n=52) or agalsidase beta (n=25). At baseline, mean (range) age was 44 (18-60) years, 47 (61%) patients were male, median eGFR was 74.5 mL/min/1.73 m2 and median (range) eGFR slope was -7.3 (-30.5, 6.3) mL/min/1.73 m2/year. At 2 years, the difference between median eGFR slopes was -0.36 mL/min/1.73 m2/year, meeting the prespecified non-inferiority margin. Minimal changes were observed in lyso-Gb3 concentrations in both treatment arms at 2 years. Proportions of patients experiencing treatment-related adverse events and mild or moderate infusion-related reactions were similar in both groups, yet exposure-adjusted rates were 3.6-fold and 7.8-fold higher, respectively, with agalsidase beta than pegunigalsidase alfa. At the end of the study, neutralising antibodies were detected in 7 out of 47 (15%) pegunigalsidase alfa-treated patients and 6 out of 23 (26%) agalsidase beta-treated patients. There were no deaths. CONCLUSIONS: Based on rate of eGFR decline over 2 years, pegunigalsidase alfa was non-inferior to agalsidase beta. Pegunigalsidase alfa had lower rates of treatment-emergent adverse events and mild or moderate infusion-related reactions. TRIAL REGISTRATION NUMBER: NCT02795676.

Published
2024

6. Clinical management of female patients with Fabry disease based on expert consensus

Author

Eva Brand, Aleš Linhart, Patrick Deegan, Ruxandra Jurcut, Antonio Pisani, Roser Torra, and Ulla Feldt-Rasmussen

Subjects
Fabry disease, Female, Early diagnosis, Enzyme replacement therapy, Patient-reported outcome measures, Medicine
Abstract

Abstract Fabry disease is an X-linked lysosomal storage disorder that causes accumulation of glycosphingolipids in body tissues and fluids, leading to progressive organ damage and life-threatening complications. It can affect both males and females and can be classified into classic or later-onset phenotypes. The disease severity in females ranges from asymptomatic to the more severe, classic phenotype. Most females are hemizygous and the X-linked inheritance is associated with variable X-activation pattern and residual enzymatic activity. The heterogeneity of clinical presentation in females requires different approaches to diagnosis and management than males. A European group of 7 physicians, experienced in the management of Fabry disease, convened to discuss patient perspectives and published guidelines. The experts discussed the need to focus on psychological treatment in relation to individual coping styles when monitoring targets, and the lack of data supporting the use of plasma globotriaosylsphingosine over enzyme activity in the diagnosis of these patients. It was suggested that the high phenotypic variability in female patients may be related to the dynamic nature of the X-chromosome inactivation process and further understanding of this process could help predict the progression of Fabry disease in females and facilitate timely intervention. Due to the range of disease severity they exhibit, female patients with Fabry disease may require a more individualized treatment approach than males. Despite current recommendations, the experts agreed that early disease-specific treatment initiation in high-risk females could improve clinical outcome.

Published
2025
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11. L-C2ST: Local Diagnostics for Posterior Approximations in Simulation-Based Inference

Author

Linhart, Julia, Gramfort, Alexandre, and Rodrigues, Pedro L. C.

Subjects
Statistics - Machine Learning, Computer Science - Artificial Intelligence, Computer Science - Machine Learning, Quantitative Biology - Neurons and Cognition
Abstract

Many recent works in simulation-based inference (SBI) rely on deep generative models to approximate complex, high-dimensional posterior distributions. However, evaluating whether or not these approximations can be trusted remains a challenge. Most approaches evaluate the posterior estimator only in expectation over the observation space. This limits their interpretability and is not sufficient to identify for which observations the approximation can be trusted or should be improved. Building upon the well-known classifier two-sample test (C2ST), we introduce L-C2ST, a new method that allows for a local evaluation of the posterior estimator at any given observation. It offers theoretically grounded and easy to interpret -- e.g. graphical -- diagnostics, and unlike C2ST, does not require access to samples from the true posterior. In the case of normalizing flow-based posterior estimators, L-C2ST can be specialized to offer better statistical power, while being computationally more efficient. On standard SBI benchmarks, L-C2ST provides comparable results to C2ST and outperforms alternative local approaches such as coverage tests based on highest predictive density (HPD). We further highlight the importance of local evaluation and the benefit of interpretability of L-C2ST on a challenging application from computational neuroscience., Comment: 27 pages, 6 figures, 3 tables, 6 appendices, NeurIPS 2023

Published
2023

12. Optical markers of magnetic phase transition in CrSBr

Author

Linhart, W. M., Rybak, M., Birowska, M., Mosina, K., Mazanek, V., Scharoch, P., Kaczorowski, D., Sofer, Z., and Kudrawiec, R.

Subjects
Condensed Matter - Materials Science, Physics - Applied Physics
Abstract

Here, we investigate the role of the interlayer magnetic ordering of CrSBr in the framework of $\textit{ab initio}$ calculations and by using optical spectroscopy techniques. These combined studies allow us to unambiguously determine the nature of the optical transitions. In particular, photoreflectance measurements, sensitive to the direct transitions, have been carried out for the first time. We have demonstrated that optically induced band-to-band transitions visible in optical measurement are remarkably well assigned to the band structure by the momentum matrix elements and energy differences for the magnetic ground state (A-AFM). In addition, our study reveals significant differences in electronic properties for two different interlayer magnetic phases. When the magnetic ordering of A-AFM to FM is changed, the crucial modification of the band structure reflected in the direct-to-indirect band gap transition and the significant splitting of the conduction bands along the $\Gamma-Z$ direction are obtained. In addition, Raman measurements demonstrate a splitting between the in-plane modes $B^2_{2g}$/$B^2_{3g}$, which is temperature dependent and can be assigned to different interlayer magnetic states, corroborated by the DFT+U study. Moreover, the $B^2_{2g}$ mode has not been experimentally observed before. Finally, our results point out the origin of interlayer magnetism, which can be attributed to electronic rather than structural properties. Our results reveal a new approach for tuning the optical and electronic properties of van der Waals magnets by controlling the interlayer magnetic ordering in adjacent layers., Comment: 33 pages, 15 figures

Published
2023

13. Validation Diagnostics for SBI algorithms based on Normalizing Flows

Author

Linhart, Julia, Gramfort, Alexandre, and Rodrigues, Pedro L. C.

Subjects
Statistics - Machine Learning, Computer Science - Artificial Intelligence, Computer Science - Machine Learning, Quantitative Biology - Quantitative Methods
Abstract

Building on the recent trend of new deep generative models known as Normalizing Flows (NF), simulation-based inference (SBI) algorithms can now efficiently accommodate arbitrary complex and high-dimensional data distributions. The development of appropriate validation methods however has fallen behind. Indeed, most of the existing metrics either require access to the true posterior distribution, or fail to provide theoretical guarantees on the consistency of the inferred approximation beyond the one-dimensional setting. This work proposes easy to interpret validation diagnostics for multi-dimensional conditional (posterior) density estimators based on NF. It also offers theoretical guarantees based on results of local consistency. The proposed workflow can be used to check, analyse and guarantee consistent behavior of the estimator. The method is illustrated with a challenging example that involves tightly coupled parameters in the context of computational neuroscience. This work should help the design of better specified models or drive the development of novel SBI-algorithms, hence allowing to build up trust on their ability to address important questions in experimental science., Comment: 7 pages, 2 figures, 1 appendix, published at "Machine Learning and the Physical Sciences" workshop (NeurIPS 2022): https://ml4physicalsciences.github.io/2022/

Published
2022

14. Effects of multiple hormonal stimulation and stripping during out-of-spawning season on sperm quality of common carp Cyprinus carpio

Author

Mohammad Abdul Momin Siddique, Nururshopa Eskander Shazada, Songpei Zhang, Otomar Linhart, and Serhii Boryshpolets

Subjects
Hormonal stimulation, multiple strippings, Sperm motility, Ionic composition, Seminal plasma, Osmolality, Aquaculture. Fisheries. Angling, SH1-691
Abstract

The availability of mature broodstock that produces high-quality gametes is one of the vital issues with fish reproduction. The effects of multiple hormonal stimulations and continuous stripping of the same individual males on spermatozoa quality are unclear. Thus, this study aimed to investigate motility parameters and seminal plasma compositions of common carp sperm during out-of-spawning continuous stripping stimulated by multiple hormonal injections. Five mature males ∼3 years old, each approximately 1.7–2.3 kg bodyweight cultured in RAS at a stable temperature of 21 °C were used in this study. Fish were treated monthly (at the beginning of each month from August to October) with carp pituitary at 1.5 mg kg−1 (b.w.) dissolved in 0.9 % (w/v) NaCl solution 24 h before milt collection. The mean sperm concentration ranged from 17.55 to 20.19 × 109 mL−1 collected during the experiments and did not significantly vary among the sampling months (F = 2.352, p = 0.1374). However, the repeated measures ANOVA showed significant effects of sampling months (F = 25.24, p = 0.0001) and individual males (F = 7.50, p = 0.0001) on the motility parameters and seminal plasma compositions, but their interaction effects were not significant (F = 1.31, p = 0.079). One-way ANOVA revealed a significant difference in spermatozoa motility (F = 10.51, p = 0.0001) and pH of the seminal plasma (F = 90.00, p = 0.0001), but did not differ in curvilinear velocity (VCL), straight-line velocity (VSL), and ionic compositions (Na+, K+, Cl-, Ca2+, total protein, and osmolality) of the seminal plasma (p > 0.05). The mean spermatozoa motility in August (88.51–94.05 %) and September (89.88–96.00 %) was significantly higher than in October (83.99–89.58 %), but spermatozoa motility was >80 % in all males for the three consecutive months. The present study indicated that multiple hormonal stimulation and continuous stripping did not suppress common carp's spermatozoa production and quality parameters.

Published
2024
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15. Adult mortality from non-communicable diseases in Fiji's major ethnic groups 2013–17

Author

Catherine Dearie, Christine Linhart, Carah Figueroa, Varanisese Saumaka, Timothy Dobbins, Stephen Morrell, and Richard Taylor

Subjects
Sustainable development goals, Cause of death, Non-communicable disease, Fiji, Mortality, Probability of dying, Infectious and parasitic diseases, RC109-216
Abstract

Background: Sustainable Development Goal 3.4.1 (SDG3.4.1) targets a one-third reduction in non-communicable disease (NCD) mortality in ages 30–69-years by 2030 (relative to 2015). Directing interventions to achieve this aim requires reliable estimates of underlying cause of death (UCoD). This may be problematic when both cardiovascular diseases (CVD) and diabetes are present due to a lack of consistency in certification of such deaths. We estimate empirically 2013–17 NCD mortality in Fiji, by sex and ethnicity, from CVD, diabetes, cancer, and chronic lower respiratory diseases (CRD), and aggregated as NCD4. Methods: UCoD was determined from Medical Certificates of Cause-of-Death (MCCD) from the Fiji Ministry of Health after pre-processing of mortality data where diabetes and/or hypertension were present in order to generate internationally comparable UCoD. If no potentially fatal complications from diabetes or hypertension accompanied these causes in Part I (direct cause) of the MCCD, these conditions were re-assigned to Part II (contributory cause). The probability of a 30-year-old dying before reaching age 70-years (PoD30–70), by cause, was calculated. Findings: The PoD30–70 from NCD4 over 2013–17 differed by sex and ethnicity: in women, it was 36% (95%CI 35–37%) in i-Taukei and 27% (26–28%) in Fijians of Indian descent (FID); in men, it was 41% (40–42%) in both i-Taukei and FID.PoD30–70 from CVD, diabetes, cancer and CRD in women was: 18%, 10%, 13% and 1·0% in i-Taukei; 13%, 10%, 5·6% and 1·1% in FID; in men was: 28%, 8.4%, 7·6% and 2·2% in i-Taukei; 31%, 8.3%, 3.5% and 3·1% in FID. Interpretation: To achieve SDG3.4.1 goals in Fiji by 2030, effective population wide and ethnic-specific interventions targeting multiple NCDs are required to reduce PoD30–70 from NCD4: from 36% to 24% in i-Taukei, and 27% to 18% in FID women; and from 41% to 27% in i-Taukei and FID men. Funding: Not applicable.

Published
2024
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16. Improving the timeliness of birth registration in Fiji through a financial incentive

Author

Christine Linhart, Neel Singh, Meli Nadakuca, Varanisese Saumaka, Carlie Congdon, Sharita Serrao, Richard Taylor, and Stephen Morrell

Subjects
Fiji, Birth registration, Timeliness, Financial incentive, Ethnicity, Adolescent, Infectious and parasitic diseases, RC109-216
Abstract

Background: Fiji is a Pacific Island nation with the predominant ethnic groups indigenous Fijians (iTaukei) (62 %) and Fijians of Indian descent (31 %). This study reports on the effect of a Parental Assistance Payment Program (PAPP) tied to on-time birth registration, available in Fiji from August 2018 to July 2020. Methods: Unit record birth registration data (n = 117,829) for children born during 2016–22 were used to calculate mean birth-to-registration intervals and the likelihood of on-time birth registration (within 365 days) before the PAPP (January 2016–July 2018) compared to during the PAPP (August 2018–July 2020), by population disaggregations (sex, ethnicity, age, marital status). Results: During the PAPP, mean birth-to-registration intervals declined sharply by 81 %, from 665 days (95 %CI: 658–671) to 124 days (121–127). The largest declines were among i-Taukei children (803 to 139 days, 83 %) compared to non-iTaukei (283 to 76 days, 73 %); mothers aged 10–19 years (880 to 134 days, 85 %) compared to ≥20 years (653 to 123 days, 81 %); and single mothers (983 to 145 days, 85 %) compared to married mothers (570 to 115 days, 80 %). On-time birth registration increased from 57 % to 93 %, and the adjusted hazard ratio showed children born during the PAPP were 2.3 times more likely (95 %CI: 2.2–2.4) to have their birth registered on-time compared to children born before the PAPP. When the PAPP was discontinued in August 2020, the birth-to-registration interval increased sharply in all population groups. Conclusions: During the two-year period the PAPP was available, it was highly effective at improving the timeliness of birth registration, particularly among iTaukei children, young mothers, and single mothers. After the PAPP was discontinued, the timeliness of birth registration deteriorated sharply. Longer post-PAPP follow-up time (≠5 years) is required to determine whether the timeliness of birth registration has deteriorated to levels similar to those during the pre-PAPP period.

Published
2024
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17. The endocannabinoid ARA-S facilitates the activation of cardiac Kv7.1/KCNE1 channels from different species

Author

Irene Hiniesto-Iñigo, Veronika A. Linhart, Ali S. Kusay, and Sara I. Liin

Subjects
Electrophysiology, IKs, KCNQ1, lipid, Therapeutics. Pharmacology, RM1-950, Physiology, QP1-981
Abstract

The endogenous endocannabinoid-like compound N-arachidonoyl-L-serine (ARA-S) facilitates activation of the human Kv7.1/KCNE1 channel and shortens a prolonged action potential duration and QT interval in guinea pig hearts. Hence, ARA-S is interesting to study further in cardiac models to explore the functional impact of such Kv7.1/KCNE1-mediated effects. To guide which animal models would be suitable for assessing ARA-S effects, and to aid interpretation of findings in different experimental models, it is useful to know whether Kv7.1/KCNE1 channels from relevant species respond similarly to ARA-S. To this end, we used the two-electrode voltage clamp technique to compare the effects of ARA-S on Kv7.1/KCNE1 channels from guinea pig, rabbit, and human Kv7.1/KCNE1, when expressed in Xenopus laevis oocytes. We found that the activation of Kv7.1/KCNE1 channels from all tested species was facilitated by ARA-S, seen as a concentration-dependent shift in the voltage-dependence of channel opening and increase in current amplitude and conductance over a broad voltage range. The rabbit channel displayed quantitatively similar effects as the human channel, whereas the guinea pig channel responded with more prominent increase in current amplitude and maximal conductance. This study suggests that rabbit and guinea pig models are both suitable for studying ARA-S effects mediated via Kv7.1/KCNE1.

Published
2024
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18. Search for central exclusive production of top quark pairs in proton-proton collisions at s $$ \sqrt{s} $$ = 13 TeV with tagged protons

Author

The CMS collaboration, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, P. S. Hussain, M. Jeitler, N. Krammer, L. Lechner, D. Liko, I. Mikulec, P. Paulitsch, F. M. Pitters, J. Schieck, R. Schöfbeck, D. Schwarz, S. Templ, W. Waltenberger, C.-E. Wulz, M. R. Darwish, T. Janssen, T. Kello, H. Rejeb Sfar, P. Van Mechelen, E. S. Bols, J. D’Hondt, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, S. Moortgat, A. Morton, D. Müller, A. R. Sahasransu, S. Tavernier, W. Van Doninck, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, K. Lee, M. Mahdavikhorrami, I. Makarenko, A. Malara, S. Paredes, L. Pétré, N. Postiau, E. Starling, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, D. Dobur, J. Knolle, L. Lambrecht, G. Mestdach, M. Niedziela, C. Rendón, C. Roskas, A. Samalan, K. Skovpen, M. Tytgat, N. Van Den Bossche, B. Vermassen, L. Wezenbeek, A. Benecke, G. Bruno, F. Bury, C. Caputo, P. David, C. Delaere, I. S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, K. Mondal, J. Prisciandaro, A. Taliercio, T. T. Tran, P. Vischia, S. Wertz, G. A. Alves, E. Coelho, C. Hensel, A. Moraes, P. Rebello Teles, W. L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, V. Dos Santos Sousa, S. Fonseca De Souza, J. Martins, C. Mora Herrera, K. Mota Amarilo, L. Mundim, H. Nogima, A. Santoro, S. M. Silva Do Amaral, A. Sznajder, M. Thiel, F. Torres Da Silva De Araujo, A. Vilela Pereira, C. A. Bernardes, L. Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, A. Aleksandrov, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Rodozov, M. Shopova, G. Sultanov, A. Dimitrov, T. Ivanov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, T. Cheng, T. Javaid, M. Mittal, L. Yuan, M. Ahmad, G. Bauer, Z. Hu, S. Lezki, K. Yi, G. M. Chen, H. S. Chen, M. Chen, F. Iemmi, C. H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, V. Milosevic, F. Monti, R. Sharma, J. Tao, J. Thomas-Wilsker, J. Wang, H. Zhang, J. Zhao, A. Agapitos, Y. An, Y. Ban, C. Chen, A. Levin, C. Li, Q. Li, X. Lyu, Y. Mao, S. J. Qian, X. Sun, D. Wang, J. Xiao, H. Yang, J. Li, M. Lu, Z. You, X. Gao, D. Leggat, H. Okawa, Y. Zhang, Z. Lin, C. Lu, M. Xiao, C. Avila, D. A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J. D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, I. Puljak, Z. Antunovic, M. Kovac, T. Sculac, V. Brigljevic, B. K. Chitroda, D. Ferencek, D. Majumder, M. Roguljic, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, G. Kole, M. Kolosova, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, H. Rykaczewski, H. Saka, M. Finger, A. Kveton, E. Ayala, E. Carrera Jarrin, S. Elgammal, A. Ellithi Kamel, M. A. Mahmoud, Y. Mohammed, S. Bhowmik, R. K. Dewanjee, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, P. Eerola, H. Kirschenmann, M. Voutilainen, S. Bharthuar, E. Brücken, J. Havukainen, M. S. Kim, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, M. Lotti, L. Martikainen, M. Myllymäki, J. Ott, M. m. Rantanen, H. Siikonen, E. Tuominen, J. Tuominiemi, P. Luukka, H. Petrow, T. Tuuva, C. Amendola, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J. L. Faure, F. Ferri, S. Ganjour, P. Gras, G. Hamel de Monchenault, P. Jarry, V. Lohezic, J. Malcles, J. Rander, A. Rosowsky, M. Ö. Sahin, A. Savoy-Navarro, P. Simkina, M. Titov, F. Beaudette, A. Buchot Perraguin, P. Busson, A. Cappati, C. Charlot, F. Damas, O. Davignon, B. Diab, G. Falmagne, B. A. Fontana Santos Alves, S. Ghosh, R. Granier de Cassagnac, A. Hakimi, B. Harikrishnan, G. Liu, J. Motta, M. Nguyen, C. Ochando, L. Portales, J. Rembser, R. Salerno, U. Sarkar, J. B. Sauvan, Y. Sirois, A. Tarabini, E. Vernazza, A. Zabi, A. Zghiche, J.-L. 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Harder, S. Harper, M.-L. Holmberg, J. Linacre, K. Manolopoulos, D. M. Newbold, E. Olaiya, D. Petyt, T. Reis, G. Salvi, T. Schuh, C. H. Shepherd-Themistocleous, I. R. Tomalin, T. Williams, R. Bainbridge, P. Bloch, S. Bonomally, J. Borg, S. Breeze, C. E. Brown, O. Buchmuller, V. Cacchio, V. Cepaitis, G. S. Chahal, D. Colling, J. S. Dancu, P. Dauncey, G. Davies, J. Davies, M. Della Negra, S. Fayer, G. Fedi, G. Hall, M. H. Hassanshahi, A. Howard, G. Iles, J. Langford, L. Lyons, A.-M. Magnan, S. Malik, A. Martelli, M. Mieskolainen, D. G. Monk, J. Nash, M. Pesaresi, B. C. Radburn-Smith, D. M. Raymond, A. Richards, A. Rose, E. Scott, C. Seez, A. Shtipliyski, R. Shukla, A. Tapper, K. Uchida, G. P. Uttley, L. H. Vage, T. Virdee, M. Vojinovic, N. Wardle, S. N. Webb, D. Winterbottom, K. Coldham, J. E. Cole, A. Khan, P. Kyberd, I. D. Reid, S. Abdullin, A. Brinkerhoff, B. Caraway, J. Dittmann, K. Hatakeyama, A. R. Kanuganti, B. McMaster, M. Saunders, S. Sawant, C. Sutantawibul, J. Wilson, R. Bartek, A. Dominguez, R. Uniyal, A. M. Vargas Hernandez, A. Buccilli, S. I. Cooper, D. Di Croce, S. V. Gleyzer, C. Henderson, C. U. Perez, P. Rumerio, C. West, A. Akpinar, A. Albert, D. Arcaro, C. Cosby, Z. Demiragli, C. Erice, E. Fontanesi, D. Gastler, S. May, J. Rohlf, K. Salyer, D. Sperka, D. Spitzbart, I. Suarez, A. Tsatsos, S. Yuan, G. Benelli, B. Burkle, X. Coubez, D. Cutts, M. Hadley, U. Heintz, J. M. Hogan, T. Kwon, G. Landsberg, K. T. Lau, D. Li, J. Luo, M. Narain, N. Pervan, S. Sagir, F. Simpson, E. Usai, W. Y. Wong, X. Yan, D. Yu, W. Zhang, J. Bonilla, C. Brainerd, R. Breedon, M. Calderon De La Barca Sanchez, M. Chertok, J. Conway, P. T. Cox, R. Erbacher, G. Haza, F. Jensen, O. Kukral, G. Mocellin, M. Mulhearn, D. Pellett, B. Regnery, D. Taylor, Y. Yao, F. Zhang, M. Bachtis, R. Cousins, A. Datta, D. Hamilton, J. Hauser, M. Ignatenko, M. A. Iqbal, T. Lam, W. A. Nash, S. Regnard, D. Saltzberg, B. Stone, V. Valuev, Y. Chen, R. Clare, J. W. Gary, M. Gordon, G. Hanson, G. Karapostoli, O. R. Long, N. Manganelli, W. Si, S. Wimpenny, J. G. Branson, P. Chang, S. Cittolin, S. Cooperstein, D. Diaz, J. Duarte, R. Gerosa, L. Giannini, J. Guiang, R. Kansal, V. Krutelyov, R. Lee, J. Letts, M. Masciovecchio, F. Mokhtar, M. Pieri, B. V. Sathia Narayanan, V. Sharma, M. Tadel, F. Würthwein, Y. Xiang, A. Yagil, N. Amin, C. Campagnari, M. Citron, G. Collura, A. Dorsett, V. Dutta, J. Incandela, M. Kilpatrick, A. J. Li, B. Marsh, P. Masterson, H. Mei, M. Oshiro, M. Quinnan, J. Richman, U. Sarica, R. Schmitz, F. Setti, J. Sheplock, P. Siddireddy, D. Stuart, S. Wang, A. Bornheim, O. Cerri, I. Dutta, J. M. Lawhorn, N. Lu, J. Mao, H. B. Newman, T. Q. Nguyen, M. Spiropulu, J. R. Vlimant, C. Wang, S. Xie, R. Y. Zhu, J. Alison, S. An, M. B. Andrews, P. Bryant, T. Ferguson, A. Harilal, C. Liu, T. Mudholkar, S. Murthy, M. Paulini, A. Roberts, A. Sanchez, W. Terrill, J. P. Cumalat, W. T. Ford, A. Hassani, G. Karathanasis, E. MacDonald, F. Marini, R. Patel, A. Perloff, C. Savard, N. Schonbeck, K. Stenson, K. A. Ulmer, S. R. Wagner, N. Zipper, J. Alexander, S. Bright-Thonney, X. Chen, D. J. Cranshaw, J. Fan, X. Fan, D. Gadkari, S. Hogan, J. Monroy, J. R. Patterson, D. Quach, J. Reichert, M. Reid, A. Ryd, J. Thom, P. Wittich, R. Zou, M. Albrow, M. Alyari, G. Apollinari, A. Apresyan, L. A. T. Bauerdick, D. Berry, J. Berryhill, P. C. Bhat, K. Burkett, J. N. Butler, A. Canepa, G. B. Cerati, H. W. K. Cheung, F. Chlebana, K. F. Di Petrillo, J. Dickinson, V. D. Elvira, Y. Feng, Freeman, A. Gandrakota, Z. Gecse, L. Gray, D. Green, S. Grünendahl, O. Gutsche, R. M. Harris, R. Heller, T. C. Herwig, J. Hirschauer, L. Horyn, B. Jayatilaka, S. Jindariani, M. Johnson, U. Joshi, T. Klijnsma, B. Klima, K. H. M. Kwok, S. Lammel, D. Lincoln, R. Lipton, T. Liu, C. Madrid, K. Maeshima, C. Mantilla, D. Mason, P. McBride, P. Merkel, S. Mrenna, S. Nahn, J. Ngadiuba, D. Noonan, V. Papadimitriou, N. Pastika, K. Pedro, C. Pena, F. Ravera, A. Reinsvold Hall, L. Ristori, E. Sexton-Kennedy, N. Smith, A. Soha, L. Spiegel, J. Strait, L. Taylor, S. Tkaczyk, N. V. Tran, L. Uplegger, E. W. Vaandering, H. A. Weber, I. Zoi, P. Avery, D. Bourilkov, L. Cadamuro, V. Cherepanov, R. D. Field, D. Guerrero, M. Kim, E. Koenig, J. Konigsberg, A. Korytov, K. H. Lo, K. Matchev, N. Menendez, G. Mitselmakher, A. Muthirakalayil Madhu, N. Rawal, D. Rosenzweig, S. Rosenzweig, K. Shi, Z. Wu, T. Adams, A. Askew, R. Habibullah, V. Hagopian, R. Khurana, T. Kolberg, G. Martinez, H. Prosper, C. Schiber, O. Viazlo, R. Yohay, J. Zhang, M. M. Baarmand, S. Butalla, T. Elkafrawy, M. Hohlmann, R. Kumar Verma, M. Rahmani, F. Yumiceva, M. R. Adams, H. Becerril Gonzalez, R. Cavanaugh, S. Dittmer, O. Evdokimov, C. E. Gerber, D. J. Hofman, D. S. Lemos, A. H. Merrit, C. Mills, G. Oh, T. Roy, S. Rudrabhatla, M. B. Tonjes, N. Varelas, X. Wang, Z. Ye, M. Alhusseini, K. Dilsiz, L. Emediato, R. P. Gandrajula, G. Karaman, O. K. Köseyan, J.-P. Merlo, A. Mestvirishvili, J. Nachtman, O. Neogi, H. Ogul, Y. Onel, A. Penzo, C. Snyder, E. Tiras, O. Amram, B. Blumenfeld, L. Corcodilos, J. Davis, A. V. Gritsan, L. Kang, S. Kyriacou, P. Maksimovic, J. Roskes, S. Sekhar, M. Swartz, T. Á. Vámi, A. Abreu, L. F. Alcerro Alcerro, J. Anguiano, P. Baringer, A. Bean, Z. Flowers, S. Khalil, J. King, G. Krintiras, M. Lazarovits, C. Le Mahieu, J. Marquez, M. Murray, M. Nickel, C. Rogan, R. Salvatico, S. Sanders, E. Schmitz, C. Smith, G. Wilson, B. Allmond, S. Duric, R. Gujju Gurunadha, A. Ivanov, K. Kaadze, Y. Maravin, T. Mitchell, A. Modak, K. Nam, J. Natoli, D. Roy, F. Rebassoo, D. Wright, E. Adams, A. Baden, O. Baron, A. Belloni, A. Bethani, S. C. Eno, N. J. Hadley, S. Jabeen, R. G. Kellogg, T. Koeth, Y. Lai, S. Lascio, A. C. Mignerey, S. Nabili, C. Palmer, C. Papageorgakis, M. Seidel, L. Wang, K. Wong, D. Abercrombie, R. Bi, W. Busza, I. A. Cali, M. D’Alfonso, J. Eysermans, C. Freer, G. Gomez-Ceballos, M. Goncharov, P. Harris, M. Hu, D. Kovalskyi, J. Krupa, Y.-J. Lee, K. Long, C. Mironov, C. Paus, D. Rankin, C. Roland, G. Roland, Z. Shi, G. S. F. Stephans, Z. Wang, B. Wyslouch, R. M. Chatterjee, B. Crossman, A. Evans, J. Hiltbrand, Sh. Jain, B. M. Joshi, C. Kapsiak, M. Krohn, Y. Kubota, J. Mans, M. Revering, R. Rusack, R. Saradhy, N. Schroeder, N. Strobbe, M. A. Wadud, L. M. Cremaldi, K. Bloom, M. Bryson, D. R. Claes, C. Fangmeier, L. Finco, F. Golf, C. Joo, I. Kravchenko, I. Reed, J. E. Siado, G. R. Snow, W. Tabb, A. Wightman, F. Yan, A. G. Zecchinelli, G. Agarwal, H. Bandyopadhyay, L. Hay, I. Iashvili, A. Kharchilava, C. McLean, M. Morris, D. Nguyen, J. Pekkanen, S. Rappoccio, A. Williams, G. Alverson, E. Barberis, Y. Haddad, Y. Han, A. Krishna, J. Lidrych, G. Madigan, B. Marzocchi, D. M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, A. Tishelman-Charny, T. Wamorkar, B. Wang, A. Wisecarver, D. Wood, J. Bueghly, Z. Chen, A. Gilbert, T. Gunter, K. A. Hahn, Y. Liu, N. Odell, M. H. Schmitt, M. Velasco, R. Band, R. Bucci, S. Castells, M. Cremonesi, A. Das, R. Goldouzian, M. Hildreth, K. Hurtado Anampa, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, K. Mohrman, C. Moore, Y. Musienko, H. Nelson, R. Ruchti, A. Townsend, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, B. Bylsma, M. Carrigan, L. S. Durkin, B. Francis, C. Hill, A. Lesauvage, M. Nunez Ornelas, K. Wei, B. L. Winer, B. R. Yates, F. M. Addesa, B. Bonham, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, S. Higginbotham, A. Kalogeropoulos, G. Kopp, S. Kwan, D. Lange, D. Marlow, K. Mei, I. Ojalvo, J. Olsen, D. Stickland, C. Tully, S. Norberg, A. S. Bakshi, V. E. Barnes, R. Chawla, S. Das, L. Gutay, M. Jones, A. W. Jung, D. Kondratyev, A. M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, A. Purohit, J. F. Schulte, M. Stojanovic, J. Thieman, F. Wang, R. Xiao, W. Xie, J. Dolen, N. Parashar, D. Acosta, A. Baty, T. Carnahan, M. Decaro, S. Dildick, K. M. Ecklund, P. J. Fernández Manteca, S. Freed, P. Gardner, F. J. M. Geurts, W. Li, B. P. Padley, R. Redjimi, J. Rotter, W. Shi, E. Yigitbasi, L. Zhang, X. Zuo, A. Bodek, P. de Barbaro, R. Demina, J. L. Dulemba, C. Fallon, T. Ferbel, M. Galanti, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, E. Ranken, R. Taus, G. P. Van Onsem, K. Goulianos, B. Chiarito, J. P. Chou, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, D. Jaroslawski, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, M. Osherson, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S. A. Thayil, S. Thomas, H. Wang, H. Acharya, A. G. Delannoy, S. Fiorendi, T. Holmes, E. Nibigira, S. Spanier, O. Bouhali, M. Dalchenko, A. Delgado, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, S. Malhotra, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, K. Lamichhane, T. Mengke, S. Muthumuni, T. Peltola, I. Volobouev, A. Whitbeck, E. Appelt, S. Greene, A. Gurrola, W. Johns, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, G. Cummings, J. Hakala, R. Hirosky, M. Joyce, A. Ledovskoy, A. Li, C. Neu, C. E. Perez Lara, B. Tannenwald, P. E. Karchin, N. Poudyal, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C. K. Koraka, A. Lanaro, A. Loeliger, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W. H. Smith, D. Teague, H. F. Tsoi, W. Vetens, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, D. Budkouski, V. Bunichev, O. Bychkova, M. Chadeeva, V. Chekhovsky, A. Dermenev, T. Dimova, I. Dremin, M. Dubinin, L. Dudko, V. Epshteyn, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, L. Kardapoltsev, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, E. Kuznetsova, A. Lanev, P. Levchenko, A. Litomin, O. Lukina, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Okhotnikov, I. Ovtin, V. Palichik, P. Parygin, V. Perelygin, M. Perfilov, G. Pivovarov, V. Popov, E. Popova, O. Radchenko, V. Rusinov, M. Savina, V. Savrin, D. Selivanova, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, D. Sosnov, A. Stepennov, V. Sulimov, A. Terkulov, O. Teryaev, I. Tlisova, M. Toms, A. Toropin, L. Uvarov, A. Uzunian, E. Vlasov, P. Volkov, A. Vorobyev, N. Voytishin, B. S. Yuldashev, A. Zarubin, I. Zhizhin, A. Zhokin, The TOTEM collaboration, G. Antchev, P. Aspell, I. Atanassov, V. Avati, J. Baechler, C. Baldenegro Barrera, V. Berardi, M. Berretti, V. Borshch, E. Bossini, U. Bottigli, M. Bozzo, H. Burkhardt, F. S. Cafagna, M. G. Catanesi, M. Deile, F. De Leonardis, M. Doubek, D. Druzhkin, K. Eggert, V. Eremin, A. Fiergolski, F. Garcia, V. Georgiev, S. Giani, L. Grzanka, J. Hammerbauer, T. Isidori, V. Ivanchenko, M. Janda, A. Karev, J. Kašpar, B. Kaynak, J. Kopal, V. Kundrát, S. Lami, R. Linhart, C. Lindsey, M. V. Lokajíček, L. Losurdo, F. Lucas Rodríguez, M. Macrí, M. Malawski, N. Minafra, S. Minutoli, K. Misan, T. Naaranoja, F. Nemes, H. Niewiadomski, E. Oliveri, F. Oljemark, M. Oriunno, K. Österberg, S. Ozkorucuklu, P. Palazzi, V. Passaro, Z. Peroutka, O. Potok, J. Procházka, M. Quinto, E. Radermacher, E. Radicioni, F. Ravotti, C. Royon, G. Ruggiero, H. Saarikko, V. D. Samoylenko, A. Scribano, J. Široký, J. Smajek, W. Snoeys, R. Stefanovitch, C. Taylor, E. Tcherniaev, N. Turini, O. Urban, V. Vacek, O. Vavroch, J. Welti, J. Williams, and J. Zich

Subjects
Hadron-Hadron Scattering, Top Physics, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract A search for the central exclusive production of top quark-antiquark pairs ( t t ¯ $$ \textrm{t}\overline{\textrm{t}} $$ ) is performed for the first time using proton-tagged events in proton-proton collisions at the LHC at a centre-of-mass energy of 13 TeV. The data correspond to an integrated luminosity of 29.4 fb −1. The t t ¯ $$ \textrm{t}\overline{\textrm{t}} $$ decay products are reconstructed using the central CMS detector, while forward protons are measured in the CMS-TOTEM precision proton spectrometer. An observed (expected) upper bound on the production cross section of 0.59 (1.14) pb is set at 95% confidence level, for collisions of protons with fractional momentum losses between 2 and 20%.

Published
2024
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19. Long‐term outcomes and reverse remodelling in recently diagnosed unexplained left ventricular systolic dysfunction

Author

Petr Kuchynka, Jana Podzimkova, Josef Marek, Barbara Anna Danek, Ivana Vitkova, Miluse Kreidlova, Lenka Roblova, Tomas Kovarnik, Stanislav Simek, Jan Horak, Jan Habasko, Ales Linhart, and Tomas Palecek

Subjects
Dilated cardiomyopathy, Endomyocardial biopsy, Left ventricular systolic dysfunction, Mortality, Reverse remodelling, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Aims In patients with recently diagnosed non‐ischaemic LV systolic dysfunction, left ventricular reverse remodelling (LVRR) and favourable prognosis has been documented in studies with short‐term follow‐up. The aim of our study was to assess the long‐term clinical course and stability of LVRR in these patients. Methods and results We prospectively studied 133 patients (37 women; 55 [interquartile range 46, 61] years) with recently diagnosed unexplained LV systolic dysfunction, with heart failure symptoms lasting

Published
2024
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20. Anderson–Fabry Disease Homozygosity: Rare Case of Late-Onset Variant

Author

Gabriela Dostalova, Jaroslav Januska, Michaela Veselá, Petra Reková, Anna Taborska, Martin Pleva, David Zemanek, and Aleš Linhart

Subjects
case report, Anderson–Fabry disease, homozygosity, exon 5, late onset, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Anderson–Fabry Disease (AFD) is a rare, X-linked lysosomal storage disorder caused by a mutation in the α-Galactosidase A gene resulting in α-Galactosidase A enzyme (α-Gal A) deficiency. The metabolic defect leads to the progressive accumulation of glycosphingolipids and the structural and functional impairment of affected organs. Due to the inheritance pattern, male patients are hemizygous with more severe manifestations of the disease as compared to females who, in most cases, are heterozygous with delayed and variable clinical presentation caused by uneven X-chromosome inactivation. Fabry disease cases are often identified by targeted screening programs in high-risk groups, such as in patients with end-stage renal disease, premature stroke, or unexplained cardiomyopathy. Here, we describe a unique case of a homozygous female patient identified by a nationwide screening program in hypertrophic cardiomyopathy patients. Before the systematic screening, the patient had a diagnosis of hypertrophic obstructive cardiomyopathy and was treated accordingly, including with alcohol septal ablation to reduce the obstructive gradient. The confirmation of Fabry disease led to the discovery of the same variant in several members of her family. The identified variant was c.644A>G, p.Asn215Ser (p.N215S), which is known to cause predominant cardiac involvement with late onset of the disease. This variant is amenable to oral therapy with the small-molecule chaperone migalastat, which was started and then interrupted due to the recurrence of the patient’s migraine and then re-initiated again after two years. During this period, the patient received enzyme replacement therapy with agalsidase beta but developed progressively worsening venous access. Our case illustrates the importance of the systematic screening of patients with clinical evidence of hypertrophic cardiomyopathy in whom the routine diagnostic process fails to discover Fabry disease, in particular variants with late-onset cardiac manifestations. Many of the late-onset variants are amenable to orally active therapy with migalastat, which significantly improves the comfort of the treatment. Its long-term results are being analyzed by a large international “Follow-me” registry, which was designed to verify the validity of pivotal trials with migalastat in Fabry disease.

Published
2024
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21. New Data Indicate Larger Decline in Morphological Diversity in Split-Footed Lacewing Larvae than Previously Estimated

Author

Laura Buchner, Simon Linhart, Florian Braig, Gideon T. Haug, Thomas Weiterschan, Carolin Haug, and Joachim T. Haug

Subjects
biodiversity, Myanmar amber, Neuroptera, Nymphidae, quantitative morphology, Science
Abstract

Modern insect decline sparks interest in similar declines of the past. Neuroptera, the group of lacewings, has been suggested to have undergone decline after the Cretaceous, and quantitative studies of larval morphology have supported this view. One of the groups within Neuroptera seeing a major decline is that of split-footed lacewings, Nymphidae. We here report 13 new larval specimens of split-footed lacewings from about 100-million-year-old Kachin amber, Myanmar. We explore how enlarging the data set to 60 specimens and expanding the investigated morphological structures affect the recognition of decline. The expanded data set has an increased morphospace, indicating a lack of saturation. The decline is, therefore, likely even larger than so far anticipated for Nymphidae. The study of head and mouthparts provides the strongest signal for a loss of diversity, which is feasible due to the direct coupling to feeding ecology. Analysis of the trunk region cannot recover a signal for loss of diversity. Sampling issues play a role here: the trunk of the larvae is less often well preserved, and the fossil larvae are more likely in early developmental stages due to the constraints of preservation.

Published
2025
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22. RATTUS (Rat Thoracic Ultrasound): diagnosis of pneumothorax in pet rats

Author

A. Piskovská, K. Kraszewska, K. Hauptman, J. Chloupek, P. Linhart, and V. Jekl

Subjects
rat, RATTUS, pneumothorax, thoracic disease, respiratory disorders, dyspnoea, Veterinary medicine, SF600-1100
Abstract

IntroductionRat thoracic ultrasound (RATTUS) is a non-invasive, easy-to-perform method for the evaluation of the pleural space and lungs in pet rats. The aim of the article is to present species-specific differences in the sonographic diagnosis of pneumothorax (PTX) in pet rats.MethodsIn total, 158 client-owned pet rats were examined during the period from July 2023 to January 2024. PTX was diagnosed in 20 of the examined rats (13.25%, the age of the animals ranged from 2 months to 32 months (19.08 ± 6.93 months; mean ± SD) and their body weight ranged from 97 g to 885 g (461.27 ± 138.97 g; mean ± SD). Radiographic confirmation of PTX was performed in all these 20 rats, in the control group radiography was used to confirm that PTX was not present.ResultsThe lung point and the barcode sign was found in 7/20 animals with sensitivity of 33.3% (95% CI, 0.16–0.59) and specificity of 100% (95% CI, 0.97–1.0). The abnormal curtain sign was found in 19/20 of animals with the sensitivity of 95% (95% CI, 0.73–0.99.7) and the specificity of 89% (95% CI, 0.82–0.93). The abnormalities in the substernal access were in 17/20 of animals with the sensitivity of 85% (95% CI, 0.61–0.96) and the specificity of 71% (95% CI, 0.62–0.78).DiscussionIn conclusion, RATTUS is a non-invasive method for the diagnosis of PTX in rats. Lung point and barcode sign are specific but not easily diagnosed signs. The curtain sign in RATTUS is not specific for PTX, as there are e.g. geriatric rats (rats older than 1,5 years) in which the abnormal curtain sign is visible without the presence of PTX. The presence of moderate to severe PTX can be assessed by the substernal approach based on the presence of cardiac displacement toward the collapsed lung lobe, and on evaluation of the lung inflation symmetry. This sign is not specific for PTX but in conjunction with other ultrasonic signs described makes the RATTUS a feasible tool for PTX diagnosis in rats.

Published
2024
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23. Optimizing extenders for short-term storage of Sterlet (Acipenser ruthenus) sperm

Author

Nururshopa Eskander Shazada, Songpei Zhang, Mohammad Abdul Momin Siddique, Yu Cheng, Marek Rodina, Sayyed Mohammad Hadi Alavi, and Otomar Linhart

Subjects
CASA, Seminal plasma, Spermatozoa motility, Spermatozoa velocity, Sturgeon, Aquaculture. Fisheries. Angling, SH1-691
Abstract

Considering endangered fish, storage of sterlet (Acipenser ruthenus) gamete is crucial, and investigating the most suitable extender for short-term storage of sperm is necessary. Therefore, the present study aimed to optimize suitable extenders for short-term storage of sterlet spermatozoa and determine the effects of storage periods and different extenders on spermatozoa motility parameters. The sperm of five mature males with good spermatozoa motility (∼80 %) were diluted with 20 different extenders having various Na+ and K+ concentrations and osmolality. Spermatozoa motility performances were assessed using a CASA system within 144 h storage at 0–2 °C. Undiluted sperm was used as a control. Seminal plasma Na+, K+, Ca2+ and Cl- concentrations were 17.56±10.12, 2.48±1.14, 0.11±0.06, and 6.20±3.42 mmol/L with osmolality of 35.60±20.70 mOsm/kg. A two-way ANOVA showed significant effects of storage time, extender, and their interaction on spermatozoa motility, curvilinear velocity (VCL), and straight-line velocity (VSL) (p3 mM resulted in lower spermatozoa motility performance. When the effects of storage time were studied, spermatozoa motility, VCL, and VSL in non-diluted sperm and those diluted with E18-E20 were decreased at 24–48 h and 72–96 h post-storage, respectively. This study shows that extenders with higher osmolality (39–62 mOsm/kg) and lower K+ (1 mmol/L) are the most suitable for storing sterlet sperm for a short period.

Published
2024
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24. Pulmonary perfusion in long‐term survivors of COVID‐19‐related severe acute respiratory distress syndrome treated by extracorporeal membrane oxygenation

Author

Lucie Miksová, Vladimír Dytrych, Václav Ptáčník, Martin Balík, Aleš Linhart, Jan Bělohlávek, and Pavel Jansa

Subjects
chronic thromboembolic pulmonary hypertension, COVID‐19 infection, extracorporeal membrane oxygenation, pulmonary perfusion, venous thromboembolic events, Diseases of the circulatory (Cardiovascular) system, RC666-701, Diseases of the respiratory system, RC705-779
Abstract

Abstract COVID‐19 associates with a hypercoagulant state and an increased risk for venous thromboembolic events (VTEs). Whether severe COVID‐19 infection requiring extracorporeal membrane oxygenation (ECMO) support might lead to chronic pulmonary perfusion abnormalities and chronic thromboembolic pulmonary disease/hypertension remains unclear. The purpose of this study was to evaluate chronic pulmonary perfusion abnormalities in long‐term survivors of COVID‐19‐related severe acute respiratory distress syndrome (ARDS) treated by ECMO at our institution. Pulmonary perfusion was examined by ventilation/perfusion (V/Q) single‐photon emission computed tomography or V/Q planar scintigraphy at least 3 months after ECMO explantation, comorbidities and incidence of thromboembolic events were recorded as well. Of 172 COVID‐19 patients treated by ECMO for severe COVID‐19 pneumonia between March 2020 and November 2021, only 80 were successfully weaned from ECMO. Of those, 37 patients were enrolled into the present analysis (27% female, mean age 52 years). Median duration of ECMO support was 12 days. In 24 (65%) patients VTE was recorded in the acute phase (23 patients developed ECMO cannula‐related deep vein thrombosis, 5 of them had also a pulmonary embolism, and one thrombus was associated with a central catheter). The median duration between ECMO explantation and assessment of pulmonary perfusion was 420 days. No segmental or larger mismatched perfusion defects were then detected in any patient. In conclusion, in long‐term survivors of COVID‐19‐related ARDS treated by ECMO, no persistent pulmonary perfusion abnormalities were detected although VTE was common.

Published
2024
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25. Characterisation of the dip-bump structure observed in proton-proton elastic scattering at $\sqrt s$ = 8 TeV

Author

The TOTEM Collaboration, Antchev, G., Aspell, P., Atanassov, I., Avati, V., Baechler, J., Barrera, C. Baldenegro, Berardi, V., Berretti, M., Borchsh, V., Bossini, E., Bottigli, U., Bozzo, M., Burkhardt, H., Cafagna, F. S., Catanesi, M. G., Csanád, M., Csörgő, T., Deile, M., De Leonardis, F., Doubek, M., Druzhkin, D., Eggert, K., Eremin, V., Ferro, F., Fiergolski, A., Forthomme, L., Garcia, F., Georgiev, V., Giani, S., Grzanka, L., Hammerbauer, J., Isidori, T., Ivanchenko, V., Janda, M., Karev, A., Kašpar, J., Kaynak, B., Kopal, J., Kundrát, V., Lami, S., Latino, G., Linhart, R., Lindsey, C., Lokajíček, M. V., Losurdo, L., Rodríguez, F. Lucas, Macrí, M., Malawski, M., Minafra, N., Minutoli, S., Naaranoja, T., Nemes, F., Niewiadomski, H., Novák, T., Oliveri, E., Oljemark5, F., Oriunno, M., Österberg, K., Palazzi, P., Passaro, V., Peroutka, Z., Procházka, J., Quinto, M., Radermacher, E., Radicioni, E., Ravotti, F., Robutti, E., Royon, C., Ruggiero, G., Saarikko, H., Samoylenko, V. D., Scribano, A., Siroky, J., Smajek, J., Snoeys, W., Stefanovitch, R., Sziklai, J., Taylor, C., Tcherniaev, E., Turini, N., Urban, O., Vacek, V., Vavroch, O., Welti, J., Williams, J., Zich, J., and Zielinski, K.

Subjects
High Energy Physics - Experiment
Abstract

The TOTEM collaboration at the CERN LHC has measured the differential cross-section of elastic proton-proton scattering at $\sqrt{s} = 8\ {\rm TeV}$ in the squared four-momentum transfer range $0.2\ {\rm GeV^{2}} < |t| < 1.9\ {\rm GeV^{2}}$. This interval includes the structure with a diffractive minimum ("dip") and a secondary maximum ("bump") that has also been observed at all other LHC energies, where measurements were made. A detailed characterisation of this structure for $\sqrt{s} = 8\ {\rm TeV}$ yields the positions, $|t|_{\rm dip} = (0.521 \pm 0.007)\ {\rm GeV^2}$ and $|t|_{\rm bump} = (0.695 \pm 0.026)\ {\rm GeV^2}$, as well as the cross-section values, ${{\rm d}\sigma/{\rm d} t}_{\rm dip} = (15.1 \pm 2.5)\ {\rm{\mu b/GeV^2}}$ and ${{\rm d}\sigma/{\rm d} t}_{\rm bump} = (29.7 \pm 1.8)\ {\rm{\mu b/GeV^2}}$, for the dip and the bump, respectively.

Published
2021

26. Wannier Diagram and Brown-Zak Fermions of Graphene on Hexagonal Boron-Nitride

Author

Fabian, Thomas, Kausel, Matthias, Linhart, Lukas, Burgdörfer, Joachim, and Libisch, Florian

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

The moir\'e potential of graphene on hexagonal boron nitride (hBN) generates a supercell sufficiently large as to thread a full magnetic flux quantum $\Phi_0$ for experimentally accessible magnetic field strengths. Close to rational fractions of $\Phi_0$, $p/q \cdot\Phi_0$, magnetotranslation invariance is restored giving rise to Brown-Zak fermions featuring the same dispersion relation as in the absence of the field. Employing a highly efficient numerical approach we have performed the first realistic simulation of the magnetoconductance for a 250 nm wide graphene ribbon on hexagonal boron nitride using a full ab-initio derived parametrization including strain. The resulting Hofstadter butterfly is analyzed in terms of a novel Wannier diagram for Landau spectra of Dirac particles that includes the lifting of the spin and valley degeneracy by the magnetic field and the moir\'e potential. This complex diagram can account for many experimentally observed features on a single-particle level, such as spin and valley degeneracy lifting and a non-periodicidy in $\Phi_0$., Comment: 6 pages, 4 figures

Published
2021
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27. Presentation of Historical Clothing Digital Replicas in Motion

Author

Tomas Dvorak, Jiri Kubista, Oldrich Linhart, Ivo Maly, David Sedlacek, and Sven Ubik

Subjects
Cultural heritage, museum, garments, fabrics, physical simulation, virtual mirror, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

The presentation of clothing collection objects in museums brings specific constraints and requirements. Textile objects are particularly sensitive to mechanical handling and prolonged exposure to light. At the same time, it is interesting to see these objects in motion as they were worn. In this paper, we propose a new method of presenting digital 3D models of clothing collection objects that allows us to display these objects in motion. The presentation is handled by two real-time applications. Virtual Wardrobe, designed especially for enthusiasts, aims at simulating the movement of the fabric as closely as possible, with the possibility of zooming in on details and showing clothing in a historicizing environment. Virtual Mirror, aimed towards the general public, allows visitors to virtually put on selected collection objects. The Virtual Mirror can display up to three visitors simultaneously and performs semi-automatic calibration to their character types. The main innovation of the proposed presentation of historical clothing objects is presentation of their detailed 3D reconstruction in motion in real time on dimensionally appropriate models of figures. This makes the solution different from the optimized models used in computer games and the non-real-time rendering used in the film industry. Both applications were subjected to a long-term usage study and a questionnaire study to determine visitor acceptance, which was positive. We summarize the experience of deploying both applications in practice at the museum exhibition.

Published
2024
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28. Workflow for Creating Animated Digital Replicas of Historical Clothing

Author

Jiri Kubista, Oldrich Linhart, David Sedlacek, and Sven Ubik

Subjects
3D reconstruction, photogrammetry, clothing digitization, animated clothing, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

Preserving and presenting historical clothing items in museum collections is challenging due to their sensitivity to handling but of great importance due to their deterioration over time. Creating digital replicas of these items can give museums unique documentation and presentation possibilities. A specific workflow is needed to create 3D digital models that can be simulated in real time to present clothing objects in motion and a realistic environment. This paper presents a detailed description of the workflow to create realistic 3D digital models of historical clothing items for motion animation. We demonstrate the use of the workflow on clothing items from the Prague City Museum’s collection.

Published
2024
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29. Indices Converting Resignation and Drop-Offs of Business Students to Retention

Author

Vnoucková, Lucie and Linhart, Zdenek

Abstract

Each new generation brings a challenge to employers, university management and teachers with new attitudes affecting their continuous matriculation and degree completion. This article discusses how to retain both business and institutional career-oriented students using real-time communication based on their attitudes, emotions resulting from logically generated synonyms by automatic data evaluation by the information system. The objective of this article is to identify these students early in their academic studies and to assess their likelihood for continuous matriculation and ultimately increase retention rates. Using data from entry questionnaire during application at university, based on their attitudinal expectation, students were categorised into groups that affected their continuous matriculation. Data used in this study were gathered by compulsory entry questionnaire of 535 students in the academic year 2017-2018. Using statistical and dimensional analysis, four groups were identified among university applicants: Proactive, Reactive, Lazy and Institutional. Responses were tested according to Complementary Distribution Function (CDF) and normal distribution as Probabilistic Distribution Function (PDF). Antagonist attitudes were found for answers corresponding to PDF and CDF. Results indicate that business and institutionally oriented students should be separated and treated individually to increase retention.

Published
2020

30. Effects of inappropriate cause-of-death certification on mortality from cardiovascular disease and diabetes mellitus in Tonga

Author

Carah A. Figueroa, Christine L. Linhart, Catherine Dearie, Latu E. Fusimalohi, Sioape Kupu, Stephen L. Morrell, and Richard J. Taylor

Subjects
Cardiovascular disease, Diabetes, Adult mortality, Cause of death, Death certification, ICD coding, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Cardiovascular disease (CVD) and diabetes mellitus are major health issues in Tonga and other Pacific countries, although mortality levels and trends are unclear. We assess the impacts of cause-of-death certification on coding of CVD and diabetes as underlying causes of death (UCoD). Methods Tongan records containing cause-of-death data (2001–2018), including medical certificates of cause-of-death (MCCD), had UCoD assigned according to International Classification of Diseases 10th revision (ICD-10) coding rules. Deaths without recorded cause were included to ascertain total mortality. Diabetes and hypertension causes were reallocated from Part 1 of the MCCD (direct cause) to Part 2 (contributory cause) if potentially fatal complications were not recorded, and an alternative UCoD was assigned. Proportional mortality by cause based on the alternative UCoD were applied to total deaths then mortality rates calculated by age and sex using census/intercensal population estimates. CVD and diabetes mortality rates for unaltered and alternative UCoD were compared using Poisson regression. Results Over 2001–18, in ages 35–59 years, alternative CVD mortality was higher than unaltered CVD mortality in men (p = 0.043) and women (p = 0.15); for 2010–18, alternative versus unaltered measures in men were 3.3/103 (95%CI: 3.0–3.7/103) versus 2.9/103 (95%CI: 2.6–3.2/103), and in women were 1.1/103 (95%CI: 0.9–1.3/103) versus 0.9/103 (95%CI: 0.8–1.1/103). Conversely, alternative diabetes mortality rates were significantly lower than the unaltered rates over 2001–18 in men (p

Published
2023
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31. Safety and efficacy of pegunigalsidase alfa in patients with Fabry disease who were previously treated with agalsidase alfa: results from BRIDGE, a phase 3 open-label study

Author

Aleš Linhart, Gabriela Dostálová, Kathy Nicholls, Michael L. West, Camilla Tøndel, Ana Jovanovic, Pilar Giraldo, Bojan Vujkovac, Tarekegn Geberhiwot, Einat Brill-Almon, Sari Alon, Raul Chertkoff, Rossana Rocco, and Derralynn Hughes

Subjects
Medicine
Abstract

Abstract Background Pegunigalsidase alfa is a novel, PEGylated α-galactosidase-A enzyme-replacement therapy approved in the EU and US to treat patients with Fabry disease (FD). Objective/methods BRIDGE is a phase 3 open-label, switch-over study designed to assess safety and efficacy of 12 months of pegunigalsidase alfa (1 mg/kg every 2 weeks) treatment in adults with FD who had been previously treated with agalsidase alfa (0.2 mg/kg every 2 weeks) for ≥ 2 years. Results Twenty-seven patients were screened; 22 met eligibility criteria; and 20 (13 men, 7 women) completed the study. Pegunigalsidase alfa was well-tolerated, with 97% of treatment-emergent adverse events (TEAEs) being of mild or moderate severity. The incidence of treatment-related TEAEs was low, with 2 (9%) discontinuations due to TEAEs. Five patients (23%) reported infusion-related reactions. Overall mean (SD; n = 22) baseline estimated glomerular filtration rate (eGFR) was 82.5 (23.4) mL/min/1.73 m2 and plasma lyso-Gb3 level was 38.3 (41.2) nmol/L (men: 49.7 [45.8] nmol/L; women: 13.8 [6.1] nmol/L). Before switching to pegunigalsidase alfa, mean (standard error [SE]) annualized eGFR slope was − 5.90 (1.34) mL/min/1.73 m2/year; 12 months post-switch, the mean eGFR slope was − 1.19 (1.77) mL/min/1.73 m2/year; and mean plasma lyso-Gb3 reduced by 31%. Seven (35%) out of 20 patients were positive for pegunigalsidase alfa antidrug antibodies (ADAs) at ≥ 1 study timepoint, two of whom had pre-existing ADAs at baseline. Mean (SE) changes in eGFR slope for ADA-positive and ADA-negative patients were + 5.47 (3.03) and + 4.29 (3.15) mL/min/1.73 m2/year, respectively, suggesting no negative impact of anti-pegunigalsidase alfa ADAs on eGFR slope. Conclusion Pegunigalsidase alfa may offer a safe and effective treatment option for patients with FD, including those previously treated with agalsidase alfa. TRN: NCT03018730. Date of registration: January 2017.

Published
2023
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32. Are the Values of Family Members Consistent With the Organizational Culture of Their Business?

Author

Marie Mikušová, Václav Friedrich, Gabriela Poláková, and Ondřej Linhart

Subjects
History of scholarship and learning. The humanities, AZ20-999, Social Sciences
Abstract

In family businesses, as in other organizations, an informal organizational culture is formed. The purpose of the research was to determine if there is a relationship between intra-family relationship and the type of organizational culture. Quantitative research has been conducted. The OCAI questionnaire was used as well as a set of questions from the authors who called it the Family Involvement Model. Data were obtained from 860 respondents, family business owners. Key findings that the values of family members are not consistent with the organizational culture in their business have been statistically confirmed. Only the hypothesis of the consistency of family values and clan organizational culture was confirmed. The study contributes to the study of family involvement in family business. Practical implications for family business owners can be seen in the building of positive influence on the creation of the organizational culture in their business. The study addresses the nature of organizational culture and the values of the family what is the originality of the research.

Published
2024
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33. Pegunigalsidase alfa: a novel, pegylated recombinant alpha-galactosidase enzyme for the treatment of Fabry disease

Author

Dominique P. Germain and Ales Linhart

Subjects
Fabry disease, PEGylation, agalsidase, non-inferiority trial, renal function, Genetics, QH426-470
Abstract

Fabry disease, a rare X-linked genetic disorder, results from pathogenic variants in GLA, leading to deficient lysosomal α-galactosidase A enzyme activity and multi-organ manifestations. Since 2001, enzyme replacement therapy (ERT), using agalsidase alfa or agalsidase beta, has been the mainstay treatment, albeit with limitations such as rapid clearance and immunogenicity. Pegunigalsidase alfa, a novel PEGylated recombinant alpha-galactosidase, offers promise as an alternative. Produced in plant cells, pegunigalsidase alfa exhibits enhanced stability, prolonged half-life, and reduced immunogenicity due to pegylation. A phase 1/2 clinical trial demonstrated Gb3 clearance from renal capillary endothelial cells and its 48-month extension study revealed notable outcomes in renal function preservation. Three phase 3 clinical trials (BRIDGE, BRIGHT, and BALANCE) have shown favorable efficacy and safety profile, although caution is warranted in interpreting the results of BRIDGE and BRIGHT which lacked control groups. In BALANCE, the pivotal phase 3 trial comparing pegunigalsidase alfa with agalsidase beta, an intention-to-treat analysis of the eGFR decline over 2 years showed that the intergroup difference [95%confidence interval] in the median slope was −0.36 mL/min/1.73 m2/year [−2.44; 1.73]. The confidence interval had a lower limit above the prespecified value of −3 mL/min/1.73 m2/year and included zero. Despite challenges such as occasional hypersensitivity reactions and immune-complex-mediated glomerulonephritis, pegunigalsidase alfa approval by the European Medicines Agency and the Food and Drug Administration represents a significant addition to Fabry disease therapeutic landscape providing an option for patients in whom enzyme replacement therapy with current formulations is poorly tolerated or poorly effective.

Published
2024
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34. Comparison of $pp$ and $p \bar{p}$ differential elastic cross sections and observation of the exchange of a colorless $C$-odd gluonic compound

Author

Abazov, V. M., Abbott, B., Acharya, B. S., Adams, M., Adams, T., Agnew, J. P., Alexeev, G. D., Alkhazov, G., Alton, A., Alves, G. A., Antchev, G., Askew, A., Aspell, P., Jesus, A. C. S. Assis, Atanassov, I., Atkins, S., Augsten, K., Aushev, V., Aushev, Y., Avati, V., Avila, C., Badaud, F., Baechler, J., Bagby, L., Barrera, C. Baldenegro, Baldin, B., Bandurin, D. V., Banerjee, S., Barberis, E., Baringer, P., Barreto, J., Bartlett, J. F., Bassler, U., Bazterra, V., Bean, A., Begalli, M., Bellantoni, L., Berardi, V., Beri, S. B., Bernardi, G., Bernhard, R., Berretti, M., Bertram, I., Besanccon, M., Beuselinck, R., Bhat, P. C., Bhatia, S., Bhatnagar, V., Blazey, G., Blessing, S., Bloom, K., Boehnlein, A., Boline, D., Boos, E. E., Borchsh, V., Borissov, G., Borysova, M., Bossini, E., Bottigli, U., Bozzo, M., Brandt, A., Brandt, O., Brochmann, M., Brock, R., Bross, A., Brown, D., Bu, X. B., Buehler, M., Buescher, V., Bunichev, V., Burdin, S., Burkhardt, H., Buszello, C. P., Cafagna, F. S., Camacho-P'erez, E., Carvahlo, W., Casey, B. C. K., Castilla-Valdez, H., Catanesi, M. G., Caughron, S., Chakrabarti, S., Chan, K. M., Chandra, A., Chapon, E., Chen, G., Cho, S. W., Choi, S., Choudhary, B., Cihangir, S., Claes, D., Clutter, J., Cooke, M., Cooper, W. E., Corcoran, M., Couderc, F., Cousinou, M. -C., Csan'ad, M., Cs"orgHo, T., Cuth, J., Cutts, D., Das, A., Davies, G., Deile, M., de Jong, S. J., De La Cruz-Burelo, E., De Leonardis, F., D'eliot, F., Demina, R., Denisov, D., Denisov, S. P., Desai, S., Deterre, C., DeVaughan, K., Diehl, H. T., Diesburg, M., Ding, P. F., Dominguez, A., Doubek, M., Drutskoy, A., Druzhkin, D., Dubey, A., Dudko, L. V., Duperrin, A., Dutt, S., Eads, M., Edmunds, D., Eggert, K., Ellison, J., Elvira, V. D., Enari, Y., Eremin, V., Evans, H., Evdokimov, A., Evdokimov, V. N., Faur'e, A., Feng, L., Ferbel, T., Ferro, F., Fiedler, F., Fiergolski, A., Filthaut, F., Fisher, W., Fisk, H. E., Forthomme, L., Fortner, M., Fox, H., Franc, J., Fuess, S., Garbincius, P. H., Garcia, F., Garcia-Bellido, A., Garc'ia-Gonz'alez, J. A., Gavrilov, V., Geng, W., Georgiev, V., Gerber, C. E., Gershtein, Y., Giani, S., Ginther, G., Gogota, O., Golovanov, G., Grannis, P. D., Greder, S., Greenlee, H., Grenier, G., Gris, Ph., Grivaz, J. -F., Grohsjean, A., Gr"unendahl, S., Gr"unewald, M. W., Grzanka, L., Guillemin, T., Gutierrez, G., Gutierrez, P., Haley, J., Hammerbauer, J., Han, L., Harder, K., Harel, A., Hauptman, J. M., Hays, J., Head, T., Hebbeker, T., Hedin, D., Hegab, H., Heinson, A. P., Heintz, U., Hensel, C., La Cruz, I. Heredia-De, Herner, K., Hesketh, G., Hildreth, M. D., Hirosky, R., Hoang, T., Hobbs, J. D., Hoeneisen, B., Hogan, J., Hohlfeld, M., Holzbauer, J. L., Howley, I., Hubacek, Z., Hynek, V., Iashvili, I., Ilchenko, Y., Illingworth, R., Isidori, T., Ito, A. S., Ivanchenko, V., Jabeen, S., Jaffr'e, M., Janda, M., Jayasinghe, A., Jeong, M. S., Jesik, R., Jiang, P., Johns, K., Johnson, E., Johnson, M., Jonckheere, A., Jonsson, P., Joshi, J., Jung, A. W., Juste, A., Kajfasz, E., Karev, A., Karmanov, D., Kavspar, J., Katsanos, I., Kaur, M., Kaynak, B., Kehoe, R., Kermiche, S., Khalatyan, N., Khanov, A., Kharchilava, A., Kharzheev, Y. N., Kiselevich, I., Kohli, J. M., Kopal, J., Kozelov, A. V., Kraus, J., Kumar, A., Kundr'at, V., Kupco, A., Kurvca, T., Kuzmin, V. A., Lami, S., Lammers, S., Latino, G., Lebrun, P., Lee, H. S., Lee, S. W., Lee, W. M., Le, X., Lellouch, J., Li, D., Li, H., Li, L., Li, Q. Z., Lim, J. K., Lincoln, D., Lindsey, C., Linhart, R., Linnemann, J., Lipaev, V. V., Lipton, R., Liu, H., Liu, Y., Lobodenko, A., Lokajicek, M., Lokaj'ivcek, M. V., de Sa, R. Lopes, Losurdo, L., Rodr'iguez, F. Lucas, Luna-Garcia, R., Lyon, A. L., Maciel, A. K. A., Macr'i, M., Madar, R., na-Villalba, R. Maga, Malawski, M., Malbouisson, H. B., Malik, S., Malyshev, V. L., Mansour, J., Mart'inez-Ortega, J., McCarthy, R., McGivern, C. L., Meijer, M. M., Melnitchouk, A., Menezes, D., Mercadante, P. G., Merkin, M., Meyer, A., Meyer, J., Miconi, F., Minafra, N., Minutoli, S., Molina, J., Mondal, N. K., Da Motta, H., Mulhearn, M., Mundim, L., Naaranoja, T., Nagy, E., Narain, M., Nayyar, R., Neal, H. A., Negret, J. P., Nemes, F., Neustroev, P., Nguyen, H. T., Niewiadomski, H., Nov'ak, T., Nunnemann, T., Oguri, V., Oliveri, E., Oljemark, F., Orduna, J., Oriunno, M., Osman, N., "Osterberg, K., Pal, A., Palazzi, P., Parashar, N., Parihar, V., Park, S. K., Partridge, R., Parua, N., Pasechnik, R., Passaro, V., Patwa, A., Penning, B., Perfilov, M., Peroutka, Z., Peters, Y., Petridis, K., Petrillo, G., P'etroff, P., Pleier, M. -A., Podstavkov, V. M., Popov, A. V., Da Silva, W. L. Prado, Prewitt, M., Price, D., Proch'azka, J., Prokopenko, N., Qian, J., Quadt, A., Quinn, B., Quinto, M., Raben, T. G., Radermacher, E., Rangel, M., Radicioni, E., Ratoff, P. N., Ravotti, F., Razumov, I., Ripp-Baudot, I., Rizatdinova, F., Robutti, E., Rodrigues, R. F., Rominsky, M., Ross, A., Royon, C., Rubinov, P., Ruchti, R., Ruggiero, G., Saarikko, H., Sajot, G., Samoylenko, V. D., S'anchez-Hern'andez, A., Sanders, M. P., Santoro, A., Santos, A. S., Savage, G., Savitskyi, M., Sawyer, L., Scanlon, T., Schamberger, R. D., Scheglov, Y., Schellman, H., Schott, M., Schwanenberger, C., Schwienhorst, R., Scribano, A., Sekaric, J., Severini, H., Shabalina, E., Shary, V., Shaw, S., Shchukin, A. A., Shkola, O., Simak, V., Siroky, J., Skubic, P., Slattery, P., Smajek, J., Snoeys, W., Snow, G. R., Snow, J., Snyder, S., S"oldner-Rembold, S., Sonnenschein, L., Soustruznik, K., Stark, J., Stefaniuk, N., Stefanovitch, R., Ster, A., Stoyanova, D. A., Strauss, M., Suter, L., Svoisky, P., Szanyi, I., Sziklai, J., Taylor, C., Tcherniaev, E., Titov, M., Tokmenin, V. V., Tsai, Y. -T., Tsybychev, D., Tuchming, B., Tully, C., Turini, N., Urban, O., Uvarov, L., Uvarov, S., Uzunyan, S., Vacek, V., Van Kooten, R., van Leeuwen, W. M., Varelas, N., Varnes, E. W., Vasilyev, I. A., Vavroch, O., Verkheev, A. Y., Vertogradov, L. S., Verzocchi, M., Vesterinen, M., Vilanova, D., Vokac, P., Wahl, H. D., Wang, C., Wang, M. H. L. S., Warchol, J., Watts, G., Wayne, M., Weichert, J., Welti, J., Welty-Rieger, L., Williams, J., Williams, M. R. J., Wilson, G. W., Wobisch, M., Wood, D. R., Wyatt, T. R., Xie, Y., Yamada, R., Yang, S., Yasuda, T., Yatsunenko, Y. A., Ye, W., Ye, Z., Yin, H., Yip, K., Youn, S. W., Yu, J. M., Zennamo, J., Zhao, T. G., Zhou, B., Zhu, J., Zich, J., Zielinski, K., Zielinski, M., Zieminska, D., and Zivkovic, L.

Subjects
High Energy Physics - Experiment
Abstract

We describe an analysis comparing the $p\bar{p}$ elastic cross section as measured by the D0 Collaboration at a center-of-mass energy of 1.96 TeV to that in $pp$ collisions as measured by the TOTEM Collaboration at 2.76, 7, 8, and 13 TeV using a model-independent approach. The TOTEM cross sections extrapolated to a center-of-mass energy of $\sqrt{s} =$ 1.96 TeV are compared with the D0 measurement in the region of the diffractive minimum and the second maximum of the $pp$ cross section. The two data sets disagree at the 3.4$\sigma$ level and thus provide evidence for the $t$-channel exchange of a colorless, $C$-odd gluonic compound, also known as the odderon. We combine these results with a TOTEM analysis of the same $C$-odd exchange based on the total cross section and the ratio of the real to imaginary parts of the forward elastic scattering amplitude in $pp$ scattering. The combined significance of these results is larger than 5$\sigma$ and is interpreted as the first observation of the exchange of a colorless, $C$-odd gluonic compound., Comment: D0 and TOTEM Collaborations

Published
2020
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35. Mirror Symmetry Breaking and Lateral Stacking Shifts in Twisted Trilayer Graphene

Author

Lei, Chao, Linhart, Lukas, Qin, Wei, Libisch, Florian, and MacDonald, Allan H.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We construct a continuum model of twisted trilayer graphene using {\it ab initio} density-functional-theory calculations, and apply it to address twisted trilayer electronic structure. Our model accounts for moir\'e variation in site energies, hopping between outside layers and within layers. We focus on the role of a mirror symmetry present in ABA graphene trilayers with a middle layer twist. The mirror symmetry is lost intentionally when a displacement field is applied between layers, and unintentionally when the top layer is shifted laterally relative to the bottom layer. We use two band structure characteristics that are directly relevant to transport measurements, the Drude weight and the weak-field Hall conductivity, and relate them via the Hall density to assess the influence of the accidental lateral stacking shifts currently present in all experimental devices on electronic properties, and comment on the role of the possible importance of accidental lateral stacking shifts for superconductivity in twisted trilayers., Comment: 14 pages, 12 figures

Published
2020
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36. Phonon Renormalization in Reconstructed MoS$_2$ Moir\'e Superlattices

Author

Quan, Jiamin, Linhart, Lukas, Lin, Miao-Ling, Lee, Daehun, Zhu, Jihang, Wang, Chun-Yuan, Hsu, Wei-Ting, Choi, Junho, Embley, Jacob, Young, Carter, Taniguchi, Takashi, Watanabe, Kenji, Shih, Chih-Kang, Lai, Keji, MacDonald, Allan H., Tan, Ping-Heng, Libisch, Florian, and Li, Xiaoqin

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

In moir\'e crystals formed by stacking van der Waals (vdW) materials, surprisingly diverse correlated electronic phases and optical properties can be realized by a subtle change in the twist angle. Here, we discover that phonon spectra are also renormalized in MoS$_2$ twisted bilayers, adding a new perspective to moir\'e physics. Over a range of small twist angles, the phonon spectra evolve rapidly due to ultra-strong coupling between different phonon modes and atomic reconstructions of the moir\'e pattern. We develop a new low-energy continuum model for phonons that overcomes the outstanding challenge of calculating properties of large moir\'e supercells and successfully captures essential experimental observations. Remarkably, simple optical spectroscopy experiments can provide information on strain and lattice distortions in moir\'e crystals with nanometer-size supercells. The newly developed theory promotes a comprehensive and unified understanding of structural, optical, and electronic properties of moir\'e superlattices., Comment: 21 pages, 4 figures

Published
2020
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37. Secondary Electron Emission by Plasmon Induced Symmetry Breaking in Highly Oriented Pyrolitic Graphite (HOPG)

Author

Werner, Wolfgang S. M., Astašauskas, Vytautas, Ziegler, Philipp, Bellissimo, Alessandra, Stefani, Giovanni, Linhart, Lukas, and Libisch, Florian

Subjects
Condensed Matter - Materials Science
Abstract

Two-particle spectroscopy with correlated electron pairs is used to establish the causal link between the secondary electron spectrum, the $(\pi+\sigma)-$plasmon peak and the unoccupied band structure of highly oriented pyrolitic graphite. The plasmon spectrum is resolved with respect to the involved interband transitions and clearly exhibits final state effects, in particular due to the energy gap between the interlayer resonances along the $\Gamma$A-direction. The corresponding final state effects can also be identified in the secondary electron spectrum. Interpretation of the results is performed on the basis of density functional theory and tight binding calculations. Excitation of the plasmon perturbs the symmetry of the system and leads to hybridisation of the interlayer resonances with atom-like $\sigma^*$ bands along the $\Gamma A$-direction. These hybrid states have a high density of states as well as sufficient mobility along the graphite $c$-axis leading to the sharp $\sim$3\ eV resonance in the spectrum of emitted secondary electrons reported throughout the literature., Comment: 9 pages, 4 figures

Published
2020
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38. Can the examination of different types of hive samples be a non-invasive method for detection and quantification of viruses in honey bee (Apis mellifera L.) colonies?

Author

Čukanová Eliška, Prodělalová Jana, Palíková Miroslava, Kováčová Kristýna, Linhart Petr, and Papežíková Ivana

Subjects
acute bee paralysis virus, black queen cell virus, deformed wing virus, honey bee viruses, sacbrood virus, Veterinary medicine, SF600-1100
Abstract

Honey bee viruses have been shown to negatively affect the vigour and longevity of European honey bees (Apis mellifera L). In the present work, beehive materials were tested for their potential to serve as non-invasive samples for honey bee virus detection.

Published
2023
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39. A search for new physics in central exclusive production using the missing mass technique with the CMS detector and the CMS-TOTEM precision proton spectrometer

Author

A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, P. S. Hussain, M. Jeitler, N. Krammer, L. Lechner, D. Liko, I. Mikulec, P. Paulitsch, F. M. Pitters, J. Schieck, R. Schöfbeck, D. Schwarz, S. Templ, W. Waltenberger, C.-E. Wulz, M. R. Darwish, T. Janssen, T. Kello, H. Rejeb Sfar, P. Van Mechelen, E. S. Bols, J. D’Hondt, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, S. Moortgat, A. Morton, D. Müller, A. R. Sahasransu, S. Tavernier, W. Van Doninck, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, K. Lee, M. Mahdavikhorrami, I. Makarenko, A. Malara, S. Paredes, L. Pétré, N. Postiau, E. Starling, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, D. Dobur, J. Knolle, L. Lambrecht, G. Mestdach, M. Niedziela, C. Rendón, C. Roskas, A. Samalan, K. Skovpen, M. Tytgat, N. Van Den Bossche, B. Vermassen, L. Wezenbeek, A. Benecke, G. Bruno, F. Bury, C. Caputo, P. David, C. Delaere, I. S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, K. Mondal, J. Prisciandaro, A. Taliercio, T. T. Tran, P. Vischia, S. Wertz, G. A. Alves, E. Coelho, C. Hensel, A. Moraes, P. Rebello Teles, W. L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, V. Dos Santos Sousa, S. Fonseca De Souza, J. Martins, C. Mora Herrera, K. Mota Amarilo, L. Mundim, H. Nogima, A. Santoro, S. M. Silva Do Amaral, A. Sznajder, M. Thiel, F. Torres Da Silva De Araujo, A. Vilela Pereira, C. A. Bernardes, L. Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, A. Aleksandrov, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Rodozov, M. Shopova, G. Sultanov, A. Dimitrov, T. Ivanov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Thakur, T. Cheng, T. Javaid, M. Mittal, L. Yuan, M. Ahmad, G. Bauer, Z. Hu, S. Lezki, K. Yi, G. M. Chen, H. S. Chen, M. Chen, F. Iemmi, C. H. Jiang, A. Kapoor, H. Kou, H. Liao, Z.-A. Liu, V. Milosevic, F. Monti, R. Sharma, J. Tao, J. Thomas-Wilsker, J. Wang, H. Zhang, J. Zhao, A. Agapitos, Y. An, Y. Ban, C. Chen, A. Levin, C. Li, Q. Li, X. Lyu, Y. Mao, S. J. Qian, X. Sun, D. Wang, J. Xiao, H. Yang, M. Lu, Z. You, X. Gao, D. Leggat, H. Okawa, Y. Zhang, Z. Lin, C. Lu, M. Xiao, C. Avila, D. A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J. D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, I. Puljak, Z. Antunovic, M. Kovac, T. Sculac, V. Brigljevic, B. K. Chitroda, D. Ferencek, D. Majumder, M. Roguljic, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, M. Kolosova, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, H. Rykaczewski, H. Saka, M. Finger, A. Kveton, E. Ayala, E. Carrera Jarrin, Y. Assran, S. Elgammal, M. A. Mahmoud, Y. Mohammed, S. Bhowmik, R. K. Dewanjee, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, P. Eerola, H. Kirschenmann, M. Voutilainen, S. Bharthuar, E. Brücken, J. Havukainen, M. S. Kim, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, M. Lotti, L. Martikainen, M. Myllymäki, J. Ott, M.m. Rantanen, H. Siikonen, E. Tuominen, J. Tuominiemi, P. Luukka, H. Petrow, T. Tuuva, C. Amendola, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J. L. Faure, F. Ferri, S. Ganjour, P. Gras, G. Hamel de Monchenault, P. Jarry, V. Lohezic, J. Malcles, J. Rander, A. Rosowsky, M.Ö. Sahin, A. Savoy-Navarro, P. Simkina, M. Titov, C. Baldenegro Barrera, F. Beaudette, A. Buchot Perraguin, P. Busson, A. Cappati, C. Charlot, F. Damas, O. Davignon, B. Diab, G. Falmagne, B. A. Fontana Santos Alves, S. Ghosh, R. Granier de Cassagnac, A. Hakimi, B. Harikrishnan, G. Liu, J. Motta, M. Nguyen, C. Ochando, L. Portales, R. Salerno, U. Sarkar, J. B. Sauvan, Y. Sirois, A. Tarabini, E. Vernazza, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Apparu, D. Bloch, G. Bourgatte, J.-M. Brom, E. C. Chabert, C. Collard, D. Darej, U. Goerlach, C. Grimault, A.-C. Le Bihan, P. Van Hove, S. Beauceron, C. Bernet, B. Blancon, G. Boudoul, A. Carle, N. Chanon, J. Choi, D. Contardo, P. Depasse, C. Dozen, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, G. Grenier, B. Ille, I. B. Laktineh, M. Lethuillier, L. Mirabito, S. Perries, L. Torterotot, M. Vander Donckt, P. Verdier, S. Viret, I. Bagaturia, I. Lomidze, Z. Tsamalaidze, V. Botta, L. Feld, K. Klein, M. Lipinski, D. Meuser, A. Pauls, N. Röwert, M. Teroerde, S. Diekmann, A. Dodonova, N. Eich, D. Eliseev, M. Erdmann, P. Fackeldey, D. Fasanella, B. Fischer, T. Hebbeker, K. Hoepfner, F. Ivone, M.y. Lee, L. Mastrolorenzo, M. Merschmeyer, A. Meyer, S. Mondal, S. Mukherjee, D. Noll, A. Novak, F. Nowotny, A. Pozdnyakov, Y. Rath, W. Redjeb, H. Reithler, A. Schmidt, S. C. Schuler, A. Sharma, L. Vigilante, S. Wiedenbeck, S. Zaleski, C. Dziwok, G. Flügge, W. Haj Ahmad, O. Hlushchenko, T. Kress, A. Nowack, O. Pooth, A. Stahl, T. Ziemons, A. Zotz, H. Aarup Petersen, M. Aldaya Martin, P. Asmuss, S. Baxter, M. Bayatmakou, O. Behnke, A. Bermúdez Martínez, S. Bhattacharya, A. A. Bin Anuar, F. Blekman, K. Borras, D. Brunner, A. Campbell, A. Cardini, C. Cheng, F. Colombina, S. Consuegra Rodríguez, G. Correia Silva, M. De Silva, L. Didukh, G. Eckerlin, D. Eckstein, L. I. Estevez Banos, O. Filatov, E. Gallo, A. Geiser, A. Giraldi, G. Greau, A. Grohsjean, V. Guglielmi, M. Guthoff, A. Jafari, N. Z. Jomhari, B. Kaech, A. Kasem, M. Kasemann, H. Kaveh, C. Kleinwort, R. Kogler, M. Komm, D. Krücker, W. Lange, D. Leyva Pernia, K. Lipka, W. Lohmann, R. Mankel, I.-A. Melzer-Pellmann, M. Mendizabal Morentin, J. Metwally, A. B. Meyer, G. Milella, M. Mormile, A. Mussgiller, A. Nürnberg, Y. Otarid, D. Pérez Adán, A. Raspereza, B. Ribeiro Lopes, J. Rübenach, A. Saggio, A. Saibel, M. Savitskyi, M. Scham, V. Scheurer, S. Schnake, P. Schütze, C. Schwanenberger, M. Shchedrolosiev, R. E. Sosa Ricardo, D. Stafford, N. Tonon, M. Van De Klundert, F. Vazzoler, A. Ventura Barroso, R. Walsh, D. Walter, Q. Wang, Y. Wen, K. Wichmann, L. Wiens, C. Wissing, S. Wuchterl, Y. Yang, A. Zimermmane Castro Santos, A. Albrecht, S. Albrecht, M. Antonello, S. Bein, L. Benato, M. Bonanomi, P. Connor, K. De Leo, M. Eich, K. El Morabit, F. Feindt, A. Fröhlich, C. Garbers, E. Garutti, M. Hajheidari, J. Haller, A. Hinzmann, H. R. Jabusch, G. Kasieczka, P. Keicher, R. Klanner, W. Korcari, T. Kramer, V. Kutzner, F. Labe, J. Lange, A. Lobanov, T. Loesche, C. Matthies, A. Mehta, L. Moureaux, M. Mrowietz, A. Nigamova, Y. Nissan, A. Paasch, K. J. Pena Rodriguez, M. Rieger, O. Rieger, D. Savoiu, P. Schleper, M. Schröder, J. Schwandt, M. Sommerhalder, H. Stadie, G. Steinbrück, A. Tews, M. Wolf, J. Bechtel, S. Brommer, M. Burkart, E. Butz, R. Caspart, T. Chwalek, A. Dierlamm, A. Droll, N. Faltermann, M. Giffels, J. O. Gosewisch, A. Gottmann, F. Hartmann, M. Horzela, U. Husemann, M. Klute, R. Koppenhöfer, S. Maier, S. Mitra, Th. Müller, M. Neukum, M. Oh, G. Quast, K. Rabbertz, J. Rauser, M. Schnepf, D. Seith, I. Shvetsov, H. J. Simonis, N. Trevisani, R. Ulrich, J. van der Linden, R. F. Von Cube, M. Wassmer, S. Wieland, R. Wolf, S. Wozniewski, S. Wunsch, X. Zuo, G. Anagnostou, P. Assiouras, G. Daskalakis, A. Kyriakis, A. Stakia, M. Diamantopoulou, D. Karasavvas, P. Kontaxakis, A. Manousakis-Katsikakis, A. Panagiotou, I. Papavergou, N. Saoulidou, K. Theofilatos, E. Tziaferi, K. Vellidis, I. Zisopoulos, G. Bakas, T. Chatzistavrou, K. Kousouris, I. Papakrivopoulos, G. Tsipolitis, A. Zacharopoulou, K. Adamidis, I. Bestintzanos, I. Evangelou, C. Foudas, P. Gianneios, C. Kamtsikis, P. Katsoulis, P. Kokkas, P. G. Kosmoglou Kioseoglou, N. Manthos, I. Papadopoulos, J. Strologas, K. Farkas, M. M. A. Gadallah, S. Lökös, P. Major, K. Mandal, G. Pásztor, A. J. Rádl, O. Surányi, G. I. Veres, M. Bartók, G. Bencze, C. Hajdu, D. Horvath, F. Sikler, V. Veszpremi, N. Beni, S. Czellar, J. Karancsi, J. Molnar, Z. 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Perelygin, S. Petrushanko, G. Pivovarov, S. Polikarpov, V. Popov, E. Popova, O. Radchenko, M. Savina, V. Savrin, D. Selivanova, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, A. Snigirev, D. Sosnov, A. Stepennov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, M. Toms, A. Toropin, L. Uvarov, A. Uzunian, E. Vlasov, A. Vorobyev, N. Voytishin, B. S. Yuldashev, A. Zarubin, I. Zhizhin, A. Zhokin, G. Antchev, P. Aspell, I. Atanassov, V. Avati, J. Baechler, V. Berardi, M. Berretti, V. Borshch, E. Bossini, U. Bottigli, M. Bozzo, H. Burkhardt, F.S. Cafagna, M.G. Catanesi, M. Csanád, T. Csörgő, M. Deile, F. De Leonardis, M. Doubek, D. Druzhkin, K. Eggert, V. Eremin, A. Fiergolski, F. Garcia, V. Georgiev, S. Giani, L. Grzanka, J. Hammerbauer, V. Ivanchenko, M. Janda, A. Karev, J. Kašpar, B. Kaynak, J. Kopal, V. Kundrát, S. Lami, R. Linhart, C. Lindsey, M.V. Lokajíček, L. Losurdo, F. Lucas Rodríguez, M. Macrí, M. Malawski, N. Minafra, S. Minutoli, K. Misan, T. Naaranoja, F. Nemes, H. Niewiadomski, T. Novák, E. Oliveri, F. Oljemark, M. Oriunno, K. Österberg, P. Palazzi, V. Passaro, Z. Peroutka, J. Procházka, M. Quinto, E. Radermacher, E. Radicioni, F. Ravotti, C. Royon, G. Ruggiero, H. Saarikko, V. D. Samoylenko, A. Scribano, J. Široký, J. Smajek, W. Snoeys, R. Stefanovitch, J. Sziklai, C. Taylor, N. Turini, O. Urban, V. Vacek, O. Vavroch, J. Welti, J. Williams, J. Zich, and CMS and TOTEM Collaborations

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract A generic search is presented for the associated production of a Z boson or a photon with an additional unspecified massive particle X, $${\textrm{pp}}\rightarrow {\textrm{pp}} +{{\textrm{Z}}}/\upgamma +{{\textrm{X}}} $$ pp → pp + Z / γ + X , in proton-tagged events from proton–proton collisions at $$\sqrt{s}=13\, \textrm{TeV}$$ s = 13 TeV , recorded in 2017 with the CMS detector and the CMS-TOTEM precision proton spectrometer. The missing mass spectrum is analysed in the 600–1600 GeV range and a fit is performed to search for possible deviations from the background expectation. No significant excess in data with respect to the background predictions has been observed. Model-independent upper limits on the visible production cross section of $${\textrm{pp}}\rightarrow {\textrm{pp}} +{{\textrm{Z}}}/\upgamma +{{\textrm{X}}} $$ pp → pp + Z / γ + X are set.

Published
2023
Full Text
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40. Search for high-mass exclusive γγ → WW and γγ → ZZ production in proton-proton collisions at s $$ \sqrt{s} $$ = 13 TeV

Author

The CMS collaboration, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, P. S. Hussain, M. Jeitler, N. Krammer, L. Lechner, D. Liko, I. Mikulec, P. Paulitsch, F. M. Pitters, J. Schieck, R. Schöfbeck, D. Schwarz, S. Templ, W. Waltenberger, C.-E. Wulz, M. R. Darwish, T. Janssen, T. Kello, H. Rejeb Sfar, P. Van Mechelen, E. S. Bols, J. D’Hondt, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, S. Moortgat, A. Morton, D. Müller, A. R. Sahasransu, S. Tavernier, W. Van Doninck, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, K. Lee, M. Mahdavikhorrami, I. Makarenko, A. Malara, S. Paredes, L. Pétré, N. Postiau, E. Starling, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, D. Dobur, J. Knolle, L. Lambrecht, G. Mestdach, M. Niedziela, C. Rendón, C. Roskas, A. Samalan, K. Skovpen, M. Tytgat, N. Van Den Bossche, B. Vermassen, L. Wezenbeek, A. Benecke, G. Bruno, F. Bury, C. Caputo, P. David, C. Delaere, I. S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, K. Mondal, J. Prisciandaro, A. Taliercio, T. T. Tran, P. Vischia, S. Wertz, G. A. Alves, E. Coelho, C. Hensel, A. Moraes, P. Rebello Teles, W. L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, V. Dos Santos Sousa, S. Fonseca De Souza, J. Martins, C. Mora Herrera, K. Mota Amarilo, L. Mundim, H. Nogima, A. Santoro, S. M. Silva Do Amaral, A. Sznajder, M. Thiel, F. Torres Da Silva De Araujo, A. Vilela Pereira, C. A. Bernardes, L. Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, A. Aleksandrov, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Rodozov, M. Shopova, G. Sultanov, A. Dimitrov, T. Ivanov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, T. Cheng, T. Javaid, M. Mittal, L. Yuan, M. Ahmad, G. Bauer, Z. Hu, S. Lezki, K. Yi, G. M. Chen, H. S. Chen, M. Chen, F. Iemmi, C. H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, V. Milosevic, F. Monti, R. Sharma, J. Tao, J. Thomas-Wilsker, J. Wang, H. Zhang, J. Zhao, A. Agapitos, Y. An, Y. Ban, C. Chen, A. Levin, C. Li, Q. Li, X. Lyu, Y. Mao, S. J. Qian, X. Sun, D. Wang, J. Xiao, H. Yang, M. Lu, Z. You, X. Gao, D. Leggat, H. Okawa, Y. Zhang, Z. Lin, C. Lu, M. Xiao, C. Avila, D. A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J. D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, I. Puljak, Z. Antunovic, M. Kovac, T. Sculac, V. Brigljevic, B. K. Chitroda, D. Ferencek, D. Majumder, M. Roguljic, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, G. Kole, M. Kolosova, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, H. Rykaczewski, H. Saka, M. Finger, A. Kveton, E. Ayala, E. Carrera Jarrin, A. A. Abdelalim, E. Salama, M. A. Mahmoud, Y. Mohammed, S. Bhowmik, R. K. Dewanjee, K. Ehataht, M. Kadastik, T. 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Cranshaw, J. Fan, X. Fan, D. Gadkari, S. Hogan, J. Monroy, J. R. Patterson, D. Quach, J. Reichert, M. Reid, A. Ryd, J. Thom, P. Wittich, R. Zou, M. Albrow, M. Alyari, G. Apollinari, A. Apresyan, L. A. T. Bauerdick, D. Berry, J. Berryhill, P. C. Bhat, K. Burkett, J. N. Butler, A. Canepa, G. B. Cerati, H. W. K. Cheung, F. Chlebana, K. F. Di Petrillo, J. Dickinson, V. D. Elvira, Y. Feng, J. Freeman, A. Gandrakota, Z. Gecse, L. Gray, D. Green, S. Grünendahl, O. Gutsche, R. M. Harris, R. Heller, T. C. Herwig, J. Hirschauer, L. Horyn, B. Jayatilaka, S. Jindariani, M. Johnson, U. Joshi, T. Klijnsma, B. Klima, K. H. M. Kwok, S. Lammel, D. Lincoln, R. Lipton, T. Liu, C. Madrid, K. Maeshima, C. Mantilla, D. Mason, P. McBride, P. Merkel, S. Mrenna, S. Nahn, J. Ngadiuba, D. Noonan, V. Papadimitriou, N. Pastika, K. Pedro, C. Pena, F. Ravera, A. Reinsvold Hall, L. Ristori, E. Sexton-Kennedy, N. Smith, A. Soha, L. Spiegel, J. Strait, L. Taylor, S. Tkaczyk, N. V. Tran, L. Uplegger, E. W. Vaandering, H. A. Weber, I. Zoi, P. Avery, D. Bourilkov, L. Cadamuro, V. Cherepanov, R. D. Field, D. Guerrero, M. Kim, E. Koenig, J. Konigsberg, A. Korytov, K. H. Lo, K. Matchev, N. Menendez, G. Mitselmakher, A. Muthirakalayil Madhu, N. Rawal, D. Rosenzweig, S. Rosenzweig, U. Shi, Z. Wu, T. Adams, A. Askew, R. Habibullah, V. Hagopian, T. Kolberg, G. Martinez, H. Prosper, C. Schiber, O. Viazlo, R. Yohay, J. Zhang, M. M. Baarmand, S. Butalla, T. Elkafrawy, M. Hohlmann, R. Kumar Verma, M. Rahmani, F. Yumiceva, M. R. Adams, H. Becerril Gonzalez, R. Cavanaugh, S. Dittmer, O. Evdokimov, C. E. Gerber, D. J. Hofman, D. S. Lemos, A. H. Merrit, C. Mills, G. Oh, T. Roy, S. Rudrabhatla, M. B. Tonjes, N. Varelas, X. Wang, Z. Ye, M. Alhusseini, K. Dilsiz, L. Emediato, R. P. Gandrajula, G. Karaman, O. K. Köseyan, J.-P. Merlo, A. Mestvirishvili, J. Nachtman, O. Neogi, H. Ogul, Y. Onel, A. Penzo, C. Snyder, E. Tiras, O. Amram, B. Blumenfeld, L. Corcodilos, J. Davis, A. V. Gritsan, L. Kang, S. Kyriacou, P. Maksimovic, J. Roskes, S. Sekhar, M. Swartz, T. Á. Vámi, A. Abreu, L. F. Alcerro Alcerro, J. Anguiano, P. Baringer, A. Bean, Z. Flowers, S. Khalil, J. King, G. Krintiras, M. Lazarovits, C. Le Mahieu, J. Marquez, M. Murray, M. Nickel, C. Rogan, R. Salvatico, S. Sanders, C. Smith, G. Wilson, B. Allmond, S. Duric, R. Gujju Gurunadha, A. Ivanov, K. Kaadze, Y. Maravin, T. Mitchell, A. Modak, K. Nam, J. Natoli, D. Roy, F. Rebassoo, D. Wright, E. Adams, A. Baden, O. Baron, A. Belloni, A. Bethani, S. C. Eno, N. J. Hadley, S. Jabeen, R. G. Kellogg, T. Koeth, Y. Lai, S. Lascio, A. C. Mignerey, S. Nabili, C. Palmer, C. Papageorgakis, L. Wang, K. Wong, D. Abercrombie, W. Busza, I. A. Cali, M. D’Alfonso, J. Eysermans, C. Freer, G. Gomez-Ceballos, M. Goncharov, P. Harris, M. Hu, D. Kovalskyi, J. Krupa, Y.-J. Lee, K. Long, C. Mironov, C. Paus, D. Rankin, C. Roland, G. Roland, Z. Shi, G. S. F. Stephans, Z. Wang, B. Wyslouch, R. M. Chatterjee, B. Crossman, A. Evans, J. Hiltbrand, Sh. Jain, B. M. Joshi, C. Kapsiak, M. Krohn, Y. Kubota, J. Mans, M. Revering, R. Rusack, R. Saradhy, N. Schroeder, N. Strobbe, M. A. Wadud, L. M. Cremaldi, K. Bloom, M. Bryson, D. R. Claes, C. Fangmeier, L. Finco, F. Golf, C. Joo, I. Kravchenko, I. Reed, J. E. Siado, G. R. Snow, W. Tabb, A. Wightman, F. Yan, A. G. Zecchinelli, G. Agarwal, H. Bandyopadhyay, L. Hay, I. Iashvili, A. Kharchilava, C. McLean, M. Morris, D. Nguyen, J. Pekkanen, S. Rappoccio, A. Williams, G. Alverson, E. Barberis, Y. Haddad, Y. Han, A. Krishna, J. Li, J. Lidrych, G. Madigan, B. Marzocchi, D. M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, A. Tishelman-Charny, T. Wamorkar, B. Wang, A. Wisecarver, D. Wood, J. Bueghly, Z. Chen, A. Gilbert, K. A. Hahn, Y. Liu, N. Odell, M. H. Schmitt, M. Velasco, R. Band, R. Bucci, S. Castells, M. Cremonesi, A. Das, R. Goldouzian, M. Hildreth, K. Hurtado Anampa, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, K. Mohrman, C. Moore, Y. Musienko, H. Nelson, R. Ruchti, A. Townsend, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, B. Bylsma, M. Carrigan, L. S. Durkin, B. Francis, C. Hill, A. Lesauvage, M. Nunez Ornelas, K. Wei, B. L. Winer, B. R. Yates, F. M. Addesa, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, S. Higginbotham, A. Kalogeropoulos, G. Kopp, S. Kwan, D. Lange, D. Marlow, K. Mei, I. Ojalvo, J. Olsen, D. Stickland, C. Tully, S. Norberg, A. S. Bakshi, V. E. Barnes, R. Chawla, S. Das, L. Gutay, M. Jones, A. W. Jung, D. Kondratyev, A. M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, A. Purohit, J. F. Schulte, M. Stojanovic, J. Thieman, F. Wang, R. Xiao, W. Xie, J. Dolen, N. Parashar, D. Acosta, A. Baty, T. Carnahan, M. Decaro, S. Dildick, K. M. Ecklund, P. J. Fernández Manteca, S. Freed, P. Gardner, F. J. M. Geurts, W. Li, B. P. Padley, R. Redjimi, J. Rotter, W. Shi, E. Yigitbasi, L. Zhang, X. Zuo, A. Bodek, P. de Barbaro, R. Demina, J. L. Dulemba, C. Fallon, T. Ferbel, M. Galanti, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, E. Ranken, R. Taus, G. P. Van Onsem, K. Goulianos, B. Chiarito, J. P. Chou, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, D. Jaroslawski, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, M. Osherson, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S. A. Thayil, S. Thomas, H. Wang, H. Acharya, A. G. Delannoy, S. Fiorendi, T. Holmes, E. Nibigira, S. Spanier, O. Bouhali, M. Dalchenko, A. Delgado, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, S. Malhotra, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, K. Lamichhane, T. Mengke, S. Muthumuni, T. Peltola, I. Volobouev, A. Whitbeck, E. Appelt, S. Greene, A. Gurrola, W. Johns, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, G. Cummings, J. Hakala, R. Hirosky, M. Joyce, A. Ledovskoy, A. Li, C. Neu, C. E. Perez Lara, B. Tannenwald, P. E. Karchin, N. Poudyal, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C. K. Koraka, A. Lanaro, A. Loeliger, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W. H. Smith, D. Teague, H. F. Tsoi, W. Vetens, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, D. Budkouski, V. Bunichev, O. Bychkova, M. Chadeeva, V. Chekhovsky, A. Dermenev, T. Dimova, I. Dremin, M. Dubinin, L. Dudko, V. Epshteyn, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, Y. Ivanov, V. Kachanov, L. Kardapoltsev, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, O. Kodolova, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, E. Kuznetsova, A. Lanev, P. Levchenko, A. Litomin, O. Lukina, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Okhotnikov, I. Ovtin, V. Palichik, P. Parygin, V. Perelygin, M. Perfilov, G. Pivovarov, V. Popov, E. Popova, O. Radchenko, V. Rusinov, M. Savina, V. Savrin, D. Selivanova, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, A. Snigirev, D. Sosnov, A. Stepennov, V. Sulimov, A. Terkulov, O. Teryaev, I. Tlisova, M. Toms, A. Toropin, L. Uvarov, A. Uzunian, E. Vlasov, A. Vorobyev, N. Voytishin, B. S. Yuldashev, A. Zarubin, I. Zhizhin, A. Zhokin, The TOTEM collaboration, G. Antchev, P. Aspell, I. Atanassov, V. Avati, J. Baechler, V. Berardi, M. Berretti, V. Borshch, E. Bossini, U. Bottigli, M. Bozzo, H. Burkhardt, F. S. Cafagna, M. G. Catanesi, M. Csanád, T. Csörgő, M. Deile, F. De Leonardis, M. Doubek, D. Druzhkin, K. Eggert, V. Eremin, A. Fiergolski, F. Garcia, V. Georgiev, S. Giani, L. Grzanka, J. Hammerbauer, T. Isidori, V. Ivanchenko, M. Janda, A. Karev, J. Kašpar, B. Kaynak, J. Kopal, V. Kundrát, S. Lami, R. Linhart, C. Lindsey, M. V. Lokajíček, L. Losurdo, F. Lucas Rodríguez, M. Macrí, M. Malawski, N. Minafra, S. Minutoli, T. Naaranoja, F. Nemes, H. Niewiadomski, T. Novák, E. Oliveri, F. Oljemark, M. Oriunno, K. Österberg, P. Palazzi, V. Passaro, Z. Peroutka, J. Procházka, M. Quinto, E. Radermacher, E. Radicioni, F. Ravotti, C. Royon, G. Ruggiero, H. Saarikko, V. D. Samoylenko, A. Scribano, J. Široký, J. Smajek, W. Snoeys, R. Stefanovitch, J. Sziklai, C. Taylor, E. Tcherniaev, N. Turini, O. Urban, V. Vacek, O. Vavroch, J. Welti, J. Williams, J. Zich, and K. Zielinski

Subjects
Forward Physics, Hadron-Hadron Scattering, Vector Boson Production, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract A search is performed for exclusive high-mass γγ → WW and γγ → ZZ production in proton-proton collisions using intact forward protons reconstructed in near-beam detectors, with both weak bosons decaying into boosted and merged jets. The analysis is based on a sample of proton-proton collisions collected by the CMS and TOTEM experiments at s $$ \sqrt{s} $$ = 13 TeV, corresponding to an integrated luminosity of 100 fb −1. No excess above the standard model background prediction is observed, and upper limits are set on the pp → pWWp and pp → pZZp cross sections in a fiducial region defined by the diboson invariant mass m(VV) > 1 TeV (with V = W, Z) and proton fractional momentum loss 0.04 < ξ < 0.20. The results are interpreted as new limits on dimension-6 and dimension-8 anomalous quartic gauge couplings.

Published
2023
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41. Electronic and optical properties of disordered getchellite: A photoreflectance, optical absorption, photoemission, and theoretical investigation

Author

Agata Sabik, Miłosz Grodzicki, Maciej P. Polak, Sandeep Gorantla, Alicja Bachmatiuk, Robert Kudrawiec, and Wojciech M. Linhart

Subjects
Biotechnology, TP248.13-248.65, Physics, QC1-999
Abstract

In this work, the optoelectronic properties of the getchellite crystal, a layered semiconducting disordered alloy with the chemical formula AsSbS3, are probed by a combination of complementary spectroscopic techniques, i.e., x-ray photoelectron spectroscopy together with a photoreflectance and a transmission spectroscopy. The experimental results are supported by a calculation based on density functional theory (DFT). The sample is an intrinsically p-type semiconductor whose optical properties are dominated by a direct transition. The energy of this transition is highly decreasing, by 0.22 eV, when the sample temperature increases from 20 to 300 K. A calculated band structure together with the transmission results reveals that of about 50 meV below the direct optical transition, an indirect one occurs associated with the fundamental bandgap of AsSbS3. Finally, the change in the fundamental bandgap character from indirect to direct during the reduction in material thickness from bulk to monolayer is demonstrated by the DFT calculations.

Published
2024
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43. NEW FOSSIL LACEWING LARVAE WITH TRUMPET-SHAPED ELONGATE EMPODIA PROVIDE INSIGHT INTO THE EVOLUTION OF THIS ATTACHMENT STRUCTURE

Author

LAURA BUCHNER, SIMON LINHART, GERGŐ KALMAR, SOFÍA ARCE, GIDEON T. HAUG, JOACHIM T. HAUG, and Carolin Haug

Subjects
Neuroptera, larvae, phylogeny, empodium, Cretaceous, Burmese amber, Geology, QE1-996.5, Paleontology, QE701-760
Abstract

The larval life phase often represents the major share of the life span of holometabolans, such as beetles or flies. Therefore, knowledge of these larvae is crucial concerning ecological functions, but also concerning the evolutionary history of the different groups. In the holometabolan group Neuroptera (lacewings), larvae have numerous specialisations, among them the venom-injecting mouthparts, the stylets. Another such very characteristic feature of many lacewing larvae is the empodium, an attachment structure at the tip of the leg, which varies in shape in the larvae of the different lacewing groups. One type of empodium is the elongate trumpet-shaped type, which is found in several lacewing groups today as well as in many fossil representatives, especially well visible due to preservation in amber. Based on the pattern of phylogenetic distribution of the elongate trumpet-shaped empodium, different reconstructions of the evolution of this structure have been put forward, some suggesting possibly convergent evolution, others repetitive losses. In this study, new lacewing larvae preserved in 100-million-year-old amber from Myanmar are presented, which expand the number of lineages with an elongate trumpet-shaped empodium. Based on these new data, the implications on the evolutionary history of the different lineages within Neuroptera are discussed. The fossils demand for an earlier evolution in some reconstructions, but especially for more and later losses of this structure.

Published
2024
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44. Optimizing aquaculture-scale common carp artificial reproduction: a novel approach to sperm cryopreservation using large-volume containers and elevated thawing temperatures

Author

Anatolii Sotnikov, Marek Rodina, David Gela, Sergii Boryshpolets, Vitaliy Kholodnyy, Vojtěch Kašpar, Otomar Linhart, and Borys Dzyuba

Subjects
sperm motility, computer-assisted sperm analysis, cryopreservation, Cypriniformes, artificial reproduction, Science, General. Including nature conservation, geographical distribution, QH1-199.5
Abstract

IntroductionThe successful cryopreservation of common carp sperm is crucial for its application in aquaculture and selective breeding programs. This study investigates the efficacy of cryopreserving sperm in large containers (5 mL) with a low dilution rate (1:1) in three different cryoprotective media and thawing in different conditions.MethodsThe developed method utilizes a low-ionic (hypotonic) cryoprotective medium, freezing with a controlled cooling rate, and high-temperature sperm thawing (60°C). The investigation employs a detailed spermatozoon motility assessment.ResultsPost-thaw motility of 32.3% ± 14% and initial curvilinear velocity of 89 ± 20 μm/s across 30 males were observed. Principal component analysis of sperm kinematic characteristics revealed distinct populations of sperm cells exhibiting varying responses to cryopreservation. The developed method achieved successful fertilization comparable to that of the non-frozen control group using sperm from a single cryotube (2.5 mL, approximately 50 * 109 spermatozoa) to fertilize 200 g of eggs (1:120,000 egg:spz).DiscussionThis novel approach demonstrates an effective cryopreservation protocol for common carp sperm in large-volume cryo-containers in combination with low-ionic cryomedia and high thawing temperature, providing methods well-suited for fisheries practices and selective breeding programs. Future studies of the biological properties of different sperm subpopulations in post-thaw sperm samples can contribute to a deeper understanding of sperm biology, improve cryopreservation techniques, and enhance the success rates of assisted reproductive technologies.

Published
2024
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45. Successful Preoperative Radiotherapy for Neglected Shoulder Liposarcoma: A Retrospective Case Report

Author

Camilla Linhart and Craig MacLeod

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

This study examines a unique case of a 61-year-old male with a 5-year history of a progressively growing mass above his right shoulder, diagnosed as a dedifferentiated pleomorphic liposarcoma. Using computerized tomography-guided core needle biopsy, the tumour was identified as intermediate to high grade. Surgical removal required preoperative radiotherapy to reduce the size of the tumour. Several unique characteristics set apart this particular case of liposarcoma: its substantial size, its unpredictable growth pattern, its absence of metastasis, and notably, its prolonged period of being untreated. This case report outlines the clinical background, diagnostic procedures, and treatment modalities employed in managing this condition, emphasizing a localized dual therapy approach combining radiotherapy and surgery. Emphasis is placed on distinguishing liposarcoma from lipoblastoma, a benign adipocyte tumour, to facilitate accurate diagnosis and appropriate treatment selection. The positive result achieved in this case could provide valuable insights for the future treatment and management of similarly sized aggressive tumours.

Published
2024
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46. Localized inter-valley defect excitons as single-photon emitters in WSe$_2$

Author

Linhart, L., Paur, M., Smejkal, V., Burgdörfer, J., Mueller, T., and Libisch, F.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Single-photon emitters play a key role in present and emerging quantum technologies. Several recent measurements have established monolayer WSe$_2$ as a promising candidate for a reliable single photon source. The origin and underlying microscopic processes have remained, however, largely elusive. We present a multi-scale tight-binding simulation for the optical spectra of WSe$_2$ under non-uniform strain and in the presence of point defects employing the Bethe-Salpeter equation. Strain locally shifts excitonic energy levels into the band gap where they overlap with localized intra-gap defect states. The resulting hybridization allows for efficient filing and subsequent radiative decay of the defect states. We identify inter-valley defect excitonic states as the likely candidate for anti-bunched single-photon emission. This proposed scenario is shown to account for a large variety of experimental observations including brightness, radiative transition rates, the variation of the excitonic energy with applied magnetic and electric fields as well as the variation of the polarization of the emitted photon with the magnetic field.

Published
2019
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47. Author Correction: Classification of pig calls produced from birth to slaughter according to their emotional valence and context of production

Author

Briefer, Elodie F., Sypherd, Ciara C.‑R., Linhart, Pavel, Leliveld, Lisette M. C., Padilla de la Torre, Monica, Read, Eva R., Guérin, Carole, Deiss, Véronique, Monestier, Chloé, Rasmussen, Jeppe H., Špinka, Marek, Düpjan, Sandra, Boissy, Alain, Janczak, Andrew M., Hillmann, Edna, and Tallet, Céline

Published
2023
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49. Lifestyle Walking Intervention for Patients With Heart Failure With Reduced Ejection Fraction: The WATCHFUL Trial

Author

Vetrovsky, Tomas, Siranec, Michal, Frybova, Tereza, Gant, Iulian, Svobodova, Iveta, Linhart, Ales, Parenica, Jiri, Miklikova, Marie, Sujakova, Lenka, Pospisil, David, Pelouch, Radek, Odrazkova, Daniela, Parizek, Petr, Precek, Jan, Hutyra, Martin, Taborsky, Milos, Vesely, Jiri, Griva, Martin, Semerad, Miroslav, Bunc, Vaclav, Hrabcova, Karolina, Vojkuvkova, Adela, Svoboda, Michal, and Belohlavek, Jan

Published
2024
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50. Verification of accuracy of qPCR method for intravital diagnostics of Macrorhabdus ornithogaster in avian droppings

Author

L Vrbasova, D Molinkova, P Linhart, and Z Knotek

Subjects
cytology, macrorhabdosis, passerines, psittacines, Veterinary medicine, SF600-1100
Abstract

The objective of this study was to verify the accuracy of the quantitative PCR (qPCR) method for in vivo detection of Macrorhabdus ornithogaster. A total of 100 faecal and gastric mucosa samples from avian cadavers were investigated, using cytological and qPCR techniques (budgerigars, Fischer's lovebirds, red-crowned parakeets, scarlet-chested parrots, eastern rosellas, domestic canaries, zebra finches, white Java sparrow). Using qPCR, the probability of detecting positive samples of droppings was significantly higher than in the faecal smear microscopy (P

Published
2023
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