1. Phase behaviour of polymer-grafted DPPC membranes for drug delivery systems design
- Author
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Matteo Pappalardo, 1 Danilo Milardi, 2 Domenico Grasso, 1, and Carmelo La Rosa 1
- Subjects
chemistry.chemical_classification ,Chromatography ,Chemistry ,phase behaviour ,Vesicle ,technology, industry, and agriculture ,Polymer ,Condensed Matter Physics ,drug delivery systems ,Membrane ,Differential scanning calorimetry ,Chemical engineering ,Phase (matter) ,Drug delivery ,PEG ratio ,polymer grafted lipids ,DPPC dispersions ,lipids (amino acids, peptides, and proteins) ,Physical and Theoretical Chemistry ,Drug carrier - Abstract
DPPC dispersions containing DPPE with attached PEG of molecular masses 350, 2000 and 5000 were investigated by DSC in order to determine their phase behaviour and potential use as drug delivery systems. In comparison with previously obtained ESR data, DSC provided a definition of the lipid composition and temperature at which the vesicles are in a liquid crystalline phase. For DPPC DPPE-PEG 350 the composition range is at molar fractions 0
- Published
- 2005
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