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锕-225（225Ac）具有高传能线密度、适宜的半衰期、短粒子射程和良好的配位能力等特性，是很有医用前景的α核素之一，在肿瘤的靶向放射性核素治疗中具有重要的研究价值。本文简要介绍了225Ac的物理和化学特性以及常用螯合剂（前列腺特异性膜抗原、奥曲肽、纳米载体等），围绕着以多肽或小分子为靶向分子、以单克隆抗体或蛋白为靶向分子和基于纳米载体的TAT药物，综述了225Ac标记的靶向药物在肿瘤中的应用和纳米材料对225Ac衰变子体的保留作用，分析其应用于治疗的价值，总结了225Ac标记方法和适宜螯合剂的选择、靶向性的提高、毒副作用，展望了225Ac国产化以满足未来的临床需求，以期为后续的225Ac标记药物研发提供参考。

This article summarized the family participatory nursing care in an elderly patient with congenital anomalies of urinary tract undergoing indwelling catheter placement. According to the nursing plan, targeted interventions were carried out. The designed health education program was provided to improve the knowledge and practice skills of primary caregivers, in order to prevent the catheter-associated complications. (本文总结1例老年尿道畸形留置尿管患者的家庭参与式护理体会。通过制定护理目标、护理计划、实施方案且对照护者进行有计划的培训和指导干预, 有效提高了照护者的理论知识、操作技能及执行力, 对预防留置尿管相关并发症起到积极作用。)

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电力负荷具有非线性和时序性的特点，为了深入研究各特征变量对于电力负荷预测的重要性，进而获得更高的电力负荷预测精度，提出了基于随机森林（random forest，RF）算法及长短期记忆网络（long short-term memory，LSTM）的混合负荷预测模型。首先根据时间日期因素及气候因素建立高维特征数据集作为随机森林模型的输入，通过随机森林算法筛选出重要特征量，并使其与历史负荷结合作为LSTM模型的输入，经过粒子群算法对LSTM模型进行参数寻优后得到RF-LSTM混合模型及负荷预测结果。使用该方法对河北电网某台区的电力负荷进行预测，结果表明该混合模型的预测精度比未经特征变量筛选的传统单一的随机森林算法、LSTM模型以及BP神经网络更为理想。

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The stress concentration at the end of spiral groove is very serious during the static tension and compression of the new machined spring,which has a great influence on the strength and fatigue life of the spring.The influence of spring basic parameters on the stress concentration coefficient was analyzed by ANSYS software,and the theoretical criterion for the existence of stress concentration in machined springs is determined.The effects of tangential stress release hole on compression deformation and stress concentration coefficient were investigated; Based on the strength theory and bending theory of curved beam,the formula of maximum equivalent stress without stress concentration was deduced.The results show that when the ratio of the width of the spiral groove to the pitch is less than 0.5,stress concentration occurs in machined springs with the middle diameter between 15 mm ～ 35 mm.The stress concentration can be basically eliminated by cutting stress release hole at the end of spiral groove and controlling its size to be close to the height of rectangular section.The error between the equivalent stress value of the inner ring and the simulation value is less than 3%.It provides an important reference for the subsequent engineering design and application of the new spring.

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The development of the smart health and elderly care industry responds to the growing demand for a better life for the elderly in the context of population aging, and integrates the development opportunities brought about by the development of modern science and technology and population aging to the transformation and upgrading of the industrial structure. Existing studies have fully affirmed the necessity of the development of smart health and elderly care industry. and put forward countermeasures and suggestions to promote the high-quality development of smart health and elderly care industry from different directions. However, on the whole, the analysis of the realistic scenario of the development of the smart health and elderly care industry needs to be further investigated, and the systematic and holistic study of the supply and demand of the smart health and elderly care industry needs to be further deepened. Based on the supply and demand analysis framework of the smart health and elderly careindustry, this paper analyzes the real demand and supply situation of the smart health and elderly care industry. It is found that the development of the smart health and elderly care industry is still in the primary stage. Supply dilemmas such as unbalanced and insufficient supply, improper connection of industry chain links, difficulty in crossing the digital divide of smart health and elderly care products, lack of professionals in smart health and elderly care services, and unsound coordination and cooperation mechanisms between the government and the market are still restricting the high-quality development of the smart health and elderly care industry. We propose high-quality supply countermeasures for the smart health and elderly care industry: set the supply according to the demand and improve the quality of industrial supply: integrate advantages and build a stable and efficient industrial chain: let the elderly enjoy smart services and promote the construction of digital accessibility: put talent first and solidify a high-quality professional team: make concerted efforts and promote a better combination of efficient market and effective government. [ABSTRACT FROM AUTHOR]

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【摘要】 目的 比较经颅超声造影（transcranial contrast-enhanced ultrasound，t-CEUS）和DSA在大脑中动脉（middle cerebral artery，MCA）狭窄性疾病中的诊断价值。 方法 收集2017年12月-2019年4月疑似MCA狭窄或闭塞的患者197例，记录其225条狭窄或闭塞的大脑中动脉的t-CEUS和DSA检查结果。根据MCA狭窄程度分为轻度狭窄（30%～50%），中度狭窄（50%～69%），重度狭窄（70%～99%）和闭塞（100%），以DSA为金标准，分析t-CEUS对轻、中和重度MCA狭窄的诊断价值。 结果 197例疑似MCA狭窄闭塞患者中，男132例，女65例，年龄43～72岁，平均（58.4±4.6）岁。经DSA确诊的狭窄和闭塞的225条MCA中，轻度狭窄16条，中度狭窄70条，重度狭窄121条，闭塞18条。t-CEUS诊断狭窄和闭塞的共224条MCA，其中，轻度狭窄18条，中度狭窄76条，重度狭窄112条，闭塞18条。t-CEUS和DSA诊断MCA狭窄和闭塞高度吻合（Kappa=0.91）。t-CEUS诊断轻度MCA狭窄的敏感度、特异度和准确度分别为80%、80%和91%；诊断中度MCA狭窄的敏感度、特异度和准确度分别为83%、93%和97%；诊断重度MCA狭窄的敏感度、特异度和准确度分别为83%、96%和96%。 结论 t-CEUS能够清楚地显示轻、中、重度MCA狭窄和闭塞，适用于MCA狭窄和闭塞类疾病患者的确诊，尤其是适用于不适合DSA检查的疑似MCA狭窄和闭塞患者。 【Abstract】 Objective To investigate the diagnostic value of transcranial contrast-enhanced ultrasound (t-CEUS) and digital subtraction angiography (DSA) for middle cerebral artery (MCA) stenosis or occlusion. Methods A total of 197 patients with suspected MCA stenosis or occlusion from December 2017 to April 2019 were enrolled. A total of 225 stenostic or occluded MCAs were diagnosed by t-CEUS and DSA, according to the degree of MCA stenosis, the MCAs were divided into four groups: mild (30%-50%), moderate (50%-69%), severe (70%-99%) and occlusion (100%). Taking DSA diagnosis as the golden standard, the specificity, sensitivity, and accuracy of t-CEUS diagnosis were analyzed by comparing the results of ultrasound imaging. Results Of all the 197 patients, 132 male and 65 female, with the average age (58.4+4.6) years and the range 43 to 72 years. Of 225 MCAs diagnosed by DSA, 16 MCAs were mild, 70 were moderate, 121 were severe, and 18 were occluded. Of 224 MCAs diagnosed by t-CEUS, 18 were mild, 76 were moderate, 112 were severe, and 18 were occluded. The diagnosis of MCA stenosis/occlusion using t-CEUS and DSA had a high consistency (Kappa=0.91). The sensitivity, specificity and accuracy of t-CEUS for the diagnosis of mild MCAs were 80%, 80%, and 91%, respectively; the sensitivity, specificity and accuracy of t-CEUS for the diagnosis of moderate MCAs were 83%, 93%, and 97%, respectively; the sensitivity, specificity and accuracy of t-CEUS for the diagnosis of severe MCA were 83%, 96%, and 96%, respectively. Conclusions t-CEUS can clearly show mild, moderate and severe stenosis and occlusion in MCAs, and it is suitable for the diagnosis of patients with MCA stenosis and occlusion, especially for the patients with suspected MCA stenosis and who are not suitable for DSA.

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