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目的探究壮通饮通过Nrf2-SCL7A11/xCT-Gpx4通路调控铁死亡对大脑中动脉栓塞模型小鼠脑缺血再灌注损伤的保护作用及其机制。方法将C57BL/6J小鼠随机分为假手术组（Sham）、模型组（MCAO）、低剂量壮通饮组（ZTY-L+MCAO），高剂量壮通饮组（ZTY-H+MCAO），每组5只。其中MCAO组采用硅胶线栓法进行造模，小鼠大脑中动脉栓塞1h，拔出线栓再灌注72h后进行心脏灌注取脑，Sham组除了不插入线栓其余操作同MCAO组。采用Zea-Longa法对小鼠神经功能进行评分；采用TTC染色评估小鼠脑梗死体积；采用HE染色、尼氏染色评估脑损伤程度；采用普鲁士蓝染色评价三价铁离子蓄积水平；qPCR检测铁离子转运相关载体受体TfR1和DMT1、脂质过氧化相关基因ACSL4以及铁死亡标志物PTGS2 mRNA表达；ELISA试剂盒检测4-HNE的含量评估小鼠大脑脂质过氧化水平；Western-blot、免疫荧光检测小鼠脑组织中Nrf2、SCL7A11/xCT、Gpx4蛋白水平。结果①壮通饮改善了MCAO/R后小鼠神经功能（P＜0.05）和大脑梗死体积（P＜0.05）及缓解MCAO/R后大脑皮层细胞病理损伤。②壮通饮减弱了MCAO/R后小鼠大脑组织的三价铁离子蓄积状态；减少MCAO/R后小鼠大脑中与铁离子转运入细胞内相关载体TfR1和DMT1 mRNA的表达（P＜0.001）；下调MCAO/R后小鼠大脑脂质过氧化物4-HNE含量和组织脂质过氧化物酶ACSL4 mRNA表达（P＜0.001）；降低MCAO/R后小鼠大脑铁死亡标志物PTGS2 mRNA表达（P＜0.001）。③壮通饮增加MCAO/R后Nrf2入核表达（P＜0.001），以及增加xCT和Gpx4在神经元中的表达（P＜0.001）。结论壮通饮能够改善MCAO/R小鼠神经功能和脑梗死体积，缓解大脑皮层细胞病理损伤，影响Nrf2-SCL7A11/xCT-Gpx4通路关键信号分子表达，所以壮通饮改善小鼠MCAO/R损伤的作用机制可能是通过Nrf2-SCL7A11/xCT-Gpx4通路调节铁死亡水平达到的。

目的探讨伴有酸中毒的家族性低钾型周期性瘫痪的诊断和治疗。方法分析先证者病史、临床表现、实验室检查和影像学特点，详细调查家系患病情况，应用二代测序技术检测低钾血症相关致病基因位点，对国内外相关文献进行归纳总结。结果明确诊断先证者为家族性低钾型周期性瘫痪，先证者的SCN4A基因有1个杂合突变，为c.2006G>A，导致氨基酸改变p.R669H。先证者的祖父、父亲和伯伯存在相同变异。结论伴酸中毒的家族性低钾型周期性瘫痪罕见，容易误诊为肾小管酸中毒，临床上要提高警惕。SCN4A基因c.2006G>A突变是该家系发病的分子基础。不同基因突变的临床表型存在差异，基因筛查有助诊断分型和治疗方案选择。

电力杆塔与5G站址开展共享共建，对提高资源利用效率、降低电信企业成本具有现实意义。构建电力杆塔与5G站址规划以及典型应用场景的规模化匹配方法，对于优化提升电力杆塔共享匹配度，摸底电力杆塔资源共享潜力，做好电力杆塔共享资源大范围推广后的统筹优化至关重要。针对电力杆塔和5G站址，构建了基于站距和站高的规模化匹配方法，以及考虑技术、政策和商业约束等情景的匹配度测算方法，并以福州长乐全域为例进行实证分析。结果显示，不同场景下电力杆塔和5G站址的匹配度差别较大，市人口密集区、工业园区匹配度可达50%，高铁沿线匹配度不足10%。若进一步考虑技术、政策、商业约束要素，则匹配度将进一步缩小，在四重要素叠加下，匹配度约为14%。虽然匹配程度不足，但考虑到全国电力杆塔和5G站址体量巨大，依然具备较大的共享潜力和良好的合作空间。

针对无线通信传统接收机的信道估计和译码分开处理是次优的问题,文章提出了一种联合信道估计和极化码译码的接收机模型。根据极化码译码器级联的循环冗余校验码的校验信息,接收机将译码器中部分硬判决信息再编码,然后将得到的码字反馈到信道估计器中,此时相当于接收机挑选了部分码字比特作为导频,信道估计器根据新的导频重新进行信道估计。文章提出的接收机模型及算法不仅减少了信道估计中导频的开销,还使得信道估计和译码两个过程相互促进,从而改善了极化码的误帧率。仿真结果表明,当归一化多普勒等于0.02时,文章提出的基于硬判决反馈的接收机相比于传统的接收机有2 dB的性能增益。

首先简要概述英国交直流输电网的发展现状，然后从交流和直流规划两方面阐述了其理念和方法。交流电网规划方面包括未来电力能源情景的选择和制定、电网模型的建立、未来电网需求分析、电网规划技术性和经济性分析等，直流输电系统规划方面包括直流输电系统对交流输电网潮流阻塞成本的影响、直流输电规划的参考成本以及直流输电系统的经济性分析等，并分别给出了实践案例。最后结合英国电网规划的理念和方法，提出了其对中国电网规划的借鉴意义，以为中国未来电网规划工作提供对比和参考。

【目的】观察应用来氟米特治疗IgA 肾病的疗效和安全性。【方法】收集符合条件的58 例IgA 肾病 患者随机分为2 组, 实验组接受来氟米特治疗, 对照组接受福辛普利治疗, 观察治疗前、后2、4、6、8、12、16、 20、24 及28 周的相关临床指标变化, 并进行评价。【结果】实验组治疗后24 h 尿蛋白定量显著减少( P< 0.05) , 血清白蛋白显著升高( P< 0.05) , 完全缓解率为61%, 总有效率为71%。与对照组比较疗效无显著性差异( P > 0.05) ,实验组的不良反应轻微, 病人耐受性良好。【结论】来氟米特可以作为治疗IgA 肾病的选择之一。

【目的】探讨血管紧张素Ⅱ-1型受体基因多态性等多个因素对高血压病患者左室重构的影响。【方法】测定148名高血压病患者血压、身高、体重、空腹血糖、总胆固醇、甘油三酯浓度;测定高血压病患者的左室重量指数并记录病程;多聚酶链式反应-限制性酶切法鉴定血管紧张素Ⅱ-1型受体基因1166位点基因型;用Logistic回归方法分析上述因素对左室重构的影响。【结果】回归方程表明,血管紧张素Ⅱ-1型受体1166AC基因型、收缩压水平、病程及血清胆固醇含量与高血压患者左室重构成正相关,OR值分别为3.216,3.218,5.327,2.076。【结论】血管紧张素Ⅱ-1型受体1166C等位基因、收缩压、病程及血清胆固醇含量是高血压患者左室重构的危险因素。

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铸造过程中存在多种职业性有害因素可能损害劳动者的健康, 其中铸造工过敏性肺炎的病例少见报道。 报道 1 例因使用铸造用黏结剂导致过敏性肺炎的病例, 该患者在某铸造企业从事模具造型工作, 因“双眼刺痛、胸闷 10 d 余, 喘憋 2 d”入院, 其胸部 CT 表现为两肺弥漫性分布的小点片状略高密度灶, 肺功能显示限制性通气功能障碍、弥 散功能下降；动脉血气分析提示伴有低氧血症（动脉血氧分压 55 mmHg）。 经脱离工作环境, 糖皮质激素及西替利嗪 抗过敏治疗后, 患者临床症状及胸部 CT 小点片影消失, 肺功能及动脉血气分析指标恢复正常。 [ABSTRACT FROM AUTHOR]

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我们根据肝癌血流动力学的特点,设计一种“生理性”肝去动脉化加肝动脉灌注化疗的方法治疗原发性肝癌(以下简称肝癌),从1983年9月至1984年8月对不能手术切除的肝癌14例进行前瞻性研临床究,从初步结果分析,疗效满意。

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Objective Optimize the latex perfusion technique and apply it to the construction of a murine craniofacial venous vascular model. Methods A total of nine 8-week-old male C57BL/6 mice weighing (25.0±1.3) g were randomly divided into three groups: 60% latex physiological saline group, 60% latex heparin group, and 30% latex heparin group. After completion of the perfusion, the specimens were immersed in 4° C formalin fixative for 24 h, followed by dissection, observation, and measurement of the extracranial blood vessel diameters. Results After 200 µL latex perfusion solution was injected into the external jugular vein, the supraorbital vein, infraorbital vein, temporal vein, retrofacial vein, masseter vein and external jugular vein were perfused in each group. After comparing the perfusion degree of the distal branches of blood vessels, sublingual vein and tip venule, it was found that the 30% latex heparin group had the best perfusion effect, followed by the 60% latex heparin group, and the 60% latex saline group had the worst perfusion effect. Conclusion The optimized latex perfusion technique can effectively infuse the veins in the head and face of mice, and this technique can provide a good reference for the study of the direction and morphology of facial veins in mice. [ABSTRACT FROM AUTHOR]

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Copyright of Atomic Energy Science & Technology is the property of Editorial Board of Atomic Energy Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)