1. Increased Alternative Complement Pathway Function and Improved Survival During Critical Illness.
- Author
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Bain, William, Li, Huihua, van der Geest, Rick, Moore, Sara R., Olonisakin, Tolani F., Ahn, Brian, Papke, Erin, Moghbeli, Kaveh, DeSensi, Rebecca, Rapport, Sarah, Saul, Melissa, Hulver, Mei, Zeyu Xiong, Mallampalli, Rama K., Ray, Prabir, Morris, Alison, Ma, Lina, Yohei Doi, Yingze Zhang, and Kitsios, Georgios D.
- Subjects
CATASTROPHIC illness ,TRANSCRIPTION factors ,PROPERDIN factor B ,SEPSIS ,IMMUNE system - Abstract
The article presents a study related to an increased alternative complement pathway function and improved survival during critical illness. It mentions that patients with elevated alternative pathway (AH50) had an increased levels of activator protein (AP) factors B, H, and properdin, and some patients showed a "hyperinflammatory" subphenotype. It mentions overexuberant activation of complement system is thought to contribute to the pathogenesis of sepsis despite its role in immune function.
- Published
- 2020
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