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In response to the challenge of mitigating flight delays, this study introduces an innovative solution that encompasses the prediction of delay durations for existing flights and the subsequent optimization of ground service processes based on these predictions. The indirect forecasting of flight delays is achieved through the construction of a random forest model, exhibiting a remarkable 100% accuracy when considering a 15-minute standard for flight delays. In light of the delay prediction outcomes, distinct delay coefficients are assigned to individual flights, facilitating the development of a ground service optimization model through the application of a genetic algorithm. Within the genetic algorithm optimization framework, significant enhancements have been implemented in the gene encoding of the initial population, incorporating a segmented encoding approach. Employing this refined model to optimize the service sequence and duration of ground service vehicles for all flights culminates in the notable accomplishment of achieving zero delays for the entire set of flights.

Abstract Severe trauma could induce sepsis due to the loss of control of the infection, which may eventually lead to death. Accurate and timely diagnosis of sepsis with severe trauma remains challenging both for clinician and laboratory. Combinations of markers, as opposed to single ones, may improve diagnosis. We compared the diagnostic characteristics of routinely used biomarkers of sepsis alone and in combination, trying to define a biomarker panel to predict sepsis in severe patients. This prospective observational study included patients with severe trauma (Injury severity score, ISS = 16 or more) in the emergency intensive care unit (EICU) at a university hospital. Blood samples were collected and plasma levels of procalcitonin (PCT), C-reactive protein (CRP), interleukin-6 (IL-6) and serum amyloid A (SAA) were measured using commercial enzyme linked immunosorbent assay (ELISA) kits. A total of 100 patients were eligible for analysis. Of these, 52 were diagnosed with sepsis. CRP yielded the highest discriminative value followed by PCT. In multiple logistic regression, SAA, CRP, and PCT were found to be independent predictors of sepsis. Bioscore which was composed of SAA, CRP, and PCT was shown to be far superior to that of each individual biomarker taken individually. Therefore, compared with single markers, the biomarker panel of PCT, CRP, and SAA was more predictive of sepsis in severe polytrauma patients.

Magnetron sputtering systems are widely used for depositing industrially important coatings. Research has been conducted to optimize and improve these structures to increase coating effectiveness and target utilization. The paper investigates the engineering problem of uneven target etching caused by an uneven magnetic field in magnetron sputtering equipment. The characteristics of the desired magnetic field distribution required by magnetron sputtering equipment are analyzed, and a corresponding excitation structure and analytical model for cylindrical magnetron sputtering equipment are proposed and calculated. The uniform magnetic field design is realized by analytical modeling of the excitation structure. The axial magnetic field distributions produced by an axisymmetric solenoid system and several similar excitation structures are analyzed and compared. The analytical results were verified through finite element simulations and experiments, demonstrating the accuracy and effectiveness of the method. The excitation structure, which is designed with a uniform magnetic field, can produce an axial component of magnetic flux density with a uniformity deviation of less than 4.3% across 73% of the target surface. The analytical model describes the distribution of the axial component of the magnetic flux density and optimizes the magnetic field. The model enables the simulation of plasma distribution and film growth, aiming to enhance the target utilization rate and substrate deposition rate. The conclusions serve as a reference for designing high-performance magnetron sputtering equipment.

Deep learning-based bone age assessment (BAA) approaches have certain drawbacks, such as ignoring the correlation of age labels and simply assuming that bone development is linearly related to bone age, which can affect the accuracy of predictions. To solve these problems, a knowledge distillation-based adaptive label distribution learning method called KDALDL is proposed. The KDALDL framework comprises a teacher model and a student model, both consisting of modules for multi-scale feature extraction, feature refinement, and label distribution learning. First, a multi-scale feature extraction module is designed based on the swin transformer to extract feature information at various scales. Subsequently, these features are fed into the feature refinement module to capture the optimal image features. Then, the discrete labels obtained from the age labels through the Gaussian formula are used to train the teacher model. Finally, the teacher model’s outputs are used to train the student model through the knowledge distillation technique, which enables the student model to achieve improved results by learning from the teacher model. The proposed method is validated using the Radiological Society of North America (RSNA) dataset, which exhibits outstanding results.

Abstract Background One-stage jaw reconstruction with fibular flap and prosthetic rehabilitation restores bony and dental continuity simultaneously. It was also called as “jaw-in-a-day (JIAD)” technique. However, bone volume and height of fibular flap may be insufficient for dental implant insertion. The provision of a considerable amount of bone makes an iliac flap the ideal choice in these cases. We present the first case report to document the use of one-stage jaw reconstruction and prosthetic rehabilitation with the iliac flap. Case presentation We modified the conventional JIAD workflow to make it suitable for iliac flap. Two cases were presented who both underwent segmental mandibulectomy for ameloblastoma. Virtual surgical planning was performed in all cases. The iliac crest was positioned upward to provide cortical bone for achieving primary stability of dental implants. Similar to the “all-on-4” procedure, the iliac bone was placed 12 to 15 mm below the occlusal plane to create adequate space for the implant-retained prosthesis. Immediate implant-based dental rehabilitation was performed at same stage. The surgery was successful in all cases without any short-term complications. In the first postoperative week, patients were given a liquid diet through a nasal feeding tube. The liquid diet is advised until 1 month after the surgery. Thereafter, a soft diet is recommended. Patients were advised to resume routine mastication and normal diet 3 months after the surgery. Peri-implantitis occurred in one patient, and additional gingival graft was required. Postoperative function and esthetics were satisfactory at the last follow-up visit. Conclusions One-stage jaw reconstruction and prosthetic rehabilitation with the iliac flap are safe and useful for restoring postoperative function and esthetics. It should be used in more cases with a longer follow-up in further studies.

Objective To investigate the occurrence of flight illusions and explore its influencing factors and countermeasures in army aviators in cold regions. Methods Comprehensive Flight Illusion Scale was applied to investigate flight illusions, related influencing factors and countermeasures among 74 army aviators in cold regions from December 2022 to February 2023. SPSS 22.0 statistics was used for statistical analysis to compare the differences among variables and identify the influencing factors of flight illusions. Results For the 74 issued questionnaires, all of them were retrieved validly, with a rate of 100%. The incidence rate of flight illusions was 32.43%. There was a statistical difference between flight time and the occurrence of flight illusions (P < 0.05). There were 3 types of flight illusions with higher incidences in cold regions, that is distance illusion (20.27%), tilt illusion (18.92%) and relative position illusion (16.22%). The 3 flight illusions with relatively lower incidences were detachment phenomenon (4.05%), rotational illusion (4.05%), and inverted flight illusion (2.70%). After occurrence of illusions, 66.67% of the aviators experienced symptoms such as tension, "hard-to-move lever" headache, dizziness and post-flight insomnia. Almost all of the aviators were of fully awareness and acceptance of the active approaches to dealing with flight illusions, but still 50% of them believed that passive waiting intervention measures could be used. The results of statistical analysis on related influencing factors indicated that statistical differences were observed in all the listed items except flight subject with the occurrence of flight illusions (P < 0.05). Conclusion During short period flight in cold regions in winter, army aviators experience obvious psychological and physiological reactions after occurrence of flight illusions, and their anxiety and fatigue state, external climate and landform environment, and cabin interface and flight parameters are all related to the occurrence.

For atmospheric melting cast Cu–15Ni–8Sn alloy, hot extrusion tests were conducted on ingots of Cu–15Ni–8Sn alloy with varying extrusion ratios (5, 12 and 16) following homogenization and annealing. The investigation employed mechanical property tests, scanning electron microscopy and transmission electron microscopy to analyze the mechanical characteristics, dynamic recrystallization and twinning behaviors of the alloys subjected to different extrusion ratios. The findings revealed a reduction in the average grain size of the alloy as the extrusion ratio increased. The alloy undergoes dynamic recrystallization during hot extrusion, and the degree of recrystallization of the alloy escalated with higher extrusion ratios. The alloy underwent completely recrystallized at an extrusion ratio of 16, primarily driven by discontinuous dynamic recrystallization (DDRX). In addition, the alloy generated twins during the DRX process, and the twin boundaries provided favorable sites for the nucleation of DRX grains, which promoted the DRX of the alloy. Notably, at an extrusion ratio of 16, the alloy demonstrated impressive mechanical properties, with an ultimate tensile strength of 836 MPa and an elongation of 13.5 %. These results presented a substantial enhancement, showcasing a 54 % increase in the extruded ultimate tensile strength and a 350 % increase in the elongation compared to that of the alloy in the homogenized annealed state.

In this study, Cu-2.7Ti-0.2Fe (CT-0.2Fe) and Cu-2.7Ti–1Fe (CT-1Fe) alloys were fabricated and underwent multi-stage thermomechanical treatment, and the microstructure and properties evolution of the alloys during aging were investigated. After aging for 60 h at 350 °C, the CT-0.2Fe and CT-1Fe alloys exhibited the yield strength of 1068/935 MPa, tensile strength of 1127/1057 MPa, elongation of 2.54%/2.21%, and electrical conductivity of 20.3/26.4 %IACS, respectively. The relatively higher electrical conductivity of CT-1Fe was primarily attributed to the formation of numerous TiFe particles. Typical modulated structure and β′-Cu4Ti precipitates formed during direct aging in both alloys. However, in the CT-1Fe alloy, the growth of β′-Cu4Ti precipitates was suppressed. During multi-stage thermomechanical treatment, the interaction of the dislocations and precipitates was enhanced, retarding the softening effects of the alloy at the elevated temperatures. The calculation results showed that work hardening and precipitation strengthening significantly contributed to enhancing the mechanical properties of the alloys.

The Cu–15Ni–8Sn alloy ingot was prepared in the medium-frequency induction melting furnace. The hot extruded alloy was treated by solid solution at 840 °C for 60 min and aging at 400 °C for different times (0 miñ480 min). The effect of aging time on the evolution of the nanophase of Cu–15Ni–8Sn alloy and the strengthening-toughening mechanism were studied. The results show that at the beginning of aging, the alloy undergoes spinodal decomposition, the wavelength of the modulated structure is approximately 3∼7 nm, the ordered phase transformation of D022 and L12 occurs simultaneously, and the ordered phase size is approximately 5 nm. With the extension of aging time, the modulated structure became coarser, and the wavelength of the modulated structure increased to 5–9 nm. At the same time, the D022 ordered phase changed to the L12 ordered phase, and a continuous distribution of elliptical discontinuous precipitation appeared at the grain boundary. The ratio of the long and short axes of the discontinuous precipitation was approximately 4.7. In the late aging period, the D022 ordered phase was basically transformed into the L12 ordered phase, and discontinuous precipitation, which is incompatible with the matrix, extended into the crystal. After 120 min of aging at 400 °C, the hardness, strength, and elongation of the alloy are 105.4 HRB, 839.8 MPa and 9.6 %, respectively. The peak-aging states D022 and L12 coexist in an orderly phase at the nanoscale, and this nanoscale strengthening phase is completely integrated with the matrix, which improves the strength and toughness of the alloy. The research results can provide support for the development of high-performance copper alloys in the ocean.

Drying is the main energy consumption in the grain industry. At present, most grain drying are using machines or drying towers, but its heat loss and energy consumption is large. Some of dryers use coal as heat source and cause serious environmental pollution. In addition, the long-term storage of grain is prone to mildew and insect pests. At the same time, long-term storage of grain will lead to low water content of grain and affect the processing quality of grain. Therefore, it’s significant to realize the high-quality-low-energy consumption drying and long-term safe storage of grain to ensure the quality of exported grain. A multifunctional grain storage system with low temperature drying, refrigeration, and humidification was proposed. The equipment was developed according to the system. It had three functions such as low temperature drying mode, low temperature storage mode, and humidification mode. The equipment can realize “one-stop” grain storage and automatic control of the whole process of grain storage. The experimental results showed the air parameters of unit outlet met the design requirements in the three working modes. The average drying rates of corn and radish were about 1.1%/h and 2.9%/h, respectively. In addition, the unit can save about 19.4% of energy compared with the dryer, and 51.7% of energy compared with the condensing and dehumidifying dryer through the energy consumption analysis of the system. The driving energy of this equipment was electric, so it was eco- friendly and easy to realize the intelligent construction of granary, coming with a prospect of broad application.

Psoriasis, an immune-mediated inflammatory skin disorder, seriously affects the quality of life of nearly four percent of the world population. Euphorbia helioscopia L. is the monarch constituent of Chinese ZeQi powder preparation for psoriasis, so it is necessary to illustrate its active ingredients. Thus, twenty-three diterpenoids, including seven new ones, were isolated from the whole herb of E. helioscopia L. Compounds 1 and 2, each featuring a 2,3-dicarboxylic functionality, are the first examples in the ent-2,3-sceo-atisane or the ent-2,3-sceo-abietane family. Extensive spectroscopic analysis (1D, 2D NMR, and HRMS data) and computational methods were used to confirm their structures and absolute configurations. According to the previous study and NMR data from the jatropha diterpenes obtained in this study, some efficient 1H NMR spectroscopic rules for assigning the relative configurations of 3α-benzyloxy-jatroph-11E-ene and 7,8-seco-3α-benzyloxy-jatropha-11E-ene were summarized. Moreover, the hyperproliferation of T cells and keratinocytes is considered a key pathophysiology of psoriasis. Anti-proliferative activities against induced T/B lymphocytes and HaCaT cells were tested, and IC50 values of some compounds ranged from 6.7 to 31.5 μM. Compounds 7 and 11 reduced the secretions of IFN-γ and IL-2 significantly. Further immunofluorescence experiments and a docking study with NF-κB P65 showed that compound 13 interfered with the proliferation of HaCaT cells by inhibiting the NF-κB P65 phosphorylation at the protein level.