Search

Your search keyword '"VITAMIN D"' showing total 75,846 results
Start Over Descriptor "VITAMIN D" Search Limiters Full Text

Refine your results

more »

more »

more »

more »

more »

more »

more »
75,846 results on '"VITAMIN D"'

66. Evidence supports a causal association between allele-specific vitamin D receptor binding and multiple sclerosis among Europeans.

Author

Adams, Cameron, Manouchehrinia, Ali, Quach, Hong, Quach, Diana, Olsson, Tomas, Kockum, Ingrid, Schaefer, Catherine, Ponting, Chris, Alfredsson, Lars, and Barcellos, Lisa

Subjects
genetics, multiple sclerosis, vitamin D, Humans, Multiple Sclerosis, Receptors, Calcitriol, Alleles, Genome-Wide Association Study, Vitamin D, Calcitriol, Polymorphism, Single Nucleotide
Abstract

Although evidence exists for a causal association between 25-hydroxyvitamin D (25(OH)D) serum levels, and multiple sclerosis (MS), the role of variation in vitamin D receptor (VDR) binding in MS is unknown. Here, we leveraged previously identified variants associated with allele imbalance in VDR binding (VDR-binding variant; VDR-BV) in ChIP-exo data from calcitriol-stimulated lymphoblastoid cell lines and 25(OH)D serum levels from genome-wide association studies to construct genetic instrumental variables (GIVs). GIVs are composed of one or more genetic variants that serve as proxies for exposures of interest. Here, GIVs for both VDR-BVs and 25(OH)D were used in a two-sample Mendelian Randomization study to investigate the relationship between VDR binding at a locus, 25(OH)D serum levels, and MS risk. Data for 13,598 MS cases and 38,887 controls of European ancestry from Kaiser Permanente Northern California, Swedish MS studies, and the UK Biobank were included. We estimated the association between each VDR-BV GIV and MS. Significant interaction between a VDR-BV GIV and a GIV for serum 25OH(D) was evidence for a causal association between VDR-BVs and MS unbiased by pleiotropy. We observed evidence for associations between two VDR-BVs (rs2881514, rs2531804) and MS after correction for multiple tests. There was evidence of interaction between rs2881514 and a 25(OH)D GIV, providing evidence of a causal association between rs2881514 and MS. This study is the first to demonstrate evidence that variation in VDR binding at a locus contributes to MS risk. Our results are relevant to other autoimmune diseases in which vitamin D plays a role.

Published
2024

79. DePTH: De-emphasize PTH

Author

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and Simon Hsu, MD, MS, Assistant Professor

Published
2024

89. Vitamin D and Omega-3 Trial (VITAL) (VITAL)

Author

National Cancer Institute (NCI), National Heart, Lung, and Blood Institute (NHLBI), Office of Dietary Supplements (ODS), National Institute of Neurological Disorders and Stroke (NINDS), National Center for Complementary and Integrative Health (NCCIH), Pharmavite LLC, Pronova BioPharma, BASF, and JoAnn E. Manson, MD, Principal Investigator

Published
2024

90. Vitamin D for COVID-19 Trial (VIVID)

Author

Harvard Medical School (HMS and HSDM), Harvard School of Public Health (HSPH), Fenway Health and Beth Israel Deaconess Medical Center, Tishcon Corporation, Takeda, Quest Diagnostics-Nichols Insitute, Laboratory Corporation of America, Trialfacts, Karolinska Institutet, Philanthropic donations, and JoAnn E. Manson, MD, Professor of Medicine

Published
2024

Catalog

Books, media, physical & digital resources
See catalog results