Search

With rapid industrialization and urbanization, the contradiction between the human exploitation of land production and living functions and natural ecosystem service functions has intensified. The issues of how to coordinate the exploitation and conservation functions of land and guide the rational distribution of human activities have become important for global sustainable development, especially considering the realization that multifunctional land use is an effective way to relieve land pressure and improve land use efficiency, that land multifunction has significant spatio-temporal heterogeneity, and that there is a mutual promotion and stress relationship between multifunctional land use. However, few existing studies have discussed the decoupling relationship among land use functions. In this study, a system of 10 sub-functions and 25 indicators was established based on the production function (PDF), living function (LVF), and ecological function (ELF) for 59 cities in the Yellow River Basin (YRB). There are both subjective and objective procedures employed to determine the weights, while an exploratory spatial data analysis is used to analyze the time-based and territorial changes in various functions of land use in the study area from 2000 to 2020. The decoupling relationship between the three functions is detected utilizing the theoretical foundation of the decoupling analysis. The results show that land use is multifunctional, LUFs develop unevenly, and their spatial distribution varies substantially. The results of the decoupling analysis demonstrate that the predominant types of correlations among the land use ELF and PDF and LVF over the research period are strong decoupling and strong negative decoupling correlations, with the former being a dilemma and the latter being a sustainable type of development. [ABSTRACT FROM AUTHOR]

Fusarium crown rot (FCR) in wheat is a prevalent soil-borne disease worldwide and poses a significant threat to the production of wheat (Triticum aestivum) in China, with F. pseudograminearum being the dominant pathogen. Currently, there is a shortage of biocontrol resources to control FCR induced by F. pseudograminearum, along with biocontrol mechanisms. In this study, we have identified 37 strains of biocontrol bacteria displaying antagonistic effects against F. pseudograminearum from over 8000 single colonies isolated from soil samples with a high incidence of FCR. Among them, QY43 exhibited remarkable efficacy in controlling FCR. Further analysis identified the isolate QY43 as Pseudomonas aeruginosa, based on its colony morphology and molecular biology. In vitro, QY43 significantly inhibited the growth, conidial germination, and the pathogenicity of F. pseudograminearum. In addition, QY43 exhibited a broad spectrum of antagonistic activities against several plant pathogens. The genomics analysis revealed that there are genes encoding potential biocontrol factors in the genome of QY43. The experimental results confirmed that QY43 secretes biocontrol factor siderophores and pyocyanin. In summary, QY43 exhibits a broad spectrum of antagonistic activities and the capacity to produce diverse biocontrol factors, thereby showing substantial potential for biocontrol applications to plant disease. [ABSTRACT FROM AUTHOR]

Summary: Soybean is one of the most economically important crops worldwide and an important source of unsaturated fatty acids and protein for the human diet. Consumer demand for healthy fats and oils is increasing, and the global demand for vegetable oil is expected to double by 2050. Identification of key genes that regulate seed fatty acid content can facilitate molecular breeding of high‐quality soybean varieties with enhanced fatty acid profiles. Here, we analysed the genetic architecture underlying variations in soybean seed fatty acid content using 547 accessions, including mainly landraces and cultivars from northeastern China. Through fatty acid profiling, genome re‐sequencing, population genomics analyses, and GWAS, we identified a SEIPIN homologue at the FA9 locus as an important contributor to seed fatty acid content. Transgenic and multiomics analyses confirmed that FA9 was a key regulator of seed fatty acid content with pleiotropic effects on seed protein and seed size. We identified two major FA9 haplotypes in 1295 resequenced soybean accessions and assessed their phenotypic effects in a field planting of 424 accessions. Soybean accessions carrying FA9H2 had significantly higher total fatty acid contents and lower protein contents than those carrying FA9H1. FA9H2 was absent in wild soybeans but present in 13% of landraces and 26% of cultivars, suggesting that it may have been selected during soybean post‐domestication improvement. FA9 therefore represents a useful genetic resource for molecular breeding of high‐quality soybean varieties with specific seed storage profiles. [ABSTRACT FROM AUTHOR]

The local land use carbon budget (LUCB) balance is an important factor in achieving regional carbon neutrality. As the basic unit of China's economic development and social governance, the county level is an important part of the realization of the "double carbon" goal. This paper focuses on 1069 county units within the Yangtze River Economic Belt (YREB). It utilizes data on land use, nighttime light, energy consumption, and social and economic factors to construct carbon emission models. The spatiotemporal characteristics of LUCB in these county units are analyzed using standard deviational ellipse (SDE) and spatial autocorrelation methods. Additionally, a zoning study is conducted by examining the economic contribution coefficient (ECC) of carbon emissions, the ecological support coefficient (ESC), and their coupling relationship. The results show that (1) the total land use carbon emissions (LUCE) increased significantly during the research period, and the total carbon sink was relatively stable. (2) The LUCB is spatially high in the east and low in the west, with the center of gravity moving to the southwest as a whole. (3) The LUCB shows positive spatial autocorrelation and has significant spatial agglomeration characteristics, which are mainly high–high and low–low regional agglomeration types. (4) The ECC is high in the east and low in the west, the ESC is high in the west and low in the east, and the coordination and coupling degrees of the two are low. (5) According to the ECC and ESC, the county unit is divided into a low-carbon conservation area, an economic development area, a carbon sink development area, and a comprehensive optimization area. This study is helpful in promoting the sustainable development of carbon neutrality and low carbon in the YREB. [ABSTRACT FROM AUTHOR]

Flowering time and active accumulated temperature (AAT) are two key factors that limit the expanded production especially for soybean across different regions. Wild soybean provides an important germplasm for functional genomics study in cultivar soybean. However, the studies on genetic basis underlying flowering time in response to AAT especially in wild soybean were rarely reported. In this study, we used 294 wild soybean accessions derived from major soybean production region characterized by different AAT in Northeast of China. Based on genome-wide association study (GWAS), we identified 96 SNPs corresponded to 342 candidate genes that significantly associated with flowering time recorded in two-year experiments. Gene Ontology enrichment analysis suggests that the pathways of photosynthesis light reaction and actin filament binding were significantly enriched. We found three lead SNPs with -log10(p-value) > 32 across the two-year experiments, i.e., Chr02:9490318, Chr04:8545910 and Chr09:49553555. Linkage disequilibrium block analysis shows 28 candidate genes within the genomic region centered on the lead SNPs. Among them, expression levels of three genes (aspartic peptidase 1, serine/threonine-protein kinase and protein SCAR2-like) were significantly differed between two subgroups possessing contrasting flowering time distributed at chromosome 2, 4 and 9, respectively. There are 6, 7 and 3 haplotypes classified on the coding regions of the three genes, respectively. Collectively, accessions with late flowering time phenotype are typically derived from AAT zone 1, which is associated with the haplotypic distribution and expression levels of the three genes. This study provides an insight into a potential mechanism responsible for flowering time in response to AAT in wild soybean, which could promote the understanding of genetic basis for other major crops. [ABSTRACT FROM AUTHOR]

We evaluate the substitution effect between formal and informal institutions based on a natural experiment in China, i.e., the targeted reserve requirement ratio cut (TRRRC) policy. TRRRC creates a large and persistent discontinuity affecting loan availability for small and micro‐enterprises (SMEs) with sales below specific cut‐offs. Using the regression discontinuity design, we show that the trade credit of SMEs is significantly lower for firms with sales below the cut‐offs, indicating a substitution effect of banking loan on trade credit. Our findings are more pronounced for firms with poor product market performance, weak mortgage capability, young age, and poor financial environment. [ABSTRACT FROM AUTHOR]

This study investigates the effect of targeted reserve requirement ratio cuts (TRRRCs) on tax avoidance among small and micro enterprises (SMEs) with operating revenues below specific cutoffs in China. Using a regression discontinuity design, we causally show that, by increasing loan availability, TRRRCs significantly alleviate the financial constraints and cash dependence of SMEs and consequently reduce tax avoidance. This is especially the case among firms with lower market power and higher entertainment and travel costs. Our findings provide evidence for the real effect of TRRRCs on corporate tax avoidance and show the inclusive effect of TRRRCs on SMEs. In doing so, we indirectly reveal a rent-seeking channel underlying bank lending, thus offering clear policy implications for regulators. [ABSTRACT FROM AUTHOR]

Fusarium crown rot (FCR) and Fusarium head blight (FHB) are caused by Fusarium pseudograminearum and are newly emerging diseases of wheat in China. In this study, we characterized FpPPR1 , a gene that encodes a protein with 12 pentatricopeptide repeat (PPR) motifs. The radial growth rate of the Δ Fpppr1 deletion mutant was significantly slower than the wild type strain WZ-8A on potato dextrose agar plates and exhibited significantly smaller colonies with sector mutations. The aerial mycelium of the mutant was almost absent in culture tubes. The Δ Fpppr1 mutant was able to produce spores, but spores of abnormal size and altered conidium septum shape were produced with a significant reduction in sporulation compared to wild type. Δ Fpppr1 failed to cause disease on wheat coleoptiles and barley leaves using mycelia plugs or spore suspensions. The mutant phenotypes were successfully restored to the wild type levels in complemented strains. FpPpr1-GFP signals in spores and mycelia predominantly overlapped with Mito-tracker signals, which substantiated the mitochondria targeting signal prediction of FpPpr1. RNAseq revealed significant transcriptional changes in the Δ Fpppr1 mutant with 1,367 genes down-regulated and 1,333 genes up-regulated. NAD-binding proteins, thioredoxin, 2Fe-2S iron-sulfur cluster binding domain proteins, and cytochrome P450 genes were significantly down-regulated in Δ Fpppr1 , implying the dysfunction of mitochondria-mediated reductase redox stress in the mutant. The mating type idiomorphic alleles MAT1-1-1, MAT1-1-2 , and MAT1-1-3 in F. pseudograminearum were also down-regulated after deletion of FpPPR1 and validated by real-time quantitative PCR. Additionally, 21 genes encoding putative heterokaryon incompatibility proteins were down-regulated. The yellow pigmentation of the mutant was correlated with reduced expression of PKS12 cluster genes. Taken together, our findings on FpPpr1 indicate that this PPR protein has multiple functions in fungal asexual development, regulation of heterokaryon formation, mating-type, and pathogenesis in F. pseudograminearum. [ABSTRACT FROM AUTHOR]

Background: Cardiovascular disease (CVD) is the most common complication and the leading cause of death in patients with chronic kidney disease (CKD). Accelerated atherosclerosis is a pathophysiological process that is vital to the occurrence of cardiovascular complications associated with CKD. Abnormal platelet activation is not only the leading cause of atherosclerosis but also plays a critical role in the occurrence of thrombotic events. Currently, antiplatelet drugs are commonly used as a secondary prevention strategy for high blood pressure, obesity, diabetes, and ischemic heart disease and can reduce the risk of CVD in the susceptible population. However, the benefits and evidence of using antiplatelet agents in patients with CKD remain controversial. This study aimed to determine whether antiplatelet therapy can safely prevent atherosclerosis in patients with CKD in the primary care setting.Methods/design: The ALTAS-CKD study is a multicenter, prospective, randomized, double-blind, placebo-controlled trial of 554 adult patients with stage 3-5 non-dialysis-dependent CKD recruited from 10 territory medical centers in China. A secured web-based computer randomization system will be used to administer aspirin 100 mg once daily or a matching inactive placebo for 36 months. The primary endpoint will be the occurrence of atherosclerosis, as measured by carotid ultrasonography. The secondary endpoints will be combined cardiovascular events, all-cause mortality, and 50% decrease in the estimated glomerular filtration rate. TRIAL REGISTRATION {2A}: Current controlled trials number: ChiCTR1900021393 . Registered on 18 February 2019. [ABSTRACT FROM AUTHOR]

In this study, we examine how intercommunity relationships affect the growth of organizational communities. Using a unique panel dataset on 53 technology development communities in China spanning 1988–2000, we found that regional community density, a community's geographic proximity to the nearest community and its domain overlap with the nearest community have an inverted U-shaped relationship with the community's growth. These non-monotonic results suggest that adjacent communities have both mutualistic and competitive effects on each other. Theoretical and managerial implications are discussed. Copyright © 2008 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Drawing upon the resource-based view and transaction cost economics, this study aims to examine how various types of managerial resources (i.e., political networking and functional experience) can be beneficial to new ventures in a transition economy. Using survey data from a sample of new ventures in China's high-technology industries, we demonstrate that managers' political networking and functional experience are positively related to new venture performance. We also find that the positive relationship between functional experience and new venture performance is moderated by the type of ownership of the ventures and the level of dysfunctional competition in their environments. Theoretical and managerial implications are discussed. Copyright © 2007 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

There is a strong normative bias toward the inherent value of trust among both marketing researchers and practitioners. Yet there is little empirical evidence of a positive impact of trust on performance. Indeed, scholars suggest that the sources of trust may provide opportunities for its abuse. Following this line of thinking, the authors investigate the dual roles of sales controls and supervisor behaviors as antecedents of salespeople's belief in the benevolence of the supervisor (i.e., supervisee trust). The authors then examine these antecedents as moderators of the relationship between supervisee trust and sales performance in the context of selling new products. Data on field salespeople from high-technology firms in China and the United States suggest that factors such as supervisor accessibility engender supervisee trust but do not necessarily enhance its impact on sales performance. In the Chinese sample, supervisee trust enhances sales performance when output control is adopted, when the supervisor has a higher level of achievement orientation style, and when the salesperson has higher role ambiguity. Furthermore, the results suggest that the supervisee trust-sales performance relationship is negative when supervisor accessibility is high. With the exception of achievement orientation and supervisor accessibility, these effects are negative or nonexistent in the U.S. sample. The authors discuss theoretical and practical implications of the study's findings. [ABSTRACT FROM AUTHOR]

Investigating the effect of product innovation strategy on the performance of new technology ventures in China, we found the innovation-performance link was contingent on both environmental factors, including environmental turbulence and institutional support, and the relationship-based strategies of the ventures, such as strategic alliances for product development and political networking. Our results suggest the need for simultaneous consideration of environment- and relationship-based strategy factors as moderators in the discourse on product innovation strategy among new technology ventures. [ABSTRACT FROM AUTHOR]

Background: Thoracic aortic dissection (TAD) is the most common life-threatening disorder, and MMP-2 is involved in TAD pathogenesis. Our purpose is to systematically evaluate the association of the MMP-2 gene with TAD risk in Chinese Han population.Methods: In our case-control study, we recruited 755 unrelated participants: 315 case participants with TAD and 440 controls. Twenty-two tag SNPs were selected from MMP-2 gene and were genotyped. Genotype data were analyzed by logistic regression.Results: Although we did not find any significant association for MMP-2 SNPs using single-marker analysis, we identified many windows with haplotype frequencies significantly different between case participants and control participants using a variable-sized sliding-window strategy. In particular, the most significant association was shown by a 2-SNP window consisting of rs2241145 and rs9928731 (omnibus test: asymptotic Pasym = 7.48 × 10 (-5) and empirical Pemp = 0.001867). There were two protective haplotypes: CT (Pasym = 0.00303; odds ratio [OR], 0.403) and GC (Pasym = 0.000976; OR, 0.448).Conclusions: MMP-2 haplotypes are associated with genetic susceptibility to thoracic aortic dissection in Chinese Han population. [ABSTRACT FROM AUTHOR]

Prior literature on foreign direct investment (FDI) spillovers has mainly focused on how the presence of FDI affects the productivity of domestic firms. In this study, we advance the literature by examining the effect of the diversity of FDI country origins on the productivity of domestic firms. We propose that the diversity of FDI country origins can facilitate FDI spillovers by increasing the variety of technologies and management practices brought by foreign firms, to which domestic firms are exposed and that they can potentially utilize. Further, the extent to which domestic firms can utilize these technologies and practices depends upon their absorptive capacity. Using panel data on Chinese manufacturing firms during the period 1998–2003, our results support these propositions. We find that the diversity of FDI country origins in an industry has a positive relationship with the productivity of domestic firms in the industry. This positive relationship is stronger when domestic firms are larger, and when the technology gap between FDI and the domestic firms is intermediate. Copyright © 2010 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

In this study, we examine the relationships between new ventures' ties with service intermediaries (i.e., technology service firms, accounting and financial service firms, law firms, and talent search firms) and their product innovation in the context of a technology cluster. Because service intermediaries sit at the intersection of many firms, organizations and industries, they maintain extensive networks in a cluster. We propose that new ventures' ties with service intermediaries enable the ventures to plug into these networks and contribute to the ventures' product innovation by broadening the scope of their external innovation search and reducing their search cost. Moreover, we argue that the positive relationships between new ventures' ties with service intermediaries and their product innovation will become stronger when search in the networks in the cluster is more important to the ventures' product innovation. Based upon a sample of new ventures in a technology cluster in China, our results support these arguments. Copyright © 2009 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

How does top management team (TMT) conflict influence entrepreneurial strategy making of new ventures? With a sample of new ventures in China’s technology industries, this study examines the conditions under which TMT cognitive conflict and affective conflict are associated with entrepreneurial strategy making. We found that cognitive conflict among TMT members had a positive relationship with entrepreneurial strategy making. Further, the positive relationship between cognitive conflict and entrepreneurial strategy making was moderated by dysfunctional competition and team deftness. [ABSTRACT FROM AUTHOR]

Presents a study which investigated the impact of research and development (R&D)-marketing interaction on new product performance in Chinese high technology firms. Relationship between information exchange and new product performance; Methodology; Results and discussion.

• The contribution of oyster reefs characteristics to the omnivorous fish intestinal microbiota was distinct. • Microbial communities in the oyster reefs and fish intestines showed various predictive functions and unique core indicators. • The microbial diversity in sediments were significantly higher than that in intestines. The habitats of oyster reefs had played various ecological services functions, as an important means of marine ecological restoration and fishery resources conservation, which had been widely used worldwide. And the characteristics of microbial communities would be inevitably affected by habitat of oyster reefs. The aim of this study was to reveal the relationship between oyster reefs and the intestinal microbiota of fish (Takifugu ocellatus , Acanthopagrus latus , Clupanodon thrissa , and Mugil cephalus). Here, based on 16S rRNA sequencing, this research analyzed the microbial communities of fishes gut in the oyster reefs from the most crucial estuary economic zone in Southern China. It was significantly lower that the bacterial alpha-diversity in the fish intestines than in the sediments of oyster reefs. The non-metric multidimensional scaling (NMDS) and analysis of similarities (ANOSIM) results showed that intestines microbiota of T. ocellatus and A. latus were more homologous to sediments microbiota, but intestines microbiota of C. thrissa and M. cephalus were more similar to the water microbiota. There were obvious differences in the contribution of oyster reefs habitat to intestinal microorganisms of four fishes. Source tracking analysis as well reached the similar conclusion. For instance, contribution of water to T. ocellatus and A. latus was lesser than sediments, which was related to their benthic habits. Based on the differences in microbial community compositions, the functional prediction analysis had demonstrated that special functional pathways and independent core indicators had been formed separately from oyster reefs and fish intestines. Overall, these findings highlighted the characteristics of microbial diversity and functions from the omnivorous fish living in oyster reefs habitats. This research proposed new insights into the function of oyster reefs habitats, which have enriched the ecological service value of oyster reefs from microbial ecology and provided a reference for the application of oyster reefs habitats in other estuaries. [ABSTRACT FROM AUTHOR]

• A multi-dimensional functional space was built to visualize the functional structure. • The functional structure and trait composition of fish in the PRE vary seasonally. • The CWM traits were mainly affected by temperature, DO, chlorophyll-a, and depth. Estuaries are one of the most important ecosystems with high biological productivity. They connect freshwater and marine ecosystems, and the fish community assemblages face intense environmental changes, so estuarine fish communities have unique ecological characteristics. With the increase of human activities and the discharge of pollutants, the pressure on the ecosystem of the Pearl River Estuary (PRE) is intensifying, and its ecosystem functions and services are inevitably affected. To better understand the functional structure of the fish community in the PRE and its response to environmental changes, we analyzed the trait composition of the community and its relationships to environmental factors based on 10 functional traits of 130 fish species collected in the PRE during the summer and winter of 2020–2021. In addition, we built a multi-dimensional functional space to visualize the overall functional structure of the PRE and explore the seasonal variation of the selected traits in the functional space. Our findings suggest that the functional traits of the fish communities in the PRE were mainly affected by temperature, dissolved oxygen, chlorophyll-a, and depth. Among them, the effects of dissolved oxygen, temperature, and chlorophyll-a on CWM traits were reflected in seasonal differences, while the effects of depth were reflected in spatial differences. We also found the main trait categories that occupied the most functional space and contributed the most to the seasonal differences in functional space. The results of this study are significant for understanding the seasonal variation of the functional structure in the PRE and how environmental gradients drive the functional traits of fish communities, and also provide insights for effective ecosystem-based management in the PRE. [ABSTRACT FROM AUTHOR]

Smart water co-governance (SWCG) is a fundamental driving force to reduce the water crisis and promote the sustainable development of water resources. To explore the applicability and development of SWCG in different regions, the authors of this paper took 31 provinces of China (with the exception Hong Kong, Macao, and Taiwan) as research districts and used the three-stage data envelopment analysis (DEA) method to measure and compare the efficiency of smart water governance (SWG) in the government-enterprise-public (G-E-P) mode and without public participation in the government-enterprise (G-E) mode in 2019. Then, the Malmquist model was used to measure the spatio-temporal evolution of the G-E-P mode from 2010 to 2019, focusing on the analysis of the top ten provinces of the China Internet Development Index in 2019. According to the empirical analysis, the following results were obtained: (1) the efficiency of SWCG in the G-E-P mode was significantly higher than that in G-E model, as 13 provinces showed a significant decline and 10 provinces had a small change. In addition, SWCG in the G-E-P mode showed a good development trend in the eastern and southern regions. (2) The governance efficiency, pure technical efficiency, and scale efficiency showed upward trends, but the technological progress index and total factor productivity were still low. Therefore, SWG should vigorously promote public participation and the independent implementation of enterprises under the guidance and restriction of the government. Meanwhile, the construction of an SWG infrastructure and the level of science and technology should be strengthened. In addition, each province should adjust the input-output structure according to its redundancy or deficiency, weigh the suitability of the input level and scale, and strengthen the matching and support of the ability of multi-subjects and factors to ensure that an appropriate input-output scale level is reached and the efficiency of SWCG is improved.

Abstract: Since December 2019, an outbreak of COVID-19 sweeping the world. Understanding the clinical and SARS-CoV-2 dynamic changes of mild and ordinary patients of COVID-19, so as to provide basis for the prevention and control of COVID-19.On February 1st, 2020, 16 SARS-CoV-2 RNA positive patients diagnosed in the same site in Beijing. The patients symptoms, signs, medication, and SARS-CoV-2 results were recorded.Of the 16 patients, 12 were female. Although they were infected at the same time in the same workplace, their clinical processes were very different and can be roughly divided into three different types: persistent sputum positive, persistent stool positive and persistent both positive. In 7 patients with mild clinical manifestations, the median days of SARS-CoV-2 RNA negative conversion in sputum samples were significantly later than those with obvious lung injury (27 days [range: 18 to 36]; 17 days, [range 6 to 25], P = .021). The negative conversion of SARS-CoV-2 RNA in stool was significant later than in sputum.There were various clinical manifestations after SARS-CoV-2 infection, even if they were infected by the same source of infection in the same place. The presence of SARS-CoV-2 virus RNA in stool samples was longer than that in respiratory tract., (Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc.)

Background: Thoracic aortic dissection (TAD) is the most common life-threatening disorder, and MMP-2 is involved in TAD pathogenesis. Our purpose is to systematically evaluate the association of the MMP-2 gene with TAD risk in Chinese Han population., Methods: In our case-control study, we recruited 755 unrelated participants: 315 case participants with TAD and 440 controls. Twenty-two tag SNPs were selected from MMP-2 gene and were genotyped. Genotype data were analyzed by logistic regression., Results: Although we did not find any significant association for MMP-2 SNPs using single-marker analysis, we identified many windows with haplotype frequencies significantly different between case participants and control participants using a variable-sized sliding-window strategy. In particular, the most significant association was shown by a 2-SNP window consisting of rs2241145 and rs9928731 (omnibus test: asymptotic Pasym = 7.48 × 10 (-5) and empirical Pemp = 0.001867). There were two protective haplotypes: CT (Pasym = 0.00303; odds ratio [OR], 0.403) and GC (Pasym = 0.000976; OR, 0.448)., Conclusions: MMP-2 haplotypes are associated with genetic susceptibility to thoracic aortic dissection in Chinese Han population.

The aim of the study was to use the ovine model to evaluate the hemocompatibility and end-organ effects of a newly developed magnetic suspension centrifugal left ventricular assist device (LVAD) by CH Biomedical Inc., Jiangsu, China. The LVADs were implanted in 6 healthy sheep, where inflow was inserted into the left ventricular apex and outflow was anastomosed to the descending aorta. All sheep received anticoagulation and antiaggregation therapy during the study. Hematologic and biochemical tests were performed to evaluate anemia, hepatorenal function, and the extent of hemolysis. The experiments lasted for up to 30 days on the beating hearts. All sheep were humanely killed at the termination of the experiments, and the end-organs were examined macroscopically and histopathologically. Autopsy was performed in all animals and there was no thrombus formation observed inside the pump. The pump's inflow and outflow conduits were also free of thrombus. Hematologic and biochemical test results were within normal limits during the study period. Postmortem examination of the explanted organs revealed no evidence of ischemia or infarction. Based on the in vivo study, this LVAD is suitable for implantation and can provide efficient support with good biocompatibility. The encouraging results in this study suggest that it is feasible to evaluate the device's long-term durability and stability.