40,637 results
Search Results
2. Feature Paper in Oral Physiology and Pathology.
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Minervini, Giuseppe
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HEAT shock factors , *BIOLOGICAL systems , *THERAPEUTICS , *MUSCULOSKELETAL system diseases , *NEMATODE infections - Abstract
The journal 'Life' has released a Special Issue that showcases a range of studies in the field of biological research. The articles in this issue cover topics such as genetics, disease biomarkers, musculoskeletal health, and therapeutic interventions. One study focuses on the link between genetic variations in the heat shock factor 1 gene and an increased risk of type 2 diabetes, particularly in overweight and obese females. Another study explores the use of biomarkers for diagnosing and treating osteoarthritis, with the goal of improving patient outcomes. The issue also addresses the impact of obesity on musculoskeletal health and the role of exercise in mitigating chemotherapy-induced peripheral neuropathy. Additionally, the intersection of autoimmune diseases and parasitic infections is examined, revealing potential therapeutic insights. The issue also highlights research on sepsis-induced coagulopathy, platelet-derived extracellular vesicles, chondrocyte biology, and innovative treatments for dermatitis associated with immunoglobulin G4-related disease. The articles emphasize the need for interdisciplinary collaboration in addressing complex health and disease challenges. Overall, this Special Issue contributes to our understanding of human health and offers potential strategies for improvement. [Extracted from the article]
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- 2024
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3. Editorial for the Special Issue "Latest Review Papers in Molecular Oncology 2023".
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Stolfi, Carmine
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MOLECULAR oncology , *LIPOSOMES , *CENTRAL nervous system cancer , *BCL-2 proteins , *THERAPEUTICS , *PROGNOSIS , *CYTOTOXIC T cells - Abstract
The International Journal of Molecular Sciences has published a special issue on molecular oncology, featuring nineteen articles written by leading experts in specific cancer research fields. The articles cover a wide range of topics, including cancer development, progression, and treatment options. Some of the areas explored include endoplasmic reticulum stress activation, immunotherapies, non-genetic determinants of cancer, environmental carcinogens, social stress, epigenetic reprogramming, drug resistance, microbiome modulation, tumor microenvironment, and the efficacy of ALK inhibitors. The issue also discusses the use of liposomes as a delivery strategy for chemotherapeutic drugs. The articles provide valuable insights into the global burden of cancer and offer potential avenues for further research and improved treatment options. The editorial expresses gratitude to the authors, reviewers, and editors for their contributions and hopes that the articles will promote further research in cancer treatment. [Extracted from the article]
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- 2024
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4. "Positioning of tucatinib in the new clinical scenario of HER2-positive metastatic breast cancer: An Italian and Spanish consensus paper".
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Conte, Pierfranco, Ciruelos, Eva, Curigliano, Giuseppe, De Laurentiis, Michelino, Del Mastro, Lucia, Gennari, Alessandra, Llombart, Antonio, Martìn, Miguel, Poggio, Francesca, Prat, Aleix, Puglisi, Fabio, and Saura, Cristina
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HER2 positive breast cancer ,METASTATIC breast cancer ,BREAST cancer ,PROTEIN-tyrosine kinase inhibitors ,THERAPEUTICS - Abstract
Advancements in monoclonal antibodies, tyrosine kinase inhibitors, and antibody drug conjugates (ADCs) have notably enhanced outcomes for metastatic HER2-positive breast cancer patients. Despite the expanding treatment options and clinical complexities, determining the optimal sequence of HER2-targeted therapies remains partly uncertain, influenced by various factors. To refine HER2-positive metastatic breast cancer management, particularly regarding tucatinib's position, a Steering Committee of leading oncologists in breast cancer care devised a panel of statements via a Delphi approach, focusing on five key topics: general clinical management, therapeutic approaches for patients with HER2-positive breast cancer and brain metastases, treatment sequence, and tucatinib's safety and efficacy. A total of 29 statements were deliberated, with strong consensus achieved for most. However, no consensus emerged regarding the management of brain progression alongside stable extracranial disease: 48 % advocated for switching to tucatinib, while 53 % favored a stereotactic brain radiotherapy (SBRT) approach if feasible. The unanimous consensus attained in this Delphi panel, particularly regarding tucatinib's efficacy and safety, underscores oncologists' recognition of its clinical significance based on existing trial data. These findings align closely with current literature, shedding light on areas necessitating further investigation, not thoroughly explored in prior studies. Moreover, the results underscore the scarcity of data on managing brain progression alongside stable extracranial disease, emphasizing the imperative for dedicated research to address these gaps and yield definitive insights. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Management of delirium in acute stroke patients: a position paper by the Austrian Stroke Society on prevention, diagnosis, and treatment.
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Kneihsl, Markus, Berger, Natalie, Sumerauer, Stefan, Asenbaum-Nan, Susanne, Höger, Franz Stefan, Gattringer, Thomas, Enzinger, Christian, Aigner, Martin, Ferrari, Julia, and Lang, Wilfried
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STROKE patients ,DELIRIUM ,STROKE units ,DIAGNOSIS ,THERAPEUTICS ,STROKE - Abstract
Delirium is a common complication in acute stroke patients, occurring in 15–35% of all stroke unit admissions and is associated with prolonged hospital stay and a poor post-stroke prognosis. Managing delirium in acute stroke patients necessitates an intensive and multiprofessional therapeutic approach, placing a significant burden on healthcare staff. However, dedicated practical recommendations for delirium management developed for the population of acute stroke patients are lacking. For this purpose, the Austrian Stroke Society, in cooperation with the Austrian Society of Neurology, the Austrian Society of Neurorehabilitation, and the Austrian Society of Psychiatry, Psychotherapy, and Psychosomatics has formulated an evidence-based position paper addressing the management of delirium in acute stroke patients. The paper outlines practical recommendations on the three pillars of care in stroke patients with delirium: (a) Key aspects of delirium prevention including stroke-specific delirium risk factors and delirium prediction scores are described. Moreover, a non-pharmacological delirium prevention bundle is presented. (b) The paper provides recommendations on timing and frequency of delirium screening to ensure early diagnosis of delirium in acute stroke patients. Moreover, it reports on the use of different delirium screening tools in stroke populations. (c) An overview of non-pharmacological and pharmacological treatment strategies in patients with delirium and acute stroke is presented and summarized as key recommendation statements. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Sequential treatment of paper and pulp industrial wastewater: Prediction of water quality parameters by Mamdani Fuzzy Logic model and phytotoxicity assessment.
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Mazhar, Sadat, Ditta, Allah, Bulgariu, Laura, Ahmad, Iftikhar, Ahmed, Munir, and Nadiri, Ata Allah
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SEWAGE , *PAPER pulp , *FUZZY logic , *WATER quality , *THERAPEUTICS , *WASTEWATER treatment - Abstract
Recycling of industrial wastewater meeting quality standards for agricultural and industrial demands is a viable option. In this study, paper and pulp industrial wastewater were treated with three biological treatments viz. aerobic, anaerobic and sequential (i.e. 20 days of anaerobic followed by 20 days of aerobic cycle), associated with simulation modeling by Mamdani Fuzzy Logic (MFL) model of some selected parameters. Electric air diffuser and minimal salt medium in sealed plastic bottles at control temperature were used for aerobic and anaerobic treatments, respectively. The significant reduction in chemical (COD: 81%) and biological oxygen demand (BOD: 71%), total suspended (TSS: 65%), dissolved solids (TDS: 60%) and turbidity (68%) was recorded during sequential treatment. The treated water was irrigated to determine its phytotoxic effects on seed germination, vigor and seedling growth of mustard (Brassica campestris). Sequential treatment greatly reduced phytotoxicity of wastewater and showed the highest germination percentage (90%) compared to aerobic (60%), anaerobic (70%) treatments and untreated wastewater (30%). Regression analysis also endorsed these findings (R2 = 0.76–0.95 between seed germination, seedling growth and vigor). MFL technique was adopted to simulate sequential treatment process. The results support higher performance of MFL model to predict TDS, TSS, COD, and BOD based on the physico-chemical water quality parameters of raw wastewater, time of treatment and treatment type variation. Based on these findings, we conclude that the sequential treatment could be a more effective strategy for treatment of pulp and paper industrial wastewater with efficiency to be used for agricultural industry without toxic effects. Image 10 • Pulp and paper wastewater was subjected to aerobic, anaerobic and sequential treatment. • Sequential treatment significantly reduced COD, BOD, TSS, TDS and turbidity. • Mamdani Fuzzy Logic technique was adopted to simulate sequential treatment process. • Sequentially treated wastewater improved seed germination, seedling growth and vigor index. • Sequential treatment is more efficient as compared to sole aerobic and anaerobic treatment. [ABSTRACT FROM AUTHOR]
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- 2019
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7. Feedback-guided exercises performed on a tablet touchscreen improve return to work, function, strength and healthcare usage more than an exercise program prescribed on paper for people with wrist, hand or finger injuries: a randomised trial.
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Blanquero, Jesús, Cortés-Vega, María-Dolores, Rodríguez-Sánchez-Laulhé, Pablo, Corrales-Serra, Berta-Pilar, Gómez-Patricio, Elena, Díaz-Matas, Noemi, and Suero-Pineda, Alejandro
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COMPARATIVE studies ,COMPUTER input-output equipment ,CONFIDENCE intervals ,EMPLOYEES ,EMPLOYMENT reentry ,EXERCISE therapy ,FINGER injuries ,BONE fractures ,HAND injuries ,HOME care services ,WORK-related injuries ,LIFE skills ,MEDICAL care ,MUSCLE strength ,PORTABLE computers ,QUESTIONNAIRES ,REHABILITATION ,RESEARCH funding ,STATISTICAL sampling ,SELF-evaluation ,SOFT tissue injuries ,TELEMEDICINE ,THERAPEUTICS ,WRIST injuries ,RANDOMIZED controlled trials ,TREATMENT effectiveness ,MOBILE apps ,DATA analysis software ,DESCRIPTIVE statistics - Abstract
In people with bone and soft tissue injuries of the wrist, hand and/or fingers, do feedback-guided exercises performed on a tablet touchscreen hasten return to work, reduce healthcare usage and improve clinical recovery more than a home exercise program prescribed on paper? Randomised, parallel-group trial with concealed allocation, assessor blinding and intention-to-treat analysis. Seventy-four workers with limited functional ability due to bone and soft tissue injuries of the wrist, hand and/or fingers. Participants in the experimental and control groups received the same in-patient physiotherapy and occupational therapy. Participants in the experimental group received a home exercise program using the ReHand tablet application, which guides exercises performed on a tablet touchscreen with feedback, monitoring and progression. Participants in the control group were prescribed an evidence-based home exercise program on paper. The primary outcome was the time taken to return to work. Secondary outcomes included: healthcare usage (number of clinical appointments); and functional ability, pain intensity, and grip and pinch strength 2 and 4 weeks after randomisation. Compared with the control group, the experimental group: returned to work sooner (MD –18 days, 95% CI –33 to –3); required fewer physiotherapy sessions (MD –7.4, 95% CI –13.1 to –1.6), rehabilitation consultations (MD –1.9, 95% CI –3.6 to 0.3) and plastic surgery consultations (MD –3.6, 95% CI –6.3 to –0.9); and had better short-term recovery of functional ability and pinch strength. In people with bone and soft-tissue injuries of the wrist, hand and/or fingers, prescribing a feedback-guided home exercise program using a tablet-based application instead of a conventional program on paper hastened return to work and improved the short-term recovery of functional ability and pinch strength, while reducing the number of required healthcare appointments. ACTRN12619000344190 [ABSTRACT FROM AUTHOR]
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- 2020
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8. Management of patients with monkeypox virus infection and contacts in the community and in healthcare settings: a French position paper.
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Lepelletier, Didier, Pozzetto, Bruno, Chauvin, Franck, and Chidiac, Christian
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MONKEYPOX , *VIRUS diseases , *COMMUNITIES , *MEDICAL personnel , *SCIENTIFIC literature , *PLANT viruses - Abstract
Since April 2022, a large number of monkeypox (MPX) cases have emerged across the globe in regions that are known to be totally free of zoonotic reservoir. The High Council for Public Health is a national institute commissioned to provide guidelines to the French Ministry of Health. The objective of these guidelines and recommendations is to inform the public, people at risk of severe MPX infection, infected patients and their families and contacts and healthcare workers in charge of infected patients. A review of the literature from the MEDLINE database was carried out using the single keyword 'monkeypox', including recent and older articles from January 2000 to June 2022. There was no filter for the type of study, except English language. The titles and summaries of all the articles were read by the experts to select articles of interest. The High Council for Public Health brought together specialists with expertise in the field to analyse the scientific literature and international recommendations. Recommendations were classified with clinical practice methodology using four levels (strong recommendation, recommendation, optional recommendation and no recommendation) without grading the level of evidence. To develop and methodologically validate the recommendations, the Appraisal of Guidelines for Research and Evaluation Instrument (AGREE-II)chart was partially used. (a) What are the therapeutic management measures for hospitalized patients with severe forms of MPX infection, and what are the preventive measures to protect healthcare professionals? (b) What are the isolation and prevention measures in the community for patients with mild or moderate severity MPX infection? (c) what are the preventive measures for contacts of an MPX-infected person? (d) Who should be vaccinated? (e) What are the specific prevention measures for children and schools? [ABSTRACT FROM AUTHOR]
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- 2022
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9. European Position Paper on Rhinosinusitis and Nasal Polyps 2020
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Fokkens, Wytske, Lund, Valerie, Hopkins, Claire, Hellings, Peter, Kern, Robert, Reitsma, Sietze, Toppila- Salmi, Sanna, Bernal-Sprekelsen, Manuel, Mullol, Joaquim, Alobid, Isam, Anselmo- Lima, Wilma Terezinha, Bachert, Claus, Baroody, Fuad, von Buchwald, Christian, Cervin, Anders, Cohen, Noam, Constantinidis, Jannis, De Gabory, Ludovic, Desrosiers, Martin, Diamant, Zuzana, Douglas, Richard, Gevaert, Philippe, Hafner, Anita, Harvey, Richard, Joos, Guy, Kalogjera, Livije, Knill, Andrew, Kocks, Janwillem, Landis, Basile, Limpens, Jacqueline, Lebeer, Sarah, Lourenco, Olga, Matricardi, Paolo, Meco, Cem, O’Mahony, Liam, Philpott, Carl, Ryan, Dermot, Schlosser, Rodney, Senior, Brent, Smith, Timothy, Teeling, Thijs, Tomazic, Peter Valentin, Wang, De Yun, Wang, Dehui, Zhang, Luo, Agius, Adrian, Ahlström-Emanuelsson, Cecilia, Alabri, Rashid, Albu, Silviu, Alhabash, Saied, Aleksic, Aleksandra, Aloulah, Mohammad, Al- Qudah, Mohannad, Alsaleh, Saad, Baban, Muaid Aziz, Baudoin, Tomislav, Balvers, Tijmen, Battaglia, Paolo, Bedoya, Juan David, Beule, Achim, Bofares, Khaled, Braverman, Itzhak, Brozek-Madry, Eliza, Byaruhanga, Richard, Callejas, Claudio, Carrie, Sean, Caulley, Lisa, Chussi, Desderius, de Corso, Eugenio, Coste, Andre, El Hadi, Usama, Elfarouk, Ahmed, Eloy, Philippe, Farrokhi, Shokrollah, Felisati, Giovanni, Ferrari, Michel, Fishchuk, Roman, Grayson, Jessica, Goncalves, Paulo, Grdinic, Boris, Grgic, Velimir, Hamizan, Aneeza, Heinichen, Julio, Husain, Salina, Ing Ping, Tang, Ivaska, Justinas, Jakimovska, Frodita, Jovancevic, Ljiljana, Kakande, Emily, Kamel, Reda, Karpischenko, Sergei, Kariyawasam, Harsha, Kawauchi, Hideyuki, Kjeldsen, Anette, Klimek, Ludger, Krzeski, Antoni, Kopacheva Barsova, Gabriela, Wam Kim, Sung, Lal, Devyani, Letort, José, Lopatin, Andrey, Mahdjoubi, Abdelhak, Mesbahi, Alireza, Netkovski, Jane, Nyenbue Tshipukane, Dieudonné, Obando-Valverde, Andrés, Okano, Mitsuhiro, Onerci111, Metin, Ong, Yew Kwang, Orlandi, Richard, Otori, Nobuyoshi, Ouennoughy, Kheir, Ozkan, Muge, Peric, Aleksandar, Plzak, Jan, Prokopakis, Emmanuel, Prepageran, Nerayanan, Psaltis, Alkis, Pugin, Benoit, Raftopulos, Marco, Rombaux, Philippe, Riechelmann, Herbert, Sahtout, Semia, Sarafoleanu, Caius-Codrut, Searyoh, Kafui, Rhee, Chae-Seo, Shi, Jianbo, Shkoukani, Mahdi, Shukuryan, Arthur, Sicak, Marian, Smyth, David, Snidvongs, Kornkiat, Soklic Kosak, Tanja, Stjärne, Pär, Sutikno, Budi, Steinsvåg, Sverre, Tantilipikorn, Pongsakorn, Thanaviratananich, Sanguansak, Tran, Thuy, Urbancic, Jure, Valiulis, Arunas, Vasquez de Aparicio, Carolina, Vicheva, Dilyana, Virkkula, Paula, Vicente, Gil, Voegels, Richard, Wagenmann, Martin, Wardani, Retno, Welge-Lussen, Antje, Witterick, Ian, Wright, Erin, Zabolotniy, Dmytro, Zsolt, Bella, Zwetsloot, Casper, HUS Inflammation Center, Department of Dermatology, Allergology and Venereology, University of Helsinki, Korva-, nenä- ja kurkkutautien klinikka, HUS Head and Neck Center, uBibliorum, Faculteit Medische Wetenschappen/UMCG, Fokkens, Wytske J., UCL - (MGD) Service d'oto-rhino-laryngologie, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service d'oto-rhino-laryngologie, Ear, Nose and Throat, and AII - Inflammatory diseases
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Adult ,medicine.medical_specialty ,Evidence-based practice ,Rhinosinusitis ,MEDLINE ,Therapeutics ,PLACEBO-CONTROLLED TRIAL ,03 medical and health sciences ,0302 clinical medicine ,Nasal Polyps ,QUALITY-OF-LIFE ,Diagnosis ,paranasal sinus diseases ,nasal polyps ,therapeutics ,diagnosis ,asthma ,prevention ,control ,Paranasal Sinus Diseases ,Humans ,Medicine ,Nasal polyps ,ENDOSCOPIC-SINUS-SURGERY ,3125 Otorhinolaryngology, ophthalmology ,Sinusitis ,Prevention and Control ,Child ,030223 otorhinolaryngology ,Intensive care medicine ,UPPER RESPIRATORY-TRACT ,TERM-FOLLOW-UP ,Rhinitis ,Science & Technology ,business.industry ,General Medicine ,Guideline ,Evidence-based medicine ,RANDOMIZED CONTROLLED-TRIAL ,medicine.disease ,ACUTE MAXILLARY SINUSITIS ,Asthma ,3. Good health ,Integrated care ,CHURG-STRAUSS-SYNDROME ,Otorhinolaryngology ,Acute Disease ,Chronic Disease ,Position paper ,PRIMARY CILIARY DYSKINESIA ,Human medicine ,business ,ALLERGIC FUNGAL RHINOSINUSITIS ,Life Sciences & Biomedicine - Abstract
The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the update of similar evidence based position papers published in 2005 and 2007 and 2012. The core objective of the EPOS2020 guideline is to provide revised, up-to-date and clear evidence-based recommendations and integrated care pathways in ARS and CRS. EPOS2020 provides an update on the literature published and studies undertaken in the eight years since the EPOS2012 position paper was published and addresses areas not extensively covered in EPOS2012 such as paediatric CRS and sinus surgery. EPOS2020 also involves new stakeholders, including pharmacists and patients, and addresses new target users who have become more involved in the management and treatment of rhinosinusitis since the publication of the last EPOS document, including pharmacists, nurses, specialised care givers and indeed patients themselves, who employ increasing self-management of their condition using over the counter treatments. The document provides suggestions for future research in this area and offers updated guidance for definitions and outcome measurements in research in different settings. EPOS2020 contains chapters on definitions and classification where we have defined a large number of terms and indicated preferred terms. A new classification of CRS into primary and secondary CRS and further division into localized and diffuse disease, based on anatomic distribution is proposed. There are extensive chapters on epidemiology and predisposing factors, inflammatory mechanisms, (differential) diagnosis of facial pain, allergic rhinitis, genetics, cystic fibrosis, aspirin exacerbated respiratory disease, immunodeficiencies, allergic fungal rhinosinusitis and the relationship between upper and lower airways. The chapters on paediatric acute and chronic rhinosinusitis are totally rewritten. All available evidence for the management of acute rhinosinusitis and chronic rhinosinusitis with or without nasal polyps in adults and children is systematically reviewed and integrated care pathways based on the evidence are proposed. Despite considerable increases in the amount of quality publications in recent years, a large number of practical clinical questions remain. It was agreed that the best way to address these was to conduct a Delphi exercise . The results have been integrated into the respective sections. Last but not least, advice for patients and pharmacists and a new list of research needs are included. The full document can be downloaded for free on the website of this journal: http://www.rhinologyjournal.com. ispartof: RHINOLOGY vol:58 issue:Suppl S29 pages:I-+ ispartof: location:Netherlands status: published
- Published
- 2020
10. COVID-19 living paper: overview of information available to support the development of medical countermeasures and interventions against COVID-19
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Martine DENIS, Valerie VANDEWEERD, Rein VERBEEKE, and Diane VAN DER VLIET
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SARS-CoV-2 ,public health ,review ,therapeutics ,diagnostics ,COVID-19 ,epidemiology ,vaccines ,living paper ,clinical ,animal models - Abstract
The living paper on the new coronavirus disease (COVID-19) provides a structured compilation of scientific data about the virus, the disease and its control.Its objective is to help scientists identify the most relevant publications on COVID-19 in the mass of information that appears every day. It is also expected to foster a global understanding of disease control and stimulate transdisciplinary initiatives. This living paper is updated on a weekly basis. It is an initiative of the journal Transciplinary Insights.
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- 2020
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11. Effectiveness, safety, and acceptance of silver diamine fluoride therapy and its implications for dental hygiene practice: Position paper and statement from the Canadian Dental Hygienists Association.
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Farmer, Julie W., Singhal, Sonica, Dempster, Laura, and Quiñonez, Carlos
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CAVITY prevention ,TREATMENT of dental caries ,TOOTH sensitivity ,FLUORIDE varnishes ,CINAHL database ,DENTAL hygiene ,PATIENT aftercare ,INFORMATION storage & retrieval systems ,MEDICAL databases ,MEDICAL information storage & retrieval systems ,SERVICES for caregivers ,MEDLINE ,QUALITY assurance ,SYSTEMATIC reviews ,LITERATURE reviews ,PARENT attitudes ,PREVENTION ,SOCIETIES ,THERAPEUTICS - Abstract
Copyright of Canadian Journal of Dental Hygiene is the property of Canadian Dental Hygienists Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
12. Machine learning methods for prediction of cancer driver genes: a survey paper.
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Andrades, Renan and Recamonde-Mendoza, Mariana
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CANCER genes , *SOMATIC mutation , *DEEP learning , *GENETIC mutation , *MACHINE learning , *THERAPEUTICS , *DIAGNOSIS , *SCIENTIFIC community - Abstract
Identifying the genes and mutations that drive the emergence of tumors is a critical step to improving our understanding of cancer and identifying new directions for disease diagnosis and treatment. Despite the large volume of genomics data, the precise detection of driver mutations and their carrying genes, known as cancer driver genes, from the millions of possible somatic mutations remains a challenge. Computational methods play an increasingly important role in discovering genomic patterns associated with cancer drivers and developing predictive models to identify these elements. Machine learning (ML), including deep learning, has been the engine behind many of these efforts and provides excellent opportunities for tackling remaining gaps in the field. Thus, this survey aims to perform a comprehensive analysis of ML-based computational approaches to identify cancer driver mutations and genes, providing an integrated, panoramic view of the broad data and algorithmic landscape within this scientific problem. We discuss how the interactions among data types and ML algorithms have been explored in previous solutions and outline current analytical limitations that deserve further attention from the scientific community. We hope that by helping readers become more familiar with significant developments in the field brought by ML, we may inspire new researchers to address open problems and advance our knowledge towards cancer driver discovery. [ABSTRACT FROM AUTHOR]
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- 2022
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13. Therapeutic oral rinsing with commercially available products: Position paper and statement from the Canadian Dental Hygienists Association.
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Asadoorian, Joanna
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GINGIVAL hyperplasia ,MOUTHWASHES ,BIOFILMS ,CINAHL database ,DECISION making ,INFORMATION storage & retrieval systems ,MEDICAL databases ,MANAGEMENT ,MEDLINE ,ONLINE information services ,TOOTH care & hygiene ,SYSTEMATIC reviews ,DENTAL associations ,PREVENTION ,THERAPEUTICS - Abstract
Copyright of Canadian Journal of Dental Hygiene is the property of Canadian Dental Hygienists Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2016
14. Ligand fishing with cellular membrane-coated cellulose filter paper: a new method for screening of potential active compounds from natural products.
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Xu, Liang, Tang, Cheng, Li, Xin, Li, Xiaofan, Yang, Huiping, Mao, Ruizhi, He, Jiahui, Li, Wanqing, Liu, Jiyang, Li, Yalong, Shi, Shuobo, Xiao, Xuefeng, and Wang, Xianhua
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NATURAL products , *PHARMACOLOGY , *METABOLITES , *CHINESE medicine , *THERAPEUTICS - Abstract
Ligand fishing is a widely used approach for screening active compounds from natural products. Recently, cell membrane (CM) as affinity ligand has been applied in ligand fishing, including cell membrane chromatography (CMC) and CM-coated magnetic bead. However, these methods possess many weaknesses, including complicated preparation processes and time-consuming operation. In this study, cheap and easily available cellulose filter paper (CFP) was selected as carrier of CM and used to fabricate a novel CM-coated CFP (CMCFP) for the first time. The type of CFP was optimized according to the amount of immobilized protein, and the immobilization of CM onto CFP by the insertion and self-fusion process was verified by confocal imaging. The CMCFP exhibited good selectivity and stability and was used for fishing potentially active compounds from extracts of Angelica dahurica. Three potentially active compounds, including bergapten, pabulenol, and imperatorin, were fished out and identified. The traditional Chinese medicine systems pharmacology database and analysis platform was used to build an active compound-target protein network, and accordingly, the gamma-aminobutyric acid receptor subunit alpha-1 (GABRA1) was deduced as potential target of CM for the active compounds of Angelica dahurica. Molecular docking was performed to evaluate the interaction between active compounds and GABRA1, and bergapten was speculated as a new potentially active compound. Compared with other methods, the fishing assay based on CMCFP was more effective, simpler, and cheaper. [ABSTRACT FROM AUTHOR]
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- 2019
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15. Computer-Based Cognitive Training vs. Paper-and-Pencil Training for Language and Cognitive Deficits in Greek Patients with Mild Alzheimer's Disease: A Preliminary Study.
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Georgopoulou, Eleni-Nefeli, Nousia, Anastasia, Siokas, Vasileios, Martzoukou, Maria, Zoupa, Elli, Messinis, Lambros, Dardiotis, Efthimios, and Nasios, Grigorios
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COGNITION disorders treatment ,TREATMENT of language disorders ,THERAPEUTICS ,COMPUTERS in medicine ,ALZHEIMER'S disease ,MANN Whitney U Test ,T-test (Statistics) ,DESCRIPTIVE statistics ,ANALYSIS of covariance ,CHI-squared test ,DATA analysis software ,COGNITIVE therapy ,DISEASE complications - Abstract
The purpose of the present study was to explore whether Computer-Based Cognitive Training (C-BCT) versus Paper-Pencil Cognitive Training (P-PCT) is more beneficial in improving cognitive and language deficits in Greek patients living with Alzheimer's disease (pwAD). Twenty pwAD were assigned to two groups: (a) the C-BCT group, receiving a computer-based cognitive training program using the RehaCom software, and (b) the P-PCT group, which received cognitive training using paper and pencil. The cognitive training programs lasted 15 weeks and were administered twice a week for approximately one hour per session. The analyses of each group's baseline versus endpoint performance demonstrated that the P-PCT group improved on delayed memory, verbal fluency, attention, processing speed, executive function, general cognitive ability, and activities of daily living. In contrast, the C-BCT group improved on memory (delayed and working), naming, and processing speed. Comparisons between the two groups (C-BCT vs. P-PCT) revealed that both methods had significant effects on patients' cognition, with the P-PCT method transferring the primary cognitive benefits to real-life activities. Our findings indicate that both methods are beneficial in attenuating cognitive and language deficits in pwAD. The need for large-scale neurobehavioral interventions to further clarify this issue, however, remains a priority. [ABSTRACT FROM AUTHOR]
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- 2023
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16. Review of Canine Lymphoma Treated with Chemotherapy—Outcomes and Prognostic Factors.
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Bennett, Peter, Williamson, Peter, and Taylor, Rosanne
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PROGNOSIS ,LEUCOCYTES ,LYMPHOMAS ,CANCER chemotherapy ,DOG walking ,THERAPEUTICS ,RITUXIMAB - Abstract
Simple Summary: Canine lymphoma is a common cancer of one of the white blood cells that is commonly treated with chemotherapy. Many papers have been published about this disease and treatment, but few comprehensive reviews of the outcomes reported after chemotherapy, and the prognostic factors that influence the outcomes, have been published. Knowledge of the potential outcomes for this disease is important for veterinarians as they guide dog owners in the decision making about treatment options. This review evaluated the papers published on this topic and found that there is a wide variation in outcomes reported, as well as the factors that influence the outlook. Additionally, while individual papers have shown a much better survival, over the last 40 years, the overall improvement in outcome has been modest at best. The use of uniform reporting in the studies is needed, and novel approaches are likely needed to significantly improve the outlook for dogs with this disease. While canine lymphoma is a relatively common and important disease seen by veterinarians, there are limited comprehensive reviews of the literature regarding the remission and survival times following chemotherapy, and the associated prognostic factors. This comprehensive thematic review covers the available veterinary literature covering treatment outcomes and identified prognostic factors. A lack of standardised approaches to evaluate and report the outcomes was identified, including factors that would alter the duration of responses by weeks, or occasionally months. After publication of the suggested reporting criteria, this has improved but is still not uniformly applied. The prognostic factors included for evaluation varied from as few as three to seventeen, with over 50 studies using only univariate analysis. Individual papers reported much longer outcomes than others, but assessing the outcomes overall, there has been minimal change over the last 40 years. This supports the belief that novel approaches for lymphoma therapy will be required to substantively improve outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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17. Reports on Obstetrics and Gynecology Findings from Department of Obstetrics and Prenatal Medicine Provide New Insights [Position Paper of the Task Force for Obstetrics and Prenatal Medicine (AGG - Section Preterm Birth) on the Placement, Removal ...]
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Premature infants -- Care and treatment -- Reports -- Research ,Obstetrics -- Reports -- Research ,Women's health -- Reports -- Research ,Pregnant women -- Care and treatment -- Reports -- Research ,Therapeutics ,Editors ,Women ,Health ,Women's issues/gender studies - Abstract
2020 JAN 9 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- New research on Women's Health - Obstetrics and Gynecology is the subject of a [...]
- Published
- 2020
18. Posicionamento da Academia Brasileira de Rinologia sobre terapias tópicas nasais Brazilian Academy of Rhinology position paper on topical intranasal therapy
- Author
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João Ferreira de Mello Júnior, Olavo de Godoy Mion, Nilvano Alves de Andrade, Wilma Terezinha Anselmo-Lima, Aldo Eden Cassol Stamm, Washingthon Luiz de Cerqueira Almeida, Pedro Oliveira Cavalcante Filho, Jair de Carvalho e Castro, Francini Grecco de Melo Padua, Fabrizio Ricci Romano, Rodrigo de Paulo Santos, Renato Roitmann, Richard Louis Voegels, Roberto Campos Meirelles, Leonardo Conrado Barbosa Sá, Moacyr Tabasnik Moacyr, Marco Cesar Jorge dos Santos, and Roberto Eustáquio Santos Guimarães
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cavidade nasal ,esquema de medicação ,nariz ,terapêutica ,medication systems ,nasal cavity ,nose ,therapeutics ,Otorhinolaryngology ,RF1-547 - Abstract
Opresente documento tem por objetivo esclarecer àqueles que tratam das doenças nasossinusais, tanto especialistas quanto generalistas, sobre as terapêuticas tópicas nasais. Por meio de uma revisão das evidências científicas, a Academia Brasileira de Rinologia vem proporcionar sua visão prática e atualizada sobre as medicações tópicas nasais mais utilizadas, excetuando-se as medicações que possuam antibióticos tópicos na sua formulação.This documents aims at educating those who treat sinonasal diseases - both general practitioners and specialists - about topical nasal treatments. By means of scientific evidence reviews, the Brazilian Academy of Rhinology provides its practical and updated guidelines on the most utilized topical nasal medication, except for the drugs that have topical antibiotics in their formulas.
- Published
- 2013
19. Medical procedures in children using a conceptual framework that keeps a focus on human dimensions of care – a discussion paper.
- Author
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Karlsson, Katarina, Galvin, Kathleen, and Darcy, Laura
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CONCEPTUAL structures , *HUMANISM , *INTERVIEWING , *MEDICAL care , *RESEARCH funding , *THERAPEUTICS , *DEHUMANIZATION - Abstract
Purpose: Children's perspectives in the context of health service delivery have historically been seen as unimportant. They have been viewed as unintelligent, unable to effectively share or tell of their experiences or fully participate in their care, potentially resulting in a sense of dehumanisation. Method: The present paper illustrates children's experiences when undergoing medical procedures, using application of the eight dimensions of humanised care theoretical framework. Results: Findings from six published papers were reflectively interrogated to identify implicit findings related to the dimensions of humanised care. These implicit findings show ways of caring for childrenwhichcan lead to enhanced human sensitivity in care or conversely where the dimensions of being human are obscured to greater or lesser degrees and can result in forms of dehumanisation. Conclusions: Inadvertent dehumanising features of practice can be mediated by encouraging the inclusion of children's own lifeworld perspective and make room for their voices in both care and research. In this way the present well documented power imbalance could be addressed. Adding the value of the theoretical framework highlights areas of need for young children to be cared for as human beings. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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20. Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology.
- Author
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Ketelhuth, Daniel F J, Lutgens, Esther, Bäck, Magnus, Binder, Christoph J, Bossche, Jan Van den, Daniel, Carolin, Dumitriu, Ingrid E, Hoefer, Imo, Libby, Peter, O'Neill, Luke, Weber, Christian, and Evans, Paul C
- Subjects
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BIOLOGY , *ATHEROSCLEROSIS , *PAPER arts , *TEAMS in the workplace , *THERAPEUTICS - Abstract
Inflammation is an important driver of atherosclerosis, and the favourable outcomes of the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial revealed the large potential of anti-inflammatory drugs for the treatment of cardiovascular disease, especially in patients with a pro-inflammatory constitution. However, the complex immune reactions driving inflammation in the vascular wall in response to an atherosclerotic microenvironment are still being unravelled. Novel insights into the cellular processes driving immunity and inflammation revealed that alterations in intracellular metabolic pathways are strong drivers of survival, growth, and function of immune cells. Therefore, this position paper presents a brief overview of the recent developments in the immunometabolism field, focusing on its role in atherosclerosis. We will also highlight the potential impact of immunometabolic markers and targets in clinical cardiovascular medicine. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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21. New Findings from Southwest University in the Area of Cancer Reported (Spontaneous Formation of Tumor Spheroid On a Hydrophilic Filter Paper for Cancer Stem Cell Enrichment)
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Cancer ,Stem cell research -- Research ,Stem cells -- Research ,Cancer research ,Tumors ,Engineering research ,Recurrence (Disease) ,Cancer metastasis ,Therapeutics ,Editors ,Health - Abstract
2019 APR 8 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- Current study results on Cancer have been published. According to news reporting originating in [...]
- Published
- 2019
22. Study of Adsorption and Desorption Performances of Zr-Based Metal-Organic Frameworks Using Paper Spray Mass Spectrometry.
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Xiaoting Wang, Ying Chen, Yajun Zheng, and Zhiping Zhang
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ADSORPTION (Chemistry) , *DESORPTION , *METAL-organic frameworks , *VERAPAMIL , *MASS spectrometry methodology , *THERAPEUTICS - Abstract
The dynamic pore systems and high surface areas of flexible metal-organic framework materials make them excellent candidates to be used in different kinds of adsorption processes. However, the adsorption and desorption behaviors of therapeutic drugs on metal-organic frameworks in solution are not fully developed. Here, we systematically investigated the adsorption and desorption behaviors of a typical therapeutic drug, verapamil, over several Zr-based metal-organic frameworks [e.g., Zr-FUM, UiO-66(Zr), UiO-66(Zr)-NH2 and UiO-66(Zr)-2COOH] as well as ZrO2 in an acetonitrile solution by using paper spray mass spectrometry. In contrast to other materials, UiO-66(Zr)-2COOH demonstrated a superior adsorption performance to verapamil due to their strong acid-base and/or hydrogen-bond interactions, and the adsorption process fitted well with the pseudo-second-order kinetic model. As verapamil-adsorbed materials were used for desorption experiments, ZrO2 demonstrated the most favorable desorption performance, whereas UiO-66(Zr)-2COOH yielded the poorest desorption capability. These Zr-based materials had also been coated at the surface with filter papers for the analysis of various drugs and proteins in the process of paper spray mass spectrometry. The results demonstrated that among the studied materials, ZrO2-coated paper gave the most favorable desorption performance as a pure drug solution, whereas the paper from UiO-66(Zr) demonstrated the optimal capability in the analyses of therapeutic drugs in a complex matrix (e.g., blood) and a protein (e.g., myoglobin). [ABSTRACT FROM AUTHOR]
- Published
- 2017
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23. Consensus statements on ablative radiotherapy for oligometastatic prostate cancer: A position paper of Italian Association of Radiotherapy and Clinical Oncology (AIRO).
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D'Angelillo, Rolando M., Francolini, Giulio, Ingrosso, Gianluca, Ravo, Vincenzo, Triggiani, Luca, Magli, Alessandro, Mazzeo, Ercole, Arcangeli, Stefano, Alongi, Filippo, Jereczek-Fossa, Barbara A., Pergolizzi, Stefano, Pappagallo, Giovanni L., and Magrini, Stefano M.
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CASTRATION-resistant prostate cancer , *PROSTATE cancer , *RADIOTHERAPY , *PROSTATE cancer treatment , *THERAPEUTICS , *DIAGNOSIS - Abstract
• Ablative radiotherapy is an effective treatment for oligometastatic prostate cancer. • The lack of randomized phase III trials hampers the generalization of this therapy. • In clinical practice, ablative radiotherapy should be adopted in some cases only. • This position paper explores available literature and proposes some recommendations. Oligometastatic prostate cancer comprises a wide spectrum of conditions, ranging from de novo oligometastatic cancer at diagnosis to oligometastatic castration-resistant disease, which are distinct entities in terms of biology and prognosis. In order to clarify and standardize the clinical role of ablative radiotherapy in oligometastatic prostate cancer, the Italian Association of Radiotherapy and Clinical Oncology (AIRO) formed an expert panel to review the current literature and develop a formal consensus. Oligometastatic prostate cancer was defined as the presence of up to three metastatic lesions involving bones or nodes outside pelvis. Thereafter, four clinical scenarios were explored: metastatic castration-sensitive disease at diagnosis and after primary treatment, and metastatic castration-resistant disease at diagnosis and during treatment, where the role of ablative radiotherapy was defined either in conjunction with systemic therapy or as the only treatment in selected cases. This paper summarizes the current literature about these issues and the proposed recommendations. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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24. Management of patients with multiple myeloma in the era of COVID-19 pandemic: a consensus paper from the European Myeloma Network (EMN)
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Evangelos Terpos, Monika Engelhardt, Gordon Cook, Francesca Gay, Maria-Victoria Mateos, Ioannis Ntanasis-Stathopoulos, Niels W. C. J. van de Donk, Hervé Avet-Loiseau, Roman Hajek, Annette Juul Vangsted, Heinz Ludwig, Sonja Zweegman, Philippe Moreau, Hermann Einsele, Mario Boccadoro, Jesus San Miguel, Meletios A. Dimopoulos, Pieter Sonneveld, Terpos, Evangelos [0000-0001-5133-1422], Mateos, Maria Victoria [0000-0003-2390-1218], Ntanasis-Stathopoulos, Ioannis [0000-0002-6328-9783], Vangsted, Annette Juul [0000-0002-2131-731X], Ludwig, Heinz [0000-0002-3302-8726], Hematology, Terpos, Evangelos, Mateos, Maria Victoria, Ntanasis-Stathopoulos, Ioannis, Vangsted, Annette Juul, and Ludwig, Heinz
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Cancer Research ,medicine.medical_treatment ,Pneumonia, Viral ,Myeloma ,Review Article ,Therapeutics ,Time-to-Treatment ,Betacoronavirus ,03 medical and health sciences ,0302 clinical medicine ,Personal hygiene ,medicine ,Humans ,Viral ,Intensive care medicine ,Pandemics ,Multiple myeloma ,Polypharmacy ,Infection Control ,SARS-CoV-2 ,business.industry ,Bortezomib ,COVID-19 ,Coronavirus Infections ,Disease Management ,Europe ,Multiple Myeloma ,Practice Guidelines as Topic ,Telemedicine ,Daratumumab ,Pneumonia ,Hematology ,medicine.disease ,Clinical trial ,Transplantation ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Infectious diseases ,business ,Watchful waiting ,medicine.drug - Abstract
Patients with multiple myeloma (MM) seem to be at increased risk for more severe COVID-19 infection and associated complications due to their immunocompromised state, the older age and comorbidities. The European Myeloma Network has provided an expert consensus statement in order to guide therapeutic decisions in the era of the COVID-19 pandemic. Patient education for personal hygiene and social distancing measures, along with treatment individualization, telemedicine and continuous surveillance for early diagnosis of COVID-19 are essential. In countries or local communities where COVID-19 infection is widely spread, MM patients should have a PCR test of nasopharyngeal swab for SARS-CoV-2 before hospital admission, starting a new treatment line, cell apheresis or ASCT in order to avoid ward or community spread and infections. Oral agent-based regimens should be considered, especially for the elderly and frail patients with standard risk disease, whereas de-intensified regimens for dexamethasone, bortezomib, carfilzomib and daratumumab should be used based on patient risk and response. Treatment initiation should not be postponed for patients with end organ damage, myeloma emergencies and aggressive relapses. Autologous (and especially allogeneic) transplantation should be delayed and extended induction should be administered, especially in standard risk patients and those with adequate MM response to induction. Watchful waiting should be considered for standard risk relapsed patients with low tumor burden, and slow biochemical relapses. The conduction of clinical trials should continue with appropriate adaptations to the current circumstances. Patients with MM and symptomatic COVID-19 disease should interrupt anti-myeloma treatment until recovery. For patients with positive PCR test for SARS-CoV-2, but with no symptoms for COVID-19, a 14-day quarantine should be considered if myeloma-related events allow the delay of treatment. The need for surveillance for drug interactions due to polypharmacy is highlighted. The participation in international COVID-19 cancer registries is greatly encouraged.
- Published
- 2020
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25. Applicability of bacterial cellulose as an alternative to paper points in endodontic treatment.
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Yoshino, Aya, Tabuchi, Mari, Uo, Motohiro, Tatsumi, Hiroto, Hideshima, Katsumi, Kondo, Seiji, and Sekine, Joji
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CELLULOSE ,ENDODONTICS ,ROOT canal treatment ,TREATMENT of dental caries ,BIOCOMPATIBILITY ,DENTAL pulp diseases ,THERAPEUTICS - Abstract
Abstract: Dental root canal treatment is required when dental caries progress to infection of the dental pulp. A major goal of this treatment is to provide complete decontamination of the dental root canal system. However, the morphology of dental root canal systems is complex, and many human dental roots have inaccessible areas. In addition, dental reinfection is fairly common. In conventional treatment, a cotton pellet and paper point made from plant cellulose is used to dry and sterilize the dental root canal. Such sterilization requires a treatment material with high absorbency to remove any residue, the ability to improve the efficacy of intracanal medication and high biocompatibility. Bacterial cellulose (BC) is produced by certain strains of bacteria. In this study, we developed BC in a pointed form and evaluated its applicability as a novel material for dental canal treatment with regard to solution absorption, expansion, tensile strength, drug release and biocompatibility. We found that BC has excellent material and biological characteristics compared with conventional materials, such as paper points (plant cellulose). BC showed noticeably higher absorption and expansion than paper points, and maintained a high tensile strength even when wet. The cumulative release of a model drug was significantly greater from BC than from paper points, and BC showed greater compatibility than paper points. Taken together, BC has great potential for use in dental root canal treatment. [Copyright &y& Elsevier]
- Published
- 2013
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26. Unresolved issues in the epidemiology and diagnosis of bacteremia: an opinion paper.
- Author
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Alonso-Menchén, David, Muñoz, Patricia, Sánchez-Carrillo, Carlos, Pérez-Latorre, Leire, and Bouza, Emilio
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BACTEREMIA ,MICROBIOLOGY ,COMMUNICABLE diseases ,THERAPEUTICS ,DIAGNOSTIC microbiology - Abstract
Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
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27. Critically appraised paper: Balance training and cognitive-behavioural therapy are most promising for reducing fatigue severity in people with multiple sclerosis.
- Author
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Plummer, Prudence
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FATIGUE prevention ,THERAPEUTICS ,MULTIPLE sclerosis ,POSTURAL balance ,COGNITIVE therapy - Published
- 2022
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28. Critically appraised paper: Balance training and cognitive-behavioural therapy are most promising for reducing fatigue severity in people with multiple sclerosis [commentary].
- Author
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Fritz, Nora
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FATIGUE prevention ,THERAPEUTICS ,MULTIPLE sclerosis ,POSTURAL balance ,SEVERITY of illness index ,COGNITIVE therapy - Published
- 2022
- Full Text
- View/download PDF
29. Abstracts of papers presented at the 2005 collegiate meetings
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Rhodes College ,Tennessee State University ,Homeopathy -- Materia medica and therapeutics ,Antineoplastic agents ,Brain tumors ,Therapeutics ,Cardiac patients ,Antimitotic agents ,Science and technology - Abstract
EASTERN REGION SOUTHERN ADVENTIST UNIVERSITY COLLEGEDALE, TENNESSEE DEMONSTRATION OF VACUUM DISTILLATION/DEMONSTRATION OF DISTILLATION OF DEET. Lindsy Collins and Robin Breeden, Walters State Community College, Morristown, Tennessee. Student prepared DEET was [...]
- Published
- 2005
30. A disposable sampling device to collect volume-measured DBS directly from a fingerprick onto DBS paper
- Author
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Sören Sandkvist, Göran Stemme, Olof Beck, Niclas Roxhed, Gabriel Lenk, and Anton Pohanka
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Paper ,Computer science ,Clinical Biochemistry ,Analytical chemistry ,behavioral disciplines and activities ,Analytical Chemistry ,Sampling device ,Fingers ,Lab-On-A-Chip Devices ,Humans ,General Pharmacology, Toxicology and Pharmaceutics ,Disposable Equipment ,Biological sciences ,Dried Blood Spot Testing ,Blood Specimen Collection ,General Medicine ,Equipment Design ,nervous system diseases ,Solutions ,Medical Laboratory Technology ,Amphetamine ,surgical procedures, operative ,nervous system ,therapeutics ,Biomedical engineering - Abstract
Background: DBS samples collected from a fingerprick typically vary in volume and homogeneity and hence make an accurate quantitative analysis of DBS samples difficult. Results: We report a prototype which first defines a precise liquid volume and subsequently stores it to a conventional DBS matrix. Liquid volumes of 2.2 µl ± 7.1% (n = 21) for deionized water and 6.1 µl ± 8.8% (n = 15) for whole blood have been successfully metered and stored in DBS paper. Conclusion: The new method of collecting a defined volume of blood by DBS sampling has the potential to reduce assay bias for the quantitative evaluation of DBS samples while maintaining the simplicity of conventional DBS sampling.
- Published
- 2015
31. The diagnosis and management of food allergies. Position paper of the Food Allergy Section the Polish Society of Allergology.
- Author
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Bartuzi, Zbigniew, Kaczmarski, Maciej, Czerwionka-Szaflarska, Mieczysława, Małaczyńska, Teresa, and Krogulska, Aneta
- Subjects
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DIAGNOSIS of food allergies , *ALLERGY treatment , *FOOD allergy , *EPIDEMIOLOGY , *IMMUNOGLOBULIN E , *THERAPEUTICS - Abstract
The paper concerns the current position of the Polish Society of Allergology Food Allergy Section on the diagnosis and management of food allergies. The aim of this position is to provide evidence-based recommendations on the diagnosis and management of patients with allergic hypersensitivity to foods. This position statement includes a systematic review of studies in three areas, namely, the epidemiology, diagnosis and management of food allergies. While taking into account the specific Polish setting, in this publication we also used the current European Academy of Allergy and Clinical Immunology (EAACI) position paper and other current position statements, including those of the United States National Institute of Allergy and Infectious Diseases (NIAID). [ABSTRACT FROM AUTHOR]
- Published
- 2017
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32. The 100 most cited papers in spinal deformity surgery: a bibliometric analysis.
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O'Neill, Shane C., Butler, Joseph S., McGoldrick, Niall, O'Leary, Robert, and Synnott, Keith
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SPINAL cord abnormalities ,SURGICAL complications ,THERAPEUTICS ,SURGERY ,BIBLIOMETRICS - Abstract
Spinal deformity is a condition that has been recognized for many millennia. There have been major advances in the treatment of spinal deformity in recent years and studies outlining new ideas can inspire others to further advance the speciality. The number of citations a paper receives may indicate the influence of that paper. It is therefore important that we evaluate and analyze the most cited works in our field. The aim of this study is to identify the 100 most cited papers relevant to spinal deformity surgery in the literature. A search through the Thomson Reuters Web of Science
TM for citations related to spinal deformity surgery was performed. The number of citations, mean citation number (total number citations/years since publication), journal, authors, year of publication and country of origin of the top 100 papers was recorded. The top 100 papers were cited a combined 17,646 times, ranging from 453 to 112. The majority of papers originated from the United States (71) and were published in 20 different journals. The decade 1990-1999 was the most prolific, with 36 of the 100 papers published during this time. Papers pertaining to the management of scoliosis (49) were the most common. This study identifies the top 100 most cited papers in the field of spinal deformity surgery. While citation is not a specific marker of the scientific quality of a paper, it is a surrogate for the influence a paper has had on the orthopedic community. This list of papers provides an invaluable resource for both those in training and those actively practicing and involved in the further development of spinal deformity surgery. [ABSTRACT FROM AUTHOR]- Published
- 2014
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33. 'Composing myself on paper' : personal journal writing and feminist influences
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Wright, Jeannie and Ranby, Pip
- Published
- 2009
34. Calcium (Ti,Zr) hexaorthophosphate bioceramics for electrically stimulated biomedical implant devices: A position paper.
- Author
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HEIMANN, ROBERT B.
- Subjects
- *
OSSEOINTEGRATION , *CALCIUM compounds , *BIOCERAMICS , *THERAPEUTICS - Abstract
Osseointegration of biomedical implants as well as healing of broken bones are supported by novel bioceramic materials that, owing to their engineered ionic conductivity, in the presence of an electric field provide accumulation of negative electrical charges close to the interface between an implant and living bone tissue, thus stimulating the rate of bone growth. In this position paper, the structure as well as the chemical, electrical, and biomedical properties of Ca (Ti,Zr) hexaorthophosphates are reviewed. In addition, based on evaluation of the material's properties, a conceptual configuration of a capacity-coupled bone growth stimulator will be presented. The advantage of the proposed novel device over already existing bone-growth stimulators is its provision of the intimate contact of a capacity-coupled electric field with the growing bone tissue as opposed to an externally applied inductively coupled electromagnetic field, which suffers substantial attenuation when transmitted through soft tissue covering the locus of bone growth. To achieve higher ionic conductivity in Ca (Ti,Zr) hexaorthophosphates, aliovalent doping with highly mobile Na or Li ions intercalated into the only partially occupied M1 sites appears to be a suitable route. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
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35. Simplified Paper Format for Detecting HIV Drug Resistance in Clinical Specimens by Oligonucleotide Ligation.
- Author
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Panpradist, Nuttada, Beck, Ingrid A., Chung, Michael H., Kiarie, James N., Frenkel, Lisa M., and Lutz, Barry R.
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HIV infections ,THERAPEUTICS ,DRUG resistance in microorganisms ,OLIGONUCLEOTIDES ,ANTIRETROVIRAL agents ,LIGATURE (Surgery) ,GENOTYPES ,GENETIC mutation - Abstract
Human immunodeficiency virus (HIV) is a chronic infection that can be managed by antiretroviral treatment (ART). However, periods of suboptimal viral suppression during lifelong ART can select for HIV drug resistant (DR) variants. Transmission of drug resistant virus can lessen or abrogate ART efficacy. Therefore, testing of individuals for drug resistance prior to initiation of treatment is recommended to ensure effective ART. Sensitive and inexpensive HIV genotyping methods are needed in low-resource settings where most HIV infections occur. The oligonucleotide ligation assay (OLA) is a sensitive point mutation assay for detection of drug resistance mutations in HIV pol. The current OLA involves four main steps from sample to analysis: (1) lysis and/or nucleic acid extraction, (2) amplification of HIV RNA or DNA, (3) ligation of oligonucleotide probes designed to detect single nucleotide mutations that confer HIV drug resistance, and (4) analysis via oligonucleotide surface capture, denaturation, and detection (CDD). The relative complexity of these steps has limited its adoption in resource-limited laboratories. Here we describe a simplification of the 2.5-hour plate-format CDD to a 45-minute paper-format CDD that eliminates the need for a plate reader. Analysis of mutations at four HIV-1 DR codons (K103N, Y181C, M184V, and G190A) in 26 blood specimens showed a strong correlation of the ratios of mutant signal to total signal between the paper CDD and the plate CDD. The assay described makes the OLA easier to perform in low resource laboratories. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
36. WHO position paper on hepatitis A vaccines -- October 2022.
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- *
HEPATITIS A vaccines , *HEPATITIS A , *DRUG administration , *DRUG dosage , *DISEASE complications , *THERAPEUTICS - Abstract
The article discusses the position paper on hepatitis A vaccines issued by the World Health Organization (WHO) Strategic Advisory Group of Experts (SAGE) on Immunization at its meeting in April 2022 and replaces the 2012 WHO position paper. Topics include data in the updated 2022 systematic evidence review, such as data on efficacy, effectiveness and safety of multidose and single dose vaccines, and evidence generated from the 2012 systematic review considered in the updated paper.
- Published
- 2022
37. The 50 Most Cited Papers in Craniofacial Anomalies and Craniofacial Surgery.
- Author
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Mahon, Nicola A., Joyce, Cormac W., Thomas, Sangeetha, Concannon, Elizabeth, and Murray, Dylan
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CRANIOFACIAL abnormalities ,CITATION analysis ,PLASTIC surgery ,THERAPEUTICS - Abstract
Background: Citation analysis is a recognized scientometric method of classifying cited articles according to the frequency of which they have been referenced. The total number of citations an article receives is considered to reflect it's significance among it's peers. Methods: Until now, a bibliometric analysis has never been performed in the specialty of craniofacial anomalies and craniofacial surgery. This citation analysis generates an extensive list of the 50 most influential papers in this developing field. Journals specializing in craniofacial surgery, maxillofacial surgery, plastic surgery, neurosurgery, genetics and pediatrics were searched to demonstrate which articles have cultivated the specialty within the past 55 years. Results: The results show an intriguing compilation of papers which outline the fundamental knowledge of craniofacial anomalies and the developments of surgical techniques to manage these patients. Conclusions: This citation analysis provides a summation of the current most popular trends in craniofacial literature. These esteemed papers aid to direct our decision making today within this specialty. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
38. Evaluation of Dried Blood Spots Collected on Filter Papers from Three Manufacturers Stored at Ambient Temperature for Application in HIV-1 Drug Resistance Monitoring.
- Author
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Rottinghaus, Erin K., Beard, R. Suzanne, Bile, Ebi, Modukanele, Mosetsanagape, Maruping, Maruping, Mine, Madisa, Nkengasong, John, and Yang, Chunfu
- Subjects
HIV infections ,THERAPEUTICS ,DRUG resistance ,DRIED blood spot testing ,ANTIRETROVIRAL agents ,REVERSE transcriptase - Abstract
As more HIV-infected people gain access to antiretroviral therapy (ART), monitoring HIV drug resistance (HIVDR) becomes essential to combat both acquired and transmitted HIVDR. Studies have demonstrated dried blood spots (DBS) are a suitable alternative in HIVDR monitoring using DBS collected on Whatman 903 (W-903). In this study, we sought to evaluate two other commercially available filter papers, Ahlstrom 226 (A-226) and Munktell TFN (M-TFN), for HIVDR genotyping following ambient temperature storage. DBS were prepared from remnant blood specimens collected from 334 ART patients and stored at ambient temperature for a median time of 30 days. HIV-1 viral load was determined using NucliSENS EasyQ® HIV-1 v2.0 RUO test kits prior to genotyping of the protease and reverse transcriptase regions of the HIV-1 pol gene using an in-house assay. Among the DBS tested, 26 specimens had a viral load ≥1000 copies/mL in all three types of filter paper and were included in the genotyping analysis. Genotyping efficiencies were similar between DBS collected on W-903 (92.3%), A-226 (88.5%), and M-TFN (92.3%) filter papers (P = 1.00). We identified 50 DR-associated mutations in DBS collected on W-903, 33 in DBS collected on A-226, and 48 in DBS collected on M-TFN, resulting in mutation detection sensitivities of 66.0% for A-226 and 88.0% for M-TFN when compared to W-903. Our data indicate that differences among filter papers may exist at this storage condition and warrant further studies evaluating filter paper type for HIVDR monitoring. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
39. Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart.
- Author
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Perrino, Cinzia, Barabási, Albert-Laszló, Condorelli, Gianluigi, Davidson, Sean Michael, De Windt, Leon, Dimmeler, Stefanie, Engel, Felix Benedikt, Hausenloy, Derek John, Addison Hill, Joseph, Van Laake, Linda Wilhelmina, Lecour, Sandrine, Leor, Jonathan, Madonna, Rosalinda, Mayr, Manuel, Prunier, Fabrice, Geradus Sluijter, Joost Petrus, Schulz, Rainer, Thum, Thomas, Ytrehus, Kirsti, and Ferdinandy, Péter
- Subjects
- *
HEART failure , *HEART failure treatment , *MYOCARDIAL reperfusion , *DIAGNOSIS , *CORONARY disease , *CORONARY heart disease treatment , *REPERFUSION injury , *TREATMENT of reperfusion injuries , *THERAPEUTICS - Abstract
Despite advances in myocardial reperfusion therapies, acute myocardial ischaemia/reperfusion injury and consequent ischaemic heart failure represent the number one cause of morbidity and mortality in industrialized societies. Although different therapeutic interventions have been shown beneficial in preclinical settings, an effective cardio-protective or regenerative therapy has yet to be successfully introduced in the clinical arena. Given the complex pathophysiology of the ischaemic heart, large scale, unbiased, global approaches capable of identifying multiple branches of the signalling networks activated in the ischaemic/reperfused heart might be more successful in the search for novel diagnostic or therapeutic targets. High-throughput techniques allow high-resolution, genome-wide investigation of genetic variants, epigenetic modifications, and associated gene expression profiles. Platforms such as proteomics and metabolomics (not described here in detail) also offer simultaneous readouts of hundreds of proteins and metabolites. Isolated omics analyses usually provide Big Data requiring large data storage, advanced computational resources and complex bioinformatics tools. The possibility of integrating different omics approaches gives new hope to better understand the molecular circuitry activated by myocardial ischaemia, putting it in the context of the human 'diseasome'. Since modifications of cardiac gene expression have been consistently linked to pathophysiology of the ischaemic heart, the integration of epigenomic and transcriptomic data seems a promising approach to identify crucial disease networks. Thus, the scope of this Position Paper will be to highlight potentials and limitations of these approaches, and to provide recommendations to optimize the search for novel diagnostic or therapeutic targets for acute ischaemia/reperfusion injury and ischaemic heart failure in the post-genomic era. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
40. Best practices for the management of local-regional recurrent chordoma: a position paper by the Chordoma Global Consensus Group.
- Author
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Stacchiotti, S., Gronchi, A., Fossati, P., Akiyama, T., Alapetite, C., Baumann, M., Blay, J. Y., Bolle, S., Boriani, S., Bruzzi, P., Capanna, R., Caraceni, A., Casadei, R., Colia, V., Debus, J., Delaney, T., Desai, A., Dileo, P., Dijkstra, S., and Doglietto, F.
- Subjects
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CHORDOMA , *BONE cancer , *CANCER relapse , *RADIOTHERAPY , *CANCER chemotherapy , *THERAPEUTICS - Abstract
Chordomas are rare, malignant bone tumors of the skull-base and axial skeleton. Until recently, there was no consensus among experts regarding appropriate clinical management of chordoma, resulting in inconsistent care and suboptimal outcomes for many patients. To address this shortcoming, the European Society of Medical Oncology (ESMO) and the Chordoma Foundation, the global chordoma patient advocacy group, convened a multi-disciplinary group of chordoma specialists to define by consensus evidence-based best practices for the optimal approach to chordoma. In January 2015, the first recommendations of this group were published, covering the management of primary and metastatic chordomas. Additional evidence and further discussion were needed to develop recommendations about the management of local-regional failures. Thus, ESMO and CF convened a second consensus group meeting in November 2015 to address the treatment of locally relapsed chordoma. This meeting involved over 60 specialists from Europe, the United States and Japan with expertise in treatment of patients with chordoma. The consensus achieved during that meeting is the subject of the present publication and complements the recommendations of the first position paper. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
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41. Development of paper-based color test-strip for drug detection in aquatic environment: Application to oxytetracycline.
- Author
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Gomes, Helena I.A.S. and Sales, M. Goreti F.
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OXYTETRACYCLINE , *ANTIBIOTICS , *DRUG monitoring , *COLOR change sensors , *FISH farming , *DRUG resistance in microorganisms , *METAL ions , *THERAPEUTICS - Abstract
The wide use of antibiotics in aquaculture has led to the emergence of resistant microbial species. It should be avoided/minimized by controlling the amount of drug employed in fish farming. For this purpose, the present work proposes test-strip papers aiming at the detection/semi-quantitative determination of organic drugs by visual comparison of color changes, in a similar analytical procedure to that of pH monitoring by universal pH paper. This is done by establishing suitable chemical changes upon cellulose, attributing the paper the ability to react with the organic drug and to produce a color change. Quantitative data is also enabled by taking a picture and applying a suitable mathematical treatment to the color coordinates given by the HSL system used by windows. As proof of concept, this approach was applied to oxytetracycline (OXY), one of the antibiotics frequently used in aquaculture. A bottom-up modification of paper was established, starting by the reaction of the glucose moieties on the paper with 3-triethoxysilylpropylamine (APTES). The so-formed amine layer allowed binding to a metal ion by coordination chemistry, while the metal ion reacted after with the drug to produce a colored compound. The most suitable metals to carry out such modification were selected by bulk studies, and the several stages of the paper modification were optimized to produce an intense color change against the concentration of the drug. The paper strips were applied to the analysis of spiked environmental water, allowing a quantitative determination for OXY concentrations as low as 30 ng/mL. In general, this work provided a simple, method to screen and discriminate tetracycline drugs, in aquaculture, being a promising tool for local, quick and cheap monitoring of drugs. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
42. New Findings on Obstetrics and Gynecology from Department of Obstetrics and Prenatal Medicine Summarized [Position Paper of the Task Force for Obstetrics and Prenatal Medicine (AGG - Section Preterm Birth) on the Placement, Removal and ...]
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Premature infants -- Care and treatment -- Research ,Obstetrics -- Research ,Women's health -- Research ,Pregnant women -- Care and treatment -- Research ,Therapeutics ,Editors ,Women ,Health - Abstract
2019 DEC 2 (NewsRx) -- By a News Reporter-Staff News Editor at OBGYN & Reproduction Week -- Researchers detail new data in Women's Health - Obstetrics and Gynecology. According to [...]
- Published
- 2019
43. Critically appraised paper: In people with chronic oedema of the leg and cellulitis, compression therapy is more effective at reducing recurrence of cellulitis than conservative treatment [synopsis].
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Cavalheri, Vinicius
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PREVENTION of chronic diseases ,DISEASE relapse prevention ,EDEMA prevention ,CELLULITIS ,HOSPITAL admission & discharge ,PATIENT aftercare ,LEG ,MEDICAL appointments ,MEDICAL care ,PATIENT education ,PATIENTS ,PUBLIC hospitals ,THERAPEUTICS ,COMPRESSION therapy ,COMPRESSION garments - Abstract
The article inform people with chronic oedema of the leg and cellulitis, is compression therapy is effective than conservative treatment at reducing recurrence of cellulitis, hospital admission and leg volume.
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- 2021
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44. My paper 20 years later: Effect of positive end-expiratory pressure on right ventricular function in humans
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Michael R. Pinsky
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Pulmonary Circulation ,medicine.medical_specialty ,Cardiac output ,Systole ,Ventricular Dysfunction, Right ,medicine.medical_treatment ,Diastole ,Hemodynamics ,Critical Care and Intensive Care Medicine ,Article ,Positive-Pressure Respiration ,Internal medicine ,mental disorders ,medicine ,Humans ,Pulmonary Wedge Pressure ,Cardiac Output ,Pulmonary wedge pressure ,Positive end-expiratory pressure ,Mechanical ventilation ,Ventricular function ,business.industry ,respiratory system ,respiratory tract diseases ,Echocardiography ,Anesthesia ,Ventricular Function, Right ,Cardiology ,business ,therapeutics ,circulatory and respiratory physiology - Abstract
In 1992, we published a report on the effect of positive end-expiratory pressure (PEEP) on right ventricular (RV) function in humans.We measured RV volumes and pressures and pericardial pressure (Ppc) as PEEP was increased from zero to 15 cm H20 in 12 patients after thoracotomy, using a pulmonary arterial catheter equipped with a rapid responding thermistor that allowed measurement of RV ejection fraction (RVef), while Ppc was measured via a pericardial balloon catheter. RV end-diastolic volume (EDV) was estimated as the ratio of stroke volume (SV) to RVef, whereas RV end-systolic volume (ESV) were estimated as RV EDV-SV. PEEP increased Ppc and Pra, but RVef unaltered. There was no relation between either RV filling pressure (Pra-Ppc) and EDV or the change in RV filling pressure and EDV, although EDV varied significantly with PEEP (p 0.05). The relations between EDV and both SV and RVef were weak (r = 0.54 and 0.55, respectively). RVef varied inversely with ESV (r = -0.77), although it showed no relation to transmural peak pulmonary artery pressure (r = 0.28). However, both absolute and relative changes in EDV corresponded closely with respective ESV values (r = 0.94). We concluded that EDV varies independently of changes in filling pressure and that changes in ESV occur independently of changes in ejection pressure. These data can be explained by assuming that the RV shape changes can dissociate changes in RV EDV from changes in RV wall stress (preload). Thus, changes in RV EDV may or may not alter SV but should proportionately change ESV to a degree dependent on election pressure and contractility.Subsequent studies confirmed our findings which can be summarized as 1) RV filling is independent of Pra; thus central venous pressure cannot be used to estimate RV preload; and 2) for cardiac output to increase by the Starling mechanism the RV must dilate increasing RV ESV. Since the pericardium limits absolute biventricular volume, there is a finite limit to which cardiac output can increase by the Starling mechanism defined not by left ventricular contractility but by RV function. And 3) if fluid loading causes Pra to increase without increasing cardiac output, then resuscitation should stop as the patient is going into acute cor pulmonale. These truths help bedside clinicians understand the echocardiographic and hemodynamic signatures of both RV failure and volume responsiveness.
- Published
- 2014
45. Overcoming the challenges in translational development of natural killer cell therapeutics: An opinion paper.
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Hong Qin, Changqiao You, Feng Yan, Kefang Tan, Changgen Xu, Rui Zhao, Ekpo, Marlene Davis, and Songwen Tan
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KILLER cells ,THERAPEUTICS - Published
- 2022
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46. Contemporary spinal cord protection during thoracic and thoracoabdominal aortic surgery and endovascular aortic repair: a position paper of the vascular domain of the European Association for Cardio-Thoracic Surgery.
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Etz, Christian D., Weigang, Ernst, Hartert, Marc, Lonn, Lars, Mestres, Carlos A., Bartolomeo, Roberto Di, Bachet, Jean E., Carrel, Thierry P., Grabenwöger, Martin, Schepens, Marc A. A. M., and Czerny, Martin
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- *
SPINAL cord injuries , *THERAPEUTICS , *SPINAL cord surgery , *SPINAL cord diseases , *ENDOVASCULAR surgery , *TREATMENT effectiveness , *PREVENTION - Abstract
Ischaemic spinal cord injury (SCI) remains the Achilles heel of open and endovascular descending thoracic and thoracoabdominal repair. Neurological outcomes have improved coincidentially with the introduction of neuroprotective measures. However, SCI (paraplegia and paraparesis) remains the most devastating complication. The aim of this position paper is to provide physicians with broad information regarding spinal cord blood supply, to share strategies for shortening intraprocedural spinal cord ischaemia and to increase spinal cord tolerance to transitory ischaemia through detection of ischaemia and augmentation of spinal cord blood perfusion. This study is meant to support physicians caring for patients in need of any kind of thoracic or thoracoabdominal aortic repair in decision-making algorithms in order to understand, prevent or reverse ischaemic SCI. Information has been extracted from focused publications available in the PubMed database, which are cohort studies, experimental research reports, case reports, reviews, short series and meta-analyses. Individual chapters of this position paper were assigned and after delivery harmonized by Christian D. Etz, Ernst Weigang and Martin Czerny. Consequently, further writing assignments were distributed within the group and delivered in August 2014. The final version was submitted to the EJCTS for review in September 2014. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
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47. Top-ten papers in pneumonia (2020-2021).
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Sancho, Susana, Fortea, Rubén, and Martín, Rubén
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PNEUMONIA ,COVID-19 pandemic ,DIAGNOSIS ,THERAPEUTICS ,MYCOSES - Abstract
Despite the fact that the last year has been marked by the SARS-CoV-2 pandemic, there have been many articles published on non-COVID pneumonia. Making the selection has not been easy, having based on those articles that we think can bring us some novelty and help in clinical practice. We have divided the selection into seven sections: patient severity, diagnosis, treatment, ventilation, novelties in the guidelines, fungal infection and organ donation. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
48. National differences in publishing papers on adverse drug reactions.
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Ferner, R. E. and Aronson, J. K.
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DRUG side effects ,SOCIOCULTURAL factors ,THERAPEUTICS ,SCIENTIFIC literature ,EPIDEMIOLOGY ,PHARMACOLOGY - Abstract
To examine how countries differ in attitudes to adverse drug reactions by examining published scientific papers.We searched Ovid EMBASE for publications indexed by the category′therapeutic agents′, and the subcategory′adverse effects′, by country for 43 countries.We counted 1 810 202 papers world-wide regarding therapeutic agents during 14 years, of which 195 154 (10.8%) were included in the adverse effects subcategory. There were substantial differences between countries, not explained by population, economic variation, overall publication rate on therapeutic agents, or the presence of large indigenous pharmaceutical companies.Many local cultural factors influence the ratio of papers on adverse reactions to all drug effects, so it may be difficult to improve their recognition and reporting by international efforts. [ABSTRACT FROM AUTHOR]
- Published
- 2005
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49. Paper microfluidic implementation of loop mediated isothermal amplification for early diagnosis of hepatitis C virus.
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Witkowska McConnell, Weronika, Davis, Chris, Sabir, Suleman R., Garrett, Alice, Bradley-Stewart, Amanda, Jajesniak, Pawel, Reboud, Julien, Xu, Gaolian, Yang, Zhugen, Gunson, Rory, Thomson, Emma C., and Cooper, Jonathan M.
- Subjects
HEPATITIS C virus ,EARLY diagnosis ,REVERSE transcriptase ,HEPATITIS C ,THERAPEUTICS ,POINT-of-care testing ,NUCLEIC acids - Abstract
The early diagnosis of active hepatitis C virus (HCV) infection remains a significant barrier to the treatment of the disease and to preventing the associated significant morbidity and mortality seen, worldwide. Current testing is delayed due to the high cost, long turnaround times and high expertise needed in centralised diagnostic laboratories. Here we demonstrate a user-friendly, low-cost pan-genotypic assay, based upon reverse transcriptase loop mediated isothermal amplification (RT-LAMP). We developed a prototype device for point-of-care use, comprising a LAMP amplification chamber and lateral flow nucleic acid detection strips, giving a visually-read, user-friendly result in <40 min. The developed assay fulfils the current guidelines recommended by World Health Organisation and is manufactured at minimal cost using simple, portable equipment. Further development of the diagnostic test will facilitate linkage between disease diagnosis and treatment, greatly improving patient care pathways and reducing loss to follow-up, so assisting in the global elimination strategy. Current HCV nucleic acid-based diagnosis is largely performed in centralised laboratories. Here, the authors present a pan-genotypic RNA assay, based on reverse transcriptase loop mediated isothermal amplification and develop a low-cost prototype paper-based lateral flow device for point-of-care use, providing a visually read result within 40 min. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
50. Review Paper: Role of Nitric Oxide on Dopamine Release and Morphine-Dependency.
- Author
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Motahari, Amir Arash, Sahraei, Hedayat, and Meftahi, Gholam Hossein
- Subjects
- *
NITRIC oxide , *DOPAMINE , *MORPHINE abuse , *THERAPEUTICS - Abstract
The catastrophic effects of opioids use on public health and the economy are documented clearly in numerous studies. Repeated morphine administration can lead to either a decrease (tolerance) or an increase (sensitization) in its behavioral and rewarding effects. Morphine-induced sensitization is a major problem and plays an important role in abuse of the opioid drugs. Studies reported that morphine may exert its effects by the release of nitric oxide (NO). NO is a potent neuromodulator, which is produced by nitric oxide synthase (NOS). However, the exact role of NO in the opioid-induced sensitization is unknown. In this study, we reviewed the role of NO on opioid-induced sensitization in 2 important, rewarding regions of the brain: nucleus accumbens and ventral tegmentum. In addition, we focused on the contribution of NO on opioid-induced sensitization in the limbic system. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
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