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1. Nitric oxide-c GMP pathway is involved in endotoxin-induced contractile dysfunction in rat hearts.

Author

Tatsumi, Tetsuya, Keira, Natsuya, Akashi, Kazuko, Kobara, Miyuki, Matoba, Sataoaki, Shiraishi, Jun, Yamanaka, Satoshi, Mano, Akiko, Takeda, Mitsuo, Nishikawa, Susumu, Asayama, Jun, Fliss, Henry, and Nakagawa, Masao

Subjects
NITRIC oxide, ENDOTOXINS, SEPTIC shock, MYOCARDIUM, HEART, LABORATORY rats
Abstract

Examines the involvement of nitric oxide (NO) in the mechanisms by which endotoxemia causes cardiac depression. Infusion of rats with lipopolysaccharide (LPS) or saline; Isolation of hearts and mounting in a Langendorff apparatus; Determination of the left ventricular developed pressure before biochemical analysis of the myocardium; Finding that the myocardial adenosine triphosphate levels were not significantly altered after LPS injection.

Published
2004
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