1. Acute kidney injury in the elderly: predisposition to chronic kidney disease and vice versa
- Author
-
Kerry C. Cho, Steven G. Coca, and Chi-yuan Hsu
- Subjects
Cardiac Catheterization ,Aging ,Population Dynamics ,030232 urology & nephrology ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,urologic and male genital diseases ,Cohort Studies ,0302 clinical medicine ,Risk Factors ,Chronic kidney disease ,Prevalence ,Medicine ,Age of Onset ,Aged, 80 and over ,Absolute number ,Incidence (epidemiology) ,Incidence ,Acute kidney injury ,Age Factors ,General Medicine ,Acute Kidney Injury ,female genital diseases and pregnancy complications ,3. Good health ,Nephrology ,Cardiovascular Diseases ,Hypertension ,Disease Progression ,Kidney Diseases ,Disease Susceptibility ,Glomerular filtration rate ,Cohort study ,Paper ,medicine.medical_specialty ,Renal function ,Diabetes Complications ,03 medical and health sciences ,Internal medicine ,Humans ,Intensive care medicine ,Aged ,business.industry ,urogenital system ,Public health ,medicine.disease ,United States ,Kidney Failure, Chronic ,Age of onset ,business ,Kidney disease - Abstract
There have been considerable advances in the past few years in our understanding of how chronic kidney disease (CKD) predisposes to acute kidney injury (AKI) and vice versa. This review shows, however, that few studies have focused on the elderly or conducted stratified analysis by age. It does appear that elderly patients with estimated glomerular filtration rate (eGFR) 45–59 ml/min/1.73 m2 are at higher risk for AKI compared with their counterparts with eGFR >60 ml/min/1.73 m2. This is a similar relationship to that seen in younger patients, although effect size appears smaller. As the incidence of AKI has been increasing over the past several years, the proportion of elderly patients surviving after AKI has also been increasing. Since AKI heightens the risk for the development and acceleration of CKD, this implies significant public health concerns with regard to the absolute number of elderly persons developing incident CKD.
- Published
- 2011