1. Clearance of Persistent SARS-CoV-2 RNA Detection in a NFκB-Deficient Patient in Association with the Ingestion of Human Breast Milk: A Case Report.
- Author
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Sabino, Janine S., Amorim, Mariene R., de Souza, William M., Marega, Lia F., Mofatto, Luciana S., Toledo-Teixeira, Daniel A., Forato, Julia, Stabeli, Rodrigo G., Costa, Maria Laura, Spilki, Fernando R., Sabino, Ester C., Faria, Nuno R., Benites, Bruno D., Addas-Carvalho, Marcelo, Stucchi, Raquel S. B., Vasconcelos, Dewton M., Weaver, Scott C., Granja, Fabiana, Proenca-Modena, José Luiz, and Vilela, Maria Marluce dos S.
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BREAST milk , *SARS-CoV-2 , *POST-acute COVID-19 syndrome , *VIRUS diseases , *COVID-19 treatment , *VIRAL antibodies , *IMMUNOGLOBULINS , *ORAL mucosa - Abstract
Currently, there are no evidence-based treatment options for long COVID-19, and it is known that SARS-CoV-2 can persist in part of the infected patients, especially those with immunosuppression. Since there is a robust secretion of SARS-CoV-2-specific highly-neutralizing IgA antibodies in breast milk, and because this immunoglobulin plays an essential role against respiratory virus infection in mucosa cells, being, in addition, more potent in neutralizing SARS-CoV-2 than IgG, here we report the clinical course of an NFκB-deficient patient chronically infected with the SARS-CoV-2 Gamma variant, who, after a non-full effective treatment with plasma infusion, received breast milk from a vaccinated mother by oral route as treatment for COVID-19. After such treatment, the symptoms improved, and the patient was systematically tested negative for SARS-CoV-2. Thus, we hypothesize that IgA and IgG secreted antibodies present in breast milk could be useful to treat persistent SARS-CoV-2 infection in immunodeficient patients. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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