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3 results on '"Bouma, Gerd"'

1. Seroprevalence of Hepatitis E Virus in Autoimmune Hepatitis Patients in the Netherlands.

Author

van Gerven, Nicole M. F., van der Eijk, Annemiek A., Pas, Suzan D., Zaaijer, Hans L., de Boer, Ynto S., Witte, Birgit I., van Nieuwkerk, Carin M. J., Mulder, Chris J. J., Bouma, Gerd, and de Man, Robert A.

Subjects
*HEPATITIS E virus, *IMMUNOCOMPROMISED patients, *AUTOIMMUNE diseases, *DISEASE prevalence, *BIOMARKERS
Abstract

Background & Aims: In recent years chronic courses of hepatitis E virus (HEV) infection have been described in immunosuppressed individuals. This may implicate a potential role for HEV in the development of autoimmune diseases, including autoimmune hepatitis (AIH). Here we investigated the prevalence of HEVantibodies in AIH patients in an endemic Central European country. Methods: HEV-specific immunoglobulin G (IgG) and HEV RNA were determined in 354 and 377 AIH patients, respectively. Clinical characteristics and disease outcome parameters were retrospectively collected. Results: No HEV viraemic patients were identified in this cohort. A total of 106 AIH patients (29.9%) tested positive for anti-HEV IgG, and this figure was slightly higher compared to the prevalence in a reference cohort including 5,329 healthy Dutch blood donors (26.7%; P>0.05). Conclusion: This is the largest study on the association between HEV infection and AIH. Apparently silent HEV infection is present in a significant proportion of AIH patients, yet appears not to have significant clinical repercussions in this immune compromised group of patients. Nevertheless, since acute hepatitis E may present with histological and biochemical features of AIH, the possibility of a (concomitant) HEV infection should be considered in this category of patients. [ABSTRACT FROM AUTHOR]

Published
2016
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2. Diagnosis of Non-Celiac Gluten Sensitivity (NCGS): The Salerno Experts’ Criteria

Author

Luca Elli, Umberto Volta, Nicoletta Pellegrini, Gerd Bouma, Wolfgang Holtmeier, Daniel A. Leffler, Fernanda Cristofori, Carlo Catassi, Kamran Rostami, Ruggiero Francavilla, Jernej Dolinsek, Chris J. J. Mulder, David S Sanders, Detlef Schuppan, Victor F. Zevallos, Giuseppe Mazzarella, Antonio Carroccio, Ute Körner, Marianne Williams, Walburga Dieterich, Marios Hadjivassiliou, Alessio Fasano, Knut E.A. Lundin, Gemma Castillejo, Gry Irene Skodje, Yurdagül Zopf, Christophe Cellier, Laura de Magistris, Reiner Ullrich, Bruno Bonaz, Catassi, C., Elli, L., Bonaz, B., Bouma, G., Carroccio, A., Castillejo, G., Cellier, C., Cristofori, F., de Magistris, L., Dolinsek, J., Dieterich, W., Francavilla, R., Hadjivassiliou, M., Holtmeier, W., Körner, U., Leffler, D., Lundin, K., Mazzarella, G., Mulder, C., Pellegrini, N., Rostami, K., Sanders, D., Skodje, G., Schuppan, D., Ullrich, R., Volta, U., Williams, M., Zevallos, V., Zopf, Y., Fasano, A., Gastroenterology and hepatology, CCA - Disease profiling, Catassi, Carlo, Elli, Luca, Bonaz, Bruno, Bouma, Gerd, Carroccio, Antonio, Castillejo, Gemma, Cellier, Christophe, Cristofori, Fernanda, DE MAGISTRIS, Laura, Dolinsek, Jernej, Dieterich, Walburga, Francavilla, Ruggiero, Hadjivassiliou, Mario, Holtmeier, Wolfgang, Körner, Ute, Leffler, Dan A., Lundin, Knut E. A., Mazzarella, Giuseppe, Mulder, Chris J., Pellegrini, Nicoletta, Rostami, Kamran, Sanders, David, Skodje, Gry Irene, Schuppan, Detlef, Ullrich, Reiner, Volta, Umberto, Williams, Marianne, Zevallos, Victor F., Zopf, Yurdagül, and Fasano, Alessio

Subjects
Diagnosis, Non-Celiac Gluten Sensitivity, Pediatrics, medicine.medical_specialty, Settore MED/09 - Medicina Interna, Glutens, diagnosis, lcsh:TX341-641, Disease, Placebo, Article, Diet, Gluten-Free, Double-Blind Method, Rating scale, Surveys and Questionnaires, Humans, Medicine, Intestinal Mucosa, Irritable bowel syndrome, double-blind placebo-controlled challenge, chemistry.chemical_classification, irritable bowel syndrome, Cross-Over Studies, Nutrition and Dietetics, business.industry, non-celiac gluten sensitivity, gastrointestinal symptom rating scale, nutritional and metabolic diseases, medicine.disease, Gluten, Crossover study, Surgery, chemistry, Immunoglobulin G, Biomarker (medicine), business, lcsh:Nutrition. Foods and food supply, Biomarkers, Food Hypersensitivity, Wheat allergy, Food Science, Diagnosi
Abstract

Non-Celiac Gluten Sensitivity (NCGS) is a syndrome characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing food, in subjects that are not affected by either celiac disease or wheat allergy. Given the lack of a NCGS biomarker, there is the need for standardizing the procedure leading to the diagnosis confirmation. In this paper we report experts' recommendations on how the diagnostic protocol should be performed for the confirmation of NCGS. A full diagnostic procedure should assess the clinical response to the gluten-free diet (GFD) and measure the effect of a gluten challenge after a period of treatment with the GFD. The clinical evaluation is performed using a self-administered instrument incorporating a modified version of the Gastrointestinal Symptom Rating Scale. The patient identifies one to three main symptoms that are quantitatively assessed using a Numerical Rating Scale with a score ranging from 1 to 10. The double-blind placebo-controlled gluten challenge (8 g/day) includes a one-week challenge followed by a one-week washout of strict GFD and by the crossover to the second one-week challenge. The vehicle should contain cooked, homogeneously distributed gluten. At least a variation of 30% of one to three main symptoms between the gluten and the placebo challenge should be detected to discriminate a positive from a negative result. The guidelines provided in this paper will help the clinician to reach a firm and positive diagnosis of NCGS and facilitate the comparisons of different studies, if adopted internationally.

Published
2015
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3. Serum intestinal-fatty acid binding protein as a biomarker for refractory celiac disease.

Author

Gross, Sascha, Adriaanse, Marlou P. M., Nijeboer, Petula, Tack, Greetje J., van Hoogstraten, Ingrid M. W., Bouma, Gerd, Mulder, Chris J., von Blomberg, B. Mary E., Vreugdenhil, Anita C. E., and Bontkes, Hetty J.

Subjects
*CARRIER proteins, *BIOMARKERS
Abstract

A letter to the editor is presented in response to the article related to use of serum intestinal-fatty acid binding protein as a biomarker in the previous issue.

Published
2015

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