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Dental CBCT and panoramic imaging play a pivotal role in dental diagnosis and treatment planning, alongside the indispensable use of computed tomography (CT) and X-ray imaging in dentistry, particularly for surgical planning. Given the widespread adoption of dental cone beam CT in clinics today, we explore a novel approach in this study—utilizing CT's three-dimensional (3D) data to reconstruct a two-dimensional (2D) panoramic dental image. This method eliminates the requirement for an extra panoramic scan. In this work, we propose a novel framework to generate an enhanced and extended 2D panoramic view by using the dental arch extracted from 3D CBCT. Our method involves segmenting the patient's dental arch from their 3D CBCT image by identifying horizontal slices with above-average intensity, followed by morphological operations, including dilation, Gaussian filtering, and skeletonization, to delineate the dental arch line. Additionally, we extend the dental arch beyond the wisdom teeth using quadratic curve fitting. Finally, we employ Maximum Intensity Projection on rotated cubic segments aligned with the dental arch curve to produce captivating panoramic images. The panoramic view produced using our proposed method, when compared to the results obtained from BlueSky and OpenInventor, exhibited superior enhancements and greater accuracy in panoramic visualization. [ABSTRACT FROM AUTHOR]

Micro cone-beam computed tomography (µCBCT) imaging is of utmost importance for carrying out extensive preclinical research in rodents. The imaging of animals is an essential step prior to preclinical precision irradiation, but also in the longitudinal assessment of treatment outcomes. However, imaging artifacts such as beam hardening will occur due to the low energetic nature of the X-ray imaging beam (i.e., 60 kVp). Beam hardening artifacts are especially difficult to resolve in a 'pancake' imaging geometry with stationary source and detector, where the animal is rotated around its sagittal axis, and the X-ray imaging beam crosses a wide range of thicknesses. In this study, a seven-layer U-Net based network architecture (vMonoCT) is adopted to predict virtual monoenergetic X-ray projections from polyenergetic X-ray projections. A Monte Carlo simulation model is developed to compose a training dataset of 1890 projection pairs. Here, a series of digital anthropomorphic mouse phantoms was derived from the reference DigiMouse phantom as simulation geometry. vMonoCT was trained on 1512 projection pairs (= 80%) and tested on 378 projection pairs (= 20%). The percentage error calculated for the test dataset was 1.7 ± 0.4%. Additionally, the vMonoCT model was evaluated on a retrospective projection dataset of five mice and one frozen cadaver. It was found that beam hardening artifacts were minimized after image reconstruction of the vMonoCT-corrected projections, and that anatomically incorrect gradient errors were corrected in the cranium up to 15%. Our results disclose the potential of Artificial Intelligence to enhance the µCBCT image quality in biomedical applications. vMonoCT is expected to contribute to the reproducibility of quantitative preclinical applications such as precision irradiations in X-ray cabinets, and to the evaluation of longitudinal imaging data in extensive preclinical studies. [ABSTRACT FROM AUTHOR]