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2 results on '"Illario, Maddalena"'

1. Is diet partly responsible for differences in COVID-19 death rates between and within countries?

Author

Bousquet, Jean, Anto, Josep M., Iaccarino, Guido, Czarlewski, Wienczyslawa, Haahtela, Tari, Anto, Aram, Akdis, Cezmi A., Blain, Hubert, Canonica, G. Walter, Cardona, Victoria, Cruz, Alvaro A., Illario, Maddalena, Ivancevich, Juan Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Larenas-Linnemann, Désirée, Mullol, Joaquim, and Papadopoulos, Nikos G.

Subjects
COVID-19, ANGIOTENSIN converting enzyme, FOOD habits, ANIMAL nutrition, REGIONAL differences
Abstract

Reported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most current debates on COVID-19 focus on the differences among countries, but little attention has been given to regional differences and diet. The low-death rate European countries (e.g. Austria, Baltic States, Czech Republic, Finland, Norway, Poland, Slovakia) have used different quarantine and/or confinement times and methods and none have performed as many early tests as Germany. Among other factors that may be significant are the dietary habits. It seems that some foods largely used in these countries may reduce angiotensin-converting enzyme activity or are anti-oxidants. Among the many possible areas of research, it might be important to understand diet and angiotensin-converting enzyme-2 (ACE2) levels in populations with different COVID-19 death rates since dietary interventions may be of great benefit. [ABSTRACT FROM AUTHOR]

Published
2020
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2. N-(Phenoxyalkyl)amides as MT(1) and MT(2) ligands: antioxidant properties and inhibition of Ca(2+)/CaM-dependent kinase II

Author

Carlo Franchini, Claudio Bruno, Maria Grazia Roselli, Alessia Catalano, Angelo Lovece, Maria Maddalena Cavalluzzi, Francesco De Santis, Annalisa De Palma, Alessia Carocci, Maddalena Illario, Giovanni Lentini, Maria Rosaria Rusciano, A., Carocci, A., Catalano, C. o., Bruno, A., Lovece, M. G., Roselli, M. M., Cavalluzzi, F., De Santi, A., De Palma, M. R., Rusciano, Illario, Maddalena, C., Franchini, and G., Lentini

Subjects
Antioxidant, Stereochemistry, Cell Survival, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Ligands, Biochemistry, Antioxidants, Melatonin, Structure-Activity Relationship, Ca2+/calmodulin-dependent protein kinase, Drug Discovery, medicine, Humans, Cytotoxicity, Molecular Biology, Protein Kinase Inhibitors, Chemistry, Kinase, Receptor, Melatonin, MT2, Receptor, Melatonin, MT1, Organic Chemistry, Stereoisomerism, Hep G2 Cells, Amides, Melatonergic, Molecular Medicine, Stereoselectivity, Calcium-Calmodulin-Dependent Protein Kinase Type 2, medicine.drug
Abstract

Recently a series of chiral N -(phenoxyalkyl)amides have been reported as potent MT 1 and MT 2 melatonergic ligands. Some of these compounds were selected and tested for their antioxidant properties by measuring their reducing effect against oxidation of 2′,7′-dichlorodihydrofluorescein (DCFH) in the DCFH-diacetate (DCFH-DA) assay. Among the tested compounds, N -[2-(3-methoxyphenoxy)propyl]butanamide displayed potent antioxidant activity that was stereoselective, the ( R )-enantiomer performing as the eutomer. This compound displayed strong cytoprotective activity against H 2 O 2 -induced cytotoxicity resulting slightly more active than melatonin, and performed as Ca 2+ /calmodulin-dependent kinase II (CaMKII) inhibitor, too.

Published
2012

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