1. Young-Onset Colon Cancer and Recurrence Risk by Gene Expression.
- Author
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Chang, George J, You, Y Nancy Y, Russell, Christy A, Tierno, Marni B, Turner, Michelle, Bennett, John P, Lau, Anna, and Hochster, Howard S
- Subjects
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CANCER relapse , *COLON cancer , *GENE expression , *CANCER patients , *OLDER patients , *COLON tumors , *RESEARCH , *AGE distribution , *RESEARCH methodology , *MEDICAL cooperation , *EVALUATION research , *TUMOR classification , *COMPARATIVE studies , *DISEASE susceptibility , *GENE expression profiling , *RESEARCH funding - Abstract
The incidence and mortality from colorectal cancer in younger adults (younger than 55 years) is increasing. We reviewed the complete database of a gene-expression test, Oncotype DX Colon Recurrence Score test, to determine age-related differences in recurrence score (RS) and single-gene results (7 cancer-related of the 12-gene assay). We included 20 478 stage II and III A and B colon cancer patients submitted to Genomic Health. RS results were grouped by low-, intermediate-, and high-risk groups. Single-gene scores were described using median and interquartile range. Of all patients 72.5% and 72.6% of those younger than 40 years had low-risk RS. Comparing older with younger patients, RS or single-gene expression did not differ by age group or stage. Young-onset colon cancer does not differ by expression of the RS component genes. Most patients with stage II and III colon cancer have low-risk disease as measured by the 12-gene assay, regardless of age. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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