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Context The effects of intensity-specific physical activity (PA) and its interaction with other lifestyle factors on serum adiponectin are currently unclear. Objective To investigate the effects of replacing sedentary time with either light-intensity PA (LPA) or moderate- to vigorous-intensity PA (MVPA) on total and high-molecular-weight (HMW) adiponectin and to examine interactions with smoking, alcohol drinking, coffee consumption, and menopausal status in a general population. Design/Setting Cross-sectional study of 4013 men and 6050 women (40 to 69 years of age). Main Outcome Measures The associations of replacing sedentary time with LPA or MVPA on total and HMW adiponectin were analyzed using an isotemporal substitution model. Results In men, reallocating 60 minutes of sedentary time to 60 minutes of LPA was associated with 9% and 13% higher total and HMW adiponectin levels even after adjusting for confounders, although such associations were not observed for MVPA. A similar pattern of results was also seen in women. The effect of replacing sedentary time with LPA on adiponectin was clearer in middle/high coffee consumers than in low coffee consumers among women. Although increasing the effect of replacing sedentary time with MVPA on adiponectin was clearer in former/current smokers than in never smokers among men, the replacement effect for MVPA on total adiponectin was clearer in premenopausal women than in postmenopausal women. Conclusions Replacing sedentary time with LPA resulted in increased levels of total and HMW adiponectin. The replacement effects for LPA or MVPA were found to be multiply modified by smoking, coffee consumption, and menopausal status. [ABSTRACT FROM AUTHOR]

Background: Accumulated evidence suggests a weak positive relationship between psychosocial stress and body mass index (BMI), but little is known about stress coping strategies and BMI. Objective: We aimed to examine if perceived stress and coping strategies are related to BMI, with any of their mutual interactions on BMI. Methods: This cross-sectional study included 5,063 men and 6,982 women aged 40-69 years. A self-administered questionnaire ascertained perceived stress and 5 items of coping strategies (emotion expression, emotional support seeking, positive reappraisal, problem solving, and disengagement). Analyses were performed by gender with adjustment for age, socioeconomic status, and lifestyle factors. Results: No significant associations were detected between perceived stress and BMI in either men (Ptrend = 0.09) or women (Ptrend = 0.58). In men, however, ‘disengagement’ showed an inverse association with BMI (Ptrend < 0.001), and ‘positive reappraisal’ and ‘problem solving’ revealed a positive association with BMI (Ptrend = 0.04 and 0.007, respectively) even after controlling for perceived stress. A possible interaction between perceived stress and ‘disengagement’ on BMI was found in men (Pinteraction = 0.027); the inverse association between ‘disengagement’ and BMI was more evident in higher levels of stress (β = −0.13, Ptrend = 0.21 in low; β = −0.22, Ptrend = 0.01 in medium; and β = −0.24, Ptrend = 0.06 in high). In men, ‘disengagement’ was inversely associated with overweight/obesity (odds ratio 0.79, 95% confidential interval 0.67-0.95), and “positive reappraisal” was positively associated with it (1.25, 1.02-1.54). Conclusions: Coping strategies may have an important role in developing overweight/obesity, particularly in men. [ABSTRACT FROM AUTHOR]

Background Secreted protein acidic and rich in cysteine (SPARC) may play a role in the prevention of colon cancer through exercise, while SPARC is considered as a promoter of insulin resistance. The purpose of the present study was to clarify the effects of replacing sedentary time with either light-intensity PA (LPA) or moderate- to vigorous-intensity PA (MVPA) on serum SPARC in a general population. Methods The study subjects were 4000 men and 6040 women (40 to 69 years) who participated in baseline surveys of a population-based cohort study. Sedentary time, LPA, and MVPA were objectively measured by an accelerometer. The serum SPARC concentration was measured by an enzyme-linked immunosorbent assay. Using an isotemporal substitution model, cross-sectional associations of replacing sedentary time with either LPA or MVPA on serum SPARC levels were analyzed according to sex. Adjustment was made for potential confounding factors. Results In men, replacing 60 min of sedentary time with 60 min of MVPA was associated with 23 ng/mL (confidence interval -43, -2) lower serum SPARC levels even after adjusting for confounders, including the BMI (P = 0.028), while no such association was observed for LPA. Furthermore, no such significant replacement effects were observed in women. Conclusions The current study showed that replacing sedentary time with MVPA results in reduced serum SPARC concentrations in men. Key messages Effect of habitual PA to decrease circulating SPARC is PA intensity-specific. [ABSTRACT FROM AUTHOR]