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2. The New Teacher Induction Experience: Tension between Curricular and Programmatic Demands and the Need for Immediate Help

Author

Mitchell, Douglas E., Howard, Barbara, Meetze-Hall, Melissa, Hendrick, Linda Scott, and Sandlin, Ruth

Abstract

Throughout the history of California's Beginning Teacher Support and Assessment (BTSA) program, new teachers have reported experiencing substantial tension between the curricular and programmatic demands arising from their induction programs' formative assessment systems and the immediate coaching help they need to deal with day-to-day classroom responsibilities. To examine some dimensions of this tension, the authors undertook in-depth case study analyses of 18 novice teacher participants in an innovative online induction program managed by the Riverside County Office of Education (RCOE). Because the online format provides reasonably complete transcriptions of the new teachers' induction experiences, the authors anticipated being able to examine this tension in some detail. Preliminary analysis does indicate that inductees see coaching as fundamental, with formative assessment activities as valued but secondary in importance to their overall perceived needs within the classroom. Additionally, when examining overall satisfaction of new teachers enrolled in an induction program, the authors found important differences associated with teacher characteristics and assignments needing interpretation. They learned, however, that the data collected from this online induction program are more fragmentary and harder to organize than expected. As a result, this report must be considered a preliminary work in progress, and the findings will need to be confirmed (or modified) by future work.

Published
2017

4. A scalable platform to discover antimicrobials of ribosomal origin

Author

Ayikpoe, Richard S., Shi, Chengyou, Battiste, Alexander J., Eslami, Sara M., Ramesh, Sangeetha, Simon, Max A., Bothwell, Ian R., Lee, Hyunji, Rice, Andrew J., Ren, Hengqian, Tian, Qiqi, Harris, Lonnie A., Sarksian, Raymond, Zhu, Lingyang, Frerk, Autumn M., Precord, Timothy W., van der Donk, Wilfred A., Mitchell, Douglas A., and Zhao, Huimin

Published
2022
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21. McrD binds asymmetrically to methyl-coenzyme M reductase improving active-site accessibility during assembly.

Author

Chadwick, Grayson L., Joiner, Aaron M. N., Ramesh, Sangeetha, Mitchell, Douglas A., and Nayak, Dipti D.

Subjects
POST-translational modification, ACTIVITY-based costing, METHANE
Abstract

Methyl-coenzyme M reductase (MCR) catalyzes the formation of methane, and its activity accounts for nearly all biologically produced methane released into the atmosphere. The assembly of MCR is an intricate process involving the installation of a complex set of posttranslational modifications and the unique Ni-containing tetrapyrrole called coenzyme F430. Despite decades of research, details of MCR assembly remain largely unresolved. Here, we report the structural characterization of MCR in two intermediate states of assembly. These intermediate states lack one or both F430 cofactors and form complexes with the previously uncharacterized McrD protein. McrD is found to bind asymmetrically to MCR, displacing large regions of the alpha subunit and increasing active-site accessibility for the installation of F430--shedding light on the assembly of MCR and the role of McrD therein. This work offers crucial information for the expression of MCR in a heterologous host and provides targets for the design of MCR inhibitors. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Antibacterial drug leads targeting isoprenoid biosynthesis

Author

Zhu, Wei, Zhang, Yonghui, Sinko, William, Hensler, Mary E., Olson, Joshua, Molohon, Katie J., Lindert, Steffen, Cao, Rong, Li, Kai, Wang, Ke, Wang, Yang, Liu, Yi-Liang, Sankovsky, Anna, de Oliveira, César Augusto F., Mitchell, Douglas A., Nizet, Victor, McCammon, J. Andrew, and Oldfield, Eric

Published
2013

26. The Political Economy of Education Policy: The Case of Class Size Reduction.

Author

Mitchell, Douglas E. and Mitchell, Ross E.

Abstract

Develops a political economy framework for mapping and interpreting the competing purposes of schooling by examining five paradoxes in national policy debates addressing class size in public elementary schools. The framework highlights answers to the question: What kind of an economic good is education? (education as a service industry, producer of durable goods, system of investment in human capital formation, and conduit for passing cultural legacies between generations). (Contains references.) (SM)

Published
2003

41. Leadership as a Way of Thinking.

Author

Mitchell, Douglas E. and Tucker, Sharon

Abstract

School performance is as closely tied to competent administration, effective supervision, and dynamic management as it is to aggressive leadership. Transformational leadership arises when leaders are more concerned about gaining staff cooperation and energetic participation than accomplishing particular tasks. (MLH)

Published
1992

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