1. H2O2/O2 self-supplementing and GSH-depleting Ca2+ nanogenerator with hyperthermia-triggered, TME-responsive capacities for combination cancer therapy.
- Author
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Sun, Qianqian, Liu, Bin, Wang, Zhao, Feng, Lili, Zhao, Ruoxi, Dong, Shuming, Dong, Yushan, Zhong, Lei, Gai, Shili, and Yang, Piaoping
- Subjects
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CANCER treatment , *COMPUTED tomography , *PHOTODYNAMIC therapy , *TUMOR growth , *COPPER ions , *HEAT stroke - Abstract
[Display omitted] • The switch for treatment was only triggered under high heat conditions, allowing for human-controlled, on-demand treatment. • CaO 2 degraded in acidic TME, producing H 2 O 2 , O 2 and Ca(OH) 2 , which could improve and remodel TME. • Free Ca2+ accumulated in tumor cells and could initiate the process of calcium overload and calcification. • Calcification could play a role in inhibiting tumor growth and aiding CT imaging. The tumor microenvironment (TME) is complex in composition and unique in nature, and is closely related to the growth, invasion and metastasis of tumor cells. Improving and remodeling the TME to return it to a normalized state can fundamentally disrupt the environment and/or nutrient supply on which tumor cells depend. To achieve this goal, based on the unique physicochemical properties and biological effects of CaO 2 , we designed and constructed a Ca2+ nanogenerator (named as CaO 2 -Cu/ICG@PCM) that enables H 2 O 2 /O 2 self-supplementation and GSH depletion. The 808 nm laser induces the heat generation of photosensitizer indocyanine green (ICG) to initiate a series of reactions, followed by the production of copper ions, H 2 O 2 , O 2 and large amounts of Ca2+, which can eventually lead to the combined treatment of photodynamic therapy (PDT), chemodynamic therapy (CDT) and calcium overload. Additionally, the reaction process is accompanied by the generation of Ca(OH) 2 , which greatly improves the acidic environment of TME and effectively promotes the oxidation process of GSH by H 2 O 2 , achieving the purpose of remodeling TME. It is worth mentioning that a large amount of free Ca2+ accumulating in tumor cells can rapidly initiate the process of calcium overload and calcification, which can not only play a role in tumor suppression, but also assist CT imaging to detect the effect of treatment. Thus, CaO 2 -Cu/ICG@PCM could be a promising candidate for bioimaging and tumor therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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