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Your search keyword '"Chi-Feng Liu"' showing total 3 results
3 results on '"Chi-Feng Liu"'

1. Tetramethylpyrazine protects mice against thioacetamide-induced acute hepatotoxicity

Author

Sheng-Chou C Tasi, Chi-Feng Liu, Edmund Cheung So, Kar-Lok Wong, and Tian-Chyuan Huang

Subjects
Interleukin 2, Male, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Pharmacology, Thioacetamide, medicine.disease_cause, Lipid peroxidation, chemistry.chemical_compound, Mice, medicine, Tetramethylpyrazine, Animals, Pharmacology (medical), Aspartate Aminotransferases, Molecular Biology, Chromatography, High Pressure Liquid, Mice, Inbred ICR, Biochemistry (medical), Alanine Transaminase, Cell Biology, General Medicine, Malondialdehyde, digestive system diseases, In vitro, chemistry, Biochemistry, Liver, Pyrazines, Interleukin-2, Hepatocellular injury, Lipid Peroxidation, Chemical and Drug Induced Liver Injury, Oxidative stress, medicine.drug
Abstract

In this study, the intraperitoneal administration of 1 mg/kg thioacetamide (TAA) produced hepatotoxicity in mice. The increase in serum SGOT and SGPT produced at 24 h by this regimen was decreased in a dose-dependent manner by coadministration of tetramethylpyrazine (TMP; 10, 25 and 50 mg/kg). A rise in serum interleukin-2 was similarly prevented. Increased concentrations of malondialdehyde (MDA) generated in vitro in liver homogenates prepared from TAA-treated mice were decreased by TMP treatments. The increase in MDA produced by TAA was also prevented by in vitro addition of TMP to liver homogenates. These results suggest that part of the hepatocellular injury induced by TAA is mediated by oxidative stress caused by the action of cytokines through lipid peroxidation. TMP appears to act by preventing lipid peroxidation.

Published
2002

2. Protective effect of tetramethylpyrazine on absolute ethanol-induced renal toxicity in mice

Author

Song Chow Lin, Chun Ching Lin, Mei Hsiu Lin, Hui Wen Chang, and Chi Feng Liu

Subjects
Male, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Cytochrome c Group, Pharmacology, urologic and male genital diseases, Kidney, Blood Urea Nitrogen, Lipid peroxidation, chemistry.chemical_compound, Mice, Oral administration, Malondialdehyde, medicine, Tetramethylpyrazine, Animals, heterocyclic compounds, Pharmacology (medical), Molecular Biology, Blood urea nitrogen, Creatinine, Mice, Inbred ICR, Ethanol, Biochemistry (medical), Kidney metabolism, Cell Biology, General Medicine, bacterial infections and mycoses, Calcium Channel Blockers, female genital diseases and pregnancy complications, medicine.anatomical_structure, chemistry, Biochemistry, Pyrazines, Toxicity, Kidney Diseases, Lipid Peroxidation, human activities
Abstract

Acute administration of absolute ethanol (10 ml/kg) per os to fasted mice produced extensive renal failure as measured by a rise in blood urea nitrogen and creatinine. Pretreatment with oral administration of tetramethylpyrazine (TMP) prevented such failure. The maximal effect against absolute ethanol-induced renal failure could be observed 1 h after TMP administration. In order to further investigate the renal protective mechanism of TMP, experiments on lipid peroxidation and superoxide scavenging activity were conducted. Renal homogenates made from mice treated with ethanol showed that TMP pretreatment had an antioxidant effect. Mice in acute renal failure had higher malonic dialdehyde concentrations than those pretreated with TMP. The renal protective mechanism of TMP was attributed, in part, to its prominent superoxide scavenging effect, which protects the kidney from superoxide-induced renal damage.

Published
2002

3. Protective Effect of Tetramethylpyrazine on Absolute Ethanol-Induced Renal Toxicity in Mice.

Author

Chi-Feng Liu, Mei-Hsiu Lin, Rodney C., Chun-Ching Lin, Hui-Wen Chang, Rodney C., and Song-Chow Lin, Rodney C.

Subjects
*ALCOHOL, *ANTIOXIDANTS, *CHEMICAL inhibitors, *PEROXIDATION, *NEPHROTOXICOLOGY, *BIOCHEMISTRY
Abstract

Acute administration of absolute ethanol (10 ml/kg) per os to fasted mice produced extensive renal failure as measured by a rise in blood urea nitrogen and creatinine. Pretreatment with oral administration of tetramethylpyrazine (TMP) prevented such failure. The maximal effect against absolute ethanol-induced renal failure could be observed 1 h after TMP administration. In order to further investigate the renal protective mechanism of TMP, experiments on lipid peroxidation and superoxide scavenging activity were conducted. Renal homogenates made from mice treated with ethanol showed that TMP pretreatment had an antioxidant effect. Mice in acute renal failure had higher malonic dialdehyde concentrations than those pretreated with TMP. The renal protective mechanism of TMP was attributed, in part, to its prominent superoxide scavenging effect, which protects the kidney from superoxide-induced renal damage.Copyright © 2002 National Science Council, ROC and S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2002
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