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10 results on '"van der Kouwe, Emiel"'

1. Myeloid lncRNA LOUP mediates opposing regulatory effects of RUNX1 and RUNX1-ETO in t(8;21) AML

Author

Trinh, Bon Q., Ummarino, Simone, Zhang, Yanzhou, Ebralidze, Alexander K., Bassal, Mahmoud A., Nguyen, Tuan M., Heller, Gerwin, Coffey, Rory, Tenen, Danielle E., van der Kouwe, Emiel, Fabiani, Emiliano, Gurnari, Carmelo, Wu, Chan-Shuo, Angarica, Vladimir Espinosa, Yang, Henry, Chen, Sisi, Zhang, Hong, Thurm, Abby R., Marchi, Francisco, Levantini, Elena, Staber, Philipp B., Zhang, Pu, Voso, Maria Teresa, Pandolfi, Pier Paolo, Kobayashi, Susumu S., Chai, Li, Di Ruscio, Annalisa, and Tenen, Daniel G.

Published
2021
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2. Blood / Core binding factor leukemia hijacks T-cell prone PU.1 antisense promoter

Author

van der Kouwe, Emiel, Heller, Gerwin, Czibere, Akos, Pulikkan, John A., Agreiter, Christiane, Castilla, Lucio H., Delwel, Ruud, Di Ruscio, Annalisa, Ebralidze, Alexander K., Forte, Maurizio, Grebien, Florian, Heyes, Elizabeth, Kazianka, Lukas, Klinger, Julian, Kornauth, Christoph, Le, Trang, Lind, Karin, Barbosa, Inês Amorim Monteiro, Pemovska, Tea, Pichler, Alexander Sebastian, Schmolke, Ann-Sofie, Schweicker, Carmen Marita, Sill, Heinz, Sperr, Wolfgang R., Spittler, Andreas, Surapally, Sridevi, Trinh, Bon Q., Valent, Peter, Vanura, Katrina, Welner, Robert S., Zuber, Johannes, Tenen, Daniel G., and Staber, Philipp B.

Published
2021

3. Rationale for the combination of venetoclax and ibrutinib in T-prolymphocytic leukemia

Author

Kornauth, Christoph, primary, Herbaux, Charles, additional, Boidol, Bernd, additional, Guillemette, Chantal, additional, Caron, Patrick, additional, Mayerhöfer, Marius E., additional, Poulain, Stéphanie, additional, Tournilhac, Olivier, additional, Pemovska, Tea, additional, Chong, Stephen J.F., additional, Van der Kouwe, Emiel, additional, Kazianka, Lukas, additional, Hopfinger, Georg, additional, Heintel, Daniel, additional, Jäger, Roland, additional, Raderer, Markus, additional, Jäger, Ulrich, additional, Simonitsch-Klupp, Ingrid, additional, Sperr, Wolfgang R., additional, Kubicek, Stefan, additional, Davids, Matthew S., additional, and Staber, Philipp B., additional

Published
2021
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4. Treatment Guided By Next Generation Functional Drug Screening Provides Clinical Benefit in Advanced Aggressive Hematological Malignancies: Final Evaluation of the Open Label, Single Arm Exalt Trial

Author

Kornauth, Christoph, primary, Pemovska, Tea, additional, Vladimer, Gregory Ian, additional, Bayer, Günther, additional, Bergmann, Michael, additional, Eder, Sandra, additional, Eichner, Ruth, additional, Esterbauer, Harald, additional, Exner, Ruth, additional, Felsleitner-Hauer, Verena, additional, Forte, Maurizio, additional, Gaiger, Alexander, additional, Greinix, Hildegard T., additional, Gstöttner, Wolfgang, additional, Hacker, Marcus, additional, Hauswirth, Alexander, additional, Heinemann, Tim, additional, Heintel, Daniel, additional, Hoda, Mir Ali Reza, additional, Jaeger, Ulrich, additional, Kazianka, Lukas, additional, Kenner, Lukas, additional, Kiesewetter, Barbara, additional, Krall, Nikolaus, additional, Le, Trang, additional, Lubowitzki, Simone, additional, Mayerhoefer, Marius E, additional, Menschel, Elisabeth, additional, Merkel, Olaf, additional, Miura, Katsuhiro, additional, Muellauer, Leonhard, additional, Neumeister, Peter, additional, Noesslinger, Thomas, additional, Ocko, Katharina, additional, Öhler, Leopold, additional, Panny, Michael, additional, Pichler, Alexander, additional, Porpaczy, Edit Anna, additional, Prager, Gerald, additional, Raderer, Markus, additional, Ristl, Robin, additional, Ruckser, Reinhard, additional, Salamon, Julius, additional, Schiefer, Ana-Iris, additional, Schmolke, Ann-Sofie, additional, Schwarzinger, Ilse, additional, Selzer, Edgar, additional, Skrabs, Cathrin, additional, Sperr, Wolfgang R., additional, Srndic, Ismet, additional, Thalhammer, Renate, additional, Valent, Peter, additional, van der Kouwe, Emiel, additional, Vanura, Katrina, additional, Vogt, Stefan, additional, Waldstein, Cora, additional, Wolf, Dominik, additional, Zielinski, Christoph, additional, Simonitsch-Klupp, Ingrid, additional, Superti-Furga, Giulio, additional, Snijder, Berend, additional, and Staber, Philipp B., additional

Published
2020
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5. Core Binding Factor Leukemias Utilize a Physiologic Sense/Antisense Promoter Switch Employed By T-Cells

Author

van der Kouwe, Emiel, primary, Heller, Gerwin, additional, Czibere, Akos, additional, Castilla, Lucio H., additional, Delwel, Ruud, additional, Di Ruscio, Annalisa, additional, Ebralidze, Alexander, additional, Forte, Maurizio, additional, Kazianka, Lukas, additional, Kornauth, Christoph, additional, Le, Trang, additional, Lind, Karin, additional, Barbosa, Ines, additional, Pichler, Alexander, additional, Pulikkan, John, additional, Schmolke, Ann-Sofie, additional, Sill, Heinz, additional, Sperr, Wolfgang R., additional, Spittler, Andreas, additional, Trinh, Bon Q., additional, Valent, Peter, additional, Vanura, Katrina, additional, Welner, Robert, additional, Zuber, Johannes, additional, Tenen, Daniel G., additional, and Staber, Philipp B., additional

Published
2020
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7. First-in-human response of BCL-2 inhibitor venetoclax in T-cell prolymphocytic leukemia

Author

Boidol, Bernd, Kornauth, Christoph, van der Kouwe, Emiel, Prutsch, Nicole, Kazianka, Lukas, Gültekin, Sinan, Hoermann, Gregor, Mayerhoefer, Marius E., Hopfinger, Georg, Hauswirth, Alexander, Panny, Michael, Aretin, Marie-Bernadette, Hilgarth, Bernadette, Sperr, Wolfgang R., Valent, Peter, Simonitsch-Klupp, Ingrid, Moriggl, Richard, Merkel, Olaf, Kenner, Lukas, Jäger, Ulrich, Kubicek, Stefan, and Staber, Philipp B.

Published
2017
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9. Myeloid lncRNA LOUPmediates opposing regulatory effects of RUNX1 and RUNX1-ETO in t(8;21) AML

Author

Trinh, Bon Q., Ummarino, Simone, Zhang, Yanzhou, Ebralidze, Alexander K., Bassal, Mahmoud A., Nguyen, Tuan M., Heller, Gerwin, Coffey, Rory, Tenen, Danielle E., van der Kouwe, Emiel, Fabiani, Emiliano, Gurnari, Carmelo, Wu, Chan-Shuo, Angarica, Vladimir Espinosa, Yang, Henry, Chen, Sisi, Zhang, Hong, Thurm, Abby R., Marchi, Francisco, Levantini, Elena, Staber, Philipp B., Zhang, Pu, Voso, Maria Teresa, Pandolfi, Pier Paolo, Kobayashi, Susumu S., Chai, Li, Di Ruscio, Annalisa, and Tenen, Daniel G.

Abstract

The mechanism underlying cell type-specific gene induction conferred by ubiquitous transcription factors as well as disruptions caused by their chimeric derivatives in leukemia is not well understood. Here, we investigate whether RNAs coordinate with transcription factors to drive myeloid gene transcription. In an integrated genome-wide approach surveying for gene loci exhibiting concurrent RNA and DNA interactions with the broadly expressed Runt-related transcription factor 1 (RUNX1), we identified the long noncoding RNA (lncRNA) originating from the upstream regulatory element of PU.1(LOUP). This myeloid-specific and polyadenylated lncRNA induces myeloid differentiation and inhibits cell growth, acting as a transcriptional inducer of the myeloid master regulator PU.1. Mechanistically, LOUPrecruits RUNX1 to both the PU.1enhancer and the promoter, leading to the formation of an active chromatin loop. In t(8;21) acute myeloid leukemia (AML), wherein RUNX1 is fused to ETO, the resulting oncogenic fusion protein, RUNX1-ETO, limits chromatin accessibility at the LOUPlocus, causing inhibition of LOUPand PU.1expression. These findings highlight the important role of the interplay between cell-type–specific RNAs and transcription factors, as well as their oncogenic derivatives in modulating lineage-gene activation and raise the possibility that RNA regulators of transcription factors represent alternative targets for therapeutic development.

Published
2021
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10. Next-Generation Functional Drug Screening for Patients with Aggressive Hematologic Malignancies

Author

Staber, Philipp Bernhard, primary, Snijder, Berend, additional, Vladimer, Gregory Ian, additional, Krall, Nikolaus, additional, Miura, Katsuhiro, additional, Schmolke, Ann-Sofie, additional, Kornauth, Christoph, additional, Lopez de la Fuente, Oscar, additional, Choi, Hye-Soo, additional, van der Kouwe, Emiel, additional, Kazianka, Lukas, additional, Bigenzahn1, Johannes, additional, Hoermann, Gregor, additional, Prutsch, Nicole, additional, Merkel, Olaf, additional, Ringler, Anna, additional, Jeryczynski, Georg, additional, Mayerhoefer, Marius, additional, Simonitsch-Klupp, Ingrid, additional, Felberbauer, Franz X, additional, Muellauer, Leonhard, additional, Prager, Gerald W, additional, Korkmaz, Belgin, additional, Kenner, Lukas, additional, Sperr, Wolfgang R., additional, Kralovics, Robert, additional, Gisslinger, Heinz, additional, Valent, Peter, additional, Kubicek, Stefan, additional, Jaeger, Ulrich, additional, and Superti-Furga, Giulio, additional

Published
2017
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