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1. Topics, Delivery Modes, and Social-Epistemological Dimensions of Web-Based Information for Patients Undergoing Renal Transplant and Living Donors During the COVID-19 Pandemic: Content Analysis

Author

van Klaveren, Charlotte W, de Jong, Peter G M, Hendriks, Renée A, Luk, Franka, de Vries, Aiko P J, van der Boog, Paul J M, and Reinders, Marlies E J

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
Abstract

BackgroundThe COVID-19 pandemic has markedly affected renal transplant care. During this time of social distancing, limited in-person visits, and uncertainty, patients and donors are relying more than ever on telemedicine and web-based information. Several factors can influence patients’ understanding of web-based information, such as delivery modes (instruction, interaction, and assessment) and social-epistemological dimensions (choices in interactive knowledge building). ObjectiveThe aim of this study was to systemically evaluate the content, delivery modes, and social-epistemological dimensions of web-based information on COVID-19 and renal transplantation at time of the pandemic. MethodsMultiple keyword combinations were used to retrieve websites on COVID-19 and renal transplantation using the search engines Google.com and Google.nl. From 14 different websites, 30 webpages were examined to determine their organizational sources, topics, delivery modes, and social-epistemological dimensions. ResultsThe variety of topics and delivery modes was limited. A total of 13 different delivery modes were encountered, of which 8 (62%) were instructional and 5 (38%) were interactional; no assessment delivery modes were observed. No website offered all available delivery modes. The majority of delivery modes (8/13, 62%) focused on individual and passive learning, whereas group learning and active construction of knowledge were rarely encountered. ConclusionsBy taking interactive knowledge transfer into account, the educational quality of eHealth for transplant care could increase, especially in times of crisis when rapid knowledge transfer is needed.

Published
2020
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5. Impact of a Public Health Emergency on Behavior, Stress, Anxiety and Glycemic Control in Patients With Pancreas or Islet Transplantation for Type 1 Diabetes

Author

Landstra, Cyril P., primary, Ruissen, Merel M., additional, Regeer, Hannah, additional, Nijhoff, Michiel F., additional, Ballieux, Bart E. P. B., additional, van der Boog, Paul J. M., additional, de Vries, Aiko P. J., additional, Huisman, Sasja D., additional, and de Koning, Eelco J. P., additional

Published
2024
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6. Ellipro scores of donor epitope specific HLA antibodies are not associated with kidney graft survival

Author

Kardol-Hoefnagel, Tineke, Senejohnny, Danial Mohammadi, Kamburova, Elena G., Wisse, Bram W., Gruijters, Maartje L., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Drop, Adriaan C.A.D., Plaisier, Loes, Melchers, Rowena C.A., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Kroesen, Bart Jan, Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Roelen, Dave L., Claas, Frans H., Bemelman, Frederike J., Heidt, Sebastiaan, Otten, Henny G., Kardol-Hoefnagel, Tineke, Senejohnny, Danial Mohammadi, Kamburova, Elena G., Wisse, Bram W., Gruijters, Maartje L., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Drop, Adriaan C.A.D., Plaisier, Loes, Melchers, Rowena C.A., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Kroesen, Bart Jan, Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Roelen, Dave L., Claas, Frans H., Bemelman, Frederike J., Heidt, Sebastiaan, and Otten, Henny G.

Abstract

In kidney transplantation, donor HLA antibodies are a risk factor for graft loss. Accessibility of donor eplets for HLA antibodies is predicted by the ElliPro score. The clinical usefulness of those scores in relation to transplant outcome is unknown. In a large Dutch kidney transplant cohort, Ellipro scores of pretransplant donor antibodies that can be assigned to known eplets (donor epitope specific HLA antibodies [DESAs]) were compared between early graft failure and long surviving deceased donor transplants. We did not observe a significant Ellipro score difference between the two cohorts, nor significant differences in graft survival between transplants with DESAs having high versus low total Ellipro scores. We conclude that Ellipro scores cannot be used to identify DESAs associated with early versus late kidney graft loss in deceased donor transplants.

Published
2024

7. Determination of the clinical relevance of donor epitope-specific HLA-antibodies in kidney transplantation

Author

Kardol-Hoefnagel, Tineke, Senejohnny, Danial Mohammadi, Kamburova, Elena G., Wisse, Bram W., Reteig, Leon, Gruijters, Maartje L., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Melchers, Rowena C.A., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Roelen, Dave L., Claas, Frans H., Bemelman, Frederike J., Senev, Aleksandar, Naesens, Maarten, Heidt, Sebastiaan, Otten, Henny G., Kardol-Hoefnagel, Tineke, Senejohnny, Danial Mohammadi, Kamburova, Elena G., Wisse, Bram W., Reteig, Leon, Gruijters, Maartje L., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Melchers, Rowena C.A., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Roelen, Dave L., Claas, Frans H., Bemelman, Frederike J., Senev, Aleksandar, Naesens, Maarten, Heidt, Sebastiaan, and Otten, Henny G.

Abstract

In kidney transplantation, survival rates are still partly impaired due to the deleterious effects of donor specific HLA antibodies (DSA). However, not all luminex-defined DSA appear to be clinically relevant. Further analysis of DSA recognizing polymorphic amino acid configurations, called eplets or functional epitopes, might improve the discrimination between clinically relevant vs. irrelevant HLA antibodies. To evaluate which donor epitope-specific HLA antibodies (DESAs) are clinically important in kidney graft survival, relevant and irrelevant DESAs were discerned in a Dutch cohort of 4690 patients using Kaplan–Meier analysis and tested in a cox proportional hazard (CPH) model including nonimmunological variables. Pre-transplant DESAs were detected in 439 patients (9.4%). The presence of certain clinically relevant DESAs was significantly associated with increased risk on graft loss in deceased donor transplantations (p < 0.0001). The antibodies recognized six epitopes of HLA Class I, 3 of HLA-DR, and 1 of HLA-DQ, and most antibodies were directed to HLA-B (47%). Fifty-three patients (69.7%) had DESA against one donor epitope (range 1–5). Long-term graft survival rate in patients with clinically relevant DESA was 32%, rendering DESA a superior parameter to classical DSA (60%). In the CPH model, the hazard ratio (95% CI) of clinically relevant DESAs was 2.45 (1.84–3.25) in deceased donation, and 2.22 (1.25–3.95) in living donation. In conclusion, the developed model shows the deleterious effect of clinically relevant DESAs on graft outcome which outperformed traditional DSA-based risk analysis on antigen level.

Published
2024

8. Ellipro scores of donor epitope specific HLA antibodies are not associated with kidney graft survival

Author

CTI Otten, CTI, CDL Cluster Speciële Diagnostiek, Cancer, Infection & Immunity, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, CDL Unit SKIM, CTI CFF, Kardol-Hoefnagel, Tineke, Senejohnny, Danial Mohammadi, Kamburova, Elena G., Wisse, Bram W., Gruijters, Maartje L., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Drop, Adriaan C.A.D., Plaisier, Loes, Melchers, Rowena C.A., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Kroesen, Bart Jan, Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Roelen, Dave L., Claas, Frans H., Bemelman, Frederike J., Heidt, Sebastiaan, Otten, Henny G., CTI Otten, CTI, CDL Cluster Speciële Diagnostiek, Cancer, Infection & Immunity, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, CDL Unit SKIM, CTI CFF, Kardol-Hoefnagel, Tineke, Senejohnny, Danial Mohammadi, Kamburova, Elena G., Wisse, Bram W., Gruijters, Maartje L., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Drop, Adriaan C.A.D., Plaisier, Loes, Melchers, Rowena C.A., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Kroesen, Bart Jan, Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Roelen, Dave L., Claas, Frans H., Bemelman, Frederike J., Heidt, Sebastiaan, and Otten, Henny G.

Published
2024

10. Antibodies against ARHGDIB are associated with long-term kidney graft loss

Author

Kamburova, Elena G., Gruijters, Maartje L., Kardol-Hoefnagel, Tineke, Wisse, Bram W., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Melchers, Rowena C.A., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Bemelman, Frederike J., and Otten, Henny G.

Published
2019
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12. Meltdose Tacrolimus Population Pharmacokinetics and Limited Sampling Strategy Evaluation in Elderly Kidney Transplant Recipients.

Author

Kamp, Jasper, Zwart, Tom C., Meziyerh, Soufian, van der Boog, Paul J. M., Nijgh, Esther E., van Duin, Koen, de Vries, Aiko P. J., and Moes, Dirk Jan A. R.

Subjects
KIDNEY transplantation, CREATININE, KIDNEYS, TACROLIMUS, OLDER people, PHARMACOKINETICS, OLDER patients
Abstract

Background: Meltdose tacrolimus (Envarsus®) has been marketed as a formulation achieving a more consistent tacrolimus exposure. Due to the narrow therapeutic window of tacrolimus, dose individualization is essential. Relaxation of the upper age limits for kidney transplantations has resulted in larger numbers of elderly patients receiving tacrolimus. However, due to the physiological changes caused by aging, the tacrolimus pharmacokinetics (PK) might be altered. The primary aim was to develop a population PK model in elderly kidney transplant recipients. Secondary aims were the development and evaluation of a limited sampling strategy (LSS) for AUC estimation. Methods: A total of 34 kidney transplant recipients aged ≥65 years, starting on meltdose tacrolimus directly after transplantation, were included. An eight-point whole blood AUC0–24h and an abbreviated dried blood spot (DBS) AUC0–24h were obtained. The PK data were analyzed using nonlinear mixed effect modeling methods. Results: The PK data were best described using a two-compartment model, including three transit compartments and a mixture model for oral absorption. The best three-sample LSS was T = 0, 2, 6 h. The best four-sample LSSs were T = 0, 2, 6, 8 h and T = 0, 1, 6, 8 h. Conclusions: The developed population PK model adequately described the tacrolimus PK data in a population of elderly kidney transplant recipients. In addition, the developed population PK model and LSS showed an adequate estimation of tacrolimus exposure, and may therefore be used to aid in tacrolimus dose individualization. [ABSTRACT FROM AUTHOR]

Published
2024
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15. eHealth to Improve Psychological Functioning and Self-Management of People With Chronic Kidney Disease:A Randomized Controlled Trial

Author

Cardol, Cinderella K., Van Middendorp, Henriët, Dusseldorp, Elise, Van Der Boog, Paul J.M., Hilbrands, Luuk B., Navis, Gerjan, Sijpkens, Yvo W.J., Evers, Andrea W.M., Van Dijk, Sandra, Cardol, Cinderella K., Van Middendorp, Henriët, Dusseldorp, Elise, Van Der Boog, Paul J.M., Hilbrands, Luuk B., Navis, Gerjan, Sijpkens, Yvo W.J., Evers, Andrea W.M., and Van Dijk, Sandra

Abstract

Objective Psychological distress is common among patients with chronic kidney disease and can interfere with disease self-management. We assessed the effectiveness of the personalized E-GOAL electronic health care pathway with screening and cognitive-behavioral therapy including self-management support, aimed to treat psychological distress and facilitate self-management among people with chronic kidney disease not on dialysis (N = 121). Methods Primary outcome of the open two-arm parallel randomized controlled trial in four Dutch hospitals was psychological distress at posttest directly after the intervention and at 3-month follow-up. Secondary outcomes were physical and mental health-related quality of life, self-efficacy, chronic disease self-management, and personalized outcomes, that is, perceived progress compared with the previous time point on functioning (e.g., mood or social functioning) and self-management (e.g., dietary or medication adherence) outcomes that were prioritized by each individual. Results Linear mixed-effects analyses showed no significant time-by-group interaction effects for psychological distress, health-related quality of life, self-efficacy, and chronic condition self-management, whereas analyses of covariance showed significantly more perceived progress in the intervention group at posttest on personally prioritized areas of functioning (b = 0.46, 95% confidence interval = 0.07-0.85) and self-management (b = 0.55, 95% confidence interval = 0.16-0.95), with Cohen d values of 0.46 and 0.54 (medium effects), respectively. Effects on personalized outcomes were maintained at follow-up. Conclusions Compared with regular care only, the electronic health intervention did not reduce psychological distress, whereas personalized outcomes did improve significantly after intervention. Future studies could consider personalized outcomes that reflect individually relevant areas and treatment goals, matching person-tailored treatments.

Published
2023

16. eHealth to Improve Psychological Functioning and Self-Management of People With Chronic Kidney Disease: A Randomized Controlled Trial

Author

Cardol, Cinderella K. (author), van Middendorp, Henriët (author), Dusseldorp, Elise (author), van der Boog, Paul J.M. (author), Hilbrands, Luuk B. (author), Navis, Gerjan (author), Sijpkens, Yvo W.J. (author), Evers, A.W.M. (author), van Dijk, Sandra (author), Cardol, Cinderella K. (author), van Middendorp, Henriët (author), Dusseldorp, Elise (author), van der Boog, Paul J.M. (author), Hilbrands, Luuk B. (author), Navis, Gerjan (author), Sijpkens, Yvo W.J. (author), Evers, A.W.M. (author), and van Dijk, Sandra (author)

Abstract

Objective Psychological distress is common among patients with chronic kidney disease and can interfere with disease self-management. We assessed the effectiveness of the personalized E-GOAL electronic health care pathway with screening and cognitive-behavioral therapy including self-management support, aimed to treat psychological distress and facilitate self-management among people with chronic kidney disease not on dialysis (N = 121). Methods Primary outcome of the open two-arm parallel randomized controlled trial in four Dutch hospitals was psychological distress at posttest directly after the intervention and at 3-month follow-up. Secondary outcomes were physical and mental health-related quality of life, self-efficacy, chronic disease self-management, and personalized outcomes, that is, perceived progress compared with the previous time point on functioning (e.g., mood or social functioning) and self-management (e.g., dietary or medication adherence) outcomes that were prioritized by each individual. Results Linear mixed-effects analyses showed no significant time-by-group interaction effects for psychological distress, health-related quality of life, self-efficacy, and chronic condition self-management, whereas analyses of covariance showed significantly more perceived progress in the intervention group at posttest on personally prioritized areas of functioning (b = 0.46, 95% confidence interval = 0.07-0.85) and self-management (b = 0.55, 95% confidence interval = 0.16-0.95), with Cohen d values of 0.46 and 0.54 (medium effects), respectively. Effects on personalized outcomes were maintained at follow-up. Conclusions Compared with regular care only, the electronic health intervention did not reduce psychological distress, whereas personalized outcomes did improve significantly after intervention. Future studies could consider personalized outcomes that reflect individually relevant areas and treatment goals, matching person-tailored treatments., Applied Ergonomics and Design

Published
2023
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17. eHealth to Improve Psychological Functioning and Self-Management of People With Chronic Kidney Disease: A Randomized Controlled Trial

Author

Cardol, Cinderella K., van Middendorp, Henriët, Dusseldorp, Elise, van der Boog, Paul J.M., Hilbrands, Luuk B., Navis, Gerjan, Sijpkens, Yvo W.J., Evers, A.W.M., van Dijk, Sandra, Health Economics (HE), Value, Affordability and Sustainability (VALUE), and Groningen Kidney Center (GKC)

Subjects
self-management, patient-tailored care, psychological distress, SDG 3 - Good Health and Well-being, randomized controlled trial, eHealth, chronic kidney disease
Abstract

Objective Psychological distress is common among patients with chronic kidney disease and can interfere with disease self-management. We assessed the effectiveness of the personalized E-GOAL electronic health care pathway with screening and cognitive-behavioral therapy including self-management support, aimed to treat psychological distress and facilitate self-management among people with chronic kidney disease not on dialysis (N = 121). Methods Primary outcome of the open two-arm parallel randomized controlled trial in four Dutch hospitals was psychological distress at posttest directly after the intervention and at 3-month follow-up. Secondary outcomes were physical and mental health-related quality of life, self-efficacy, chronic disease self-management, and personalized outcomes, that is, perceived progress compared with the previous time point on functioning (e.g., mood or social functioning) and self-management (e.g., dietary or medication adherence) outcomes that were prioritized by each individual. Results Linear mixed-effects analyses showed no significant time-by-group interaction effects for psychological distress, health-related quality of life, self-efficacy, and chronic condition self-management, whereas analyses of covariance showed significantly more perceived progress in the intervention group at posttest on personally prioritized areas of functioning (b = 0.46, 95% confidence interval = 0.07-0.85) and self-management (b = 0.55, 95% confidence interval = 0.16-0.95), with Cohen d values of 0.46 and 0.54 (medium effects), respectively. Effects on personalized outcomes were maintained at follow-up. Conclusions Compared with regular care only, the electronic health intervention did not reduce psychological distress, whereas personalized outcomes did improve significantly after intervention. Future studies could consider personalized outcomes that reflect individually relevant areas and treatment goals, matching person-tailored treatments.

Published
2023

19. The impact of reclassification by the 2022 ACR/EULAR classification criteria on risk factors for relapse in patients with ANCA-associated vasculitis.

Author

Leeuwen, Jolijn R van, Hafemann, Sophia, van der Boog, Paul, van der Woude, Diane, Rabelink, Ton, and Teng, Y K Onno

Subjects
DISEASE risk factors, VASCULITIS, CHURG-Strauss syndrome, MICROSCOPIC polyangiitis
Abstract

This article discusses the impact of the 2022 ACR/EULAR classification criteria on risk factors for relapse in patients with ANCA-associated vasculitis (AAV). AAV is a rare and life-threatening disease characterized by inflammation of the small vessels. The new classification criteria aim to improve the subtyping of AAV patients and ensure homogeneous populations for clinical trials. The study found that the criteria had a minimal impact on patient selection for granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) studies, but potentially negative consequences for eosinophilic granulomatosis with polyangiitis (EGPA) studies. Reclassification also affected the distribution of risk factors for relapse in different AAV subtypes. [Extracted from the article]

Published
2023
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20. COVID-box Experiences of Patients and Health Care Professionals (COVID-box Project): Single-Center, Retrospective, Observational Study

Author

Dirikgil, Ebru, primary, Brons, Kim, additional, Duindam, Michael, additional, Groeneveld, Geert H, additional, Geelhoed, J J Miranda, additional, Heringhaus, Christian, additional, van der Boog, Paul J M, additional, Rabelink, Ton J, additional, Bos, Willem Jan W, additional, Chavannes, Niels H, additional, Atsma, Douwe E, additional, and Teng, Y K Onno, additional

Published
2022
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22. Didactical characteristics of Dutch websites about kidney transplantation targeted for kidney patients and living donors:An exploratory study

Author

van Klaveren, Charlotte W., de Jong, Peter G.M., Hendriks, Renée A., Luk, Franka, de Vries, Aiko P.J., van der Boog, Paul J.M., Rabelink, A. J., Reinders, Marlies E.J., van Klaveren, Charlotte W., de Jong, Peter G.M., Hendriks, Renée A., Luk, Franka, de Vries, Aiko P.J., van der Boog, Paul J.M., Rabelink, A. J., and Reinders, Marlies E.J.

Abstract

Objective: The aim was to explore the origin, content topics, teaching modes (instruction, interaction, and assessment), and corresponding social-epistemological dimensions (choices in knowledge transfer vs. knowledge building, and individual vs. group learning) of web-based information on kidney transplantation targeted for patients and living donors. Methods: Dutch websites on kidney transplantation were retrieved using the search engine Google.nl. From 24 websites, 250 webpages were examined on origin, content topics, teaching modes, and corresponding social-epistemological dimensions. Results: The majority of the websites had a professional organization as origin (20/24). The number and distribution of content topics varied among the websites. Of the 16 different teaching modes found, 11 were instructional, 4 were interactional, and 1 assessment mode was found. The websites offered almost exclusively teaching modes on individual and passive learning, whereas group learning and interactive knowledge building was hardly encountered. Conclusion: The diversity in teaching modes and social-epistemological dimensions of Dutch websites on kidney transplantation targeted for patients and living donors is limited. The websites only provided a partial view on kidney transplantation; information regarding contact with others, e.g. support, was limited. A more balanced availability of teaching approaches and content topics is desirable to fit with the didactical goals to make well-considered health decisions.

Published
2022

23. Digital tools/eHealth to support CKD self-management:A qualitative study of perceptions, attitudes and needs of patients and health care professionals in China

Author

Shen, Hongxia, van der Kleij, Rianne, van der Boog, Paul J.M., Wang, Wenjiao, Song, Xiaoyue, Li, Zhengyan, Brakema, Evelyn, Lou, Xiaoping, Chavannes, Niels, Shen, Hongxia, van der Kleij, Rianne, van der Boog, Paul J.M., Wang, Wenjiao, Song, Xiaoyue, Li, Zhengyan, Brakema, Evelyn, Lou, Xiaoping, and Chavannes, Niels

Abstract

Background: A growing body of evidence supports the potential effectiveness of electronic health (eHealth) self-management interventions in improving disease self-management skills and health outcomes of patients suffering from chronic kidney disease (CKD). However, current research on CKD eHealth self-management interventions has almost exclusively focused on high-income, western countries. Objective: To inform the adaptation of a tailored eHealth self-management intervention for patients with CKD in China based on the Dutch Medical Dashboard (MD) intervention, we examined the perceptions, attitudes and needs of Chinese patients with CKD and health care professionals (HCPs) towards eHealth based (self-management) interventions in general and the Dutch MD intervention in specific. Methods: We conducted a basic interpretive, cross-sectional qualitative study comprising semi-structured interviews with 11 patients with CKD and 10 HCPs, and 2 focus group discussions with 9 patients with CKD. This study was conducted in the First Affiliated Hospital of Zhengzhou University in China. Data collection continued until data saturation was reached. All data were transcribed verbatim and analyzed using a framework approach. Results: Three themes emerged: (1) experience with eHealth in CKD (self-management), (2) needs for supporting CKD self-management with the use of eHealth, and (3) adaptation and implementation of the Dutch MD intervention in China. Both patients and HCPs had experience with and solely mentioned eHealth to ‘inform, monitor and track’ as potentially relevant interventions to support CKD self-management, not those to support ‘interaction’ and ‘data utilization’. Factors reported to influence the implementation of CKD eHealth self-management interventions included information barriers (i.e. quality and consistency of the disease-related information obtained via eHealth), perceived trustworthiness and safety of eHealth sources, clinical compatibility and compl

Published
2022

25. Understanding Health-Related Quality of Life in Kidney Transplant Recipients: The Role of Symptom Experience and Illness Perceptions.

Author

Yiman Wang, Van Der Boog, Paul, Hemmelder, Marc H., Dekker, Friedo W., De Vries, Aiko, and Meuleman, Yvette

Subjects
*KIDNEY transplantation, *QUALITY of life, *SYMPTOMS
Abstract

The purpose of our article is to investigate the impact of symptom experience on health related quality of life (HRQOL) in kidney transplant recipients (KTRs) and whether illness perceptions mediated this impact. Symptom experience, illness perceptions, and HRQOL were measured at transplantation and 6 weeks after transplantation in KTRs in an ongoing Dutch cohort study. Multivariable linear regression models were used for the analysis. 90 KTRs were analyzed. Fatigue and lack of energy were the most prevalent and burdensome symptoms at transplantation. Mental HRQOL at 6 weeks after transplantation was comparable to that of the general Dutch population (mean [standard deviation, SD]: 49.9 [10.7]) versus 50.2 [9.2]), while physical HRQOL was significantly lower (38.9 [9.1] versus 50.6 [9.2]). Experiencing more symptoms was associated with lower physical and mental HRQOL, and the corresponding HRQOL reduced by −0.15 (95%CI, −0.31; 0.02) and −0.23 (95%CI, −0.42; −0.04) with each additional symptom. The identified mediation effect suggests that worse symptom experiences could cause more unhelpful illness perceptions and consequently lead to lower HRQOL. Illness perceptions may explain the negative impact of symptom experience on HRQOL. Future studies at later stages after kidney transplantation are needed to further explore the mediation effect of illness perceptions and guide clinical practice to improve HRQOL. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Patients' and healthcare professionals' beliefs, perceptions and needs towards chronic kidney disease self-management in China:A qualitative study

Author

Shen, Hongxia, Van Der Kleij, Rianne M.J.J., Van Der Boog, Paul J.M., Wang, Wenjiao, Song, Xiaoyue, Li, Zhengyan, Lou, Xiaoping, Chavannes, Niels, Shen, Hongxia, Van Der Kleij, Rianne M.J.J., Van Der Boog, Paul J.M., Wang, Wenjiao, Song, Xiaoyue, Li, Zhengyan, Lou, Xiaoping, and Chavannes, Niels

Abstract

Objectives To support the adaptation and translation of an evidence-based chronic kidney disease (CKD) self-management intervention to the Chinese context, we examined the beliefs, perceptions and needs of Chinese patients with CKD and healthcare professionals (HCPs) towards CKD self-management. Design A basic interpretive, cross-sectional qualitative study comprising semistructured interviews and observations. Setting One major tertiary referral hospital in Henan province, China. Participants 11 adults with a diagnosis of CKD with CKD stages G1-G5 and 10 HCPs who worked in the Department of Nephrology. Results Four themes emerged: (1) CKD illness perceptions, (2) understanding of and motivation towards CKD self-management, (3) current CKD practice and (4) barriers, (anticipated) facilitators and needs towards CKD self-management. Most patients and HCPs solely mentioned medical management of CKD, and self-management was largely unknown or misinterpreted as adherence to medical treatment. Also, the majority of patients only mentioned performing disease-specific acts of control and not, for instance, behaviour for coping with emotional problems. A paternalistic patient-HCP relationship was often present. Finally, the barriers, facilitators and needs towards CKD self-management were frequently related to knowledge and environmental context and resources. Conclusions The limited understanding of CKD self-management, as observed, underlines the need for educational efforts on the use and benefits of self-management before intervention implementation. Also, specific characteristics and needs within the Chinese context need to guide the development or tailoring of CKD self-management interventions. Emphasis should be placed on role management and emotional coping skills, while self-management components should be tailored by addressing the existing paternalistic patient-HCP relationship. The use of electronic health innovations can be an essential facilitator for implem

Published
2021

28. Home monitoring reduced short stay admissions in suspected COVID-19 patients: COVID-box project

Author

Dirikgil, Ebru, primary, Roos, Rick, additional, Groeneveld, Geert H., additional, Heringhaus, Christian, additional, Silven, Anna V., additional, Petrus, Annelieke H.J., additional, Villalobos-Quesada, Maria, additional, Tsonaka, Roula, additional, van der Boog, Paul J.M., additional, Rabelink, Ton J., additional, Bos, Willem Jan W., additional, Chavannes, Niels H., additional, Atsma, Douwe E., additional, and Teng, Y.K. Onno, additional

Published
2021
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30. SERIES: eHealth in primary care. Part 2: Exploring the ethical implications of its application in primary care practice

Author

Medical Humanities Onderzoek Team 2, Circulatory Health, JC onderzoeksprogramma Methodologie, Child Health, HAG Diabetes, Boers, Sarah N., Jongsma, Karin R., Lucivero, Federica, Aardoom, Jiska, Büchner, Frederike L., de Vries, Martine, Honkoop, Persijn, Houwink, Elisa J.F., Kasteleyn, Marise J., Meijer, Eline, Pinnock, Hilary, Teichert, Martina, van der Boog, Paul, van Luenen, Sanne, van der Kleij, Rianne M.J.J., Chavannes, Niels H., Medical Humanities Onderzoek Team 2, Circulatory Health, JC onderzoeksprogramma Methodologie, Child Health, HAG Diabetes, Boers, Sarah N., Jongsma, Karin R., Lucivero, Federica, Aardoom, Jiska, Büchner, Frederike L., de Vries, Martine, Honkoop, Persijn, Houwink, Elisa J.F., Kasteleyn, Marise J., Meijer, Eline, Pinnock, Hilary, Teichert, Martina, van der Boog, Paul, van Luenen, Sanne, van der Kleij, Rianne M.J.J., and Chavannes, Niels H.

Published
2020

33. Illness Perceptions and Medication Nonadherence to Immunosuppressants After Successful Kidney Transplantation: A Cross-Sectional Study.

Author

Yiman Wang, Veltkamp, Denise M. J., van der Boog, Paul J. M., Hemmelder, Marc H., Dekker, Friedo W., de Vries, Aiko P. J., and Meuleman, Yvette

Subjects
KIDNEY transplantation, IMMUNOSUPPRESSIVE agents, CROSS-sectional method, ACADEMIC medical centers, PATIENT compliance
Abstract

Background: Medication nonadherence to immunosuppressants is a well-known risk factor for suboptimal health outcomes in kidney transplant recipients (KTRs). This study examined the relationship between illness perceptions and medication nonadherence in prevalent Dutch KTRs and whether this relationship depended on post-transplant time. Methods: Eligible KTRs transplanted in Leiden University Medical Center were invited for this cross-sectional study. The illness perceptions and medication nonadherence were measured via validated questionnaires. Associations between illness perceptions and medication nonadherence were investigated using multivariable logistic regression models. Results: For the study, 627 participating KTRs were analyzed. 203 (32.4%) KTRs were considered nonadherent to their immunosuppressants with "taking medication more than 2 h from the prescribed dosing time" as the most prevalent nonadherent behaviour (n = 171; 27.3%). Three illness perceptions were significantly associated withmedication nonadherence: illness identity (adjusted odds ratio [ORadj] = 1.07; 95% confidence interval [CI], 1.00-1.14), concern (ORadj = 1.07; 95%CI,1.00-1.14), and illness coherence (ORadj = 1.11; 95% CI,1.01-1.22). The relationships between illness perceptions and medication nonadherence did not differ depending on post-transplant time (p-values ranged from 0.48 to 0.96). Conclusion: Stronger negative illness perceptions are associated with medication nonadherence to immunosuppressants. Targeting negative illness perceptions by means of psychoeducational interventions could optimize medication adherence and consequently improve health outcomes in KTRs. [ABSTRACT FROM AUTHOR]

Published
2022
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35. Allocation to highly sensitized patients based on acceptable mismatches results in low rejection rates comparable to nonsensitized patients

Author

Heidt, Sebastiaan, Haasnoot, Geert W., Witvliet, Marian D., van der Linden-van Oevelen, Marissa J.H., Kamburova, Elena G., Wisse, Bram W., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Sanders, Jan-Stephan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Marielle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Otten, Henny G., Roelen, Dave L., and Claas, Frans H.J.

Published
2019
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39. Nurse-led self-management support after organ transplantation-protocol of a multicentre, stepped-wedge randomized controlled trial.

Author

van Zanten, Regina, van Dijk, Monique, van Rosmalen, Joost, Beck, Denise, Zietse, Robert, Van Hecke, Ann, van Staa, AnneLoes, Massey, Emma K., On behalf of the aanZET study group, Goedendorp, Marleen, van den Hoogen, Martijn, Ista, Erwin, Maasdam, Louise, Manintveld, Olivier, de Weerd, Annelies, Been-Dahmen, Janet, Bisschop, Jeannet, van der Boog, Paul, Konijn, Maaike, and van Helden, Marjo

Abstract

Background: Recipients of an organ transplantation face a number of challenges and often need to change their health behaviour. Good self-management skills are essential for optimal clinical outcomes. However, few interventions are available to support post-transplant self-management. To fill this gap, we developed a self-management support intervention offered by nurse practitioners. The primary aim of the study is to implement and test the effectiveness of the ZENN intervention in promoting self-management skills among heart, kidney liver and lung transplant recipients in comparison to standard care. The secondary aim is to assess the self-management support skills of nurse practitioners who will deliver the intervention.Methods: This multi-centre stepped-wedge randomized controlled trial will take place from September 2020 until May 2023. All departments will commence with inclusion of patients in the control period. Each department will be randomly assigned to a start date (step in the wedge) to commence the experimental period. Patients in the control period will receive standard care and will be asked to complete questionnaires at baseline (T0), 6 months (T1) and 12 months (T2), to assess self-management, self-regulation, quality of life and adherence. During the experimental period, patients will receive standard care plus the ZENN intervention and receive the same set of questionnaires as participants in the control period. Nurse practitioners will complete a baseline and follow-up questionnaire to assess differences in self-management support skills. Video recordings of outpatient clinic consultations during the control and experimental periods will determine the differences in nurses' needs-thwarting and needs-supporting skills between the control and experimental period.Discussion: The ZENN intervention could be a useful approach to support patients' self-management skills after organ transplantation and thus promote clinical outcomes as well as avoid adverse events.Trial Registration: Dutch Trial Register NL8469 . Registered on March 19, 2020. [ABSTRACT FROM AUTHOR]

Published
2022
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41. Antibodies against ARHGDIB are associated with long-term kidney graft loss

Author

Kamburova, Elena G, Gruijters, Maartje L, Kardol-Hoefnagel, Tineke, Wisse, Bram W, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Cornelis E, van Reekum, Franka E, van Zuilen, Arjan D, Verhaar, Marianne C, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Melchers, Rowena C A, Seelen, Marc A J, Sanders, Jan Stephan, Hepkema, Bouke G, Lambeck, Annechien J A, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christina E, Wieten, Lotte, van Duijnhoven, Elly M, Gelens, Mariëlle A C J, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A M I, van der Weerd, Neelke C, Ten Berge, Ineke J M, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Bemelman, Frederike J, Otten, Henny G, Kamburova, Elena G, Gruijters, Maartje L, Kardol-Hoefnagel, Tineke, Wisse, Bram W, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Cornelis E, van Reekum, Franka E, van Zuilen, Arjan D, Verhaar, Marianne C, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Melchers, Rowena C A, Seelen, Marc A J, Sanders, Jan Stephan, Hepkema, Bouke G, Lambeck, Annechien J A, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christina E, Wieten, Lotte, van Duijnhoven, Elly M, Gelens, Mariëlle A C J, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A M I, van der Weerd, Neelke C, Ten Berge, Ineke J M, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Bemelman, Frederike J, and Otten, Henny G

Published
2019

42. Effect of initial immunosuppression on long-term kidney transplant outcome in immunological low-risk patients

Author

Michielsen, Laura A., van Zuilen, Arjan D., Verhaar, Marianne C., Wisse, Bram W., Kamburova, Elena G., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Sanders, Jan Stephan F., Hepkema, Bouke G., Lambeck, Annechien J., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christien E., Wieten, Lotte, van Duijnhoven, Elizabeth M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A., van der Weerd, Neelke C., Ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Otten, Henderikus G., Hilbrands, Luuk B., Michielsen, Laura A., van Zuilen, Arjan D., Verhaar, Marianne C., Wisse, Bram W., Kamburova, Elena G., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Sanders, Jan Stephan F., Hepkema, Bouke G., Lambeck, Annechien J., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christien E., Wieten, Lotte, van Duijnhoven, Elizabeth M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A., van der Weerd, Neelke C., Ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Otten, Henderikus G., and Hilbrands, Luuk B.

Published
2019

43. Toward a sensible single antigen bead cut-off based on kidney graft survival

Author

Wisse, Bram W., Kamburova, Elena G., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Stephan Sanders, Jan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., Ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries J., van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Otten, Henny G., Wisse, Bram W., Kamburova, Elena G., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Stephan Sanders, Jan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., Ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries J., van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., and Otten, Henny G.

Published
2019

44. A paired kidney analysis on the impact of pre-transplant anti-HLA antibodies on graft survival

Author

Michielsen, Laura A, Wisse, Bram W, Kamburova, Elena G, Verhaar, Marianne C, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Erik, van Reekum, Franka E, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Seelen, Marc A J, Sanders, Jan-Stephan F, Hepkema, Bouke G, Lambeck, Annechien J, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christien E, Wieten, Lotte, van Duijnhoven, Elizabeth M, Gelens, Mariëlle, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A, van der Weerd, Neelke C, Ten Berge, Ineke J M, Bemelman, Frederike J, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Otten, Henderikus G, van Zuilen, Arjan D, Michielsen, Laura A, Wisse, Bram W, Kamburova, Elena G, Verhaar, Marianne C, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Erik, van Reekum, Franka E, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Seelen, Marc A J, Sanders, Jan-Stephan F, Hepkema, Bouke G, Lambeck, Annechien J, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christien E, Wieten, Lotte, van Duijnhoven, Elizabeth M, Gelens, Mariëlle, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A, van der Weerd, Neelke C, Ten Berge, Ineke J M, Bemelman, Frederike J, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Otten, Henderikus G, and van Zuilen, Arjan D

Published
2019

45. Guided or factual computer support for kidney patients with different experience levels and medical health situations: Preferences and usage

Author

Wang, W. (author), van Lint, Céline L. (author), Brinkman, W.P. (author), Rövekamp, Ton J.M. (author), van Dijk, Sandra (author), van der Boog, Paul (author), Neerincx, M.A. (author), Wang, W. (author), van Lint, Céline L. (author), Brinkman, W.P. (author), Rövekamp, Ton J.M. (author), van Dijk, Sandra (author), van der Boog, Paul (author), and Neerincx, M.A. (author)

Abstract

Personalization of eHealth systems is a promising technique for improving patients’ adherence. This paper explores the possibility of personalisation based on the patients’ medical health situation and on their health literacy. The study is set within the context of a self-management support system (SMSS) for renal transplant patients. A SMSS is designed with layering, nudging, emphaticizing, and focusing principles. It has two communication styles: (1) a guided style that provided more interpretation support and addressed emotional needs; and (2) a factual style that showed only measurement history, medical information, and recommendations. To evaluate the design, 49 renal transplant patients with three different experience levels participated in a lab study, in which they used the system in imaginary scenarios to deal with three medical health situations (alright, mild concern, and concern). A 96% understanding and 87% adherence rate was observed, with a significant interaction effect on adherence between patient group and health situation. Furthermore, compared to recently transplanted patients, not recently transplanted patients were relatively more positive towards the factual than the guided communication style in the “alright” condition. Furthermore, additional medical information was searched more often in health situations that causes mild concern and a majority of patients did not change the communication style to their preferred styles. By attuning the communication style to patient’s experience and medical health situation according to the applied principles and acquired insights, SMSSs are expected to be better used., Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public., Interactive Intelligence

Published
2019
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46. A paired kidney analysis on the impact of pre-transplant anti-HLA antibodies on graft survival

Author

MS Nefrologie, Infection & Immunity, CTI Otten, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, CDL Patiëntenzorg MI, CDL Celdiagnostiek, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CTI, CDL unit Immunoserologie, Michielsen, Laura A, Wisse, Bram W, Kamburova, Elena G, Verhaar, Marianne C, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Erik, van Reekum, Franka E, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Seelen, Marc A J, Sanders, Jan-Stephan F, Hepkema, Bouke G, Lambeck, Annechien J, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christien E, Wieten, Lotte, van Duijnhoven, Elizabeth M, Gelens, Mariëlle, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A, van der Weerd, Neelke C, Ten Berge, Ineke J M, Bemelman, Frederike J, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Otten, Henderikus G, van Zuilen, Arjan D, MS Nefrologie, Infection & Immunity, CTI Otten, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, CDL Patiëntenzorg MI, CDL Celdiagnostiek, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CTI, CDL unit Immunoserologie, Michielsen, Laura A, Wisse, Bram W, Kamburova, Elena G, Verhaar, Marianne C, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Erik, van Reekum, Franka E, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Seelen, Marc A J, Sanders, Jan-Stephan F, Hepkema, Bouke G, Lambeck, Annechien J, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christien E, Wieten, Lotte, van Duijnhoven, Elizabeth M, Gelens, Mariëlle, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A, van der Weerd, Neelke C, Ten Berge, Ineke J M, Bemelman, Frederike J, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Otten, Henderikus G, and van Zuilen, Arjan D

Published
2019

47. Toward a sensible single antigen bead cut-off based on kidney graft survival

Author

Infection & Immunity, CTI Otten, CDL Patiëntenzorg MI, CTI, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Mondziekten/Kaakchirurgie, CDL Celdiagnostiek, UMC Utrecht, Wisse, Bram W., Kamburova, Elena G., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Stephan Sanders, Jan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., Ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries J., van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Otten, Henny G., Infection & Immunity, CTI Otten, CDL Patiëntenzorg MI, CTI, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Mondziekten/Kaakchirurgie, CDL Celdiagnostiek, UMC Utrecht, Wisse, Bram W., Kamburova, Elena G., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Stephan Sanders, Jan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., Ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries J., van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., and Otten, Henny G.

Published
2019

48. Antibodies against ARHGDIB are associated with long-term kidney graft loss

Author

CTI Otten, Infection & Immunity, CDL Patiëntenzorg MI, CTI, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CDL Celdiagnostiek, CDL unit Immunoserologie, Kamburova, Elena G, Gruijters, Maartje L, Kardol-Hoefnagel, Tineke, Wisse, Bram W, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Cornelis E, van Reekum, Franka E, van Zuilen, Arjan D, Verhaar, Marianne C, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Melchers, Rowena C A, Seelen, Marc A J, Sanders, Jan Stephan, Hepkema, Bouke G, Lambeck, Annechien J A, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christina E, Wieten, Lotte, van Duijnhoven, Elly M, Gelens, Mariëlle A C J, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A M I, van der Weerd, Neelke C, Ten Berge, Ineke J M, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Bemelman, Frederike J, Otten, Henny G, CTI Otten, Infection & Immunity, CDL Patiëntenzorg MI, CTI, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CDL Celdiagnostiek, CDL unit Immunoserologie, Kamburova, Elena G, Gruijters, Maartje L, Kardol-Hoefnagel, Tineke, Wisse, Bram W, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Cornelis E, van Reekum, Franka E, van Zuilen, Arjan D, Verhaar, Marianne C, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Melchers, Rowena C A, Seelen, Marc A J, Sanders, Jan Stephan, Hepkema, Bouke G, Lambeck, Annechien J A, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christina E, Wieten, Lotte, van Duijnhoven, Elly M, Gelens, Mariëlle A C J, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A M I, van der Weerd, Neelke C, Ten Berge, Ineke J M, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Bemelman, Frederike J, and Otten, Henny G

Published
2019

49. Allocation to highly sensitized patients based on acceptable mismatches results in low rejection rates comparable to nonsensitized patients

Author

UMC Utrecht, CTI Otten, Infection & Immunity, CDL Patiëntenzorg MI, CTI, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Mondziekten/Kaakchirurgie, CDL Celdiagnostiek, Heidt, Sebastiaan, Haasnoot, Geert W., Witvliet, Marian D., van der Linden-van Oevelen, Marissa J.H., Kamburova, Elena G., Wisse, Bram W., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Marielle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Otten, Henny G., Roelen, Dave L., Claas, Frans H.J., UMC Utrecht, CTI Otten, Infection & Immunity, CDL Patiëntenzorg MI, CTI, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Mondziekten/Kaakchirurgie, CDL Celdiagnostiek, Heidt, Sebastiaan, Haasnoot, Geert W., Witvliet, Marian D., van der Linden-van Oevelen, Marissa J.H., Kamburova, Elena G., Wisse, Bram W., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Marielle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Otten, Henny G., Roelen, Dave L., and Claas, Frans H.J.

Published
2019

50. Effect of initial immunosuppression on long-term kidney transplant outcome in immunological low-risk patients

Author

Nefro Vasculaire Geneeskunde, MS Nefrologie, Circulatory Health, Regenerative Medicine and Stem Cells, Infection & Immunity, CDL Patiëntenzorg MI, CTI, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CDL unit Immunoserologie, MS Mondziekten/Kaakchirurgie, CDL Celdiagnostiek, Michielsen, Laura A., van Zuilen, Arjan D., Verhaar, Marianne C., Wisse, Bram W., Kamburova, Elena G., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Sanders, Jan Stephan F., Hepkema, Bouke G., Lambeck, Annechien J., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christien E., Wieten, Lotte, van Duijnhoven, Elizabeth M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A., van der Weerd, Neelke C., Ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Otten, Henderikus G., Hilbrands, Luuk B., Nefro Vasculaire Geneeskunde, MS Nefrologie, Circulatory Health, Regenerative Medicine and Stem Cells, Infection & Immunity, CDL Patiëntenzorg MI, CTI, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CDL unit Immunoserologie, MS Mondziekten/Kaakchirurgie, CDL Celdiagnostiek, Michielsen, Laura A., van Zuilen, Arjan D., Verhaar, Marianne C., Wisse, Bram W., Kamburova, Elena G., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Sanders, Jan Stephan F., Hepkema, Bouke G., Lambeck, Annechien J., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christien E., Wieten, Lotte, van Duijnhoven, Elizabeth M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A., van der Weerd, Neelke C., Ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Otten, Henderikus G., and Hilbrands, Luuk B.

Published
2019

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