22 results on '"hormonal profiles"'
Search Results
2. COMPARATIVE EVALUATION OF SOLVENT EXTRACTS OF AZANZA GARCKEANA FRUIT PULP ON HORMONAL PROFILES, SPERMIOGRAM AND ANTIOXIDANT ACTIVITIES IN RABBIT BUCKS.
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Itodo, Joy Iyojo, Ayo, Joseph Olusegun, Rekwot, Ibrahim Peter, Aluwong, Tagang, Allam, Lushiakyaa, and Ibrahim, Shettima
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RABBITS ,LUTEINIZING hormone ,SOLVENT extraction ,SUPEROXIDE dismutase ,ETHYL acetate - Abstract
The study investigated the comparative influence of different extraction solvents on spermiogram, hormonal profiles and antioxidant activities in rabbit bucks. Adult New Zealand White rabbit bucks (n=18), with average live weight of 1.2±0.03 kg and aged 10-18 mo were fed ad libitum on a commercial diet. They were administered five different Azanza garckeana (AG) fruit pulp extracts at 500 mg/kg via oral gavage, comprising control group (Con), crude (AG Cr), methanol (AG M), n-hexane (AG H), ethyl acetate (AG E) and aqueous (AG AQ) for four weeks. The extracts improved the spermiogram in rabbit bucks administered methanol (AG M) and the reaction time was significantly (P<0.05) lower in AG E group when compared to other groups. The ejaculate volume, sperm motility, pH and sperm concentration were significantly (P<0.05) higher in the AG M group when compared to the other groups. There was a significant (P<0.05) increase in concentrations of blood testosterone, follicle-stimulating hormone and luteinising hormone in methanol extract group (AG M). While the glutathione and malondialdehyde concentrations were (P<0.05) lower, catalase and superoxide dismutase activities were significantly (P<0.05) higher in the groups administered methanol extract (AG M). It was concluded that AG M extracts of AG pulp elicited the best response in spermiogram, hormonal concentrations and antioxidant activities in New Zealand White rabbit bucks. Its use as the extraction solvent is recommended. [ABSTRACT FROM AUTHOR]
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- 2022
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3. Carnitine and chromium co-supplementation affects mental health, hormonal, inflammatory, genetic, and oxidative stress parameters in women with polycystic ovary syndrome
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Mehri Jamilian, Fatemeh Foroozanfard, Elham Kavossian, Esmat Aghadavod, Elaheh Amirani, Mostafa Mahdavinia, Alireza Mafi, and Zatollah Asemi
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carnitine ,chromium ,mental health ,hormonal profiles ,inflammatory markers ,polycystic ovary syndrome ,Gynecology and obstetrics ,RG1-991 - Abstract
Objective: The aim of this study was to evaluate the effect of the co-administration of carnitine and chromium on mental health, hormonal, inflammatory and genetic parameters in women with PCOS. Methods: This randomized, double-blinded, placebo-controlled clinical trial was conducted on 54 subjects, aged 18–40 years old. Subjects were randomly allocated to take either 1000 mg/d carnitine plus 200 µg/d chromium as chromium picolinate (n = 26) or placebo (n = 27) for 12 weeks. Results: Carnitine and chromium co-supplementation, compared with the placebo, significantly improved beck depression inventory (β − 0.84; 95% CI, −1.51, −0.17; p = 0.01), general health questionnaire scores (β − 1.13; 95% CI, −2.13, −0.14; p = 0.02) and depression anxiety and stress scale scores (β − 0.96; 95% CI, −0.78, −0.14; p = 0.02). Participants who received carnitine plus chromium supplements had significantly lower total testosterone (β − 0.15 ng/mL; 95% CI, −0.24, −0.06; p = 0.002), hirsutism (β − 0.48; 95% CI, −0.91, −0.06; p = 0.02), high-sensitivity C-reactive protein (hs-CRP) (β − 1.02 mg/L; 95% CI, −1.79, −0.25; p = 0.01), and malondialdehyde (MDA) levels (β − 0.38 µmol/L; 95% CI, −0.56, −0.20; p
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- 2019
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4. Vitamin D and probiotic co-supplementation affects mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome
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Vahidreza Ostadmohammadi, Mehri Jamilian, Fereshteh Bahmani, and Zatollah Asemi
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Vitamin D ,Probiotic ,Mental health ,Hormonal profiles ,Inflammatory markers ,Polycystic ovary syndrome ,Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Objective The aim of this study was to determine the effect of vitamin D and probiotic co-administration on mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome (PCOS). Methods This randomized, double-blinded, placebo-controlled clinical trial was carried out on 60 subjects, aged 18–40 years old. Subjects were randomly allocated to take either 50,000 IU vitamin D every 2 weeks plus 8 × 109 CFU/day probiotic (n = 30) or placebo (n = 30) for 12 weeks. Results Vitamin D and probiotic co-supplementation, compared with the placebo, significantly improved beck depression inventory [β (difference in the mean of outcomes measures between treatment groups) − 0.58; 95% CI, − 1.15, − 0.02; P = 0.04], general health questionnaire scores (β − 0.93; 95% CI, − 1.78, − 0.08; P = 0.03) and depression, anxiety and stress scale scores (β − 0.90; 95% CI, − 1.67, − 0.13; P = 0.02). Vitamin D and probiotic co-supplementation was associated with a significant reduction in total testosterone (β − 0.19 ng/mL; 95% CI, − 0.28, − 0.10; P
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- 2019
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5. The effects of probiotic and selenium co-supplementation on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome
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Mehri Jamilian, Shirin Mansury, Fereshteh Bahmani, Zahra Heidar, Elaheh Amirani, and Zatollah Asemi
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Probiotic ,Selenium ,Mental health ,Hormonal profiles ,Inflammatory markers ,Polycystic ovary syndrome ,Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background The aim of this study was to evaluate the effect of the co-administration of probiotic and selenium on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with PCOS. Data on the effects of selenium and probiotic co-supplementation on mental health, hormonal and inflammatory parameters of patients with polycystic ovary syndrome (PCOS) are scarce. This investigation was carried out to evaluate the effects of selenium and probiotic co-supplementation on mental health, hormonal and inflammatory parameters in women with PCOS. Methods This randomized, double-blinded, placebo-controlled clinical trial was conducted on 60 subjects, aged 18–40 years old. Participants were randomly allocated into two groups to intake 8 × 109 CFU/day probiotic plus 200 μg/day selenium supplements (n = 30) or placebo (n = 30) for 12 weeks. Hormonal and inflammatory parameters were measured at baseline and after the 12-week intervention. Results Probiotic and selenium co-supplementation resulted in a significant improvement in beck depression inventory (β − 0.76; 95% CI, − 1.26, − 0.26; P = 0.003), general health questionnaire scores (β − 1.15; 95% CI, − 1.97, − 0.32; P = 0.007) and depression anxiety and stress scale scores (β − 1.49; 95% CI, − 2.59, − 0.39; P = 0.009) compared with the placebo. Furthermore, probiotic and selenium co-supplementation significantly reduced total testosterone (β − 0.26 ng/mL; 95% CI, − 0.51, − 0.02; P = 0.03), hirsutism (β − 0.43; 95% CI, − 0.74, − 0.11; P = 0.008), high-sensitivity C-reactive protein (hs-CRP) (β − 0.58 mg/L; 95% CI, − 0.97, − 0.19; P = 0.004) and malondialdehyde (MDA) levels (β − 0.29 μmol/L; 95% CI, − 0.56, − 0.02; P = 0.03), and significantly increased total antioxidant capacity (TAC) (β + 84.76 mmol/L; 95% CI, + 48.08, + 121.44; P
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- 2018
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6. Effects of Melatonin Supplementation on Hormonal, Inflammatory, Genetic, and Oxidative Stress Parameters in Women With Polycystic Ovary Syndrome
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Mehri Jamilian, Fatemeh Foroozanfard, Naghmeh Mirhosseini, Elham Kavossian, Esmat Aghadavod, Fereshteh Bahmani, Vahidreza Ostadmohammadi, Mersedeh Kia, Tahereh Eftekhar, Elnaz Ayati, Mostafa Mahdavinia, and Zatollah Asemi
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melatonin ,hormonal profiles ,inflammatory markers ,polycystic ovary syndrome ,oxidative stress ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Purpose: The aim of the current study was to evaluate the effect of melatonin administration on clinical, hormonal, inflammatory, and genetic parameters in women with polycystic ovarian syndrome (PCOS).Methods: The present randomized, double-blinded, placebo-controlled clinical trial was conducted among 56 patients with PCOS, aged 18–40 years old. Subjects were randomly allocated to take either 5 mg melatonin supplements (n = 28) or placebo (n = 28) twice a day for 12 weeks.Results: Melatonin administration significantly reduced hirsutism (β −0.47; 95% CI, −0.86, −0.09; P = 0.01), serum total testosterone (β −0.11 ng/mL; 95% CI, −0.21, −0.02; P = 0.01), high-sensitivity C-reactive protein (hs-CRP) (β −0.61 mg/L; 95% CI, −0.95, −0.26; P = 0.001), and plasma malondialdehyde (MDA) levels (β −0.25 μmol/L; 95% CI, −0.38, −0.11; P < 0.001), and significantly increased plasma total antioxidant capacity (TAC) levels (β 106.07 mmol/L; 95% CI, 62.87, 149.28; P < 0.001) and total glutathione (GSH) (β 81.05 μmol/L; 95% CI, 36.08, 126.03; P = 0.001) compared with the placebo. Moreover, melatonin supplementation downregulated gene expression of interleukin-1 (IL-1) (P = 0.03) and tumor necrosis factor alpha (TNF-α) (P = 0.01) compared with the placebo.Conclusions: Overall, melatonin administration for 12 weeks to women with PCOS significantly reduced hirsutism, total testosterone, hs-CRP, and MDA, while increasing TAC and GSH levels. In addition, melatonin administration reduced gene expression of IL-1 and TNF-α.Clinical Trial Registration:www.irct.ir, identifier IRCT2017082733941N9, Available online at: https://www.irct.ir/trial/26051
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- 2019
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7. Effects of Melatonin Supplementation on Hormonal, Inflammatory, Genetic, and Oxidative Stress Parameters in Women With Polycystic Ovary Syndrome.
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Jamilian, Mehri, Foroozanfard, Fatemeh, Mirhosseini, Naghmeh, Kavossian, Elham, Aghadavod, Esmat, Bahmani, Fereshteh, Ostadmohammadi, Vahidreza, Kia, Mersedeh, Eftekhar, Tahereh, Ayati, Elnaz, Mahdavinia, Mostafa, and Asemi, Zatollah
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MELATONIN ,OXIDATIVE stress ,POLYCYSTIC ovary syndrome ,GLUTATHIONE ,INTERLEUKIN-1 - Abstract
Purpose: The aim of the current study was to evaluate the effect of melatonin administration on clinical, hormonal, inflammatory, and genetic parameters in women with polycystic ovarian syndrome (PCOS). Methods: The present randomized, double-blinded, placebo-controlled clinical trial was conducted among 56 patients with PCOS, aged 18–40 years old. Subjects were randomly allocated to take either 5 mg melatonin supplements (n = 28) or placebo (n = 28) twice a day for 12 weeks. Results: Melatonin administration significantly reduced hirsutism (β −0.47; 95% CI, −0.86, −0.09; P = 0.01), serum total testosterone (β −0.11 ng/mL; 95% CI, −0.21, −0.02; P = 0.01), high-sensitivity C-reactive protein (hs-CRP) (β −0.61 mg/L; 95% CI, −0.95, −0.26; P = 0.001), and plasma malondialdehyde (MDA) levels (β −0.25 μmol/L; 95% CI, −0.38, −0.11; P < 0.001), and significantly increased plasma total antioxidant capacity (TAC) levels (β 106.07 mmol/L; 95% CI, 62.87, 149.28; P < 0.001) and total glutathione (GSH) (β 81.05 μmol/L; 95% CI, 36.08, 126.03; P = 0.001) compared with the placebo. Moreover, melatonin supplementation downregulated gene expression of interleukin-1 (IL-1) (P = 0.03) and tumor necrosis factor alpha (TNF-α) (P = 0.01) compared with the placebo. Conclusions: Overall, melatonin administration for 12 weeks to women with PCOS significantly reduced hirsutism, total testosterone, hs-CRP, and MDA, while increasing TAC and GSH levels. In addition, melatonin administration reduced gene expression of IL-1 and TNF-α. Clinical Trial Registration: www.irct.ir, identifier IRCT2017082733941N9, Available online at: https://www.irct.ir/trial/26051 [ABSTRACT FROM AUTHOR]
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- 2019
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8. Effect of Prebiotic Dietary Supplement Acacia senegal on Hormonal and Metabolic Markers in Polycystic Ovary Syndrome Patients: A Pilot Study.
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Mohamed RI, Daoud IM, Suliman AG, and Kaddam L
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Background The most prevalent endocrine condition affecting women of reproductive age is polycystic ovarian syndrome (PCOS), which is linked to a variety of metabolic abnormalities. Although the pathogenesis of PCOS is not fully understood, it is known that oxidative stress, altered gut microbiome, and increased gonadotrophin-releasing hormone play a significant role. Gum arabic (GA) is an edible, dried, gummy exudate from the Acacia senegal tree, well-known for its prebiotic and antioxidant effects. The main objective of the study was to assess the changes in hormonal and metabolic profiles in PCOS patients after the ingestion of gum arabic. Method This was a clinical trial conducted on fifteen patients suffering from PCOS, with a mean age of 27.8 years (20-39 years). All patients experienced irregular cycles. Hormonal and metabolic markers (follicular stimulating hormone (FSH), luteinizing hormone (LH), total testosterone (TT), fasting insulin, total cholesterol (TC), and glycosylated hemoglobin (HBA1c) were measured before and after the ingestion of gum arabic (30 g/day of GA dissolved in 250 ml water for eight weeks) on the second day of the menstrual cycle after granting ethical approval from the National Medicine and Poisons Board and from the participants of the study. Results The study demonstrated a significant decrease in the luteinizing hormone level, FSH/LH ratio, and cholesterol pre- and post-gum arabic ingestion (p-values 0.001, 0.013, and 0.007, respectively). Follicular stimulating hormone slightly reduced post-ingestion with no significant difference (p-value 0.414). No significant changes were seen in the testosterone, insulin, or HBA1c levels. Conclusion The study concluded that gum arabic ingestion for eight weeks decreases the luteinizing hormone and LH/FSH ratio and improves the metabolic profile by reducing the cholesterol level in PCOS patients., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2023, Mohamed et al.)
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- 2023
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9. Effects of Probiotic Supplementation on Hormonal Profiles, Biomarkers of Inflammation and Oxidative Stress in Women With Polycystic Ovary Syndrome: A Randomized, Double- Blind, Placebo-Controlled Trial.
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Karamali, Maryam, Eghbalpour, Sara, Rajabi, Sajad, Jamilian, Mehri, Bahmani, Fereshteh, Tajabadi-Ebrahimi, Maryam, Keneshlou, Fariba, Mirhashemi, Seyyed Mehdi, Chamani, Maryam, Gelougerdi, Sara Hashem, and Asemi, Zatollah
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POLYCYSTIC ovary syndrome , *BIOMARKERS , *C-reactive protein , *DIETARY supplements , *GLOBULINS , *HORMONES , *INFLAMMATION , *PLACEBOS , *PROBABILITY theory , *STATISTICAL sampling , *TESTOSTERONE , *MALONDIALDEHYDE , *OXIDATIVE stress , *RANDOMIZED controlled trials , *PROBIOTICS , *BLIND experiment , *DESCRIPTIVE statistics , *PREVENTION - Abstract
Background: To the best of our knowledge, data on effects of probiotic administration on hormonal profiles, biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome (PCOS) are scarce. This investigation was conducted to assess the effects of probiotic supplementation on hormonal profiles, biomarkers of inflammation and oxidative stress in women with PCOS. Methods: This randomized, double-blind, placebo-controlled trial was conducted on 60 women with PCOS, aged 18-40 years old. Subjects were randomly assigned into 2 groups to receive either probiotics or placebo (n = 30 each group) for 12 weeks. Metabolic profiles were quantified at baseline and after a 12-week intervention. Results: After the 12-week intervention, compared with placebo, probiotic supplementation significantly increased serum sex hormone-binding globulin (SHBG) (+25.9 ± 32.5 vs. +0.5 ± 15.6 nmol/L, P < 0.001) and plasma total antioxidant capacity (TAC) (+8.8 ± 120.5 vs. -98.3 ± 246.4 mmol/L, P = 0.04), and significantly decreased serum total testosterone (-0.2 ± 0.7 vs. +0.2 ± 0.6 ng/mL, P = 0.03), modified Ferriman-Gallwey (mF-G) scores (-1.7 ± 1.5 vs. -0.2 ± 1.0, P < 0.001), serum high-sensitivity C-reactive protein (hs-CRP) (-1150.0 ± 1295.2 vs. +202.5 ± 1426.3 ng/mL, P < 0.001) and plasma malondialdehyde (MDA) concentrations (-0.2 ± 0.6 vs. +0.9 ± 1.3 µmol/L, P < 0.001). We did not observe any detrimental effect of probiotic supplementation on other metabolic profiles. Conclusion: Overall, probiotic supplementation of PCOS women for 12 weeks had beneficial effects on total testosterone, SHBG, mFG scores, hs-CRP, TAC and MDA levels but did not affect other metabolic profiles. [ABSTRACT FROM AUTHOR]
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- 2018
10. Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome.
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Jamilian, Mehri, Foroozanfard, Fatemeh, Rahmani, Elham, Talebi, Maesoomeh, Bahmani, Fereshteh, and Asemi, Zatollah
- Abstract
This study was carried out to evaluate the effects of vitamin D supplementation on the metabolic profiles of insulin-resistant subjects with polycystic ovary syndrome (PCOS). This randomized double-blind, placebo-controlled trial was conducted on 90 insulin-resistant women with PCOS. Participants were randomly assigned to three groups to intake either 4000 IU of vitamin D or 1000 IU of vitamin D or placebo (n = 30 each group) daily for 12 weeks. Vitamin D supplementation (4000 IU), compared with vitamin D (1000 IU) and placebo, led to significant reductions in total testosterone (-0.2 ± 0.2 vs. -0.1 ± 0.6 and +0.1 ± 0.2 ng/mL, respectively, p = 0.02), free androgen index (FAI) (-0.06 ± 0.12 vs. -0.02 ± 0.12 and +0.004 ± 0.04, respectively, p = 0.04), hirsutism (-1.1 ± 1.1 vs. -0.8 ± 1.2 and -0.1 ± 0.4, respectively, p = 0.001) and high-sensitivity C-reactive protein (hs-CRP) (-0.7 ± 1.4 vs. -0.5 ± 0.9 and +0.5 ± 2.4 mg/L, respectively, p = 0.01). In addition, we found significant elevations in mean change of sex hormone-binding globulin (SHBG) (+19.1 ± 23.0 vs. +4.5 ± 11.0 and +0.7 ± 10.4 nmol/L, respectively, p < 0.001) and total antioxidant capacity (TAC) (+130 ± 144 vs. +33 ± 126 and -36 ± 104 mmol/L, respectively, p < 0.001) in the high-dose vitamin D group compared with low-dose vitamin D and placebo groups. Overall, high-dose vitamin D administration for 12 weeks to insulin-resistant women with PCOS had beneficial effects on total testosterone, SHBG, FAI, serum hs-CRP and plasma TAC levels compared with low-dose vitamin D and placebo groups. [ABSTRACT FROM AUTHOR]
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- 2017
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11. Effect of strategic supplementation of limiting nutrients on milk production performance in crossbred cows under field conditions.
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CHANDRASEKHARAIAH, M., SOREN, N. M., REDDY, I. J., RAO, S. B. N., and THULASI, A.
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MILK yield ,NUTRITIONAL value of milk ,CATTLE crossbreeding ,HEALTH of cattle ,LACTATION in cattle - Abstract
An on-farm lactation trial of 4 months duration was conducted to study the effect of feeding strategic limiting nutrient supplements on milk production performance and hormonal profile of crossbred cows under field condition. Crossbred cows (36) were equally divided into 6 groups (control and experimental) based on lactation number, milk yield and stage of lactation. Strategic nutrient supplements (1, 2, 3, 4 and 5) were prepared with 65% of locally available bypass rich protein/amino acid supplements and 30% of the bypass fat and 5% of area specific mineral mixture (ASMM), respectively in all the supplements. Protected soybean extraction (0.9% formaldehyde treated; PS) was added as a source of bypass rich protein/amino acid supplement in supplement 1, PS and maize gluten meal (MGM) (60: 40) in supplement 2, cottonseed cake (CSC) and MGM (60:40) in supplement 3, PS, MGM and CSC (70:15:15) in supplement 4 and PS, MGM and CSC (40:40: 20) in supplement 5. The cows in control group were fed local mixed grass with supplements such as groundnut cake (GNC) and wheat bran as practiced by the farmers. Animals in experimental groups (G 1, 2, 3, 4 and 5) were fed local mixed grass with GNC, wheat bran and supplements 1, 2, 3, 4 and 5, respectively @ 200g/day/animal by replacing the double the quantity of GNC in the experimental groups. There was an increase of 16, 14, 9, 10 and 2 % in 4% fat-corrected milk (FCM) yield in animals fed with limiting nutrient supplements 1, 2, 3, 4 and 5, respectively when compared to control. Plasma hormonal profiles of growth hormone, insulin like growth factor 1, estradiol-17β, progesterone, triiodothyronine and thyroxine hormone were positively correlated (r=0.69; P<0.05) with milk yield in cows fed with strategic nutrient supplements (SNS). The study showed that feeding of supplements 1 and 2 in experimental groups-1 and 2 significantly (P<0.05) increased FCM yield and reduced the feed cost in medium yielding cows on local mixed grass based diets and increased the overall income of the farmers. [ABSTRACT FROM AUTHOR]
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- 2017
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12. Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome
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Mehri Jamilian, Fatemeh Foroozanfard, Elham Rahmani, Maesoomeh Talebi, Fereshteh Bahmani, and Zatollah Asemi
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vitamin D supplementation ,hormonal profiles ,insulin-resistant ,polycystic ovary syndrome ,Nutrition. Foods and food supply ,TX341-641 - Abstract
This study was carried out to evaluate the effects of vitamin D supplementation on the metabolic profiles of insulin-resistant subjects with polycystic ovary syndrome (PCOS). This randomized double-blind, placebo-controlled trial was conducted on 90 insulin-resistant women with PCOS. Participants were randomly assigned to three groups to intake either 4000 IU of vitamin D or 1000 IU of vitamin D or placebo (n = 30 each group) daily for 12 weeks. Vitamin D supplementation (4000 IU), compared with vitamin D (1000 IU) and placebo, led to significant reductions in total testosterone (−0.2 ± 0.2 vs. −0.1 ± 0.6 and +0.1 ± 0.2 ng/mL, respectively, p = 0.02), free androgen index (FAI) (−0.06 ± 0.12 vs. −0.02 ± 0.12 and +0.004 ± 0.04, respectively, p = 0.04), hirsutism (−1.1 ± 1.1 vs. −0.8 ± 1.2 and −0.1 ± 0.4, respectively, p = 0.001) and high-sensitivity C-reactive protein (hs-CRP) (−0.7 ± 1.4 vs. −0.5 ± 0.9 and +0.5 ± 2.4 mg/L, respectively, p = 0.01). In addition, we found significant elevations in mean change of sex hormone-binding globulin (SHBG) (+19.1 ± 23.0 vs. +4.5 ± 11.0 and +0.7 ± 10.4 nmol/L, respectively, p < 0.001) and total antioxidant capacity (TAC) (+130 ± 144 vs. +33 ± 126 and −36 ± 104 mmol/L, respectively, p < 0.001) in the high-dose vitamin D group compared with low-dose vitamin D and placebo groups. Overall, high-dose vitamin D administration for 12 weeks to insulin-resistant women with PCOS had beneficial effects on total testosterone, SHBG, FAI, serum hs-CRP and plasma TAC levels compared with low-dose vitamin D and placebo groups.
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- 2017
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13. Influence of detoxified neem seed cake on diet digestibility, body weight change, hormonal profiles, immune response and testicular gene expression in male sheep.
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Rao, S.B.N., Jash, Soumitra, Dineshkumar, D., Krishnamoorthy, P., Elangovan, A.V., Sivaram, M., Parthipan, S., and Selvaraju, S.
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NEEM , *DIET , *BODY weight , *IMMUNE response , *GENE expression - Abstract
The present study was conducted to find out the effect of supplementing defatted and detoxified neem ( Azadirachta indica ) seed cake as a partial replacement of soybean meal (SBM) in the diet of growing lambs. Male lambs of uniform body weight (8.31 ± 0.32 kg) were randomly allotted to three groups such as control (diet containing SBM) and two test diets with defatted and detoxified neem cake (DNC) at two levels (34 g and 68 g per kg of diet) replacing 25% and 50% nitrogen of SBM (DNC-25 and DNC-50). The respective diets (concentrate mixtures along with finger millet ( Eleucine corocana ) straw) were fed individually to lambs for a period of 140 days. The repeated measure ANOVA indicated that lambs on DNC treatments grew on par with control across all the periods and no interaction was observed. The difference in the dry matter intake was not found to be significant ( P > 0.05) in any of the three study groups. Similarly apparent nutrient digestibility, nitrogen balance, rumen and hormonal profiles did not differ ( P > 0.05) across the groups. Humoral and cell mediated immune response measured in terms of antibody titre and lymphocyte proliferation assay was also the same ( P > 0.05) across the groups. The relative gene expression of IGF-I and LHR transcripts in testes tissue was positively influenced ( P < 0.05) in DNC-50 treatment (3–4 fold increase) as compared to control and DNC-25. No histopathological changes were observed in vital organs of sheep fed DNC diets compared to control. It can be concluded that based on the studied parameters, DNC can replace 50% of SBM nitrogen with 3–4 fold increase in gene expression in testes tissue. [ABSTRACT FROM AUTHOR]
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- 2016
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14. Comparative characteristics of hormonal profiles in autonomic-dyshormonal myocardial dystrophy of various ethiology
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V. R. Mkrtchyan
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autonomic-dyshormonal myocardial dystrophy ,various ethiology ,hormonal profiles ,women ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
The aim of the study was to identify the changes in estradiol, progesterone, testosterone, luteotropic (LTH), follicle-stimulating (FSH), thyreotropic (TTH) hormones, prolactin, triiodothyronine (T3), and thyroxine (T4) in autonomicdyshormonal myocardiodystrofy (ADM) of various ethiology. Hormone levels were measured in 52 menopausal women with pathological climax, women with uterine fibromyoma (n=45), premenstrual syndrome, PMS (n=36), and with post-castration syndrome (n=42). Mean estradiol level in ADM of various genesis was close to lower norm limit. Estradiol level disturbances were identified in more than 50% of all cases, typically manifesting in lower concentrations. High prevalence of normal estradiol levels in all four groups was an evidence of ADM pathogenesis complexity. Progesterone and testosterone levels were also not significant in ADM development. In uterine myoma and, to a lesser extent, in PMS, increased LTH levels were more prevalent. In PMS and, especially, in uterine myoma, FSH levels were usually elevated. Nevertheless, the role of these disturbances in ADM pathogenesis is still understudied. Mean prolactin level in myoma patients was higher than normal or that in ADM of another genesis. TTG, T3, and T4 levels in all four groups were normal, and couldn't play a significant role in ADM development.
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- 2005
15. Vitamin D and probiotic co-supplementation affects mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome
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Ostadmohammadi, Vahidreza, Jamilian, Mehri, Bahmani, Fereshteh, and Asemi, Zatollah
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- 2019
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16. Effects of Melatonin Supplementation on Hormonal, Inflammatory, Genetic, and Oxidative Stress Parameters in Women With Polycystic Ovary Syndrome
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Fereshteh Bahmani, Vahidreza Ostadmohammadi, Mehri Jamilian, Elnaz Ayati, Esmat Aghadavod, Mersedeh Kia, Fatemeh Foroozanfard, Elham Kavossian, Mostafa Mahdavinia, Zatollah Asemi, Naghmeh Mirhosseini, and Tahereh Eftekhar
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,melatonin ,medicine.disease_cause ,Placebo ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,Melatonin ,03 medical and health sciences ,chemistry.chemical_compound ,Endocrinology ,0302 clinical medicine ,Internal medicine ,medicine ,oxidative stress ,Testosterone ,hirsutism ,lcsh:RC648-665 ,business.industry ,medicine.disease ,Malondialdehyde ,inflammatory markers ,Clinical Trial ,Polycystic ovary ,030104 developmental biology ,chemistry ,polycystic ovary syndrome ,hormonal profiles ,business ,Oxidative stress ,medicine.drug ,Hormone - Abstract
Purpose: The aim of the current study was to evaluate the effect of melatonin administration on clinical, hormonal, inflammatory, and genetic parameters in women with polycystic ovarian syndrome (PCOS). Methods: The present randomized, double-blinded, placebo-controlled clinical trial was conducted among 56 patients with PCOS, aged 18-40 years old. Subjects were randomly allocated to take either 5 mg melatonin supplements (n = 28) or placebo (n = 28) twice a day for 12 weeks. Results: Melatonin administration significantly reduced hirsutism (β -0.47; 95% CI, -0.86, -0.09; P = 0.01), serum total testosterone (β -0.11 ng/mL; 95% CI, -0.21, -0.02; P = 0.01), high-sensitivity C-reactive protein (hs-CRP) (β -0.61 mg/L; 95% CI, -0.95, -0.26; P = 0.001), and plasma malondialdehyde (MDA) levels (β -0.25 μmol/L; 95% CI, -0.38, -0.11; P < 0.001), and significantly increased plasma total antioxidant capacity (TAC) levels (β 106.07 mmol/L; 95% CI, 62.87, 149.28; P < 0.001) and total glutathione (GSH) (β 81.05 μmol/L; 95% CI, 36.08, 126.03; P = 0.001) compared with the placebo. Moreover, melatonin supplementation downregulated gene expression of interleukin-1 (IL-1) (P = 0.03) and tumor necrosis factor alpha (TNF-α) (P = 0.01) compared with the placebo. Conclusions: Overall, melatonin administration for 12 weeks to women with PCOS significantly reduced hirsutism, total testosterone, hs-CRP, and MDA, while increasing TAC and GSH levels. In addition, melatonin administration reduced gene expression of IL-1 and TNF-α. Clinical Trial Registration: www.irct.ir, identifier IRCT2017082733941N9, Available online at: https://www.irct.ir/trial/26051.
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- 2019
17. Vitamin D and probiotic co-supplementation affects mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome
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Fereshteh Bahmani, Mehri Jamilian, Zatollah Asemi, and Vahidreza Ostadmohammadi
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0301 basic medicine ,Hirsutism ,Hormonal profiles ,Inflammatory markers ,Probiotic ,Gastroenterology ,law.invention ,chemistry.chemical_compound ,0302 clinical medicine ,law ,Malondialdehyde ,Medicine ,Testosterone ,Vitamin D ,hirsutism ,Polycystic ovary syndrome ,Obstetrics and Gynecology ,Vitamins ,Polycystic ovary ,Glutathione ,C-Reactive Protein ,Mental Health ,Oncology ,030220 oncology & carcinogenesis ,Female ,Adult ,medicine.medical_specialty ,Adolescent ,Placebo ,lcsh:Gynecology and obstetrics ,03 medical and health sciences ,Young Adult ,Double-Blind Method ,Internal medicine ,Vitamin D and neurology ,Humans ,lcsh:RG1-991 ,Inflammation ,business.industry ,Research ,Probiotics ,Beck Depression Inventory ,medicine.disease ,Oxidative Stress ,030104 developmental biology ,chemistry ,business - Abstract
The aim of this study was to determine the effect of vitamin D and probiotic co-administration on mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome (PCOS). This randomized, double-blinded, placebo-controlled clinical trial was carried out on 60 subjects, aged 18–40 years old. Subjects were randomly allocated to take either 50,000 IU vitamin D every 2 weeks plus 8 × 109 CFU/day probiotic (n = 30) or placebo (n = 30) for 12 weeks. Vitamin D and probiotic co-supplementation, compared with the placebo, significantly improved beck depression inventory [β (difference in the mean of outcomes measures between treatment groups) − 0.58; 95% CI, − 1.15, − 0.02; P = 0.04], general health questionnaire scores (β − 0.93; 95% CI, − 1.78, − 0.08; P = 0.03) and depression, anxiety and stress scale scores (β − 0.90; 95% CI, − 1.67, − 0.13; P = 0.02). Vitamin D and probiotic co-supplementation was associated with a significant reduction in total testosterone (β − 0.19 ng/mL; 95% CI, − 0.28, − 0.10; P
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- 2019
18. The effects of probiotic and selenium co-supplementation on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome
- Author
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Jamilian, Mehri, Mansury, Shirin, Bahmani, Fereshteh, Heidar, Zahra, Amirani, Elaheh, and Asemi, Zatollah
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- 2018
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- View/download PDF
19. The effects of probiotic and selenium co-supplementation on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome
- Author
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Shirin Mansury, Zahra Heidar, Elaheh Amirani, Fereshteh Bahmani, Zatollah Asemi, and Mehri Jamilian
- Subjects
0301 basic medicine ,Adult ,medicine.medical_specialty ,Adolescent ,Hormonal profiles ,Inflammatory markers ,chemistry.chemical_element ,Placebo ,Probiotic ,lcsh:Gynecology and obstetrics ,Gastroenterology ,law.invention ,03 medical and health sciences ,chemistry.chemical_compound ,Selenium ,Young Adult ,0302 clinical medicine ,Double-Blind Method ,law ,Internal medicine ,medicine ,Humans ,lcsh:RG1-991 ,Testosterone ,hirsutism ,Polycystic ovary syndrome ,Inflammation ,030219 obstetrics & reproductive medicine ,business.industry ,Research ,Probiotics ,Beck Depression Inventory ,Obstetrics and Gynecology ,Malondialdehyde ,medicine.disease ,Polycystic ovary ,Oxidative Stress ,030104 developmental biology ,Mental Health ,Oncology ,chemistry ,Female ,business ,Biomarkers - Abstract
The aim of this study was to evaluate the effect of the co-administration of probiotic and selenium on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with PCOS. Data on the effects of selenium and probiotic co-supplementation on mental health, hormonal and inflammatory parameters of patients with polycystic ovary syndrome (PCOS) are scarce. This investigation was carried out to evaluate the effects of selenium and probiotic co-supplementation on mental health, hormonal and inflammatory parameters in women with PCOS. This randomized, double-blinded, placebo-controlled clinical trial was conducted on 60 subjects, aged 18–40 years old. Participants were randomly allocated into two groups to intake 8 × 109 CFU/day probiotic plus 200 μg/day selenium supplements (n = 30) or placebo (n = 30) for 12 weeks. Hormonal and inflammatory parameters were measured at baseline and after the 12-week intervention. Probiotic and selenium co-supplementation resulted in a significant improvement in beck depression inventory (β − 0.76; 95% CI, − 1.26, − 0.26; P = 0.003), general health questionnaire scores (β − 1.15; 95% CI, − 1.97, − 0.32; P = 0.007) and depression anxiety and stress scale scores (β − 1.49; 95% CI, − 2.59, − 0.39; P = 0.009) compared with the placebo. Furthermore, probiotic and selenium co-supplementation significantly reduced total testosterone (β − 0.26 ng/mL; 95% CI, − 0.51, − 0.02; P = 0.03), hirsutism (β − 0.43; 95% CI, − 0.74, − 0.11; P = 0.008), high-sensitivity C-reactive protein (hs-CRP) (β − 0.58 mg/L; 95% CI, − 0.97, − 0.19; P = 0.004) and malondialdehyde (MDA) levels (β − 0.29 μmol/L; 95% CI, − 0.56, − 0.02; P = 0.03), and significantly increased total antioxidant capacity (TAC) (β + 84.76 mmol/L; 95% CI, + 48.08, + 121.44; P
- Published
- 2018
20. Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome
- Author
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Elham Rahmani, Maesoomeh Talebi, Mehri Jamilian, Zatollah Asemi, Fereshteh Bahmani, and Fatemeh Foroozanfard
- Subjects
0301 basic medicine ,Blood Glucose ,Dietary Fiber ,vitamin D supplementation ,hormonal profiles ,insulin-resistant ,polycystic ovary syndrome ,0302 clinical medicine ,Sex hormone-binding globulin ,Sex Hormone-Binding Globulin ,Testosterone ,Vitamin D ,hirsutism ,Nutrition and Dietetics ,biology ,Anthropometry ,Polycystic ovary ,C-Reactive Protein ,Androgens ,Metabolome ,Female ,Dietary Proteins ,lcsh:Nutrition. Foods and food supply ,Adult ,medicine.medical_specialty ,Globulin ,Adolescent ,030209 endocrinology & metabolism ,lcsh:TX341-641 ,Placebo ,Article ,03 medical and health sciences ,Young Adult ,Double-Blind Method ,Internal medicine ,Vitamin D and neurology ,medicine ,Dietary Carbohydrates ,Humans ,030109 nutrition & dietetics ,Dose-Response Relationship, Drug ,Free androgen index ,business.industry ,medicine.disease ,Dietary Fats ,Diet ,Oxidative Stress ,Endocrinology ,Nutrition Assessment ,Dietary Supplements ,biology.protein ,Insulin Resistance ,business ,Biomarkers ,Food Science - Abstract
This study was carried out to evaluate the effects of vitamin D supplementation on the metabolic profiles of insulin-resistant subjects with polycystic ovary syndrome (PCOS). This randomized double-blind, placebo-controlled trial was conducted on 90 insulin-resistant women with PCOS. Participants were randomly assigned to three groups to intake either 4000 IU of vitamin D or 1000 IU of vitamin D or placebo (n = 30 each group) daily for 12 weeks. Vitamin D supplementation (4000 IU), compared with vitamin D (1000 IU) and placebo, led to significant reductions in total testosterone (−0.2 ± 0.2 vs. −0.1 ± 0.6 and +0.1 ± 0.2 ng/mL, respectively, p = 0.02), free androgen index (FAI) (−0.06 ± 0.12 vs. −0.02 ± 0.12 and +0.004 ± 0.04, respectively, p = 0.04), hirsutism (−1.1 ± 1.1 vs. −0.8 ± 1.2 and −0.1 ± 0.4, respectively, p = 0.001) and high-sensitivity C-reactive protein (hs-CRP) (−0.7 ± 1.4 vs. −0.5 ± 0.9 and +0.5 ± 2.4 mg/L, respectively, p = 0.01). In addition, we found significant elevations in mean change of sex hormone-binding globulin (SHBG) (+19.1 ± 23.0 vs. +4.5 ± 11.0 and +0.7 ± 10.4 nmol/L, respectively, p < 0.001) and total antioxidant capacity (TAC) (+130 ± 144 vs. +33 ± 126 and −36 ± 104 mmol/L, respectively, p < 0.001) in the high-dose vitamin D group compared with low-dose vitamin D and placebo groups. Overall, high-dose vitamin D administration for 12 weeks to insulin-resistant women with PCOS had beneficial effects on total testosterone, SHBG, FAI, serum hs-CRP and plasma TAC levels compared with low-dose vitamin D and placebo groups.
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- 2017
21. Group housing of sows in early pregnancy: A review of success and risk factors
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Nicoline M. Soede, Hans A.M. Spoolder, C.M.C. van der Peet-Schwering, and M.J. Geudeke
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Veterinary medicine ,aggressive-behavior ,media_common.quotation_subject ,Reproduction (economics) ,Fertility ,Animal welfare ,reproductive-performance ,medicine ,Adaptatiefysiologie ,media_common ,Pregnancy ,General Veterinary ,Reproductive success ,Aggression ,female pigs ,nonstarch polysaccharides ,space allowance ,Animal husbandry ,medicine.disease ,embryo survival ,commercial pigs ,group-housed sows ,WIAS ,Adaptation Physiology ,hormonal profiles ,social interactions ,Animal Science and Zoology ,medicine.symptom ,Psychology ,Welfare ,Wageningen Livestock Research ,Demography - Abstract
A recent telephone survey of 735 Dutch farmers with group housing of sows in early pregnancy suggested a wide variation in reproductive success, irrespective of husbandry system. The reason for these differences between farms is not known, but of great importance to the pig industry which is moving worldwide from individual to group housing systems, mainly for animal welfare reasons. Therefore, the aim of this review is to list the most likely success and risk factors for group housing of sows in early pregnancy, in relation to reproduction (such as pregnancy rate) and animal welfare (such as aggression and health). The review first considers a limited number of group housing comparisons and finds that the results of the few studies performed are not very conclusive, neither on fertility nor on leg problems, longevity and welfare of sows. As a consequence, it is hard to draw any significant practical conclusions, and the review proceeds to look at studies in which single factors were addressed. For the effects on fertility it is concluded that especially factors causing chronic stress (e.g. due to unfavourable social, management or climatic conditions) and a low feed intake may impact reproductive performance. The vulnerable period lies in weeks 2 and 3 of pregnancy. On leg problems and longevity an important factor seems to be the quality of the floor, regardless of other aspects of the housing system. The use of straw seems to be advantageous. Finally, on aggression it is argued that this will never be eliminated from systems in which sows are housed as a group. However, it can be properly managed and key factors in this are a gradual familiarisation of unfamiliar animals, sufficient space and pen structure during initial mixing, minimising opportunities for dominant sows to steal food from subordinates, the provision of a good quality floor and the use of straw bedding. The review concludes with a series of practical recommendations to improve welfare and reproduction in group housed sows.
- Published
- 2009
22. Group housing of sows in early pregnancy: A review of success and risk factors
- Author
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Spoolder, H.A.M., Geudeke, M.J., van der Peet-Schwering, C.M.C., Soede, N.M., Spoolder, H.A.M., Geudeke, M.J., van der Peet-Schwering, C.M.C., and Soede, N.M.
- Abstract
A recent telephone survey of 735 Dutch farmers with group housing of sows in early pregnancy suggested a wide variation in reproductive success, irrespective of husbandry system. The reason for these differences between farms is not known, but of great importance to the pig industry which is moving worldwide from individual to group housing systems, mainly for animal welfare reasons. Therefore, the aim of this review is to list the most likely success and risk factors for group housing of sows in early pregnancy, in relation to reproduction (such as pregnancy rate) and animal welfare (such as aggression and health). The review first considers a limited number of group housing comparisons and finds that the results of the few studies performed are not very conclusive, neither on fertility nor on leg problems, longevity and welfare of sows. As a consequence, it is hard to draw any significant practical conclusions, and the review proceeds to look at studies in which single factors were addressed. For the effects on fertility it is concluded that especially factors causing chronic stress (e.g. due to unfavourable social, management or climatic conditions) and a low feed intake may impact reproductive performance. The vulnerable period lies in weeks 2 and 3 of pregnancy. On leg problems and longevity an important factor seems to be the quality of the floor, regardless of other aspects of the housing system. The use of straw seems to be advantageous. Finally, on aggression it is argued that this will never be eliminated from systems in which sows are housed as a group. However, it can be properly managed and key factors in this are a gradual familiarisation of unfamiliar animals, sufficient space and pen structure during initial mixing, minimising opportunities for dominant sows to steal food from subordinates, the provision of a good quality floor and the use of straw bedding. The review concludes with a series of practical recommendations to improve welfare and reprodu
- Published
- 2009
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