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5 results on '"healthy donor effect"'

1. The healthy donor effect and survey participation, becoming a donor and donor career

Author

Brodersen, Thorsten, Rostgaard, Klaus, Lau, Cathrine Juel, Juel, Knud, Erikstrup, Christian, Nielsen, Kasper Rene, Ostrowski, Sisse Rye, Titlestad, Kjell, Sækmose, Susanne G., Pedersen, Ole B.V., Hjalgrim, Henrik, Brodersen, Thorsten, Rostgaard, Klaus, Lau, Cathrine Juel, Juel, Knud, Erikstrup, Christian, Nielsen, Kasper Rene, Ostrowski, Sisse Rye, Titlestad, Kjell, Sækmose, Susanne G., Pedersen, Ole B.V., and Hjalgrim, Henrik

Abstract

Background: The healthy donor effect (HDE) is a selection bias caused by the health criteria blood donors must meet. It obscures investigations of beneficial/adverse health effects of blood donation and complicates the generalizability of findings from blood donor cohorts. To further characterize the HDE we investigated how self-reported health and lifestyle are associated with becoming a blood donor, lapsing, and donation intensity. Furthermore, we examined differences in mortality based on donor status. Study Design and Methods: The Danish National Health Survey was linked to the Scandinavian Donations and Transfusions (SCANDAT) database and Danish register data. Logistic- and normal regression was used to compare baseline characteristics and participation. Poisson regression was used to investigate future donation choices. Donation intensity was explored by the Anderson-Gill model and Poisson regression. Mortality was investigated using Poisson regression. Results: Blood donors were more likely to participate in the surveys, OR = 2.45 95% confidence interval (2.40–2.49) than non-donors. Among survey participants, better self-reported health and healthier lifestyle were associated with being or becoming a blood donor, donor retention, and to some extent donation intensity, for example, current smoking conveyed lower likelihood of becoming a donor, OR = 0.70 (0.66–0.75). We observed lower mortality for donors and survey participants, respectively, compared with non-participating non-donors. Conclusion: We provide evidence that blood donation is associated with increased likelihood to participate in health surveys, possibly a manifestation of the HDE. Furthermore, becoming a blood donor, donor retention, and donation intensity was associated with better self-reported health and healthier lifestyles.

Published
2023

2. Exploration of the Healthy Donor Effect Among 0.6 Million Blood Donors in China: Longitudinal Study.

Author

Su S, Sun Y, Gu X, Wu W, Su X, Ma T, Song A, Xie X, Wang L, Cheng Q, Guo L, Zhang L, and Yang J

Subjects
Humans, Female, Male, Middle Aged, Longitudinal Studies, Cohort Studies, Retrospective Studies, China epidemiology, Blood Donors
Abstract

Background: The World Health Organization emphasizes the importance of completely voluntary blood donation to maintain safe and sustainable blood supplies. However, the benefits of blood donation for donors, such as reducing the risk of disease, remain a topic of debate due to the existence of the healthy donor effect (HDE). This effect arises because of inherent health differences between blood donors and the general population, and it is also considered a methodological issue., Objective: This study aims to generate a more detailed health profile of blood donors from a donor cohort study to mitigate and quantify the HDE and properly interpret the association between blood donation and disease outcomes among blood donors., Methods: A retrospective cohort study was conducted between January 2012 and December 2018 among donors before their first donation. One-to-one propensity score matching was conducted through a random selection of individuals without any history of blood donation, as reported from their electronic health records. We conducted a Poisson regression between blood donors and non-blood donors before the first donation to estimate the adjusted incidence rate ratio (AIRR) of selected blood donation-related diseases, as defined by 13 categories of International Classification of Diseases, Tenth Revision (ICD-10) codes., Results: Of the 0.6 million blood donors, 15,115 had an inpatient record before their first donation, whereas 17,356 non-blood donors had an inpatient record. For the comparison between blood donors and the matched non-blood donors, the HDE (the disease incidence rate ratio between non-blood donors and blood donors) was an AIRR of 1.152 (95% CI 1.127-1.178; P<.001). Among disease categories not recommended for blood donation in China, the strongest HDE was observed in the ICD-10 D50-D89 codes, which pertain to diseases of the blood and blood-forming organs as well as certain disorders involving the immune mechanism (AIRR 3.225, 95% CI 2.402-4.330; P<.001). After age stratification, we found that people who had their first blood donation between 46-55 years old had the strongest HDE (AIRR 1.816, 95% CI 1.707-1.932; P<.001). Both male and female donors had significant HDE (AIRR 1.082, 95% CI 1.05-1.116; P=.003; and AIRR 1.236, 95% CI 1.196-1.277; P<.001, respectively) compared with matched non-blood donors., Conclusions: : Our research findings suggest that the HDE is present among blood donors, particularly among female donors and those who first donated blood between the ages of 46 and 55 years., Trial Registration: Chinese Clinical Trial Registry ChiCTR2200055983; https://www.chictr.org.cn/showproj.html?proj=51760., (©Shu Su, Yang Sun, Xiaoyun Gu, Wenjie Wu, Xiaodong Su, Ting Ma, Aowei Song, Xinxin Xie, Liqin Wang, Qianke Cheng, Lingxia Guo, Lei Zhang, Jiangcun Yang. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org), 22.02.2024.)

Published
2024
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3. The healthy donor effect and survey participation, becoming a donor and donor career

Author

Thorsten Brodersen, Klaus Rostgaard, Cathrine Juel Lau, Knud Juel, Christian Erikstrup, Kasper Rene Nielsen, Sisse Rye Ostrowski, Kjell Titlestad, Susanne G. Sækmose, Ole B. V. Pedersen, and Henrik Hjalgrim

Subjects
donor health, Immunology, healthy donor effect, Immunology and Allergy, blood donors, survey participation, Hematology, donation behavior
Abstract

BACKGROUND: The healthy donor effect (HDE) is a selection bias caused by the health criteria blood donors must meet. It obscures investigations of beneficial/adverse health effects of blood donation and complicates the generalizability of findings from blood donor cohorts. To further characterize the HDE we investigated how self-reported health and lifestyle are associated with becoming a blood donor, lapsing, and donation intensity. Furthermore, we examined differences in mortality based on donor status.STUDY DESIGN AND METHODS: The Danish National Health Survey was linked to the Scandinavian Donations and Transfusions (SCANDAT) database and Danish register data. Logistic- and normal regression was used to compare baseline characteristics and participation. Poisson regression was used to investigate future donation choices. Donation intensity was explored by the Anderson-Gill model and Poisson regression. Mortality was investigated using Poisson regression.RESULTS: Blood donors were more likely to participate in the surveys, OR = 2.45 95% confidence interval (2.40-2.49) than non-donors. Among survey participants, better self-reported health and healthier lifestyle were associated with being or becoming a blood donor, donor retention, and to some extent donation intensity, for example, current smoking conveyed lower likelihood of becoming a donor, OR = 0.70 (0.66-0.75). We observed lower mortality for donors and survey participants, respectively, compared with non-participating non-donors.CONCLUSION: We provide evidence that blood donation is associated with increased likelihood to participate in health surveys, possibly a manifestation of the HDE. Furthermore, becoming a blood donor, donor retention, and donation intensity was associated with better self-reported health and healthier lifestyles.

Published
2023
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4. The healthy donor effect impacts self‐reported physical and mental health – results from the Danish Blood Donor Study (DBDS)

Author

Axel Skytthe, Kirsten Ohm Kyvik, Henrik Hjalgrim, Henrik Ullum, Christian Erikstrup, Andreas S. Rigas, Mikkel Steen Petersen, Ole Birger Pedersen, and Klaus Rostgaard

Subjects
Adult, Male, Gerontology, Adolescent, Denmark, healthy donor effect, Blood Donors, 030204 cardiovascular system & hematology, Danish, 03 medical and health sciences, 0302 clinical medicine, Quality of life, self-reported health, Journal Article, Humans, Medicine, Prospective Studies, Aged, Multivariable linear regression, business.industry, Age Factors, Physical health, Hematology, Middle Aged, Mental health, Self Concept, language.human_language, Mental Health, Blood donor, Quality of Life, language, blood donors, Female, Smoking status, Self Report, Healthy donor, business, 030215 immunology, Demography
Abstract

AIMS: This study aimed at quantifying the healthy donor effect by comparing self-perceived mental and physical health between blood donors and non-donors.BACKGROUND: In theory, the selection process known as the healthy donor effect should result in better self-perceived, health-related quality of life in donors than in non-donors.METHODS: The Short Form-12 data from the Danish Twin Registry (DTR) was compared with the data from the Danish Blood Donor Study (DBDS). Data on age, sex and smoking status were included in the analyses. The multivariable linear regression analysis was stratified by sex and age group intervals. Outcome variables were the mental component score (MCS) and the physical component score (PCS).RESULTS: A total of 28 982 and 36 913 participants from the DTR and the DBDS, respectively, were included in this study. Younger donors had higher MCS than non-donors, whereas MCS was only marginally high in older donors compared with non-donors. In contrast, PCS was almost similar for both young donors and non-donors. With the increase in age, non-donors had lower PCS than donors.CONCLUSIONS: Two selection patterns were revealed. Among young individuals, better self-perceived mental health was associated with a blood donor. With the increase in age, better self-perceived physical health was associated with blood donation.

Published
2017
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5. The healthy donor effect impacts self-reported physical and mental health - results from the Danish Blood Donor Study (DBDS)

Author

Rigas, A S, Skytthe, A, Erikstrup, C, Rostgaard, K, Petersen, M S, Hjalgrim, H, Ullum, H., Kyvik, K O, Pedersen, O. B., Rigas, A S, Skytthe, A, Erikstrup, C, Rostgaard, K, Petersen, M S, Hjalgrim, H, Ullum, H., Kyvik, K O, and Pedersen, O. B.

Abstract

AIMS: This study aimed at quantifying the healthy donor effect by comparing self-perceived mental and physical health between blood donors and non-donors.BACKGROUND: In theory, the selection process known as the healthy donor effect should result in better self-perceived, health-related quality of life in donors than in non-donors.METHODS: The Short Form-12 data from the Danish Twin Registry (DTR) was compared with the data from the Danish Blood Donor Study (DBDS). Data on age, sex and smoking status were included in the analyses. The multivariable linear regression analysis was stratified by sex and age group intervals. Outcome variables were the mental component score (MCS) and the physical component score (PCS).RESULTS: A total of 28 982 and 36 913 participants from the DTR and the DBDS, respectively, were included in this study. Younger donors had higher MCS than non-donors, whereas MCS was only marginally high in older donors compared with non-donors. In contrast, PCS was almost similar for both young donors and non-donors. With the increase in age, non-donors had lower PCS than donors.CONCLUSIONS: Two selection patterns were revealed. Among young individuals, better self-perceived mental health was associated with a blood donor. With the increase in age, better self-perceived physical health was associated with blood donation.

Published
2019

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