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Your search keyword '"Zhou, Xue-ming"' showing total 20 results
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6. Alkaloids from the stems of Fissistigma maclurei Merr. inhibit the proliferation of synoviocytes

Author

Liang, Mu-Tao, Zhang, Xiao-Zheng, Chen, Zi-Hao, Fu, Chuan-Shan, Li, Duo-Jiang, Chen, Guo-Ze, Yi, Ji-Ling, and Zhou, Xue-Ming

Subjects
Organic Chemistry, Plant Science, Biochemistry, Analytical Chemistry
Abstract

Two new aporphine-derived alkaloids, aporaloids C and D (1 and 2), along with eight known biogenetically related alkaloids (3–10) were isolated from the stems of Fissistigma maclurei Merr. Their structures were elucidated by detailed analysis of NMR, HRESIMS, MS, IR, UV and Optical rotations data. Compounds 1 and 2 represent a rare example of N-methylol aporphine-derived alkaloids from natural sources. The inhibitory effect of all compounds on the proliferation of primary synovial cells was evaluated. Compound 3 showed potent inhibitory effect on the proliferation of synoviocytes with an IC50 value of 4.8 μM. Compounds 1, 2, 6–9 and 10 exhibited moderate inhibitory activity on synoviocytes, with IC50 values of 36.8, 37.1, 31.2 μM, 32.5, 36.3, 36.8 and 18.2 μM, respectively.

Published
2023
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7. Three new long-chain polyenes from the mangrove-derived fungus Penicillium herquei JX4

Author

Long, Kai-Yuan, Dai, De-Cai, Zheng, Cai-Juan, Wang, Yi-Tong, Song, Xin-Ming, Chen, Xuan, Zhou, Xue-Ming, and Chen, Guang-Ying

Subjects
Pharmacology, Complementary and alternative medicine, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, General Medicine, Analytical Chemistry
Abstract

One new epimer pair of long-chain polyenes penicilqueis E (1) and F (2), and one new long-chain polyene pinophol G (3), along with one known compound (4), were obtained from EtOAc extract of the mangrove-derived fungus Penicillium herquei JX4. Their structures were elucidated by detailed analysis of comprehensive spectroscopic data. The inhibitory activities of all compounds against the nitric oxide (NO) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells in vitro were evaluated.

Published
2022
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9. Additional file 1 of Saikosaponin D exerts antidepressant effect by regulating Homer1-mGluR5 and mTOR signaling in a rat model of chronic unpredictable mild stress

Author

Liu, Chen-Yue, Chen, Jian-Bei, Liu, Yue-Yun, Zhou, Xue-Ming, Zhang, Man, Jiang, You-Ming, Ma, Qing-Yu, Xue, Zhe, Zhao, Zong-Yao, Li, Xiao-Juan, and Chen, Jia-Xu

Abstract

Additional file 1. Describes the Behavioral testing, RT-QPCR, Western blot analysis, Immunohistochemistry experimental procedure, and Statistical analysis in detail.

Published
2022
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10. Two new anthraquinone derivatives from Saprosma crassipes H. S. Lo

Author

Ji, Xin-Shu, Dai, De-Cai, Wang, Yi-Tong, Cui, Jing-Yi, Li, Hai-Xiang, Song, Xin-Ming, Yi, Ji-Ling, and Zhou, Xue-Ming

Subjects
Organic Chemistry, Plant Science, Biochemistry, Analytical Chemistry
Abstract

Two new anthraquinone derivatives sapranquinones A and B (1 and 2) together with two known biogenetically related anthraquinone derivatives (3 and 4) were isolated from the stems of Saprosma crassipes H. S. Lo. The structures of these compounds were elucidated using comprehensive spectroscopic methods. Compounds 1-4 were evaluated for their antibacterial activities and compounds 1 and 3 had a broad spectrum antibacterial activity against Staphylococcus albus, Escherichia coli, Bacillus cereus, Micrococcus tetragenus, and Micrococcus luteus with MIC values ranging from 1.25 to 5 μg/mL.

Published
2022
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13. A new triterpenoid glucoside from Leucas zeylanica

Author

Guang-Ying Chen, Zhang, Bin, Zhao, Ting, Nidhal, Najat, Jia-Li, Wang, Zhou, Xue-Ming, and Chun-Yan, Dai

Abstract

A new triterpenoid glucoside, leuctriterpencoside (1), along with two known compounds (2–3) were isolated from Leucas zeylanica. The structure of the new compound was elucidated using comprehensive spectroscopic methods. Compound 1 showed significant inhibitory activity against α-glucosidase (IC50 value of 0.85 ± 0.12 μM).

Published
2019
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20. Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction.

Author

Shi HL, Liu CH, Ding LL, Zheng Y, Fei XY, Lu L, Zhou XM, Yuan JY, and Xie JQ

Subjects
Animals, Calcitonin Gene-Related Peptide metabolism, Chromogranin A metabolism, Colon innervation, Colon metabolism, Disease Models, Animal, Hyperalgesia drug therapy, Hyperalgesia metabolism, Hyperalgesia physiopathology, Intestinal Mucosa innervation, Intestinal Mucosa metabolism, Irritable Bowel Syndrome metabolism, Irritable Bowel Syndrome physiopathology, Male, Pain Threshold drug effects, Pressure, RNA-Binding Proteins metabolism, Rats, Sprague-Dawley, Receptor, PAR-2 metabolism, Signal Transduction drug effects, Time Factors, Transient Receptor Potential Channels metabolism, Tumor Necrosis Factor-alpha metabolism, Colon drug effects, Drugs, Chinese Herbal pharmacology, Gastrointestinal Motility drug effects, Intestinal Mucosa drug effects, Irritable Bowel Syndrome drug therapy, Receptor, PAR-2 drug effects, Serotonin metabolism, Transient Receptor Potential Channels drug effects
Abstract

Aim: To determine the molecular mechanisms of Shugan decoction (SGD) in the regulation of colonic motility and visceral hyperalgesia (VHL) in irritable bowel syndrome (IBS)., Methods: The chemical compounds contained in SGD were measured by high-performance liquid chromatography. A rat model of IBS was induced by chronic water avoidance stress (WAS). The number of fecal pellets was counted after WAS and the pain pressure threshold was measured by colorectal distension. Morphological changes in colonic mucosa were detected by hematoxylin-eosin staining. The contents of tumor necrosis factor (TNF)-α in colonic tissue and calcitonin-gene-related peptide (CGRP) in serum were measured by ELISA. The protein expression of serotonin [5-hydroxytryptamide (5-HT)], serotonin transporter (SERT), chromogranin A (CgA) and CGRP in colon tissue was measured by immunohistochemistry., Results: SGD inhibited colonic motility dysfunction and VHL in rats with IBS. Blockers of transient receptor potential (TRP) vanilloid 1 (TRPV1) (Ruthenium Red) and TRP ankyrin-1 (TRPA1) (HC-030031) and activator of protease-activated receptor (PAR)4 increased the pain pressure threshold, whereas activators of PAR2 and TRPV4 decreased the pain pressure threshold in rats with IBS. The effect of SGD on pain pressure threshold in these rats was abolished by activators of TRPV1 (capsaicin), TRPV4 (RN1747), TRPA1 (Polygodial) and PAR2 (AC55541). In addition, CGRP levels in serum and colonic tissue were both increased in these rats. TNF-α level in colonic tissue was also significantly upregulated. However, the levels of 5-HT, SERT and CgA in colonic tissue were decreased. All these pathological changes in rats with IBS were attenuated by SGD., Conclusion: SGD alleviated VHL and attenuated colon motility in IBS, partly by regulating TRPV1, TRPV4, TRPA1, PAR2, 5-HT, CgA and SERT, and reducing CGRP and TNF-α level.

Published
2015
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