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Objective To explore the clinical efficacy and changes in hemodynamic parameters before and after incomplete stent angioplasty with percutaneous transluminal angioplasty and stenting (PTAS) for severe intracranial atherosclerotic stenosis. Methods A total of 52 patients with severe intracranial artery stenosis (> 70%) who underwent incomplete stent angioplasty with PTAS at Shijiazhuang People's Hospital in Hebei from February 2018 to February 2023 were selected. The residual stenosis rate after implantation of stent was evaluated, and neurological function was evaluated before and 6 months after surgery by modified Rankin Scale (mRS). The MeshLab software was used to analyze three⁃dimensional imaging data of arterial vessels, perform virtual repair of arterial stenosis approaching normal vessel diameter, and obtain hemodynamic parameters of each segment of the arterial wall and lumen before and after implantation of stent. Results The residual stenosis rate after stent implantation was (15.34 ± 6.12)%, which was better than the stenosis rate before stent implantation [(84.60 ± 7.20)%; t = 98.672, P =0.000]. The mRS score 6 months after surgery was (0.38 ± 0.21) points, which was lower than before surgery [(1.21 ± 0.43) points; t = 24.124, P = 0.000]. Compared with the hemodynamic parameters of each segment of the arterial wall before stent implantation, the dynamic pressure, total pressure, shear stress,shear rate, and cell Reynolds number of the proximal normal segment, stenotic and distal normal segment of the artery decreased after stent implantation (P = 0.000, for all), also the dynamic pressure (P = 0.000), total pressure (P = 0.000), shear stress (P = 0.000), shear rate (P = 0.008), and cell Reynolds number (P = 0.000) of the narrowed branch root decreased. Compared with the hemodynamic parameters related to the lumen of each segment of the artery before stent implantation, the dynamic pressure (P = 0.000), total pressure (P = 0.000), blood flow velocity (P = 0.000), vorticity (P = 0.005), turbulence kinetic energy (P = 0.000), turbulence intensity (P = 0.000), turbulence dissipation rate (P = 0.000), and turbulence Reynolds number (P = 0.000) of the proximal normal segment of the artery decreased after stent implantation, while the cell Reynolds number increased (P = 0.000). Excluding blood flow velocity (P = 0.138), the dynamic pressure, total pressure, vorticity, turbulence kinetic energy, turbulence intensity, turbulence dissipation rate, and turbulence Reynolds number of the root and segment of the artery decreased (P = 0.000, for all). The dynamic pressure, total pressure, blood flow velocity, vorticity, turbulence kinetic enery, turbulence intensity, turbulence dissipation rate, and turbulence Reynolds number of stenotic segment of the artery decreased (P = 0.000, for all). The dynamic pressure (P = 0.000), total pressure (P = 0.000), blood flow velocity (P = 0.001), vorticity (P = 0.000), turbulence kinetic energy (P = 0.000), turbulence intensity (P =0.000), turbulence dissipation rate (P = 0.000), and turbulence Reynolds number (P = 0.000) of the distal normal segment decreased, while the cell Reynolds number increased (P = 0.000). The hemodynamic parameters of the wall and lumen after virtual repair of artery stenosis were close to those after stent implantation. Conclusions The use of incomplete stent angioplasty with PTAS for severe intracranial atherosclerotic stenosis can significantly alleviate clinical symptoms, improve hemodynamic parameters in each segment of the stenosis, reduce the damage of turbulent blood flow to the arterial wall, and lower the risk of plaque fragmentation, detachment, and embolism of distal brain tissue caused by complete dilation of the stenosis.

Objective To analyze the prognosis and risk factors of the anterior and posterior circulation tandem lesions (TLs) patients after recanalization treatment. Methods The general and clinical data of 42 patients with TLs who received recanalization treatment in Shijiazhuang People's Hospital from April 2019 to August 2022 were retrospectively collected. The prognosis of 90 d after surgery was evaluated by the modified Rankin Scale (mRS). Univariate and multivariate stepwise Logistic regression analyses were used to investigated the risk factors of poor prognosis of TLs. Results According to mRS scores at the 90 d after surgery, the patients were divided into good prognosis group (mRS ≤ 2, n = 21) and poor prognosis group (mRS > 2, n = 21). The National Institutes of Health Stroke Scale (NIHSS) score at admission (Z = ⁃ 2.916, P = 0.004), time from onset to recanalization (Z = ⁃ 2.048, P = 0.041), mechanical thrombectomy times ≥ 3 (χ2 = 4.725, P = 0.030) and the proportion of hematoma type hemorrhagic transformation (χ2 = 8.400, P = 0.004) in the poor prognosis group were higher than those in good prognosis group. Logistic regression analysis showed that high NIHSS score at admission (OR = 12.457, 95%CI: 2.066-75.120; P = 0.006), mechanical thrombectomy times ≥ 3 (OR = 9.387, 95%CI: 1.222-72.140; P = 0.031) and postoperative hemorrhagic transformation (OR = 7.237, 95%CI: 1.019-51.403; P = 0.048) wererisk factors of poor prognosis of TLs. Conclusions Anterior and posterior circulation TLs patients with lower NHISS score at admission, mechanical thrombectomy times < 3 and without postoperative hemorrhagic transformation may have good prognosis.

This study investigated the differences in the physicochemical indexes, volatile flavor substances and microbial community composition of three different colored Daqu (black, yellow and white). Physicochemical analyses showed that the acidity, moisture content and saccharifying power of black Daqu were intermediate between those of yellow and white Daqu, white Daqu had the highest saccharifying power, fermenting power, and esterifying power, and yellow Daqu contained the highest starch content. Flavor substance analysis indicated significant differences in the contents of ethyl caproate, ethyl acetate, phenylethyl alcohol, 1-hexanol and furfural among the three types of Daqu. Microbial community structure analysis revealed that Bacillus and Scopulibacillus were the dominant bacteria, and Thermomyces and Thermoascus were the major fungi in all three types of Daqu. Redundancy analysis (RDA) suggested that Bacillus and Thermomyces had a positive correlation with fermenting power, esterifying power and saccharifying power. Spearman correlation analysis showed that Scopulibacillus, Virgibacillus and Aspergillus were positively correlated with most key flavor compounds. This study provides reference data for the rational application of Daqu in the production of Jiang-flavor Baijiu and is of great value for the standardization of Jiang-flavor Baijiu production.

The reform of test and evaluation is a critical component of the US defense acquisition system reform and the digital transformation of the US military. Facing the challenges of test and evaluation brought by the development of emerging technologies such as artificial intelligence and autonomy, as well as the systematic operational requirements like multi-domain warfare and all-domain warfare, to the delivery of weapon equipment capabilities, the US Department of Defense is actively promoting digital transformation in the field of test and evaluation. One of the crucial measures is to put forward the concept of test and evaluation as a continuum, aiming to continuously optimize test strategies and evaluation processes with the help of digital engineering concepts, and further enhance the efficiency and qua-lity of acquiring weapon equipment. This article briefly outlines the development of test and evaluation as a continuum, analyzes its framework content and conceptual implications, discusses the specific capability elements required for implementation, and provides insights into the digital transformation of test and evaluation for weapon equipment.

This article considers the computation of the matrix exponential eA{{\rm{e}}}^{A} with numerical quadrature. Although several quadrature-based algorithms have been proposed, they focus on (near) Hermitian matrices. In order to deal with non-Hermitian matrices, we use another integral representation including an oscillatory term and consider applying the double exponential (DE) formula specialized to Fourier integrals. The DE formula transforms the given integral into another integral whose interval is infinite, and therefore, it is necessary to truncate the infinite interval. In this article, to utilize the DE formula, we analyze the truncation error and propose two algorithms. The first one approximates eA{{\rm{e}}}^{A} with the fixed mesh size, which is a parameter in the DE formula affecting the accuracy. The second one computes eA{{\rm{e}}}^{A} based on the first one with automatic selection of the mesh size depending on the given error tolerance.

To investigate the water-binding mechanism of fresh sweet potato residue, the water distribution in starch processing residues from 10 varieties of sweet potato was determined by low-field nuclear magnetic resonance (LF-NMR), and the correlation between water states and major organic components was analyzed. Then, the causal relationship was verified through enzymatic hydrolysis experiments. The results showed that three or four states of water were found in the 10 varieties of fresh sweet potato residues, namely compound (T21, 0.658–2.310 ms), immobilized (T22, 7.055–21.550 ms), entrapped (T23, 377.410–705.480 ms) and free flowing water (T24, 705.480–3 764.936 ms). The percentage of entrapped water in sweet potato residues was the highest (93.59% on average), followed by immobilized water (5.15% on average). The percentages of compound water and free flowing water were only 0.85% and 0.41%, respectively. The percentage of entrapped water was significantly positively correlated with the contents of pectin, dietary fiber, and insoluble dietary fiber. The amount of water discharged from sweet potato residues significantly increase after being hydrolyzed by pectinase, but did not significantly change after being hydrolyzed by cellulase, hemicellulase or lignin peroxidase. Under scanning electron microscopy (SEM), it was observed that most of starch particles were encapsulated or bound to cell wall debris. This study can provide a theoretical basis for the development of an efficient dehydration technology for sweet potato residues.

RAM target has complex motion, which puts forward higher requirements for tracking system. Aiming at particle degradation and other problems existing in the process of particle filter solving RAM target tracking, this paper calculates the posterior probability density function as the prior probability density function of the particle filter through unscented transformation, so as to improve the fitting degree of the posterior probability density function and finally improve the particle effectiveness. At the same time, qr decomposition is used to replace part of Cholesky decomposition in the process of unscented transformation, so that the variance matrix of the output signal remains non-negative. Finally, this paper establishes a dynamic model for a reentry target trajectory, and simulates with Matlab to verify the effectiveness of the proposed algorithm.

Background Hypertension is a common chronic non-communicable disease in clinical practice, and its prevalence is on the rise globally due to population aging and changes in human lifestyles. Prolonged high blood pressure can lead to damage to various target organs such as the heart, brain, kidneys, and retina, severely threatening human health and being a major cause of global disease burden. The left ventricle, as the primary target of end-organ damage, its structural changes are also the pathological basis for the development of many cardiovascular diseases. Objective This study aims to explore the relationship between the atherogenic index of plasma (AIP) and serum lipoprotein-associated phospholipase A2 (Lp-PLA2) levels and left ventricular hypertrophy (LVH) in patients with primary hypertension. Methods A total of 167 patients with primary hypertension who visited the Department of Cardiovascular Medicine at the Second Affiliated Hospital of Zhengzhou University from October 2021 to June 2023 were enrolled in this study. Baseline data of the patients were collected, and fasting venous blood biochemical markers were measured. Echocardiograms were conducted within 24 hours of admission to calculate left ventricular mass (LVM) and left ventricular mass index (LVMI). Patients were divided into non-left ventricular hypertrophy (NLVH) group (87 patients) and LVH group (80 patients) based on LVMI. Pearson correlation test and Spearman rank correlation analysis were used to investigate the correlation between serum Lp-PLA2 level, AIP and echocardiographic parameters. Multivariate Logistic regression analysis was used to explore the influencing factors of LVH in hypertensive patients. Receiver operating characteristic (ROC) curve was plotted to explore the diagnostic value of serum Lp-PLA2 level and AIP in hypertensive patients with LVH, and the area under ROC curve (AUC) was calculated. Results Patients in the LVH group had higher age, duration of hypertension, levels of N-terminal pro B-type natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein (hs-CRP), left ventricular posterior wall thickness (LVWPT), interventricular septal thickness (IVST), left ventricular end-diastolic diameter (LVEDd), left atrial end-systolic diameter (LAESd), Lp-PLA2 levels, AIP, LVM, and LVMI compared to the NLVH group (P

In order to explore the pork spoilage potential of Pseudomonas fragi and the antibacterial mechanism of garlic essential oil, P. fragi was isolated from chilled pork under aerobic storage conditions and tested its spoilage capacity. The isolates with strong spoilage capacity were selected for further investigation. The antibacterial activity of garlic essential oil against the selected strains was evaluated by determining the minimum inhibitory concentration (MIC) and plotting the bacterial growth curve. Furthermore, the antibacterial mechanism was investigated by scanning electron microscopic (SEM) observation as well as measuring cell membrane permeability, bacterial motility and metabolic activity. The results showed that P. fragi could cause pork spoilage. Garlic essential oil exhibited a strong inhibitory effect against P. fragi derived from pork, with a MIC of 0.125 μL/mL. Garlic essential oil could disrupt the normal structural morphology of P. fragi, enhance the permeability of the cell membrane, and inhibit bacterial metabolic activity and mobility. The results from this study can provide a theoretical foundation for the application of garlic essential oil as a natural food preservative.

Background Thyroid autoantibody is a marker for the diagnosis of Hashimoto's thyroiditis (HT), and B cells are essential in the pathogenesis of HT. Enhancer of Zeste homolog 2 (EZH2), which is an important epigenetic regulator, plays an important role in the regulation of lymphocytes development and function. Objective To investigate EZH2 expression in plasmoblasts and plasma cells in HT, and further explore the therapeutic effect of EZH2 inhibitors in experimental autoimmune thyroiditis (EAT) model. Methods The thyroid tissues from 6 patients who underwent thyroidectomy (3 HT patients with PTC, 3 patients with PTC alone) in Peking University First Hospital between 2010 and 2020 were obtained from the contralateral lobe with thyroid cancer, and screened for the expression of B-lymphocyte-related genes by RNA-seq; thyroid tissues from 16 HT patients and 8 normal thyroid tissues were collected and verified for the the expression of EZH2 in B cells in HT thyroid tissues by immunohistochemistry or immunofluorescence, respectively. Fine-needle aspiration (FNA) samples from patients with HT (n=25), and peripheral blood from patients with HT (n=19) or healthy donors (n=12) were analyzed by flow cytometry to define altered EZH2 expression in plasmablasts and plasma cells. Fifteen seven-week-old NOD.H-2h4 mice were randomly divided into the control (n=5), EAT without injection group (n=5), and EZH2 inhibitor+ GSK126 injection group (10 mg/kg, intraperitoneal injection 3 times /week, n=5). The degree of thyroid inflammation and changes in TgAb levels were observed after 8 weeks. Results RNA sequencing analysis showed that EZH2 and genes associated with the B-cell phenotype such as CD19, CD27, CD38, CD52 were higher expressed in HT hyroid tissues compared with normal thyroid tissues. Immunohistochemical results showed that immunohistochemical staining for EZH2 in 16 HT thyroid tissue specimens was strongly positive with positive cells observed in the GC region, and no positive cells were observed in the staining of 8 normal thyroid tissues. EZH2 staining in HT thyroid tissue was highly expressed in the GC region, and EZH2 was specifically expressed in CD19+ B cells. The results of flow cytometry assay showed that the proportion of CD19+ B cells, plasmablasts and plasma cells in HT FNA samples was higher than that of HD peripheral blood and HT peripheral blood samples (P

We consider the convolution equation F*X=BF* X=B, where F∈R3×3F\in {{\mathbb{R}}}^{3\times 3} and B∈Rm×nB\in {{\mathbb{R}}}^{m\times n} are given and X∈Rm×nX\in {{\mathbb{R}}}^{m\times n} is to be determined. The convolution equation can be regarded as a linear system with a coefficient matrix of special structure. This fact has led to many studies including efficient numerical algorithms for solving the convolution equation. In this study, we show that the convolution equation can be represented as a generalized Sylvester equation. Furthermore, for some realistic examples arising from image processing, we show that the generalized Sylvester equation can be reduced to a simpler form, and we analyze the unique solvability of the convolution equation.

In order to investigate the effect of long-term consumption of yak milk on the intestinal flora and metabolism and to explore the correlation between acclimation to monodiet and yak milk intake in high-altitude pastoral areas, this study used metagenomics and metabolomics to evaluate the gut microbial community structure and metabolites of mice fed yak milk or Holstein cow milk. Results showed that compared with the control group (normal saline solution), at the phylum level, ingestion of yak milk improved the relative abundance of Actinobacteria (33.27%), Bacteroidetes (24.31%) and Verrucomicrobia (11.08%), while ingestion of Holstein cow milk increased the relative abundance of Firmicutes (43.74%) and Bacteroidetes (24.75%). At the genus level, yak milk consumption increased the relative abundance of Ackermania (11.80%), Bacteroides (6.09%) and Limosilactobacillus (4.77%), while Holstein cow milk consumption increased the relative abundance of Lactobacillus (28.62%), Duncaniella (6.15%) and Limosilactobacillus (6.49%). Both yak and Holstein cow milk up-regulated carbohydrate and nucleotide metabolism. Furthermore, yak milk significantly up-regulated amino acid metabolism, cofactor and vitamin metabolism, energy metabolism, the biosynthesis of secondary metabolites, and the biosynthesis and metabolism of peptidoglycan. Metabolomics revealed that yak milk increased the contents of metabolites such as VB1, (+/-) 12 (13)-DiHOME, coenzyme Q2 and sulfonymethazine, as well as steroid hormone biosynthesis, cofactor biosynthesis, 2-oxyarboxylate metabolism, VB6 metabolism and phenylalanine metabolism in mice. Investigation of intestinal tissue morphology showed that the intestinal wall became thicker with increasing diversity and richness of the gut microbiota and the intestinal villi became longer and denser without deformity or breakage. In conclusion, yak milk has a positive effect on the intestinal flora and metabolism in mice, and this study provides a scientific basis for further development and utilization of yak milk.

An improved acetyl chloride-methanol method was established for the rapid and accurate determination of linoleic acid, α-linolenic acid, docosahexaenoic acid (DHA) and arachidonic acid (ARA) in infant foods for special medicinal purpose with deeply hydrolyzed milk proteins and amino acids. The results showed that the optimal pretreatment conditions were 6 mL of reaction reagent, reaction for 60 minutes, and use of isooctane as extraction solvent. The linear range of linolenic acid and α-linolenic acid were 0.8–8.0 and 0.2–2.0 mg/mL, respectively. The linear ranges of DHA and ARA were 0.02–0.40 mg/mL, and the determination coefficients for all analytes were greater than or equal to 0.999 7. The limits of detection (LOD) and limits of quantitation (LOQ) of the developed method were 2 and 5 mg/100 g, respectively. This method was characterized by good repeatability (relative standard deviation (RSD) ≤ 3.3%), high precision (RSD ≤ 3.8%), good stability (RSD ≤ 2.6%), and high spiked recovery (ranging from 93.1% to 101.7%). Compared with its original version, the developed method could effectively solve the problem of incomplete reaction due to caking, with an at least 100% higher working efficiency.

"First, a layer of inorganic self-assembled microencapsulated ammonium polyphosphate （APP) （SiO2@APP) was formed on the surface of APP using alkaline silica sol, and then grafting modified APP （KH 580-SiO2@APP) flame retardant was prepared via grafting modification of the silane coupling agent 3-mercaptopropyltriethoxysilane （KH 580) onto the surface of SiO2@APP by sol-gel method. Meanwhile, natural rubber （NR) composites were prepared by the application of KH 580-SiO2@APP to NR, and the effects of APP surface modification on the hydrophobicity, thermal stability, flame retardancy, and physical and mechanical properties of NR composite materials were studied. The results indicated that the surface modification of APP was successful. Compared with APP, the water contact angle of the resulting SiO2@APP increased by 205.7% and the thermal stability increased by about 25.7% after the modification with alkaline silica sol, and in the meantime, compared with APP/NR composite material, the tensile strength of SiO2@APP/NR composite increased by 43.7%, but the limited oxygen index （LOI) decreased. After the modification of SiO2@APP with the silane coupling agent KH 580, the water contact angle of the resul-ting KH 580-SiO2@APP increased by 9.1% and the increase in thermal stability was nearly 11.6%. In additon, the tensile strength of KH 580-SiO2@APP/NR composite was improved to 16.2 MPa, and the elongation at break increased by 539%, while the LOI decreased slightly to 24.3%. "

为解决传统植脂奶油所用部分氢化植物油中饱和脂肪酸与反式脂肪酸带来的健康问题，以椰子油-葵花籽油混合油（质量比1∶ 1）为基料油，β-环糊精和大豆卵磷脂为复合乳化剂，采用物理复配法制备植脂奶油，采用单因素试验研究了水分含量、β-环糊精和大豆卵磷脂添加量对植脂奶油持油性、持水性和稳定性的影响，并通过响应面法优化了制备工艺条件。结果表明：植脂奶油最优制备工艺条件为β-环糊精添加量6.0%、大豆卵磷脂添加量1.1%、水分含量38.0%，在此条件下植脂奶油的持油性和持水性分别达到98.9%和93.8%；对植脂奶油的稳定性分析也进一步说明了持油性、持水性与稳定性之间的正向关系。综上，以β-环糊精和大豆卵磷脂为复合乳化剂，采用物理复配法制备的椰子油-葵花籽油基植脂奶油是一种潜在的营养健康植脂奶油。Aiming to resolve the health issues caused by saturated fatty acids and trans fatty acids in part hydrogenated vegetable oils used in traditional vegetable cream, using coconut oil-sunflower seed oil mixture(mass ratio 1∶ 1 ) as the base oil, β-cyclodextrin and soybean lecithin as compound emulsifiers,vegetable cream was prepared by physical compound method.The effects of water content, addition amounts of β-cyclodextrin and soybean lecithin on the oil holding capacity, water holding capacity, and stability of the vegetable cream were investigated by single factor experiment, then response surface methodology was used to optimize the preparation conditions of vegetable cream. The results showed that the optimal conditions were as follows: β-cyclodextrin addition amount 6.0%, soybean lecithin addition amount 11% and water content 38.0%. Under the optimal conditions, the oil holding capacity and water holding capacity of the vegetable cream reached 98.9% and 93.8%, respectively. Additionally, the analysis of stability of the vegetable cream showed that there was a positive relationship between oil holding capacity, water holding capacity and stability. Coconut oil-sunflower seed oil based vegetable cream prepared by physical compound method with β-cyclodextrin and soybean lecithin as compound emulsifiers is a potential nutritious and healthy vegetable cream.

Wheat, an essential crop for global food security, is well adapted to a wide variety of soils. However, the gene networks shaping different root architectures remain poorly understood. We report here that dosage differences in a cluster of monocot-specific 12-OXOPHYTODIENOATE REDUCTASE genes from subfamily III (OPRIII) modulate key differences in wheat root architecture, which are associated with grain yield under water-limited conditions. Wheat plants with loss-of-function mutations in OPRIII show longer seminal roots, whereas increased OPRIII dosage or transgenic over-expression result in reduced seminal root growth, precocious development of lateral roots and increased jasmonic acid (JA and JA-Ile). Pharmacological inhibition of JA-biosynthesis abolishes root length differences, consistent with a JA-mediated mechanism. Transcriptome analyses of transgenic and wild-type lines show significant enriched JA-biosynthetic and reactive oxygen species (ROS) pathways, which parallel changes in ROS distribution. OPRIII genes provide a useful entry point to engineer root architecture in wheat and other cereals.