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3. Could the Long-Term Oncological Safety of Laparoscopic Surgery in Low-Risk Endometrial Cancer also Be Valid for the High–Intermediate- and High-Risk Patients? A Multi-Center Turkish Gynecologic Oncology Group Study Conducted with 2745 Endometrial Cancer Cases. (TRSGO-End-001)

Author

Vardar, Mehmet Ali, primary, Guzel, Ahmet Baris, additional, Taskin, Salih, additional, Gungor, Mete, additional, Ozgul, Nejat, additional, Salman, Coskun, additional, Kucukgoz-Gulec, Umran, additional, Khatib, Ghanim, additional, Taskiran, Cagatay, additional, Dünder, Ilkkan, additional, Ortac, Firat, additional, Yuce, Kunter, additional, Terek, Cosan, additional, Simsek, Tayup, additional, Ozsaran, Aydın, additional, Onan, Anil, additional, Coban, Gonca, additional, Topuz, Samet, additional, Demirkiran, Fuat, additional, Takmaz, Ozguc, additional, Kose, M. Faruk, additional, Gocmen, Ahmet, additional, Seydaoglu, Gulsah, additional, Gumurdulu, Derya, additional, and Ayhan, Ali, additional

Published
2021
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5. Lymph node metastasis in grossly apparent clinical stage Ia epithelial ovarian cancer: Hacettepe experience and review of literature

Author

Yuce Kunter, Usubutun Alp, Gultekin Murat, Desteli Guldeniz, and Ayhan Ali

Subjects
Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Lymphadenectomy is an integral part of the staging system of epithelial ovarian cancer. However, the extent of lymphadenectomy in the early stages of ovarian cancer is controversial. The objective of this study was to identify the lymph node involvement in unilateral epithelial ovarian cancer apparently confined to the one ovary (clinical stage Ia). Methods A prospective study of clinical stage I ovarian cancer patients is presented. Patient's characteristics and tumor histopathology were the variables evaluated. Results Thirty three ovarian cancer patients with intact ovarian capsule were evaluated. Intraoperatively, neither of the patients had surface involvement, adhesions, ascites or palpable lymph nodes (supposed to be clinical stage Ia). The mean age of the study group was 55.3 ± 11.8. All patients were surgically staged and have undergone a systematic pelvic and paraaortic lymphadenectomy. Final surgicopathologic reports revealed capsular involvement in seven patients (21.2%), contralateral ovarian involvement in two (6%) and omental metastasis in one (3%) patient. There were two patients (6%) with lymph node involvement. One of the two lymph node metastasis was solely in paraaortic node and the other metastasis was in ipsilateral pelvic lymph node. Ovarian capsule was intact in all of the patients with lymph node involvement and the tumor was grade 3. Conclusion In clinical stage Ia ovarian cancer patients, there may be a risk of paraaortic and pelvic lymph node metastasis. Further studies with larger sample size are needed for an exact conclusion.

Published
2010
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8. Widespread Recurrence 7 Years after Radical Abdominal Trachelectomy for Early Cervical Adenocarcinoma

Author

Salman, M. Coskun, Ozgul, Nejat, and Yuce, Kunter

Subjects
Article Subject
Abstract

Cervical cancer is the third most common female cancer worldwide and the use of routine screening resulted in earlier stage and younger age at diagnosis. Fertility preservation via radical trachelectomy comes up as an option in such patients. Recent literature reviews confirm the safety of this operation with excellent oncologic outcomes in appropriately chosen patients. However, recurrent disease is likely and a strict follow-up is recommended to detect recurrences at an early stage following radical trachelectomy. In this report, a case who underwent radical trachelectomy and developed widespread recurrences 7 years after initial surgery possibly due to the lack of oncologic follow-up is discussed.

Published
2015
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12. Multicenter Analysis of Gestational Trophoblastic Neoplasia in Turkey

Author

Ozalp, Sabit Sinan, primary, Telli, Elcin, additional, Oge, Tufan, additional, Tulunay, Gokhan, additional, Boran, Nurettin, additional, Turan, Taner, additional, Yenen, Mufit, additional, Kurdoglu, Zehra, additional, Ozler, Ali, additional, Yuce, Kunter, additional, Ulker, Volkan, additional, Arvas, Macit, additional, Demirkiran, Fuat, additional, Bese, Tugan, additional, Tokgozoglu, Nedim, additional, Onan, Anil, additional, Sanci, Muzaffer, additional, Gokcu, Mehmet, additional, Tosun, Gokhan, additional, Dikmen, Yilmaz, additional, Ozsaran, Aydin, additional, Terek, Mustafa Cosan, additional, Akman, Levent, additional, Yetimalar, Hakan, additional, Kilic, Derya Sakarya, additional, Gungor, Tayfun, additional, Ozgu, Emre, additional, Yildiz, Yunus, additional, Kokcu, Arif, additional, Kefeli, Mehmet, additional, Kuruoglu, Serkan, additional, Yuksel, Hasan, additional, Guvenal, Tevfik, additional, Hasdemir, Pinar Solmaz, additional, Ozcelik, Bulent, additional, Serin, Serdar, additional, Dolanbay, Mehmet, additional, Arioz, Dagistan Tolga, additional, Tuncer, Nadire, additional, Bozkaya, Hasan, additional, Guven, Suleyman, additional, Kulaksiz, Deniz, additional, Varol, Fusun, additional, Ali, Yanik, additional, Ogurlu, Gonca, additional, Simsek, Tayyup, additional, Toptas, Tayfun, additional, Dogan, Selen, additional, Camuzoglu, Hakan, additional, Api, Murat, additional, Guzin, Kadir, additional, Eray, Caliskan, additional, and Doger, Emek, additional

Published
2014
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13. HPV types in Turkey: multicenter hospital based evaluation of 6388 patients in turkish gynecologic oncology group centers

Author

Dursun, Polat, primary, Ayhan, Ali, additional, Mutlu, Levent, additional, Caglar, Mete, additional, Haberal, Ali, additional, Gungor, Taygun, additional, Ozat, Mustafa, additional, Ozgu, Emre, additional, Onan, Anil, additional, Taskiran, Cagatay, additional, Guner, Haldun, additional, Yetimalar, Hakan, additional, Kasap, Burcu, additional, Yuce, Kunter, additional, Salman, M. Coskun, additional, Sayal, Berkan, additional, Dogan, Selen, additional, Harma, Muge, additional, Harma, Mehmet, additional, Basaran, Mustafa, additional, Aydogmus, Huseyin, additional, Ergun, Yusuf, additional, Sehirali, Salim, additional, Gultekin, Emre, additional, Kose, Sukran, additional, Yildirim, Yusuf, additional, Yenen, Mufit, additional, Dede, Murat, additional, Alanbay, Ibrahim, additional, Karaca, Riza, additional, Metindir, Jale, additional, Keskin, Levent, additional, Ustuner, Isik, additional, Avsar, Filiz, additional, Yuksel, Hasan, additional, and Kirdar, Selim, additional

Published
2013
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19. Widespread Recurrence 7 Years after Radical Abdominal Trachelectomy for Early Cervical Adenocarcinoma

Author

Coskun Salman, M., Ozgul, Nejat, and Yuce, Kunter

Abstract

Cervical cancer is the third most common female cancer worldwide and the use of routine screening resulted in earlier stage and younger age at diagnosis. Fertility preservation via radical trachelectomy comes up as an option in such patients. Recent literature reviews confirm the safety of this operation with excellent oncologic outcomes in appropriately chosen patients. However, recurrent disease is likely and a strict follow-up is recommended to detect recurrences at an early stage following radical trachelectomy. In this report, a case who underwent radical trachelectomy and developed widespread recurrences 7 years after initial surgery possibly due to the lack of oncologic follow-up is discussed.

Published
2015
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20. Prognostic Factors in Squamous Cell Carcinoma of the Vulva: a Retrospective Multicenter Study.

Author

KURU, Oguzhan, AKGOR, Utku, CAKIR, Ilker, TOSUN, Ozgur, YUKSEL, Ilkbal Temel, ULKER, Volkan, MEYDANLI, Mutlu, SANCI, Muzaffer, GOKCU, Mehmet, TOPUZ, Samet, YILDIZ, Ferah, SAKINCI, Mehmet, SALMAN, Mehmet Coskun, OZGUL, Nejat, YUCE, Kunter, and AYHAN, Ali

Subjects
*SQUAMOUS cell carcinoma, *VULVA, *VULVAR cancer, *LYMPHADENECTOMY, *SURGICAL site, *MEDICAL records
Abstract

The study aim to determine the clinicopathological factors for disease-free survival (DFS) and overall survival (OS) in women with vulvar cancer and to analyze the the possible effect of metformin on survival of the patients. From 2011 to 2017, medical records of 142 patients who underwent primary radical surgery for VC at 6 referral centers in Turkey were collected, retrospectively. The median age of the cohort was 67.0 years. 124 patients underwent radical surgery and inguinofemoral lymphadenectomy. The overall recurrence rate was 33.8% within a median follow-up time of 22 months. Five-year DFS and OS rates were 55.8% and 62.6%, respectively. Multivariate analysis showed surgical margin (HR:6.4, p= 0.017 for DFS; HR:13.6, p=0.009 for OS) and lymph node metastasis (HR: 4.1, p= 0.014 for DFS; HR: 6.3, p= 0.020 for OS) were the independent prognostic factors. There was no statistically difference in DFS and OS for patients who had used metformin. [ABSTRACT FROM AUTHOR]

Published
2020
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22. Multicenter Analysis of Gestational Trophoblastic Neoplasia in Turkey

Author

Zehra Kurdoglu, Arif Kokcu, Taner Turan, Selen Dogan, Mustafa Cosan Terek, Bülent Özçelik, Sabit Sinan Özalp, Tolgay Tuyan Ilhan, Hasan Bozkaya, Gökhan Tosun, Yılmaz Dikmen, Muzaffer Sanci, Bulent Cakmak, Müfit Cemal Yenen, Hasan Yüksel, Mehmet Kefeli, Kunter Yuce, Derya Sakarya Kilic, Yunus Yıldız, Tayfun Gungor, Fusun Varol, Kadir Guzin, Anil Onan, Eray Caliskan, Nadire Tuncer, Volkan Ulker, Tevfik Guvenal, Fuat Demirkiran, Mehmet Dolanbay, Serdar Serin, Hakan Camuzoglu, T Simsek, Tayfun Toptas, Macit Arvas, Tugan Bese, Mehmet Gökçü, Murat Api, Ali Ozler, Elcin Telli, Aydın Özsaran, Serkan Kuruoglu, Pinar Solmaz Hasdemir, Nurettin Boran, Deniz Kulaksiz, Ali Yanık, Levent Akman, Emre Özgü, Hakan Yetimalar, Emek Doğer, Dagistan Tolga Arioz, Suleyman Guven, Gökhan Tulunay, Tufan Oge, Nedim Tokgozoglu, Gonca Ogurlu, Ege Üniversitesi, [Ozalp, Sabit Sinan -- Telli, Elcin -- Oge, Tufan] Eskisehir Osmangazi Univ, Sch Med, Dept Obstet & Gynecol, Eskisehir, Turkey -- [Tulunay, Gokhan -- Boran, Nurettin -- Turan, Taner] Etlik Zubeyde Hanim Womens Hlth Teaching & Res Ho, Ankara, Turkey -- [Yenen, Mufit] Gulhane Mil Med Acad, Ankara, Turkey -- [Yuce, Kunter] Hacettepe Univ, Sch Med, Ankara, Turkey -- [Onan, Anil] Gazi Univ, Sch Med, Ankara, Turkey -- [Gungor, Tayfun -- Ozgu, Emre -- Yildiz, Yunus] Zekai Tahir Burak Womens Hlth Educ & Res Hosp, Ankara, Turkey -- [Kurdoglu, Zehra] Yuzuncu Yil Univ, Sch Med, Van, Turkey -- [Ozler, Ali] Dicle Univ, Sch Med, Diyarbakir, Turkey -- [Ulker, Volkan] Kanuni Sultan Suleyman Teaching & Res Hosp, Istanbul, Turkey -- [Arvas, Macit -- Demirkiran, Fuat -- Bese, Tugan -- Tokgozoglu, Nedim] Cerrahpasa Univ, Sch Med, Istanbul, Turkey -- [Api, Murat] Zeynep Kamil Matern & Pediat, Res & Training Hosp, Istanbul, Turkey -- [Guzin, Kadir] Istanbul Medeniyet Univ, Goztepe Training & Res Hosp, Istanbul, Turkey -- [Sanci, Muzaffer -- Gokcu, Mehmet -- Tosun, Gokhan] Ege Gynecol & Matern Training & Res Hosp, Izmir, Turkey -- [Dikmen, Yilmaz -- Ozsaran, Aydin -- Terek, Mustafa Cosan -- Akman, Levent] Ege Univ, Sch Med, Izmir, Turkey -- [Yetimalar, Hakan -- Kilic, Derya Sakarya] Ataturk Training & Res Hosp, Izmir, Turkey -- [Kokcu, Arif -- Kefeli, Mehmet -- Kuruoglu, Serkan] Ondokuz Mayis Univ, Sch Med, Samsun, Turkey -- [Yuksel, Hasan] Adnan Menderes Univ, Sch Med, Aydin, Turkey -- [Guvenal, Tevfik -- Hasdemir, Pinar Solmaz] Celal Bayar Univ, Sch Med, Manisa, Turkey -- [Ozcelik, Bulent -- Serin, Serdar -- Dolanbay, Mehmet] Erciyes Univ, Sch Med, Kayseri, Turkey -- [Arioz, Dagistan Tolga -- Tuncer, Nadire] Afyon Kocatepe Univ, Sch Med, Afyon, Turkey -- [Bozkaya, Hasan -- Guven, Suleyman -- Kulaksiz, Deniz] Karadeniz Tech Univ, Sch Med, Trabzon, Turkey -- [Varol, Fusun] Trakya Univ, Sch Med, Edirne, Turkey -- [Yanik, Ali -- Ogurlu, Gonca] Cumhuriyet Univ, Sch Med, Sivas, Turkey -- [Simsek, Tayyup -- Toptas, Tayfun -- Dogan, Selen] Akdeniz Univ, Sch Med, TR-07058 Antalya, Turkey -- [Camuzoglu, Hakan] Harran Univ, Sch Med, Sanliurfa, Turkey -- [Caliskan, Eray -- Doger, Emek] Kocaeli Univ, Sch Med, Kocaeli, Turkey -- [Cakmak, Bulent] Gaziosmanpasa Univ, Sch Med, Tokat, Turkey -- [Ilhan, Tolgay Tuyan] Selcuk Univ, Sch Med, Konya, Turkey, gokcu, mehmet -- 0000-0002-3187-2317, Ozgu, Emre -- 0000-0002-8444-9694, Kurdoglu, Zehra -- 0000-0001-5191-1072, Gungor, Tayfun -- 0000-0002-7869-9662, Selçuk Üniversitesi, and OMÜ

Subjects
Adult, Cancer Research, medicine.medical_specialty, Gestational trophoblastic disease, Adolescent, Turkey, Epidemiology, medicine.medical_treatment, Trophoblastic Tumor, Hysterectomy, Cohort Studies, Trophoblastic Tumor, Placental Site, Young Adult, Pregnancy, Antineoplastic Combined Chemotherapy Protocols, gestational trophoblastic neoplasia, Humans, Medicine, Choriocarcinoma, Young adult, Retrospective Studies, Gynecology, Hydatidiform Mole, Invasive, business.industry, Obstetrics, Incidence (epidemiology), Public Health, Environmental and Occupational Health, Retrospective cohort study, Middle Aged, Prognosis, medicine.disease, Oncology, Uterine Neoplasms, incidence, Female, business, Cohort study
Abstract

WOS: 000338633500049, PubMed: 24870768, Background: To evaluate the incidence, diagnosis and management of GTN among 28 centers in Turkey. Materials and Methods: A retrospective study was designed to include GTN patients attending 28 centers in the 10-year period between January 2003 and May 2013. Demographical characteristics of the patients, histopathological diagnosis, the International Federation of Gynecology and Obstetrics (FIGO) anatomical and prognostic scores, use of single-agent and multi-agent chemotherapy, surgical interventions and prognosis were evaluated. Results: From 2003-2013, there were 1,173,235 deliveries and 456 GTN cases at the 28 centers. The incidence was calculated to be 0.38 per 1,000 deliveries. According to the evaluated data of 364 patients, the median age at diagnosis was 31 years (range, 15-59 years). A histopathological diagnosis was present for 45.1% of the patients, and invasive mole, choriocarcinoma and PSTTs were diagnosed in 22.3% (n=81), 18.1% (n=66) and 4.7% (n=17) of the patients, respectively. Regarding final prognosis, 352 (96.7%) of the patients had remission, and 7 (1.9%) had persistence, whereas the disease was mortal for 5 (1.4%) of the patients. Conclusions: Because of the differences between countries, it is important to provide national registration systems and special clinics for the accurate diagnosis and treatment of GTN.

Published
2014

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