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Maryam Zarghami Dehaghani,1 Farrokh Yousefi,2 Farzad Seidi,1 S Mohammad Sajadi,3,4 Navid Rabiee,5 Sajjad Habibzadeh,6 Amin Esmaeili,7 Amin Hamed Mashhadzadeh,8 Christos Spitas,8 Ebrahim Mostafavi,9,10 Mohammad Reza Saeb11 1Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources and Joint International Research Lab of Lignocellulosic Functional Materials, Nanjing Forestry University, Nanjing, 210037, People’s Republic of China; 2Department of Physics, University of Zanjan, Zanjan, 45195-313, Iran; 3Department of Nutrition, Cihan University-Erbil, Erbil, Iraq; 4Department of Phytochemistry, SRC, Soran University, Soran, Iraq; 5Department of Physics, Sharif University of Technology, Tehran, Iran; 6Department of Chemical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, 1591639675, Iran; 7Department of Chemical Engineering, School of Engineering Technology and Industrial Trades, College of the North Atlantic — Qatar, Doha, Qatar; 8Mechanical and Aerospace Engineering, School of Engineering and Digital Sciences, Nazarbayev University, Nur-Sultan, 010000, Kazakhstan; 9Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; 10Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; 11Department of Polymer Technology, Faculty of Chemistry, Gdańsk University of Technology, Gdańsk, 80-233, PolandCorrespondence: Amin Hamed MashhadzadehMechanical and Aerospace Engineering, School of Engineering and Digital Sciences, Nazarbayev University, Nur-Sultan, 010000, KazakhstanEmail amin.hamed.m@gmail.com; amin.hamedmashhadzadeh@nu.edu.kzEbrahim MostafaviStanford Cardiovascular Institute, Stanford University School of Medicine, Biomedical Innovation Building, 240 Pasteur Drive, Palo Alto, Stanford, CA 94304, USAEmail ebimsv@Stanford.edu; ebi.mostafavi@gmail.comIntroduction: Carbon nanotubes (CNTs) have been widely employed as biomolecule carriers, but there is a need for further functionalization to broaden their therapeutic application in aqueous environments. A few reports have unraveled biomolecule–CNT interactions as a measure of response of the nanocarrier to drug-encapsulation dynamics.Methods: Herein, the dynamics of encapsulation of the antimicrobial peptide HA-FD-13 (accession code 2L24) into CNTs and hydroxylated CNTs (HCNTs) is discussed.Results: The van der Waals (vdW) interaction energy of CNT–peptide and HCNT–peptide complexes decreased, reaching − 110.6 and − 176.8 kcal.Mol− 1, respectively, once encapsulation of the peptide inside the CNTs had been completed within 15 ns. The free energy of the two systems decreased to − 43.91 and − 69.2 kcal.Mol− 1 in the same order.Discussion: The peptide was encased in the HCNTs comparatively more rapidly, due to the presence of both electrostatic and vdW interactions between the peptide and HCNTs. However, the peptide remained encapsulated throughout the vdW interaction in both systems. The negative values of the free energy of the two systems showed that the encapsulation process had occurred spontaneously. Of note, the lower free energy in the HCNT system suggested more stable peptide encapsulation.Keywords: drug delivery, hydroxylation, carbon nanotubes, molecular dynamic simulation, encapsulation, antimicrobial peptide

Maryam Zarghami Dehaghani,1,* Babak Bagheri,2,* Farrokh Yousefi,3 Abbasali Nasiriasayesh,4 Amin Hamed Mashhadzadeh,5 Payam Zarrintaj,6 Navid Rabiee,7 Mojtaba Bagherzadeh,7 Vanessa Fierro,8 Alain Celzard,8 Mohammad Reza Saeb,5 Ebrahim Mostafavi9,10 1School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran; 2Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea; 3Department of Physics, University of Zanjan, Zanjan, 45195-313, Iran; 4Industrial Management Institute, Tehran, Iran; 5Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, 14155-6455, Iran; 6School of Chemical Engineering, Oklahoma State University, Stillwater, OK, 74078, USA; 7Department of Chemistry, Sharif University of Technology, Tehran, Iran; 8Université De Lorraine, CNRS, IJL, Epinal, 88000, France; 9Stanford Cardiovascular Institute, Stanford, CA, USA; 10Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA*These authors contributed equally to this workCorrespondence: Ebrahim MostafaviStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USAEmail ebimsv@stanford.eduAmin Hamed MashhadzadehCenter of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, 14155-6455, IranEmail amin.hamed.m@gmail.comIntroduction: Nanotube-based drug delivery systems have received considerable attention because of their large internal volume to encapsulate the drug and the ability to penetrate tissues, cells, and bacteria. In this regard, understanding the interaction between the drug and the nanotube to evaluate the encapsulation behavior of the drug in the nanotube is of crucial importance.Methods: In this work, the encapsulation process of the cationic antimicrobial peptide named cRW3 in the biocompatible boron nitride nanotube (BNNT) was investigated under the Canonical ensemble (NVT) by molecular dynamics (MD) simulation.Results: The peptide was absorbed into the BNNT by van der Waals (vdW) interaction between cRW3 and the BNNT, in which the vdW interaction decreased during the simulation process and reached the value of − 142.7 kcal·mol− 1 at 4 ns.Discussion: The increase in the potential mean force profile of the encapsulated peptide during the pulling process of cRW3 out of the nanotube showed that its insertion into the BNNT occurred spontaneously and that the inserted peptide had the desired stability. The energy barrier at the entrance of the BNNT caused a pause of 0.45 ns when half of the peptide was inside the BNNT during the encapsulation process. Therefore, during this period, the peptide experienced the weakest movement and the smallest conformational changes.Keywords: boron nitride nanotube, drug delivery, antimicrobial peptide, molecular dynamic simulation, encapsulation

Introduction: Employees' perceptions of their hospital, makes up the organizational climate. The job satisfaction of employees is one of the most common internal factors influence organizational climate. The aim of this study was to determine the relationship between organizational climate with job satisfaction of employees in Ghods, Besat and Tohid hospitals in Sanandaj. Methodology: This research was a descriptive – analytical study. The sample of 189 nurses from three hospitals of Ghods, Besat and Tohid were participated in this study which was selected through census sampling in 2017 (Three groups of 63 people). The instruments that used in this study are JDI job satisfaction questionnaire and the questionnaire of organizational climate description by Halpin and Kraft. For data analysis, descriptive statistics and Pearson correlation test were used. Findings: There was a negative significant correlation between the variables of team spirit and harassment with job satisfaction (P

Intruduction: Today suicide is a major problem in the realm of mental health, and usually it has a psychological theme. Since the psychiatric patients gives so much attention in this scope, so, as a major aims of this study, studying the relation between suicide and demographic variables, psychiatric diagnosis and duration of mental illness among psychiatric patients is needed. Method: As an analytic-descriptive study, among all patients who have the inclusion criteria, those who admit informed consent (152 participant), complete questionnaires and other needed information’s. Then other necessary data’s were gives from the psychiatric documentations of the patients. Alongside data’s which gives from the patients and their hospital documentations, the Beck scale for suicidal ideation was used. The 20th version of SPSS software was used to analyzing data’s and it did through these statistical analyses: Pearson’s Coloration Coefficient, independent T test, and one-way ANOVA. Finding: With regard to statistical analysis there was not any significant relationship between suicide grade and demographic variables, psychiatric diagnosis and the duration of mental illness among patients. Conclusion: the distribution of the sample scores not relies on any demographic variables. It seems that cultural and social variables are important to keep in our mind. With taking account our limitations, further studies need to find exclusive and specific data’s.

Background: Substantial evidence indicates that exposure to electromagnetic fields (EMF) above certain levels can affect human health through triggering some biological responses. According to WHO, short-term exposure to EMF at the levels present in the home/environment do not cause any apparent detrimental effects in healthy individuals. However, now, there is a debate on whether long-term exposure to low level EMF can evoke detrimental biological responses. Although based on the Communications Act of 1934, selling, advertising, using, or importing mobile jammers which block cell phone calls and text messages are illegal acts, in some countries these devices are being used for security purpose and for prevention of cheating during examinations. Methods: In this study 30 male Wistar rats were randomly divided into 3 groups of 10 each. The control group received no radiation. The sham exposure group was exposed to a switched-off jammer device. After fasting for 12 hours, the exposure group was exposed to EMFs at a distance of 50 cm from the jammer. Blood samples were collected from the tail vein after 24, 48 and72 hours and fasting blood sugar was measured by using a common blood glucose monitor (BIONIME GM110, Taiwan). The significance level was considered 5% and SPSS Ver. 21 was used for statistical analysis. The data were analyzed by ANOVA followed by Tukey’s test. Results: A statistically significant difference was observed between blood sugar level in the control and exposure groups after 24, 48 and 72 hours of continuous irradiation (p values were

Nitrogen (N) loss from irrigated cropland, especially in rice paddies, results in low N-use efficiency and groundwater contamination. Soil conditions that increase ammonium and nitrate ion retention alleviate these problems. [...]

This experiment was conducted to investigate the effects of foliar spray of polyamines on some morphological and physiological characteristics of rose.

The museum of science and technology is a center based on science to present the up-to-date achievements of sciences and technologies from all over the world with the goal of improvement in knowledge and science of society by exhibits, equipment and devices, how people can learn science practically. On the other hand, the museum of science and technology is a place for presenting sciences that convert to visual and practical actions and exhibits that visitors, based on their interest, previous knowledge and capacity, can learn new things in a simple way during a short course. Several valuable benefits have been presented by museums of science and technology from all over the world, such as useful scientific and non-scientific jobs, economic development, exchange of sciences between universities, research centers and other museums of science and technology. This review, evaluate the structure, goals and achievements of the museum of science and technology and its benefits for society, people, city and country. [ABSTRACT FROM AUTHOR]

Background: Helicobacter pylori (H.pylori) infection may contribute to the development of extra-gastrointestinal manifestations like cardiovascular diseases. Detection of Helicobacter pylori in Athrosclerotic plaques is a strong evidence for this association which may play a role in pathogenesis of atherosclerosis with classic cardiovascular risk factor such as hypertension and lipid profile. The aim of this study was to explore the influence of H. pylori infection on lipid profiles in a large community- based study. Material and Methods: A total of 1754 (50.8% Female & 49.2% male) subjects (age >25 years old) were selected randomely from Monica Healthy Heart Study project. H. pylori status was determined by IgG ELISA method. Subjects with titers > 30 Iu/ml were cansidered seropositive. Data were analazed by using statistical software Spss version 18 and probability values <0.05 were considered statistically significant. Results: In multiple logistic regression analyses H.pylori infection did not show significant association with Lipid profiles (low HDL- cholesterol and High LDL- cholesterol) after controlling for age, sex, body mass index, hypertension, type 2 diabetes mellitus, smoking and circulating hsCRP levels.(P>0.05) Conclusion: According to this large -- scale population- based study in large northern cities of Persian Gulf, there was no significant association between H.pylori IgG seropositivity and lipid profiles in both men and women. [ABSTRACT FROM AUTHOR]

Background: Based on previous studies, tobacco smoking generally and water pipe smoking particularly, have high prevalence in Bushehr province. This study is a new analysis of the Persian Gulf healthy heart study with goal of determination of prevalence and pattern of cigarette and water pipe smoking in Bushehr province. Materials and methods: A total of 3735 men and women aged 25 years old or higher from three districts of Bushehr province (Bushehr, Genaveh, and Deylam) were participated in the study phase I in 2003, from which 1833 persons (49.7%) were participated in the phase II 6 years later in 2009. Demographic data and pattern of smoking, either cigarette or water pipe, were collected with personal interview. Gender specific crude and directly standardized prevalence of cigarette and water pipe smoking was calculated for both phases of the study. Results: Prevalence of cigarette smoking were 11.9% and 7.5% for the first and second phase, respectively. 21.6% of men and 0.4% of women in the first phase and 13% of men and 0.7% of women in the second phase were cigarette smokers. Prevalence of water pipe smoking were 17.9% and 12.9% in the first and second phase, respectively. 10.7% of men and 25.8% of women in the first phase and 7.1% of men and 19.05% of women in second phase were water pipe smokers. Conclusion: Water pipe smoking in women in Bushehr province was significantly higher than other non- southern areas of Iran. More studies are needed to determine main causes of women tendency in water pipe smoking in southern provinces of Iran. [ABSTRACT FROM AUTHOR]

Background: Muslims participation in Mecca & Medina (Saudi Arabia) for Hajj which is the largest organized annual mass gathering in the world. In addition of Hajj, many pilgrims attend in Saudi Arabia for Umrah that is performed year-round. This great human immigration is an important challenge of health care and infection control systems. Current study reviews the most prevalent infectious diseases among pilgrims during Hajj along with their mode of transmission and control. Materials and methods: A comprehensive search was done on PubMed, Science Direct & Google Scholar databases by using Hajj, Pilgrims, Infectious Diseases & Mecca as keywords. Our search was restricted to English & Persian papers from 1994 to 2014. Results: Overall, 97 papers were found. After omitting old and repeated reports, 64 articles were reviewed finally. Conclusion: Due to scale of Hajj and prevalence of various infectious diseases such as meningococcal infections, diarrheal diseases and Influenza preventive measures and vaccination are recommended both before and during pilgrimage. Pilgrims and health care workers must be educated about health hazards and protective behaviors. [ABSTRACT FROM AUTHOR]

Most cities in our country Iran has been located on compactable frames caused by water flow from gorges and deltas. There have been a number of significant investigations on potential geo morphological factors which are considered as a threat to the integrity of our cities however villages and countryside locations and their glaciers have never been a matter of such attention. In Iran civil centers have great similarities in common however differ significantly in terms of artistic entity. Rural civil centers follow Quarter sequence. It primarily follows balance of water and ice then elongates to precipitate surfaces. Topographical maps of the city of Sanandaj reveal the fact that this area in turn follows these characteristics and indicates that this city has never been a focal point of civil growth. Ethnical alteration has also been a factor in this regard. Area under investigation was designated after evaluation of topographical maps of Geo. In this work GIS software was employed for analyzing cooperative effect of internal and external centers and isothermal rates of past and present obtained for city of Sanandaj and snow lines was evaluated then through right program. In the latter stage Surfer software was employed and cooperates of adiabatic. At the end all maps were overlade and topographical map was obtained for snow line and rural area disparity. Glacier summits were as high as 2000 and these change in rout has significant effects which in turn shows frigidity in fourth period. Shape of graphical illustration indicates high synovial shape which indicates the exertion of fridge in the region. Theses surfaces are formed primarily due to the movements of ice lines along with mountainous fridge summit. Pinpointing snow line through utilization of Right procedure shows that yearly temperature is of significant in 2000 meter height. Designation of different circus of 99 small and big sizes indicates that circuses played a significant role in construction of fridge line in the region. Distribution of rural areas in city of Sanandaj follows the exact fridge summits proves the overall identity of fridge summits. [ABSTRACT FROM AUTHOR]

Background: It has been suggested that moderate shrimp consumption in normolipidemic subjects will not adversely affect the overall lipoprotein profile. Hence, shrimp consumption can be included in "healthy heart" nutritional guidelines. However, the effects of cultured shrimp on serum lipoproteins of normal subjects have not yet investigated. Material and Methods: Twenty-five healthy normolipidemic men who were workers of a shrimp farm in Bushehr province participated in a quasi-experimental study. In a crossover six weeks trial, the effect of three days per week diet (containing 300 g cultured shrimp Litopenaeus vannamei /day) on serum lipid profile was compared with a zero-marine baseline diet. Results: After six weeks trial, serum triglyceride and HDL-cholesterol levels were not significantly changed from the baseline levels (p>0.05). However, total cholesterol and LDL-cholesterol levels, total cholesterol to HDL-cholesterol and LDL-cholesterol to HDL-cholesterol ratios were significantly increased (p<0.0001). Conclusion: Moderate cultured shrimp (Litopenaeus vannamei) consumption can increase total cholesterol and LDL-cholesterol levels in normolipidemic men. Although a diet containing native shrimp has many benefits for healthy persons, but we do not recommend cultured shrimp in a healthy heart diet for persons with dyslipidemia or cardiovascular diseases. [ABSTRACT FROM AUTHOR]

Background. Some recent suggestions could show omega-3 condition deficiency following prolonged hemodialysis; however, these claims and speculations have not been well demonstrated with sufficient evidences. Hence, we attempted to assess the beneficial effects of omega-3 on lipid profile in patients with end-stage renal disease (ESRD) undergoing hemodialysis.

Background: The emergence of a new pandemic SARS-CoV-2 (COVID-19) resulted in a high mortality rate across the world. This study sought to comprehensively analyze the Case Fatality Rate (CFR) associated with COVID-19 in the Khuzestan province of Iran". The primary objective was to discern patterns and determinants influencing CFR, shedding light on the evolving impact of the pandemic on morbidity and mortality., Methods: A retrospective examination was performed on a dataset encompassing confirmed COVID-19 cases and related fatalities in Khuzestan. Data, spanning from December 2020 to April 2022, underwent rigorous statistical analysis. Demographic variables, comorbidities, and temporal trends were scrutinized to identify key factors influencing CFR., Results: Preliminary findings revealed dynamic shifts in CFR, capturing the nuanced nature of the pandemic over time. Demographic nuances, particularly age and gender, emerged as significant determinants impacting CFR, the reported CFR of COVID-19 in Khuzestan province was 1.79%., Conclusion: This study contributes critical insights into the CFR landscape of COVID-19 in Khuzestan, providing a foundation for evidence-based decision-making in public health. The identified factors influencing mortality rates offer valuable information for tailoring interventions and optimizing resource allocation. Continuous monitoring and further investigations are recommended to adapt strategies to the evolving nature of the pandemic., Competing Interests: Declarations. Competing interests: The authors declare no competing interests., (© 2024. The Author(s).)

Bacterial contamination of angiographic materials and fluids has been shown to occur during human angiographic procedures. Angiographic examinations and experiments must be performed under sterile conditions to avoid complications due to contamination and possible subsequent infections. However, data regarding the frequency and the clinical consequences are limited. Our aim was to investigate the incidence of bacterial contamination during experimental angiographies. We tested angiographic fluids, syringes and endovascular materials from the angiographic supply tables for bacterial contamination, collecting 252 samples during 18 experimental angiographies in pigs. After sterile filtration, samples were cultured on media, and individual colony-forming units were identified by matrix-assisted laser desorption ionization-time of flight mass spectrometry. Contamination was detected in the majority of samples (60%). There was no angiography in which all samples remained sterile. The highest contamination rates (94%) were found in fluids from the working bowls and on the outer surface of syringes (85%) at the end of angiography. At this time, working bowls were significantly more frequently and extensively contaminated than the control bowls. Among the samples, the frequency and extent of contamination increased with the duration of the experimental angiographic procedures. Our findings show that bacterial contamination during angiography is common and the manipulation of endovascular working materials as well as the duration of angiographic procedures both increase bacterial contamination. While the clinical impact on the laboratory animal remains unclear, the quality of biomedical research mandates that efforts to minimize bacterial contamination should be taken as far as possible., Competing Interests: Martin Wiesmann has the following disclosures: Consultancy: Stryker; Payment for lectures: Bracco, Medtronic, Siemens, and Stryker; Educational Presentations: Bracco, Codman, Medtronic, Phenox, and Siemens; has received grants for research projects or educational exhibits from Ab medica, Acandis, Bracco Imaging, Cerenovus, Kaneka Pharmaceuticals, Medtronic, Mentice AB, Microvention, Phenox, Siemens Healthcare, and Stryker Neurovascular Omid Nikoubashman has the following disclosures: Grants: Stryker Payment for lectures: Stryker & Phenox, and Werfen Hani Ridwan has the following disclosures: Consultancy: ThrombX Medical Inc. This does not alter our adherence to PLOS ONE policies on sharing data and materials., (Copyright: © 2024 Franz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

The glycoprotein IIb/IIIa antagonist tirofiban has been shown to prevent thromboembolic events during endovascular procedures, but the benefits and risks of its prophylactic early intraprocedural administration for stand-alone coil embolization of acutely ruptured aneurysms are still unclear. We conducted a retrospective single-center analysis of patients treated for aneurysmal subarachnoid hemorrhage with stand-alone coil embolization. Two study cohorts were compared according to the primary prophylactic antithrombotic medication during the procedure: patients receiving only intravenous heparin (HEP) versus patients receiving tirofiban in addition to heparin prior to final aneurysm obliteration (HEP + TF). Outcome endpoints were the incidence of angiographically visible thrombus formation or distal embolization, and the incidence of periprocedural intracranial hemorrhage (ICH). Of 204 cases, 159 were prophylactically treated with HEP and 45 with HEP + TF. Intraprocedural thromboembolic events were less frequent with HEP + TF before and after propensity score matching (PSM) (2.5% vs. 19.7%, p = 0.017). The incidence of ICH and symptomatic ICH did not differ between HEP + TF and HEP before and after PSM (20.5% vs. 30.7%, p = 0.29; and 5.1% vs. 4%, p = 0.88). Early intraprocedural tirofiban administration may be effective in preventing thromboembolic complications during stand-alone coil embolization of acutely ruptured aneurysms without increasing the risk of ICH., (© 2024. The Author(s).)

Chest pain is a frequent complaint in emergency departments, with various differential diagnoses from benign to life-threatening. Hereby, we described a 60-year-old man presented with chest pain and hypotension who initially misdiagnosed as acute coronary syndrome, but was ultimately diagnosed with necrotizing fasciitis. This case highlights the importance of considering rare causes of chest pain., Competing Interests: The authors declare that they have no conflict of interest., (© 2024 The Author(s). Clinical Case Reports published by John Wiley & Sons Ltd.)