14 results on '"Yalcinkaya, Tamer"'
Search Results
2. The pregnancy outcome of retrieved excess eggs collected during selective follicular reduction from patients with three or more preovulatory follicles undergoing controlled ovarian stimulation and IUI
- Author
-
Akar, Munire Erman, Johnston-MacAnanny, Erika B., Carrillo, Alberto J., Miller, Julie, and Yalcinkaya, Tamer M.
- Published
- 2010
- Full Text
- View/download PDF
3. A Mechanism for Virilization of Female Spotted Hyenas in Utero
- Author
-
Yalcinkaya, Tamer M., Siiteri, Pentti K., Vigne, Jean-Louis, Licht, Paul, Pavgi, Sushama, Frank, Laurence G., and Glickman, Stephen E.
- Published
- 1993
4. The ESEP study: Salpingostomy versus salpingectomy for tubal ectopic pregnancy; The impact on future fertility: A randomised controlled trial
- Author
-
van Mello Norah M, Nilsson Kerstin, Klinte Ingemar, Hogström Lars, Hoek Annemieke, Thurkow Andreas L, Graziosi Giuseppe CM, van der Linden Paul JQ, Koks Carolien AM, Verhoeve Harold R, Yalcinkaya Tamer, Jurkovic Davor, Strandell Annika, Mol Femke, Ankum Willem M, van der Veen Fulco, Mol Ben WM, and Hajenius Petra J
- Subjects
Gynecology and obstetrics ,RG1-991 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background For most tubal ectopic pregnancies (EP) surgery is the treatment of first choice. Whether surgical treatment should be performed conservatively (salpingostomy) or radically (salpingectomy) in women wishing to preserve their reproductive capacity, is subject to debate. Salpingostomy preserves the tube, but bears the risks of both persistent trophoblast and repeat ipsilateral tubal EP. Salpingectomy, avoids these risks, but leaves only one tube for reproductive capacity. This study aims to reveal the trade-off between both surgical options: whether the potential advantage of salpingostomy, i.e. a better fertility prognosis as compared to salpingectomy, outweighs the potential disadvantages, i.e. persistent trophoblast and an increased risk for a repeat EP. Methods/Design International multi centre randomised controlled trial comparing salpingostomy versus salpingectomy in women with a tubal EP without contra lateral tubal pathology. Hemodynamically stable women with a presumptive diagnosis of tubal EP, scheduled for surgery, are eligible for inclusion. Patients pregnant after in vitro fertilisation (IVF) and/or known documented tubal pathology are excluded. At surgery, a tubal EP must be confirmed. Only women with a tubal EP amenable to both interventions and a healthy contra lateral tube are included. Salpingostomy and salpingectomy are performed according to standard procedures of participating hospitals. Up to 36 months after surgery, women will be contacted to assess their fertility status at six months intervals starting form the day of the operation. The primary outcome measure is the occurrence of spontaneous viable intra uterine pregnancy. Secondary outcome measures are persistent trophoblast, repeat EP, all pregnancies including those resulting from IVF and financial costs. The analysis will be performed according to the intention to treat principle. A cost-effectiveness analysis will be performed within a decision analysis framework, based on costs per live birth, including IVF treatment whenever a spontaneous pregnancy does not occur. Patients' preferences will be assessed using a discrete choice experiment. Discussion This trial will provide evidence on the trade off between salpingostomy and salpingectomy for tubal EP in view of the pros and cons of both interventions and will offer guidance to clinicians in making the right treatment choice. Trial registration Current Controlled Trials ISRCTN37002267
- Published
- 2008
- Full Text
- View/download PDF
5. Cost-effectiveness of salpingotomy and salpingectomy in women with tubal pregnancy (a randomized controlled trial)
- Author
-
Broekmans, FJM, Mol, F., Mello, N.M., Strandell, Annika, Strandell, Karin, Jurkovic, Davor, Ross, Jackie, Barnhart, K., Yalcinkaya, Tamer, Verhoeve, H.R., Graziosi, G.C.M., Koks, Carolien A M, Klinte, Ingmar, Hogstrom, Lars, Janssen, Ineke, Kragt, Harry, Hoek, Annemieke, Trimbos-Kemper, Trudy, Willemsen, Wim, Ankum, W.M., Mol, Benwillem, Wely, M., van der Veen, Fulco, Hajenius, Petra J, Reproductive Origins of Adult Health and Disease (ROAHD), ARD - Amsterdam Reproduction and Development, Center for Reproductive Medicine, Obstetrics and Gynaecology, Other departments, Other Research, APH - Amsterdam Public Health, Obstetrics and gynaecology, Amsterdam Reproduction & Development (AR&D), VU University medical center, Division 1, Plastic, Reconstructive and Hand Surgery, and Pediatric surgery
- Subjects
Adult ,medicine.medical_specialty ,Cost effectiveness ,Cost-Benefit Analysis ,medicine.medical_treatment ,media_common.quotation_subject ,laparoscopy ,Fertility ,Research Support ,law.invention ,surgery ,Salpingectomy ,Postoperative Complications ,Randomized controlled trial ,Pregnancy ,law ,Journal Article ,medicine ,Humans ,Comparative Study ,Non-U.S. Gov't ,Laparoscopy ,Salpingostomy ,cost-effectiveness ,media_common ,medicine.diagnostic_test ,Ectopic pregnancy ,Obstetrics ,business.industry ,Research Support, Non-U.S. Gov't ,Rehabilitation ,Obstetrics and Gynecology ,medicine.disease ,Confidence interval ,ECTOPIC PREGNANCY ,Multicenter Study ,Reproductive Medicine ,Randomized Controlled Trial ,ectopic pregnancy ,Female ,Pregnancy, Tubal ,business - Abstract
STUDY QUESTION: Is salpingotomy cost effective compared with salpingectomy in women with tubal pregnancy and a healthy contralateral tube?SUMMARY ANSWER: Salpingotomy is not cost effective over salpingectomy as a surgical procedure for tubal pregnancy, as its costs are higher without a better ongoing pregnancy rate while risks of persistent trophoblast are higher.WHAT IS KNOWN ALREADY: Women with a tubal pregnancy treated by salpingotomy or salpingectomy in the presence of a healthy contralateral tube have comparable ongoing pregnancy rates by natural conception. Salpingotomy bears the risk of persistent trophoblast necessitating additional medical or surgical treatment. Repeat ectopic pregnancy occurs slightly more often after salpingotomy compared with salpingectomy. Both consequences imply potentially higher costs after salpingotomy.STUDY DESIGN, SIZE, DURATION: We performed an economic evaluation of salpingotomy compared with salpingectomy in an international multicentre randomized controlled trial in women with a tubal pregnancy and a healthy contralateral tube. Between 24 September 2004 and 29 November 2011, women were allocated to salpingotomy (n = 215) or salpingectomy (n = 231). Fertility follow-up was done up to 36 months post-operatively.PARTICIPANTS/MATERIALS, SETTINGS, METHODS: We performed a cost-effectiveness analysis from a hospital perspective. We compared the direct medical costs of salpingotomy and salpingectomy until an ongoing pregnancy occurred by natural conception within a time horizon of 36 months. Direct medical costs included the surgical treatment of the initial tubal pregnancy, readmissions including reinterventions, treatment for persistent trophoblast and interventions for repeat ectopic pregnancy. The analysis was performed according to the intention-to-treat principle.MAIN RESULTS AND THE ROLE OF CHANCE: Mean direct medical costs per woman in the salpingotomy group and in the salpingectomy group were €3319 versus €2958, respectively, with a mean difference of €361 (95% confidence interval €217 to €515). Salpingotomy resulted in a marginally higher ongoing pregnancy rate by natural conception compared with salpingectomy leading to an incremental cost-effectiveness ratio €40 982 (95% confidence interval -€130 319 to €145 491) per ongoing pregnancy. Since salpingotomy resulted in more additional treatments for persistent trophoblast and interventions for repeat ectopic pregnancy, the incremental cost-effectiveness ratio was not informative.LIMITATIONS, REASONS FOR CAUTION: Costs of any subsequent IVF cycles were not included in this analysis. The analysis was limited to the perspective of the hospital.WIDER IMPLICATIONS OF THE FINDINGS: However, a small treatment benefit of salpingotomy might be enough to cover the costs of subsequent IVF. This uncertainty should be incorporated in shared decision-making. Whether salpingotomy should be offered depends on society's willingness to pay for an additional child.STUDY FUNDING/COMPETING INTERESTS: Netherlands Organisation for Health Research and Development, Region Västra Götaland Health & Medical Care Committee.TRIAL REGISTRATION NUMBER: ISRCTN37002267.
- Published
- 2015
6. Cost-effectiveness of salpingotomy and salpingectomy in women with tubal pregnancy (a randomized controlled trial)
- Author
-
MS VPG/Gynaecologie, Child Health, Broekmans, FJM, Mol, F., Mello, N.M., Strandell, Annika, Strandell, Karin, Jurkovic, Davor, Ross, Jackie, Barnhart, K., Yalcinkaya, Tamer, Verhoeve, H.R., Graziosi, G.C.M., Koks, Carolien A M, Klinte, Ingmar, Hogstrom, Lars, Janssen, Ineke, Kragt, Harry, Hoek, Annemieke, Trimbos-Kemper, Trudy, Willemsen, Wim, Ankum, W.M., Mol, Benwillem, Wely, M., van der Veen, Fulco, Hajenius, Petra J, MS VPG/Gynaecologie, Child Health, Broekmans, FJM, Mol, F., Mello, N.M., Strandell, Annika, Strandell, Karin, Jurkovic, Davor, Ross, Jackie, Barnhart, K., Yalcinkaya, Tamer, Verhoeve, H.R., Graziosi, G.C.M., Koks, Carolien A M, Klinte, Ingmar, Hogstrom, Lars, Janssen, Ineke, Kragt, Harry, Hoek, Annemieke, Trimbos-Kemper, Trudy, Willemsen, Wim, Ankum, W.M., Mol, Benwillem, Wely, M., van der Veen, Fulco, and Hajenius, Petra J
- Published
- 2015
7. The ESEP study : salpingostomy versus salpingectomy for tubal ectopic pregnancy; the impact on future fertility : a randomised controlled trial
- Author
-
Mol, Femke, Strandell, Annika, Jurkovic, Davor, Yalcinkaya, Tamer, Verhoeve, Harold R., Koks, Carolien A. M., van der Linden, Paul J. Q., Graziosi, Giuseppe C. M., Thurkow, Andreas L., Hoek, Annemieke, Hogström, Lars, Klinte, Ingemar, Nilsson, Kerstin, van Mello, Norah M., Ankum, Willem M., van der Veen, Fulco, Mol, Ben W. M., Hajenius, Petra J., Mol, Femke, Strandell, Annika, Jurkovic, Davor, Yalcinkaya, Tamer, Verhoeve, Harold R., Koks, Carolien A. M., van der Linden, Paul J. Q., Graziosi, Giuseppe C. M., Thurkow, Andreas L., Hoek, Annemieke, Hogström, Lars, Klinte, Ingemar, Nilsson, Kerstin, van Mello, Norah M., Ankum, Willem M., van der Veen, Fulco, Mol, Ben W. M., and Hajenius, Petra J.
- Abstract
BACKGROUND: For most tubal ectopic pregnancies (EP) surgery is the treatment of first choice. Whether surgical treatment should be performed conservatively (salpingostomy) or radically (salpingectomy) in women wishing to preserve their reproductive capacity, is subject to debate. Salpingostomy preserves the tube, but bears the risks of both persistent trophoblast and repeat ipsilateral tubal EP. Salpingectomy, avoids these risks, but leaves only one tube for reproductive capacity. This study aims to reveal the trade-off between both surgical options: whether the potential advantage of salpingostomy, i.e. a better fertility prognosis as compared to salpingectomy, outweighs the potential disadvantages, i.e. persistent trophoblast and an increased risk for a repeat EP. METHODS/DESIGN: International multi centre randomised controlled trial comparing salpingostomy versus salpingectomy in women with a tubal EP without contra lateral tubal pathology. Hemodynamically stable women with a presumptive diagnosis of tubal EP, scheduled for surgery, are eligible for inclusion. Patients pregnant after in vitro fertilisation (IVF) and/or known documented tubal pathology are excluded. At surgery, a tubal EP must be confirmed. Only women with a tubal EP amenable to both interventions and a healthy contra lateral tube are included. Salpingostomy and salpingectomy are performed according to standard procedures of participating hospitals. Up to 36 months after surgery, women will be contacted to assess their fertility status at six months intervals starting form the day of the operation.The primary outcome measure is the occurrence of spontaneous viable intra uterine pregnancy. Secondary outcome measures are persistent trophoblast, repeat EP, all pregnancies including those resulting from IVF and financial costs. The analysis will be performed according to the intention to treat principle. A cost-effectiveness analysis will be performed within a decision analysis framework, based on cos
- Published
- 2008
- Full Text
- View/download PDF
8. The first case described: monozygotic twin sisters with the fragile X premutation but with a different phenotype for premature ovarian failure
- Author
-
Johnston-MacAnanny, Erika B., primary, Koty, Patrick, additional, Pettenati, Mark, additional, Brady, Megan, additional, Yalcinkaya, Tamer M., additional, and Schmidt, David W., additional
- Published
- 2011
- Full Text
- View/download PDF
9. Robotic-assisted laparoscopic ovarian tissue transplantation
- Author
-
Akar, Munire Erman, primary, Carrillo, Alberto J., additional, Jennell, Jamie L., additional, and Yalcinkaya, Tamer M., additional
- Published
- 2011
- Full Text
- View/download PDF
10. Early postoperative small bowel obstruction after laparoscopic myomectomy
- Author
-
Erman-Akar, Munire, primary, Mullany, Sally, additional, Huffman, Josie, additional, and Yalcinkaya, Tamer M., additional
- Published
- 2010
- Full Text
- View/download PDF
11. Robot-assisted laparoscopic management of a case with juvenile cystic adenomyoma
- Author
-
Akar, Munire Erman, primary, Leezer, Kristen H., additional, and Yalcinkaya, Tamer M., additional
- Published
- 2010
- Full Text
- View/download PDF
12. Assessing the pulsatility of luteinizing hormone in female vervet monkeys (Chlorocebus aethiops sabaeus).
- Author
-
Stephens SM, Pau FK, Yalcinkaya TM, May MC, Berga SL, Post MD, Appt SE, and Polotsky AJ
- Subjects
- Animals, Chlorocebus aethiops physiology, Estradiol blood, Female, Follicular Phase blood, Humans, Luteal Phase blood, Chlorocebus aethiops blood, Luteinizing Hormone blood, Menstrual Cycle blood
- Abstract
Specific alterations in the pulsatility of luteinizing hormone (LH) are linked to obesity-related subfertility in ovulatory women. Vervet monkeys (Chlorocebus aethiops sabaeus) are an Old World nonhuman primate that develops obesity and has a menstrual cycle similar to humans. We evaluated follicular-phase LH pulses in 12 adult normal-weight female vervets. Serum was collected every 10 min for 4 h by using a tether device in conscious, freely moving monkeys on menstrual cycle days 2 through 5. Serum estradiol was collected daily during the follicular phase to identify the luteal-follicular transition. For comparison, we used data from 12 ovulatory normal-weight women who had undergone frequent blood sampling of early-follicular LH. LH pulse frequency was similar, with 2.8 ± 0.7 LH pulses during 4 h in vervets compared with 2.3 ± 0.7 LH pulses during 4 h in women. The LH pulse mass (percentage change in the pulse peak over the preceding nadir) was 123.2% ± 27.4% in vervets and 60.9% ± 14.9% in humans. The first day of low serum estradiol after the follicular-phase peak was denoted as the day of the luteal-follicular transition. Luteectomy was performed on luteal days 7 through 9, and corpora lutea were confirmed by histology. We demonstrate that follicular LH patterns in vervets are similar to those in humans and that the luteal phase is easily identified by monitoring daily serum estradiol. These findings demonstrate that vervet monkeys are a suitable animal model for evaluating LH pulse dynamics longitudinally in studies of diet-induced obesity.
- Published
- 2013
13. The ESEP study: salpingostomy versus salpingectomy for tubal ectopic pregnancy; the impact on future fertility: a randomised controlled trial.
- Author
-
Mol F, Strandell A, Jurkovic D, Yalcinkaya T, Verhoeve HR, Koks CA, van der Linden PJ, Graziosi GC, Thurkow AL, Hoek A, Hogström L, Klinte I, Nilsson K, van Mello NM, Ankum WM, van der Veen F, Mol BW, and Hajenius PJ
- Subjects
- Adolescent, Adult, Female, Follow-Up Studies, Gynecologic Surgical Procedures adverse effects, Humans, Pregnancy, Pregnancy, Tubal pathology, Salpingostomy adverse effects, Salpingostomy methods, Treatment Outcome, Trophoblasts pathology, Fertility, Gynecologic Surgical Procedures methods, Pregnancy, Tubal surgery
- Abstract
Background: For most tubal ectopic pregnancies (EP) surgery is the treatment of first choice. Whether surgical treatment should be performed conservatively (salpingostomy) or radically (salpingectomy) in women wishing to preserve their reproductive capacity, is subject to debate. Salpingostomy preserves the tube, but bears the risks of both persistent trophoblast and repeat ipsilateral tubal EP. Salpingectomy, avoids these risks, but leaves only one tube for reproductive capacity. This study aims to reveal the trade-off between both surgical options: whether the potential advantage of salpingostomy, i.e. a better fertility prognosis as compared to salpingectomy, outweighs the potential disadvantages, i.e. persistent trophoblast and an increased risk for a repeat EP., Methods/design: International multi centre randomised controlled trial comparing salpingostomy versus salpingectomy in women with a tubal EP without contra lateral tubal pathology. Hemodynamically stable women with a presumptive diagnosis of tubal EP, scheduled for surgery, are eligible for inclusion. Patients pregnant after in vitro fertilisation (IVF) and/or known documented tubal pathology are excluded. At surgery, a tubal EP must be confirmed. Only women with a tubal EP amenable to both interventions and a healthy contra lateral tube are included. Salpingostomy and salpingectomy are performed according to standard procedures of participating hospitals. Up to 36 months after surgery, women will be contacted to assess their fertility status at six months intervals starting form the day of the operation. The primary outcome measure is the occurrence of spontaneous viable intra uterine pregnancy. Secondary outcome measures are persistent trophoblast, repeat EP, all pregnancies including those resulting from IVF and financial costs. The analysis will be performed according to the intention to treat principle. A cost-effectiveness analysis will be performed within a decision analysis framework, based on costs per live birth, including IVF treatment whenever a spontaneous pregnancy does not occur. Patients' preferences will be assessed using a discrete choice experiment., Discussion: This trial will provide evidence on the trade off between salpingostomy and salpingectomy for tubal EP in view of the pros and cons of both interventions and will offer guidance to clinicians in making the right treatment choice., Trial Registration: Current Controlled Trials ISRCTN37002267.
- Published
- 2008
- Full Text
- View/download PDF
14. Utilizing Chlamydia trachomatis IgG serology with HSG to diagnose tuboperitoneal-factor infertility.
- Author
-
Bernstein RC and Yalcinkaya TM
- Subjects
- Female, Humans, Laparoscopy, Middle Aged, Pilot Projects, Retrospective Studies, Salpingitis complications, Chlamydia trachomatis virology, Hysterosalpingography methods, Immunoglobulin G blood, Infertility, Female diagnosis
- Abstract
To evaluate if Chlamydia trachomatis IgG serology combined with hysterosalpingography can make it easier to detect tuboperitoneal factor infertility, we conducted a chart review of 76 consecutive patients at an infertility practice at West Virginia University from 1999-2001. We checked the charts for results of Chlamydia trachomatis IgG serology, Hysterosalpingography (HSG) and laparoscopy. Results of these tests were reviewed along with age, parity, previous reproductive tract disease surgery and duration of infertility. Complete data was found on 32 of the 76 patients. Chlamydia serology in conjunction with the HSG had a sensitivity of 80% for tuboperitoneal factor (tubal obstruction or pelvic adhesions), and a specificity of 82.3%. The positive predictive value was 80% and the negative predictive value was 82%. Since Chlamdia trachomatis IgG serologic testing is non-invasive and relatively inexpensive, we recommend combining it with hysterosalpingography as an infertility work-up. More invasive testing such as laparoscopy may be postponed or completely eliminated.
- Published
- 2003
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.