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6 results on '"Xuanzhong Xiao"'

1. Conjugated polymer nanomaterials for theranostics

Author

Xuanzhong Xiao, Jicheng Yu, Mei Dong, Zhen Gu, Yu-Lei Chen, Qun-Dong Shen, Peijian Feng, Quanyin Hu, and Chenggen Qian

Subjects
conjugated polymer, theranostics, photothermal therapy, Materials science, Theranostic Nanomedicine, Polymers, medicine.medical_treatment, Nanotechnology, Photodynamic therapy, Review, 02 engineering and technology, Conjugated system, 010402 general chemistry, 01 natural sciences, Nanomaterials, Drug Delivery Systems, Medical imaging, medicine, Pharmacology (medical), Pharmacology, stimuli-responsive drug delivery, General Medicine, Photothermal therapy, 021001 nanoscience & nanotechnology, Nanostructures, 0104 chemical sciences, photodynamic therapy, Photochemotherapy, Drug delivery, biomedical imaging, 0210 nano-technology, Preclinical imaging
Abstract

Conjugated polymer nanomaterials (CPNs), as optically and electronically active materials, hold promise for biomedical imaging and drug delivery applications. This review highlights the recent advances in the utilization of CPNs in theranostics. Specifically, CPN-based in vivo imaging techniques, including near-infrared (NIR) imaging, two-photon (TP) imaging, photoacoustic (PA) imaging, and multimodal (MM) imaging, are introduced. Then, CPN-based photodynamic therapy (PDT) and photothermal therapy (PTT) are surveyed. A variety of stimuli-responsive CPN systems for drug delivery are also summarized, and the promising trends and translational challenges are discussed.

Published
2017
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2. 3D‐Printed Soft Magnetoelectric Microswimmers for Delivery and Differentiation of Neuron‐Like Cells

Author

Xuanzhong Xiao, Salvador Pané, Xiaopu Wang, Josep Puigmartí-Luis, Harun Torlakcik, Siyu Deng, Xiang-Zhong Chen, Bradley J. Nelson, Xiao-Hua Qin, Fajer Mushtaq, Hongsoo Choi, Ana Paula Pêgo, Qun-Dong Shen, Caihong Zhu, Anastasia Terzopoulou, and Mei Dong

Subjects
piezoelectrics, 3d printed, Materials science, soft robots, Nanotechnology, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, 0104 chemical sciences, Electronic, Optical and Magnetic Materials, Biomaterials, magnetoelectrics, microrobots, neuron cell differentiation, medicine.anatomical_structure, Electrochemistry, medicine, Neuron, 0210 nano-technology
Abstract

Advanced Functional Materials, 30 (17), ISSN:1616-3028, ISSN:1616-301X

Published
2020
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3. ATP-Responsive and Near-Infrared-Emissive Nanocarriers for Anticancer Drug Delivery and Real-Time Imaging

Author

Xuanzhong Xiao, Sha Zhu, Chenggen Qian, Xin Tang, Zhen Gu, Peijian Feng, Yu-Lei Chen, Quanyin Hu, Wujin Sun, Lei Zhang, Qun-Dong Shen, Yue Lu, and Jicheng Yu

Subjects
theranostics, Medicine (miscellaneous), Antineoplastic Agents, Nanotechnology, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Theranostic Nanomedicine, stimuli-responsive, chemistry.chemical_compound, Adenosine Triphosphate, In vivo, ATP-responsive, Humans, Phenylboronic acid, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Drug Carriers, Liver Neoplasms, Optical Imaging, Hep G2 Cells, 021001 nanoscience & nanotechnology, Boronic Acids, nanomedicine, Controlled release, Conjugated Polyelectrolytes, 0104 chemical sciences, 3. Good health, chemistry, Doxorubicin, conjugated polymers, drug delivery, Drug delivery, Nanoparticles, Nanomedicine, Nanocarriers, 0210 nano-technology, Drug carrier, Research Paper
Abstract

Stimuli-responsive and imaging-guided drug delivery systems hold vast promise for enhancement of therapeutic efficacy. Here we report an adenosine-5'-triphosphate (ATP)-responsive and near-infrared (NIR)-emissive conjugated polymer-based nanocarrier for the controlled release of anticancer drugs and real-time imaging. We demonstrate that the conjugated polymeric nanocarriers functionalized with phenylboronic acid tags on surface as binding sites for ATP could be converted to the water-soluble conjugated polyelectrolytes in an ATP-rich environment, which promotes the disassembly of the drug carrier and subsequent release of the cargo. In vivo studies validate that this formulation exhibits promising capability for inhibition of tumor growth. We also evaluate the metabolism process by monitoring the fluorescence signal of the conjugated polymer through the in vivo NIR imaging.

Published
2016
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4. Light-Activated Hypoxia-Responsive Nanocarriers for Enhanced Anticancer Therapy

Author

Chenggen Qian, Zhen Gu, Peijian Feng, Xuanzhong Xiao, Quanyin Hu, Yu-Lei Chen, Wujin Sun, Jicheng Yu, Chao Wang, and Qun-Dong Shen

Subjects
Materials science, Light, Cell Survival, medicine.medical_treatment, Transplantation, Heterologous, Mice, Nude, Photodynamic therapy, Antineoplastic Agents, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Article, chemistry.chemical_compound, Mice, Microscopy, Electron, Transmission, Neoplasms, medicine, Animals, Humans, General Materials Science, Doxorubicin, Drug Carriers, Microscopy, Confocal, Singlet Oxygen, Singlet oxygen, Mechanical Engineering, Optical Imaging, Hypoxia (medical), Hydrogen-Ion Concentration, 021001 nanoscience & nanotechnology, Cell Hypoxia, 0104 chemical sciences, chemistry, Mechanics of Materials, Polyvinyl Alcohol, Drug delivery, Cancer research, Nanomedicine, Nanoparticles, medicine.symptom, Nanocarriers, 0210 nano-technology, Drug carrier, medicine.drug, HeLa Cells
Abstract

A light-activated hypoxia-responsive conjugated polymer-based nanocarrier is developed for efficiently producing singlet oxygen ((1) O2 ) and inducing hypoxia to promote release of its cargoes in tumor cells, leading to enhanced antitumor efficacy. This dual-responsive nanocarrier provides an innovative design guideline for enhancing traditional photodynamic therapeutic efficacy integrated with a controlled drug-release modality.

Published
2015

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