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Your search keyword '"Xie, Yuqiao"' showing total 8 results
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8 results on '"Xie, Yuqiao"'

1. Restoring thalamocortical circuit dysfunction by correcting HCN channelopathy in Shank3 mutant mice

Author

Guo, Baolin, Liu, Tiaotiao, Choi, Soonwook, Mao, Honghui, Wang, Wenting, Xi, Kaiwen, Jones, Carter, Hartley, Nolan D., Feng, Dayun, Chen, Qian, Liu, Yingying, Wimmer, Ralf D., Xie, Yuqiao, Zhao, Ningxia, Ou, Jianjun, Arias-Garcia, Mario A., Malhotra, Diya, Liu, Yang, Lee, Sihak, Pasqualoni, Samuel, Kast, Ryan J., Fleishman, Morgan, Halassa, Michael M., Wu, Shengxi, and Fu, Zhanyan

Published
2024
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2. Restoring the Function of Thalamocortical Circuit Through Correcting Thalamic Kv3.2 Channelopathy Normalizes Fear Extinction Impairments in a PTSD Mouse Model

Author

Xiao, Haoxiang, primary, Xi, Kaiwen, additional, Wang, Kaifang, additional, Zhou, Yongsheng, additional, Dong, Baowen, additional, Xie, Jinyi, additional, Xie, Yuqiao, additional, Zhang, Haifeng, additional, Ma, Guaiguai, additional, Wang, Wenting, additional, Feng, Dayun, additional, Guo, Baolin, additional, and Wu, Shengxi, additional

Published
2023
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3. Restoring the Function of Thalamocortical Circuit Through Correcting Thalamic Kv3.2 Channelopathy Normalizes Fear Extinction Impairments in a PTSD Mouse Model.

Author

Xiao, Haoxiang, Xi, Kaiwen, Wang, Kaifang, Zhou, Yongsheng, Dong, Baowen, Xie, Jinyi, Xie, Yuqiao, Zhang, Haifeng, Ma, Guaiguai, Wang, Wenting, Feng, Dayun, Guo, Baolin, and Wu, Shengxi

Subjects
EQUALIZERS (Electronics), MACHINE learning, LABORATORY mice, POST-traumatic stress disorder, ANIMAL disease models
Abstract

Impaired extinction of fear memory is one of the most common symptoms in post‐traumatic stress disorder (PTSD), with limited therapeutic strategies due to the poor understanding of its underlying neural substrates. In this study, functional screening is performed and identified hyperactivity in the mediodorsal thalamic nucleus (MD) during fear extinction. Furthermore, the encoding patterns of the hyperactivated MD is investigated during persistent fear responses using multiple machine learning algorithms. The anterior cingulate cortex (ACC) is also identified as a functional downstream region of the MD that mediates the extinction of fear memory. The thalamocortical circuit is comprehensively analyzed and found that the MD‐ACC parvalbumin interneurons circuit is preferentially enhanced in PTSD mice, disrupting the local excitatory and inhibitory balance. It is found that decreased phosphorylation of the Kv3.2 channel contributed to the hyperactivated MD, primarily to the malfunctioning thalamocortical circuit. Using a lipid nanoparticle‐based RNA therapy strategy, channelopathy is corrected via a methoxylated siRNA targeting the protein phosphatase 6 catalytic subunit and restored fear memory extinction in PTSD mice. These findings highlight the function of the thalamocortical circuit in PTSD‐related impaired extinction of fear memory and provide therapeutic insights into Kv3.2‐targeted RNA therapy for PTSD. [ABSTRACT FROM AUTHOR]

Published
2024
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4. CB1R dysfunction of inhibitory synapses in the ACC drives chronic social isolation stress-induced social impairments in male mice

Author

Guo, Baolin, primary, Xi, Kaiwen, additional, Mao, Honghui, additional, Ren, Keke, additional, Xiao, Haoxiang, additional, Hartley, Nolan D., additional, Zhang, Yangming, additional, Kang, Junjun, additional, Liu, Yingying, additional, Xie, Yuqiao, additional, Zhou, Yongsheng, additional, Zhu, Yuanyuan, additional, Zhang, Xia, additional, Fu, Zhanyan, additional, Chen, Jiang-Fan, additional, Hu, Hailan, additional, Wang, Wenting, additional, and Wu, Shengxi, additional

Published
2023
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5. Reversal of hyperactive higher-order thalamus attenuates defensiveness in a mouse model of PTSD

Author

Xi, Kaiwen, primary, Xiao, Haoxiang, additional, Huang, Xin, additional, Yuan, Ziduo, additional, Liu, Mingyue, additional, Mao, Honghui, additional, Liu, Haiying, additional, Ma, Guaiguai, additional, Cheng, Zishuo, additional, Xie, Yuqiao, additional, Liu, Yang, additional, Feng, Dayun, additional, Wang, Wenting, additional, Guo, Baolin, additional, and Wu, Shengxi, additional

Published
2023
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