23,056 results on '"Xiao, Yan"'
Search Results
2. Geodesic Motion of Test Particles around the Scalar Hairy Black Holes with Asymmetric Vacua
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Chen, Hongyu, Chew, Xiao Yan, and Fan, Wei
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General Relativity and Quantum Cosmology - Abstract
An asymptotically flat hairy black hole (HBH) can exhibit distinct characteristics when compared to the Schwarzschild black hole, due to the evasion of no-hair theorem by minimally coupling the Einstein gravity with a scalar potential which possesses asymmetric vacua, i.e, a false vacuum $(\phi=0)$ and a true vacuum $(\phi=\phi_1)$. In this paper, we investigate the geodesic motion of both massive test particles and photons in the vicinity of HBH with $\phi_1=0.5$ and $\phi_1=1.0$ by analyzing their effective potentials derived from the geodesic equation. By fixing $\phi_1$, the effective potential of a massive test particle increases monotonically when its angular momentum $L$ is very small. When $L$ increases to a critical value, the effective potential possesses an inflection point which is known as the innermost stable of circular orbit (ISCO), where the test particle can still remain stable in a circular orbit with a minimal radius without being absorbed by the HBH or fleeing to infinity. Beyond the critical value of $L$, the effective potential possesses a local minimum and a local maximum, indicating the existence of unstable and stable circular orbits, respectively. Moreover, the HBH possesses an unstable photon sphere but its location slightly deviates from the Schwarzschild black hole. The trajectories of null geodesics in the vicinity of HBH can also be classified into three types, which are the direct, lensing and photon sphere, based on the deflection angle of light, but the values of impact parameters can vary significantly than the Schwarzschild black hole., Comment: 11 pages with total 11 figures
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- 2024
3. Monte Carlo Study of Critical Fermi Surface with Spatial Disorder Interactions
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Hong, Tu and Xu, Xiao Yan
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Condensed Matter - Strongly Correlated Electrons - Abstract
Non-Fermi liquids are an important topic in condensed matter physics, as their characteristics challenge the framework of traditional Fermi liquid theory and reveal the complex behavior of electrons in strongly interacting systems. Despite some progress in this field, linear-in-temperature resistance and inverse-in-frequency tail of optical conductivity are unresolved issues in non-Fermi liquids. Both the experimentally observed smeared region and the theoretically predicted marginal Fermi liquid suggest that spatial disorder seems to be an important driver of these phenomena. By performing large-scale determinant quantum Monte Carlo (DQMC) simulations in the ferromagnetic spin-fermion model, we investigated the role of spatial disorder in the critical Fermi surface (FS) of this model. We proposed a corrected theory of our system, which is based on a modified Eliashberg theory and a universal theory of strange metals. This theory agrees well with the data obtained from DQMC. Our findings offer strong and unbiased validation of the universal theory of strange metals, broaden the applicability of the modified Eliashberg theory and provide insights for numerically searching for marginal Fermi liquid and linear-in-temperature resistance.
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- 2024
4. Exploring and Lifting the Robustness of LLM-powered Automated Program Repair with Metamorphic Testing
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Xue, Pengyu, Wu, Linhao, Yang, Zhen, Li, Xinyi, Yu, Zhongxing, Jin, Zhi, Li, Ge, Xiao, Yan, and Wu, Jingwen
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Computer Science - Software Engineering - Abstract
In recent years, Large language model-powered Automated Program Repair (LAPR) techniques have achieved state-of-the-art bug-fixing performance and have been pervasively applied and studied in both industry and academia. Nonetheless, LLMs were proved to be highly sensitive to input prompts, with slight differences in the expressions of semantically equivalent programs potentially causing repair failures. Therefore, it is crucial to conduct robustness testing on LAPR techniques before their practical deployment. However, related research is scarce. To this end, we propose MT-LAPR, a Metamorphic Testing framework exclusively for LAPR techniques, which summarizes nine widely-recognized Metamorphic Relations (MRs) by developers across three perturbation levels: token, statement, and block. Afterward, our proposed MRs are applied to buggy codes to generate test cases, which are semantically equivalent yet to affect the inference of LAPR. Experiments are carried out on two extensively examined bug-fixing datasets, i.e., Defect4J and QuixBugs, and four bug-fixing abled LLMs released recently, demonstrating that 34.4% - 48.5% of the test cases expose the instability of LAPR techniques on average, showing the effectiveness of MT-LAPR and uncovering a positive correlation between code readability and the robustness of LAPR techniques. Inspired by the above findings, this paper uses the test cases generated by MT-LAPR as samples to train a CodeT5-based code editing model aiming at improving code readability and then embeds it into the LAPR workflow as a data preprocessing step. Extensive experiments demonstrate that this approach significantly enhances the robustness of LAPR by 49.32% at most.
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- 2024
5. Probing blackbody components in gamma-ray bursts from black hole neutrino-dominated accretion flows
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Li, Xiao-Yan, Liu, Tong, Huang, Bao-Quan, Li, Guo-Yu, Lin, Da-Bin, Chen, Zhi-Lin, and Wang, Yun
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
A stellar-mass black hole (BH) surrounded by a neutrino-dominated accretion flow (NDAF) is generally considered to be the central engine of gamma-ray bursts (GRBs). Neutrinos escaping from the disk will annihilate out of the disk to produce the fireball that could power GRBs with blackbody (BB) components. The initial GRB jet power and fireball launch radius are related to the annihilation luminosity and annihilation height of the NDAFs, respectively. In this paper, we collect 7 GRBs with known redshifts and identified BB components to test whether the NDAF model works. We find that, in most cases, the values of the accretion rates and the central BH properties are all in the reasonable range, suggesting that these BB components indeed originate from the neutrino annihilation process., Comment: 8 pages, 1 table, 1 figure, accepted for publication in ApJ
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- 2024
6. Tur\'an-Type Inequalities for Gaussian Hypergeometric Functions, and Baricz's Conjecture
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Qiu, Song-Liang, Ma, Xiao-Yan, and Xiang, Xue-Yan
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Mathematics - Classical Analysis and ODEs ,33Co5, 33C75 - Abstract
In 2007, \'A. Baricz put forward a conjecture concerning Tur\'an-type inequalities for Gaussian hypergeometric functions (see Conjecture \ref{ConjA} in Section \ref{Sec1}). In this paper, the authors disprove this conjecture with several methods, and present Tur\'an-type double inequalities for Gaussian hypergeometric functions, and sharp bounds for complete and generalized elliptic integrals of the first kind., Comment: 23 pages
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- 2024
7. HiMA: Hierarchical Quantum Microarchitecture for Qubit-Scaling and Quantum Process-Level Parallelism
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Zhou, Qi, Mei, Zi-Hao, Shi, Han-Qing, Guo, Liang-Liang, Yang, Xiao-Yan, Wang, Yun-Jie, Xu, Xiao-Fan, Xue, Cheng, Kong, Wei-Cheng, Wang, Jun-Chao, Wu, Yu-Chun, Chen, Zhao-Yun, and Guo, Guo-Ping
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Computer Science - Hardware Architecture ,Quantum Physics - Abstract
Quantum computing holds immense potential for addressing a myriad of intricate challenges, which is significantly amplified when scaled to thousands of qubits. However, a major challenge lies in developing an efficient and scalable quantum control system. To address this, we propose a novel Hierarchical MicroArchitecture (HiMA) designed to facilitate qubit scaling and exploit quantum process-level parallelism. This microarchitecture is based on three core elements: (i) discrete qubit-level drive and readout, (ii) a process-based hierarchical trigger mechanism, and (iii) multiprocessing with a staggered triggering technique to enable efficient quantum process-level parallelism. We implement HiMA as a control system for a 72-qubit tunable superconducting quantum processing unit, serving a public quantum cloud computing platform, which is capable of expanding to 6144 qubits through three-layer cascading. In our benchmarking tests, HiMA achieves up to a 4.89x speedup under a 5-process parallel configuration. Consequently, to the best of our knowledge, we have achieved the highest CLOPS (Circuit Layer Operations Per Second), reaching up to 43,680, across all publicly available platforms.
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- 2024
8. Can a naked singularity be formed during the gravitational collapse of a Janis-Newman-Winicour solution?
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Chew, Xiao Yan, Choi, Il Gyeong, Kim, Hyuk Jung, and Yeom, Dong-han
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General Relativity and Quantum Cosmology ,High Energy Physics - Theory - Abstract
The Janis-Newman-Winicour (JNW) spacetime possesses a naked singularity, although it represents an exact particle-like solution to the Einstein-Klein-Gordon theory with a massless scalar field. Here, we investigate the possible formation of a naked singularity in the JNW spacetime, using the thin-shell approximation to describe the gravitational collapse. By introducing different matter contents to construct thin-shells, we demonstrate the impossibility of naked singularity formation during the gravitational collapse unless the causality or null energy condition of the thin-shell is violated. Therefore, the weak cosmic censorship is satisfied even with the naked singularity of the JNW spacetime., Comment: 13 pages, 6 figures
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- 2024
9. Realization of Conditional Operations through Transition Pathway Engineering
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Zhang, Sheng, Duan, Peng, Wang, Yun-Jie, Wang, Tian-Le, Wang, Peng, Zhao, Ren-Ze, Yang, Xiao-Yan, Zhao, Ze-An, Guo, Liang-Liang, Chen, Yong, Zhang, Hai-Feng, Du, Lei, Tao, Hao-Ran, Li, Zhi-Fei, Wu, Yuan, Jia, Zhi-Long, Kong, Wei-Cheng, Chen, Zhao-Yun, Wu, Yu-Chun, and Guo, Guo-Ping
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Quantum Physics - Abstract
In the NISQ era, achieving large-scale quantum computing demands compact circuits to mitigate decoherence and gate error accumulation. Quantum operations with diverse degrees of freedom hold promise for circuit compression, but conventional approaches encounter challenges in simultaneously adjusting multiple parameters. Here, we propose a transition composite gate (TCG) scheme grounded on state-selective transition path engineering, enabling more expressive conditional operations. We experimentally validate a controlled unitary (CU) gate as an example, with independent and continuous parameters. By adjusting the parameters of $\rm X^{12}$ gate, we obtain the CU family with a fidelity range of 95.2% to 99.0% leveraging quantum process tomography (QPT). To demonstrate the capability of circuit compression, we use TCG scheme to prepare 3-qubit Greenberger-Horne-Zeilinger (GHZ) and W states, with the fidelity of 96.77% and 95.72%. TCG can achieve the reduction in circuit depth of about 40% and 44% compared with the use of CZ gates only. Moreover, we show that short-path TCG (SPTCG) can further reduce the state-preparation circuit time cost. The TCG scheme exhibits advantages in certain quantum circuits and shows significant potential for large-scale quantum algorithms., Comment: 21 pages, 12 figures
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- 2024
10. A Unified Intracellular pH Landscape with SITE-pHorin: a Quantum-Entanglement-Enhanced pH Probe
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Li, Shu-Ang, Meng, Xiao-Yan, Zhang, Su, Zhang, Ying-Jie, Yang, Run-Zhou, Wang, Dian-Dian, Yang, Yang, Liu, Pei-Pei, and Kang, Jian-Sheng
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Quantitative Biology - Quantitative Methods ,Physics - Biological Physics ,Quantitative Biology - Biomolecules ,Quantitative Biology - Subcellular Processes - Abstract
An accurate map of intracellular organelle pH is crucial for comprehending cellular metabolism and organellar functions. However, a unified intracellular pH spectrum using a single probe is still lack. Here, we developed a novel quantum entanglement-enhanced pH-sensitive probe called SITE-pHorin, which featured a wide pH-sensitive range and ratiometric quantitative measurement capabilities. Subsequently, we measured the pH of various organelles and their sub-compartments, including mitochondrial sub-spaces, Golgi stacks, endoplasmic reticulum, lysosomes, peroxisomes, and endosomes in COS-7 cells. For the long-standing debate on mitochondrial compartments pH, we measured the pH of mitochondrial cristae as 6.60 \pm 0.40, the pH of mitochondrial intermembrane space as 6.95 \pm 0.30, and two populations of mitochondrial matrix pH at approximately 7.20 \pm 0.27 and 7.50 \pm 0.16, respectively. Notably, the lysosome pH exhibited a single, narrow Gaussian distribution centered at 4.79 \pm 0.17. Furthermore, quantum chemistry computations revealed that both the deprotonation of the residue Y182 and the discrete curvature of deformed benzene ring in chromophore are both necessary for the quantum entanglement mechanism of SITE-pHorin. Intriguingly, our findings reveal an accurate pH gradient (0.6-0.9 pH unit) between mitochondrial cristae and matrix, suggesting prior knowledge about \Delta pH (0.4-0.6) and mitochondrial proton motive force (pmf) are underestimated., Comment: 64 pages, 7 figures, the supplemental material contains 13 supplemental figures and 4 supplemental tables
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- 2024
11. Enabling Large-Scale and High-Precision Fluid Simulations on Near-Term Quantum Computers
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Chen, Zhao-Yun, Ma, Teng-Yang, Ye, Chuang-Chao, Xu, Liang, Tan, Ming-Yang, Zhuang, Xi-Ning, Xu, Xiao-Fan, Wang, Yun-Jie, Sun, Tai-Ping, Chen, Yong, Du, Lei, Guo, Liang-Liang, Zhang, Hai-Feng, Tao, Hao-Ran, Wang, Tian-Le, Yang, Xiao-Yan, Zhao, Ze-An, Wang, Peng, Zhang, Sheng, Zhang, Chi, Zhao, Ren-Ze, Jia, Zhi-Long, Kong, Wei-Cheng, Dou, Meng-Han, Wang, Jun-Chao, Liu, Huan-Yu, Xue, Cheng, Zhang, Peng-Jun-Yi, Huang, Sheng-Hong, Duan, Peng, Wu, Yu-Chun, and Guo, Guo-Ping
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Physics - Computational Physics ,Quantum Physics - Abstract
Quantum computational fluid dynamics (QCFD) offers a promising alternative to classical computational fluid dynamics (CFD) by leveraging quantum algorithms for higher efficiency. This paper introduces a comprehensive QCFD method, including an iterative method "Iterative-QLS" that suppresses error in quantum linear solver, and a subspace method to scale the solution to a larger size. We implement our method on a superconducting quantum computer, demonstrating successful simulations of steady Poiseuille flow and unsteady acoustic wave propagation. The Poiseuille flow simulation achieved a relative error of less than $0.2\%$, and the unsteady acoustic wave simulation solved a 5043-dimensional matrix. We emphasize the utilization of the quantum-classical hybrid approach in applications of near-term quantum computers. By adapting to quantum hardware constraints and offering scalable solutions for large-scale CFD problems, our method paves the way for practical applications of near-term quantum computers in computational science., Comment: 31 pages, 10 figures
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- 2024
12. Apparent fake neutrino mixture due to seesaw mechanism responsible for oscillation
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Wang, Xiao-Yan
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High Energy Physics - Phenomenology - Abstract
This paper assumes that neutrino flavor conversion is induced by right-handed neutrino mixture via seesaw mechanism, which leads to apparent fake neutrino mixture with neutrino mass eigenstate consistent with flavor state of left-handed neutrino rather than mixture of flavor state. The transition probability between right-handed neutrinos due to mixture can be explained well by boson intermediating flavor flip interaction between right-handed neutrinos and neutrino oscillation can be considered macro phenomenon before all flavor flip interactions arrive at balance.
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- 2024
13. Gravitating Scalarons with Inverted Higgs Potential
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Chew, Xiao Yan and Lim, Kok-Geng
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General Relativity and Quantum Cosmology ,High Energy Physics - Theory ,Nonlinear Sciences - Pattern Formation and Solitons - Abstract
Previously, a class of regular and asymptotically flat gravitating scalar solitons (scalarons) has been constructed in the Einstein--Klein--Gordon (EKG) theory by adopting a phantom field with Higgs-like potential where the kinetic term has the wrong sign and the scalaron possesses the negative Arnowitt--Deser--Misner (ADM) mass as a consequence. In this paper, we demonstrate that the use of the phantom field can be avoided by inverting the Higgs-like potential in the EKG system when the kinetic term has a proper sign, such that the corresponding gravitating scalaron can possess the positive ADM mass. We systematically study the basic properties of the gravitating scalaron, such as the ADM mass, the energy conditions, the geodesics of test particles, etc. Moreover, we find that it can be smoothly connected to the counterpart hairy black hole solutions from our recent work in the small horizon limit., Comment: 18 pages with 9 figures. Special Issue of the Universe (MDPI): Compact Objects (invited contribution)
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- 2024
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14. GRB afterglows with energy injections in AGN accretion disks
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Huang, Bao-Quan, Liu, Tong, Li, Xiao-Yan, and Wei, Yun-Feng
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Active galactic nucleus (AGN) disks are widely considered potential hosts for various high-energy transients, including gamma-ray bursts (GRBs). The reactivation of GRB central engines can provide additional energy to shocks formed during the interaction of the initially ejected GRB jets with the circumburst material, commonly referred to as energy injections. In this paper, we study GRBs occurring in AGN disks within the context of energy injections. We adopt the standard external forward shock (EFS) model and consider both short- and long-duration GRB scenarios. Light curves for two types of radiation, namely the radiation from the heated disk material (RHDM) and GRB afterglows, are computed. We find that the energy injection facilitates the EFS to break out from the photosphere of the low-density AGN disk at relativistic velocity. Moreover, the energy injection almost does not affect the RHDM but significantly enhances the peak flux of the GRB afterglows., Comment: 12 pages, 6 figures, 2 tables, accepted for publication in ApJ
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- 2024
15. The simplest model of a scalarized black hole in the Einstein-Klein-Gordon theory
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Chew, Xiao Yan and Myung, Yun Soo
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General Relativity and Quantum Cosmology ,High Energy Physics - Theory - Abstract
We investigate scalarized black holes in the Einstein-minimally coupled scalar theory with a negative potential $V(\phi)=-\alpha^2\phi^6$. The tachyonic instability is absent from analyzing the linearized scalar equation, which could not allow for spontaneous scalarization. However, we obtain the black hole solutions with scalar hair by solving three full equations because this scalar potential violates the weak energy condition. This shows clearly that scalarized black holes can be obtained without introducing a non-minimal scalar coupling term. We perform the stability analysis for scalarized black holes by adopting radial perturbations, implying that all scalarized black holes belonging to a single branch are unstable., Comment: 18 pages with 8 figures (To match with the published version)
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- 2024
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16. Adaptive Catalyst Discovery Using Multicriteria Bayesian Optimization with Representation Learning
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Chen, Jie, Ou, Pengfei, Chang, Yuxin, Zhang, Hengrui, Li, Xiao-Yan, Sargent, Edward H., and Chen, Wei
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Computer Science - Machine Learning ,Computer Science - Computational Engineering, Finance, and Science ,Physics - Chemical Physics - Abstract
High-performance catalysts are crucial for sustainable energy conversion and human health. However, the discovery of catalysts faces challenges due to the absence of efficient approaches to navigating vast and high-dimensional structure and composition spaces. In this study, we propose a high-throughput computational catalyst screening approach integrating density functional theory (DFT) and Bayesian Optimization (BO). Within the BO framework, we propose an uncertainty-aware atomistic machine learning model, UPNet, which enables automated representation learning directly from high-dimensional catalyst structures and achieves principled uncertainty quantification. Utilizing a constrained expected improvement acquisition function, our BO framework simultaneously considers multiple evaluation criteria. Using the proposed methods, we explore catalyst discovery for the CO2 reduction reaction. The results demonstrate that our approach achieves high prediction accuracy, facilitates interpretable feature extraction, and enables multicriteria design optimization, leading to significant reduction of computing power and time (10x reduction of required DFT calculations) in high-performance catalyst discovery.
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- 2024
17. Boosting Determinant Quantum Monte Carlo with Submatrix Updates: Unveiling the Phase Diagram of the 3D Hubbard Model
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Sun, Fanjie and Xu, Xiao Yan
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Condensed Matter - Strongly Correlated Electrons ,High Energy Physics - Lattice - Abstract
The study of strongly correlated fermionic systems, crucial for understanding condensed matter physics, has been significantly advanced by numerical computational methods. Among these, the Determinant Quantum Monte Carlo (DQMC) method stands out for its ability to provide exact numerical solutions. However, the computational complexity of DQMC, particularly in dealing with large system sizes and the notorious sign problem, limits its applicability. We introduce an innovative approach to enhance DQMC efficiency through the implementation of submatrix updates. Building upon the foundational work of conventional fast updates and delay updates, our method leverages a generalized submatrix update algorithm to address challenges in simulating strongly correlated fermionic systems with both onsite and extended interactions at both finite and zero temperatures. We demonstrate the method's superiority by comparing it with previous update methods in terms of computational complexity and efficiency. Specifically, our submatrix update method significantly reduces the computational overhead, enabling the simulation of system sizes up to 8,000 sites without pushing hard. This advancement allows for a more accurate determination of the finite temperature phase diagram of the 3D Hubbard model at half-filling. Our findings not only shed light on the phase transitions within these complex systems but also pave the way for more effective simulations of strongly correlated electrons, potentially guiding experimental efforts in cold atom simulations of the 3D Hubbard model., Comment: 18 pages, 12 figures, 3 tables, note added
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- 2024
18. Insights and guidelines on the Cauchy horizon theorems
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Chew, Xiao Yan and Yeom, Dong-han
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- 2024
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19. A Cysteinyl-tRNA Synthetase Mutation Causes Novel Autosomal-Dominant Inheritance of a Parkinsonism/Spinocerebellar-Ataxia Complex
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Liu, Han-Kui, Hao, Hong-Lin, You, Hui, Feng, Feng, Qi, Xiu-Hong, Huang, Xiao-Yan, Hou, Bo, Tian, Chang-Geng, Wang, Han, Yang, Huan-Ming, Wang, Jian, Wu, Rui, Fang, Hui, Zhou, Jiang-Ning, Zhang, Jian-Guo, and Zhang, Zhen-Xin
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- 2024
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20. High-altitude exposure leads to increased modularity of brain functional network with the increased occupation of attention resources in early processing of visual working memory
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Zhou, Jing, Wang, Nian-Nian, Huang, Xiao-Yan, Su, Rui, Li, Hao, Ma, Hai-Lin, Liu, Ming, and Zhang, De-Long
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- 2024
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21. Two-Stage Evaluation of the Pre-merger Potential Gains of Taiwan Financial Holding Companies: Dynamic Network Slack-Based Measure Analysis Approach
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Hsu, Shao-Yin, Lu, Ching-Cheng, Xiao, Yan-Hui, and Chiu, Yung-ho
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- 2024
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22. Residual entropy from temperature incremental Monte Carlo method
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Dai, Zenan and Xu, Xiao Yan
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Condensed Matter - Statistical Mechanics ,Condensed Matter - Strongly Correlated Electrons - Abstract
Residual entropy, indicative of the degrees of freedom in a system at absolute zero, is a cornerstone for understanding quantum and classical ground states. Despite its critical role in elucidating low-temperature phenomena and ground state degeneracy, accurately quantifying residual entropy remains a formidable challenge due to significant computational hurdles. In this Letter, we introduce the Temperature Incremental Monte Carlo (TIMC) method, our novel solution crafted to surmount these challenges. The TIMC method incrementally calculates the partition function ratio of neighboring temperatures within Monte Carlo simulations, enabling precise entropy calculations and providing insights into a spectrum of other temperature-dependent observables in a single computational sweep of temperatures. We have rigorously applied TIMC to a variety of complex systems, such as the frustrated antiferromagnetic Ising model on both C60 and 2D triangular lattices, the Newman-Moore spin glass model, and a 2D quantum transverse field Ising model. Notably, our method surmounts the traditional obstacles encountered in partition function measurements when mapping $d$-dimensional quantum models to $d+1$-dimensional classical counterparts. The TIMC method's finesse in detailing entropy across the entire temperature range enriches our comprehension of critical phenomena in condensed matter physics. This includes insights into spin glasses, phases exhibiting spontaneous symmetry breaking, topological states of matter and fracton phases. Our approach not only advances the methodology for probing the entropic landscape of such systems but also paves the way for exploring their broader thermodynamic and quantum mechanical properties., Comment: 5 pages, 5 figures
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- 2024
23. RITFIS: Robust input testing framework for LLMs-based intelligent software
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Xiao, Mingxuan, Xiao, Yan, Dong, Hai, Ji, Shunhui, and Zhang, Pengcheng
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Computer Science - Software Engineering ,Computer Science - Computation and Language - Abstract
The dependence of Natural Language Processing (NLP) intelligent software on Large Language Models (LLMs) is increasingly prominent, underscoring the necessity for robustness testing. Current testing methods focus solely on the robustness of LLM-based software to prompts. Given the complexity and diversity of real-world inputs, studying the robustness of LLMbased software in handling comprehensive inputs (including prompts and examples) is crucial for a thorough understanding of its performance. To this end, this paper introduces RITFIS, a Robust Input Testing Framework for LLM-based Intelligent Software. To our knowledge, RITFIS is the first framework designed to assess the robustness of LLM-based intelligent software against natural language inputs. This framework, based on given threat models and prompts, primarily defines the testing process as a combinatorial optimization problem. Successful test cases are determined by a goal function, creating a transformation space for the original examples through perturbation means, and employing a series of search methods to filter cases that meet both the testing objectives and language constraints. RITFIS, with its modular design, offers a comprehensive method for evaluating the robustness of LLMbased intelligent software. RITFIS adapts 17 automated testing methods, originally designed for Deep Neural Network (DNN)-based intelligent software, to the LLM-based software testing scenario. It demonstrates the effectiveness of RITFIS in evaluating LLM-based intelligent software through empirical validation. However, existing methods generally have limitations, especially when dealing with lengthy texts and structurally complex threat models. Therefore, we conducted a comprehensive analysis based on five metrics and provided insightful testing method optimization strategies, benefiting both researchers and everyday users.
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- 2024
24. Double-Masked, Vehicle-Controlled, Randomized, Phase II Study of the Ocular Hypotensive Activity and Safety of VVN539 Ophthalmic Solution
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Wirta, David, Li, Xiao-Yan, Shen, Wang, Lu, Caroline, Novack, Gary D, Group, VVN539-CS201 Study, Christie, William, Hartman, Paul J, Tafoya, Lawrence, Tekwani, Navin, and Louis, St
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Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Neurosciences ,Clinical Research ,Clinical Trials and Supportive Activities ,Eye Disease and Disorders of Vision ,Patient Safety ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Eye ,VVN539-CS201 Study Group ,Glaucoma ,Intraocular pressure ,Ocular hypertension ,Rho-kinase inhibitor ,VVN539 - Abstract
To assess safety and ocular hypotensive efficacy of VVN539 ophthalmic solution in a first-in-human study. Multicenter, double-masked, randomized, vehicle-controlled, dose-response, parallel-comparison study. Sixty-eight subjects with ocular hypertension (OHT) or open-angle glaucoma enrolled at 5 private practices. After washout of ocular hypotensive medications as required, the subjects were randomized to receive either VVN539 ophthalmic solution 0.02%, 0.04%, or vehicle once-daily (QD) in the morning (5 days), once-daily in the evening (6 days) and then twice-daily (6 days). Comparison of VVNM539 to its vehicle in mean intraocular pressure (IOP) at each diurnal time point (8:00am, 10:00am, and 4:00pm) at visit 4 (day 7), visit 5 (day 14), and visit 6 (day 21). Mean IOP decreased throughout dosing in the active groups to between 18 and 20 mmHg in both active groups, to between 22 to 23 mmHg in the vehicle group. VVN539 0.04% was statistically superior to vehicle at all 9 diurnal time points (QD AM, QD PM, and twice daily, P ≤ 0.0109). VVN539 0.02% was statistically superior to vehicle at only 6 of 9 diurnal time points (selected QD times and twice daily). The most common ocular treatment-emergent adverse event was conjunctival hyperemia (11 [47.8%], 10 [4.5%], and 1 [4.3%]), followed by ocular hyperemia (3 [13.0%], 5 [22.7%] and 0), respectively. There were no clinically significant changes of note in visual acuity, biomicroscopy, dilated ophthalmoscopy, blood chemistry, hematology, or cardiovascular measures. In conclusion, the results of this initial phase II study indicate that VVN539 ophthalmic solution showed clinically and statistically significant ocular hypertensive activity and was relatively well tolerated for the treatment of subjects with primary open-angle glaucoma or OHT. Additional studies will be required for a more complete evaluation of the utility of VVN539 ophthalmic solution. Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
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- 2024
25. Entanglement R\'{e}nyi Negativity of Interacting Fermions from Quantum Monte Carlo Simulations
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Wang, Fo-Hong and Xu, Xiao Yan
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Condensed Matter - Strongly Correlated Electrons ,High Energy Physics - Lattice ,Quantum Physics - Abstract
Many-body entanglement unveils additional aspects of quantum matter and offers insights into strongly correlated physics. While ground-state entanglement has received much attention in the past decade, the study of mixed-state quantum entanglement using negativity in interacting fermionic systems remains largely unexplored. We demonstrate that the partially transposed density matrix of interacting fermions, similar to their reduced density matrix, can be expressed as a weighted sum of Gaussian states describing free fermions, enabling the calculation of rank-$n$ R\'{e}nyi negativity within the determinant quantum Monte Carlo framework. We conduct the first calculation of the rank-two R\'{e}nyi negativity for the half-filled Hubbard model and the spinless $t$-$V$ model. Our calculation reveals that the area law coefficient of the R\'{e}nyi negativity for the spinless $t$-$V$ model has a logarithmic finite-size scaling at the finite-temperature transition point. Our work contributes to the calculation of entanglement and sets the stage for future studies on quantum entanglement in various fermionic many-body mixed states., Comment: 8+10 pages, 3+2 figures
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- 2023
26. Black hole growths in gamma-ray bursts driven by the Blandford-Znajek mechanism
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Li, Xiao-Yan and Liu, Tong
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The Blandford-Znajek (BZ) mechanism in stellar-mass black hole (BH) hyperaccretion systems is generally considered to power gamma-ray bursts (GRBs). Based on observational GRB data, we use the BZ mechanism driven by the BH hyperaccretion disc to investigate the evolution of the BH mass and spin after the jets break out from the progenitors. We find that the BH growths are almost independent of initial BH masses. Meanwhile, the BH growths will be more efficient with smaller initial spin parameters. We conclude that (i) the BZ mechanism is efficient for triggering BH growths for only 1 of 206 typical long-duration GRBs; (ii) the mean BH mass growths of ultra-long GRBs are marginal for all 7 samples collected; (iii) for the short-duration GRBs, the results that BHs show minimal growths is consistent with the mass supply limitation in the scenario of compact object mergers., Comment: 12 pages, 3 figures, 3 tables, accepted for publication in MNRAS
- Published
- 2023
27. Abdominal Pain in Inflammatory Bowel Disease-Epidemiology, Pathophysiology, and Management: A Narrative Review
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Tan, Wei-wei, Liu, Zi-xuan, Liu, Xiao-Yan, Zhang, Wei-bing, Zheng, Lie, Zhang, Ya-Li, and Dai, Yan-Cheng
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- 2024
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28. Effect of Teachers' Charismatic Leadership Perceived by College Students on Their Entrepreneurial Intentions: The Mediating Role of Entrepreneurial Passion
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Li, Xiao-yan and Huang, Jian-hao
- Abstract
The present research examined the perceived teachers' charismatic leadership and entrepreneurial intentions of college students. Based on the theory of emotional contagion, this study proposes a mediating model of entrepreneurial passion between college students' perception of teachers' charismatic leadership and entrepreneurial intentions. A questionnaire survey was conducted in 420 college students in Jiangsu Province, China. The results showed that college students' perceived teachers' charismatic leadership had a significant positive effect on entrepreneurial passion. Moreover, perceived teachers' charismatic leadership of college students was found to have a significant positive predictive effect on entrepreneurial intentions, and entrepreneurial passion had a significant positive effect on entrepreneurial intentions. The mediation model analysis indicated that entrepreneurial passion played a partial mediating role between college students' perception of teachers' charismatic leadership and entrepreneurial intentions. The study results deepened our understanding of the inner influence mechanism of college students' perception of teachers' charismatic leadership and entrepreneurial intentions, in addition to providing a practical basis for college educators.
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- 2023
29. Acetylcytidine modification of Amotl1 by N-acetyltransferase 10 contributes to cardiac fibrotic expansion in mice after myocardial infarction
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Wang, Xiu-xiu, Zhao, Yi-ming, Zhang, Qian-yun, Zhao, Jing-xuan, Yin, Dao-hong, Zhang, Zi-zhen, Jin, Xiao-yan, Li, Shuai-nan, Ji, Hao-yu, Chen, Hong-yang, Guo, Xiao-fei, Yu, Yang, Ma, Wen-ya, Yan, Hong, Li, Han, Ou-Yang, Qi-meng, Pan, Zhen-wei, Liang, Hai-hai, Wang, Ning, Chen, Wei, Cai, Ben-zhi, and Liu, Yu
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- 2024
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30. Yang-Mills instantons as the end point of black hole evaporation
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Chen, Pisin, Chew, Xiao Yan, Sasaki, Misao, and Yeom, Dong-han
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General Relativity and Quantum Cosmology ,High Energy Physics - Theory - Abstract
Non-perturbative contributions of the Euclidean path integral are important to understand the information loss paradox. In this paper, we revisit the Yang-Mills instantons in the Einstein-Yang-Mills theory. There exists a globally regular solution that is known as the Bartnik-McKinnon solution and a black hole solution. The regular and the black hole solutions are smoothly connected in the small horizon limit. Their Euclidean action is solely characterized by the ADM mass, and the transition probability follows the usual Bekenstein-Hawking entropy formula. Therefore, the Yang-Mills instantons provide a non-perturbative channel to the black hole evaporation, which competes effectively with perturbative processes, and becomes dominant toward the end of evaporation. We show that these instantons provide a smooth transition mechanism from a black hole to regular spacetime., Comment: 17 pages, 5 figures
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- 2023
31. The interplay of phase fluctuations and nodal quasiparticles: ubiquitous Fermi arcs in two-dimensional d-wave superconductors
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Wang, Xu-Cheng, Xu, Xiao Yan, and Qi, Yang
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Condensed Matter - Superconductivity ,Condensed Matter - Strongly Correlated Electrons - Abstract
We investigate the role of superconducting phase fluctuations in generic 2D superconductors. For nodal d-wave superconductors, it is found that the thermal (static) phase fluctuations in the normal state significantly broaden the d-wave nodes, and lead to the pseudogap and accompanying Fermi arcs in a quite general manner. The formation of Fermi arcs can be depicted by the intertwinement between d-wave superconductivity and the scattering of Cooper pairs. To support our theoretical findings, we numerically report the observation of Fermi arcs in a concrete lattice model, proposed originally by X. Y. Xu and T. Grover in Phys. Rev. Lett. 126, 217002 (2021), using the determinant quantum Monte Carlo (DQMC) method without the infamous sign problem. As far as we noticed, it is the first time in a highly-correlated model that the Fermi arcs are identified with unbiased DQMC simulations. Despite the conciseness of our theory, our simulation results confirm the theoretical predictions qualitatively., Comment: 6 pages, 5 figures for the main text; 8 pages, 5 figures for the supplementary material
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- 2023
32. Empirical Study on Transformer-based Techniques for Software Engineering
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Xiao, Yan, Zuo, Xinyue, Xue, Lei, Wang, Kailong, Dong, Jin Song, and Beschastnikh, Ivan
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Computer Science - Software Engineering - Abstract
Many Transformer-based pre-trained models for code have been developed and applied to code-related tasks. In this paper, we review the existing literature, examine the suitability of model architectures for different tasks, and look at the generalization ability of models on different datasets, and their resource consumption. We examine three very representative pre-trained models for code: CodeBERT, CodeGPT, and CodeT5, and conduct experiments on the top-4 most targeted software engineering tasks that we found in our literature survey: Code Summarization, Bug Fixing, Bug Detection, and Code Search. In our study, we showcase the capability of decoder-only models (CodeGPT) for specific generation tasks under state-of-the-art evaluation metrics and contest the common belief that the encoder-decoder architecture is optimal for general-purpose coding tasks. Additionally, we found that the most frequently used models are not necessarily the most suitable for certain applications and the developers' needs are not adequately addressed by current research. As well, we found that the benchmark and frequent dataset for Bug Fixing and Code Summarization both fail to enable models to generalize onto other datasets for the same task (the frequent dataset refers to the dataset with the highest frequency used in literature other than the benchmark). We use statistical testing to support our conclusions from experiments. Finally, CodeBERT is highly efficient for understanding tasks, whereas CodeT5's efficiency for generation tasks is in doubt, as the highest resource consumption does not guarantee a consistent better performance on different metrics. We also discuss the numerous practical issues in advancing future research on transformer-based models for code-related tasks.
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- 2023
33. A transcriptome data set for comparing skin, muscle and dorsal root ganglion between acute and chronic postsurgical pain rats
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Xiao-yan Meng, Lan Bu, Ling Shen, and Kun-ming Tao
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Science - Abstract
Abstract Chronic postsurgical pain (CPSP), with a high prevalence and rising epidemic of opioids crisis, is typically derived from acute postoperative pain. Our knowledge on the forming of chronic pain mostly derives from mechanistic studies of pain processing in the brain and spinal cord circuits, yet most pharmacological interventions targeting CNS came to be unhelpful in preventing CPSP. Revealing the peripheral mechanisms behind the transition from acute to chronic pain after surgery could shine a light on the novel analgesic regimens. Based on two recognized animal models in simulation of acute and chronic postsurgical pain, we provide a next-generation RNA sequencing (RNA-seq) data set to evaluate the time-course transcriptomic variation in the tissue of skin, muscle and dorsal root ganglion (DRG) in these two pain models. The aim of this study is to identify the potential origin and mechanism of the persistent postoperative pain, and further to explore effective and safer analgesic regimens for surgical patients.
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- 2024
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34. Abnormal changes of brain function and structure in patients with T2DM-related cognitive impairment: a neuroimaging meta-analysis and an independent validation
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Pan Dai, Ying Yu, Qian Sun, Yang Yang, Bo Hu, Hao Xie, Si-Ning Li, Xin-Yu Cao, Min-Hua Ni, Yan-Yan Cui, Xiao-Yan Bai, Jia-Jun Bi, Guang-Bin Cui, and Lin-Feng Yan
- Subjects
Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Abstract Type 2 diabetes mellitus (T2DM) seriously threatens human health and the quality of life, cognitive impairment is considered as a common complication of T2DM. Neuroimaging meta-analysis found brain functional and structural abnormality in patients with T2DM. Therefore, the purpose of the meta-analysis was to identify brain regions of patients with T2DM-related cognitive impairment (T2DM-CI) where functional and structural indicators changed together or could not synchronize. A literature screening of neuroimaging studies on cognitive impairment in T2DM was conducted from 1 January 2007 to 26 May 2023 in PubMed, Web of Science, Cochrane Library, and Medline databases. The functional indicators we studied were amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo) and degree centrality (DC), while the structural indicator was gray matter (GM), which included gray matter volume (GMV) and cerebral cortical thickness. Studies reporting ALFF, ReHo, DC and GM abnormalities between T2DM-CI and healthy controls (HCs) were selected and their significant peak coordinates (x, y, z) and effect size (t-value) were extracted to perform a meta-analysis using anisotropic effect size sign differential mapping (AES-SDM) 5.15 software. Moreover, the brain regions with significant differences obtained from meta-analysis were saved as masks and then validated in our data. Total 19 studies and 20 datasets were involved in this study. Compared to HCs, combining ALFF, ReHo, and DC measurements, the brain activity of the left anterior cingulate/paracingulate gyri (ACC.L, BA24) in T2DM-CI patients increased significantly, while the brain activity of the left lingual gyrus (LING.L, BA18) in T2DM-CI patients decreased significantly. The GM indicator of the right superior temporal gyrus (STG.R, BA42) and left inferior occipital gyrus (IOG.L, BA19) in T2DM-CI patients decreased significantly. Meta-regression analysis showed the negative relationship between the brain activity reduction in LING.L and the percentage of female patients, as well as the negative relationship between GM reduction in IOG.L and T2DM duration. Furthermore, we validated a decrease in brain activity in the LING.L of T2DM-CI patients in our independent dataset. The decrease of brain activity in LING.L and the decrease of GM in IOG.L were closely related to visual impairment in T2DM-CI patients. These abnormal brain regions may be the main targets for future research, early intervention can delay the further development of cognitive impairment in T2DM patients and improve their quality of life, which also provided early biomarkers for clarifying the mechanism of cognitive impairment in T2DM.
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- 2024
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35. Elevated serum direct bilirubin is predictive of a poor prognosis for primary myelodysplastic syndrome
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Ying Chen, Danqing Zhou, Chao Ma, Jie Cao, Qiming Ying, Lixia Sheng, Xiao Yan, Guifang Ouyang, and Qitian Mu
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Myelodysplastic syndromes ,Direct bilirubin ,Prognosis ,IPSS-R ,IPSS-M ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background The aim of this study was to assess the prognostic significance of serum direct bilirubin (DBIL) for patients newly diagnosed with myelodysplastic syndromes (MDS). Methods The clinical, laboratory, and follow-up data of MDS patients were collected, and the associations of DBIL levels with overall survival (OS) and leukemia-free survival (LFS) were analyzed. Result In total, 262 MDS patients were assigned to the high DBIL level group or the normal DBIL level group in the retrospective study. High DBIL was associated with older age, reduced hemoglobin, higher levels of β2-microglobin, lactate dehydrogenase, and serum ferritin, along with the number of co-mutations (> 1) and a higher frequency of ASXL1, KIT, and KRAS mutations. Multivariate analyses found that high DBIL level was an independent adverse predictor for OS (p = 0.002, hazard ratio = 2.723, 95%CI = 1.442–5.143) but not for LFS (p = 0.057, hazard ratio = 1.678, 95%CI = 0.986–2.857). A novel nomogram based on DBIL, sex, age, β2-microglobulin, lactate dehydrogenase, the Revised International Prognostic Scoring System (IPSS-R) was constructed, which demonstrated superior accuracy compared with the IPSS-R (C-index, 0.790 vs. 0.731, respectively). Conclusion An elevated DBIL level was identified as an independent adverse prognostic factor for MDS patients. An individualized prediction model was established and validated to improve prediction of OS and LFS.
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- 2024
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36. Abdominal Pain in Inflammatory Bowel Disease-Epidemiology, Pathophysiology, and Management: A Narrative Review
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Wei-wei Tan, Zi-xuan Liu, Xiao-Yan Liu, Wei-bing Zhang, Lie Zheng, Ya-Li Zhang, and Yan-Cheng Dai
- Subjects
Inflammatory bowel disease ,Crohn’s disease ,Ulcerative colitis ,Abdominal pain ,Pathophysiology ,Management ,Anesthesiology ,RD78.3-87.3 - Abstract
Abstract Abdominal pain is a major symptom of inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, and has a significant impact on patients’ quality of life. Given the evolving understanding of IBD pathology and management strategies, there is an urgent need to review the recent research findings. In this review, we have analyzed the epidemiology, pathophysiology, and management of abdominal pain in IBD over the past decade. We draw on the current literature and highlight emerging trends, challenges, and advances in this field. By synthesizing key findings, this review provides insights into the complex interplay between abdominal pain, disease progression, and therapeutic interventions for IBD.
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- 2024
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37. Estimation bias and serial dependence in speed perception
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Si-Yu Wang, Xiao-Yan Zhang, and Qi Sun
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Speed perception ,Central tendency ,Serial dependence ,Slow-speed bias ,Efficient encoding ,Bayesian decoding ,Psychology ,BF1-990 - Abstract
Abstract Studies have found that feature estimates are systematically compressed towards the distribution center, showing a central tendency. Additionally, the estimate of current features is affected by the previously seen feature, showing serial dependence or adaptation effect. However, these all remain unclear in the speed estimation. To address this question, we asked participants to estimate the speed of moving Gabor patches. In Experiment 1, speeds were selected from three uniform distributions with different lower and upper boundaries (i.e., slow, moderate, and fast ranges). In Experiment 2, speeds were arranged in an increasing, uniform, or decreasing distribution. The boundaries of three distributions were the same. The results found that speed estimates were systematically compressed towards the center of the uniform distribution center, showing a central tendency, and its size increased with the range boundaries. However, in the decreasing and increasing distributions, aside from central tendency, the speed estimates were also showed a bias away from the heavy tail of the distributions. Moreover, there was an attractive serial dependence that was not affected by the speed range. In summary, the current study, along with previous studies that reveal a slow-speed bias, comprehensively reveals various estimation biases in speed perception.
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- 2024
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38. Face super resolution with a high frequency highway
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Dan Zeng, Wen Jiang, Xiao Yan, Weibao Fu, Qiaomu Shen, Raymond Veldhuis, and Bo Tang
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image enhancement ,image processing ,image restoration ,image resolution ,Photography ,TR1-1050 ,Computer software ,QA76.75-76.765 - Abstract
Abstract Face shape priors such as landmarks, heatmaps, and parsing maps are widely used to improve face super resolution (SR). It is observed that face priors provide locations of high‐frequency details in key facial areas such as the eyes and mouth. However, existing methods fail to effectively exploit the high‐frequency information by using the priors as either constraints or inputs. This paper proposes a novel high frequency highway (H2F) framework to better utilize prior information for face SR, which dynamically decomposes the final SR face into a coarse SR face and a high frequency (HF) face. The coarse SR face is reconstructed from a low‐resolution face via a texture branch, using only pixel‐wise reconstruction loss. Meanwhile, the HF face is directly generated from face priors via an HF branch that employs the proposed inception–hourglass model. As a result, H2F allows the face priors to have a direct impact on the SR face by adding the outputs of both branches as the final result and provides an extra face editing function. Extensive experiments show that H2F significantly outperforms state‐of‐the‐art face SR methods, is general for different texture branch models and face priors, and is robust to dataset mismatch and pose variations.
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- 2024
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39. Prediction of allograft function in pre-transplant kidneys using sound touch elastography (STE): an ex vivo study
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Fu-shun Pan, Dao-peng Yang, Guo-dong Zhao, Shu-qi Huang, Yan Wang, Ming Xu, Jiang Qiu, Yan-ling Zheng, Xiao-yan Xie, and Gang Huang
- Subjects
Donor Kidney ,Sound touch elastography ,Allograft function ,Remuzzi score ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Background The purpose of the study was to evaluate renal quality and predict posttransplant graft function using ex vivo sound touch elastography (STE). Methods In this prospective study, 106 donor kidneys underwent ex vivo STE examination and biopsy from March 2022 to August 2023. The mean stiffness of the superficial cortex (STEsc), deep cortex (STEdc), and medulla (STEme) was obtained and synthesized into one index (STE) through the factor analysis method. Additionally, 100 recipients were followed up for 6 months. A random forest algorithm was employed to explore significant predictive factors associated with the Remuzzi score and allograft function. The performance of parameters was evaluated by using the area under the receiver operating characteristic curve (AUC). Results STE had AUC values of 0.803 for diagnosing low Remuzzi and 0.943 for diagnosing high Remuzzi. Meanwhile, STE had an AUC of 0.723 for diagnosing moderate to severe ATI. Random forest algorithm identified STE and Remuzzi score as significant predictors for 6-month renal function. The AUC for STE in predicting postoperative allograft function was 0.717, which was comparable with that of the Remuzzi score (AUC = 0.756). Nevertheless, the specificity of STE was significantly higher than that of Remuzzi (0.913 vs 0.652, p
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- 2024
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40. The learning curve of a dynamic navigation system used in endodontic apical surgery
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Si-Min Liu, Li Peng, Yi-Jiao Zhao, Bing Han, Xiao-Yan Wang, and Zu-Hua Wang
- Subjects
Learning curve ,Dynamic navigation ,Endodontic apical surgery ,Computer-aided design ,Dentistry ,RK1-715 - Abstract
Background/purpose: Quantitative in vitro research was conducted on the learning process of a dynamic navigation system. This study provides guidance for the promotion and application of dynamic navigation technology in the endodontic apical surgery field. Materials and methods: Standardized models were designed and 3D printed to form the approach operation of endodontic apical surgery. 6 clinicians with no experience in dynamic navigation performed the operation. The distance deviation tolerance was set as 0.6 mm, and the angle deviation tolerance was set as 5°. Fifteen mm deep approach operation was completed using dynamic navigation. Each operator performed 10 consecutive exercises on the models. The positioning deviation and operation time of each operator for each practice were recorded. Based on this, the learning curve of the dynamic navigation of every operator was mapped. The learning difficulty of dynamic navigation was evaluated. Results: The learning curves of all operators reached a stable level after the 7th practice, which can ensure that the distance and angle deviations are maintained within the deviation tolerances (0.6 mm, 5°). Conclusion: Operators with no experience in dynamic navigation technology need practice to master dynamic navigation operations. For this navigation system, operators with no operational experience can master dynamic navigation operations after 7 exercises.
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- 2024
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41. Ultrasomics differentiation of malignant and benign focal liver lesions based on contrast-enhanced ultrasound
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Hang-Tong Hu, Ming-De Li, Jian-Chao Zhang, Si-Min Ruan, Shan-Shan Wu, Xin-Xin Lin, Hai-Yu Kang, Xiao-Yan Xie, Ming-De Lu, Ming Kuang, Er-Jiao Xu, and Wei Wang
- Subjects
Focal liver lesion ,Contrast-enhanced ultrasound ,Ultrasomics ,Nomogram ,Medical technology ,R855-855.5 - Abstract
Abstract Objectives To establish a nomogram for differentiating malignant and benign focal liver lesions (FLLs) using ultrasomics features derived from contrast-enhanced ultrasound (CEUS). Methods 527 patients were retrospectively enrolled. On the training cohort, ultrasomics features were extracted from CEUS and b-mode ultrasound (BUS). Automatic feature selection and model development were performed using the Ultrasomics-Platform software, outputting the corresponding ultrasomics scores. A nomogram based on the ultrasomics scores from artery phase (AP), portal venous phase (PVP) and delayed phase (DP) of CEUS, and clinical factors were established. On the validation cohort, the diagnostic performance of the nomogram was assessed and compared with seniorexpert and resident radiologists. Results In the training cohort, the AP, PVP and DP scores exhibited better differential performance than BUS score, with area under the curve (AUC) of 84.1-85.1% compared with the BUS (74.6%, P
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- 2024
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42. Epidemiological characteristics of human rabies cases reported by sites in China from 2006 to 2022
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Jia-Jia Liu, Na Zhang, Shu-Jun Ding, Zeng-Qiang Kou, Xiao-Yan Tao, and Wu-Yang Zhu
- Subjects
Rabies ,Epidemiologic characteristics ,Post-exposure prophylaxis ,Influencing factor ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Rabies is an incessant public health threat in China. The Ministry of Health implemented the Central Payment for Rabies Prevention and Control Project to assist with rabies prevention and control in a few representative provinces in 2006. Methods Data on human rabies cases reported by the National Infectious Disease Reporting Information Management System and national surveillance sites from 2006 to 2022 were collected, and statistical and multivariate analyses were then used to assess the effectiveness of current prevention and control efforts. Results During 2006–2022, a total of 2025 human rabies cases were collected by the national surveillance sites, with incidence rates far above the national average, but the incidence rate was consistent with the national trend. Human rabies cases demonstrated a dual peak distribution in terms of exposure and onset dates, with the peak exposure dates falling mostly in the spring and summer and the peak onset dates occurring mostly in the summer and autumn. Three danger categories are shown by the geographical distribution: high, medium and low. Dogs had a high infection rate (86.93%), with own domesticated dogs accounting for the majority of infections. The rates of post-exposure prophylaxis are not constant. The median incubation period was 71 days. Conclusions Various measures and policies implemented by the government have played a key role in reducing the incidence of rabies. To effectively prevent and control the resurgence of epidemics and halt the spread of the virus among host animals, it is imperative to prioritize and implement a robust dog management system, accelerate research and development of animal vaccines and improve the level of post-exposure prophylaxis.
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- 2024
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43. Impact of ginsenoside Rb1 on gut microbiome and associated changes in pharmacokinetics in rats
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Yue Chen, Kang-xi Zhang, Hui Liu, Yue Zhu, Qing-yun Bu, Shu-xia Song, Ya-chun Li, Hong Zou, Xiao-yan You, and Guo-ping Zhao
- Subjects
Ginsenoside Rb1 ,Pharmacokinetics ,Gut microbiome ,Glycoside hydrolase ,Bacteroides cellulosilyticus ,Medicine ,Science - Abstract
Abstract Ginsenoside Rb1 exhibits a wide range of biological activities, and gut microbiota is considered the main metabolic site for Rb1. However, the impact of gut microbiota on the pharmacokinetics of Rb1 are still uncertain. In this study, we investigated the gut microbiome changes and the pharmacokinetics after a 30 d Rb1 intervention. Results reveal that the systemic exposure and metabolic clearance rate of Rb1 and Rd were substantially affected after orally supplementing Rb1 (60 mg/kg) to rats. Significant increase in the relative abundance of Bacteroides cellulosilyticus in gut microbiota and specific glycoside hydrolase (GH) families, such as GH2, GH92, and GH20 were observed based on microbiome and metagenomic analysis. Moreover, a robust association was identified between the pharmacokinetic parameters of Rb1 and the relative abundance of specific Bacteroides species, and glycoside hydrolase families. Our study demonstrates that Rb1 administration significantly affects the gut microbiome, revealing a complex relationship between B. cellulosilyticus, key GH families, and Rb1 pharmacokinetics.
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- 2024
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44. The correlation between the thyroid function and urinary iodine/creatinine ratio of pregnant women attending a tertiary hospital in Beijing, China, during different trimesters
- Author
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Xiao-Yan Guo and Yan Long
- Subjects
Thyroid function ,Urinary iodine/Creatinine ratio (UI/Cr) ,Pregnant women ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Abstract Objective This study investigated the correlation between thyroid function and urinary iodine/creatinine ratio (UI/Cr) in pregnant women during different trimesters and explored potential influencing factors. Methods In this cross-sectional study, serum levels of thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), and UI/Cr were measured in 450 pregnant women. Correlations were analyzed using Pearson’s correlation coefficient and multiple linear regression. Subgroup analyses were performed based on age, body mass index (BMI), parity, gestational age, education, occupation, and family history of thyroid disorders. Results UI/Cr was positively correlated with FT4 levels in the first and second trimesters, particularly in women with older age, higher BMI, multiparity, higher education, and employment. No significant correlations were found between UI/Cr and TSH or FT3 levels. Conclusion UI/Cr is positively correlated with FT4 levels in early pregnancy, especially in women with certain risk factors. Regular monitoring of iodine status and thyroid function is recommended for pregnant women to ensure optimal maternal and fetal health.
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- 2024
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45. Bilateral choroidal ganglioneuroma: a comprehensive analysis of vision decline in a 6-year-old boy
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Yi-Zhe Cheng, Li-Mei Sun, Min-Er Yuan, Lin-Yan Zhang, Shu-Ya Ke, and Xiao-Yan Ding
- Subjects
Ophthalmology ,RE1-994 - Published
- 2024
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46. Leucine zipper protein 1 attenuates pressure overload-induced cardiac hypertrophy through inhibiting Stat3 signaling
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Di Fan, Wan-li Jiang, Zhi-li Jin, Jian-lei Cao, Yi Li, Tao He, Wei Zhang, Li Peng, Hui-xia Liu, Xiao-yan Wu, Ming Chen, Yong-zhen Fan, Bo He, Wen-xi Yu, Hai-rong Wang, Xiao-rong Hu, and Zhi-bing Lu
- Subjects
Cardiac hypertrophy ,Fibrosis ,LUZP1 ,SHP1 ,Stat3 ,Medicine (General) ,R5-920 ,Science (General) ,Q1-390 - Abstract
Introduction: Cardiac hypertrophy is an important contributor of heart failure, and the mechanisms remain unclear. Leucine zipper protein 1 (LUZP1) is essential for the development and function of cardiovascular system; however, its role in cardiac hypertrophy is elusive. Objectives: This study aims to investigate the molecular basis of LUZP1 in cardiac hypertrophy and to provide a rational therapeutic approach. Methods: Cardiac-specific Luzp1 knockout (cKO) and transgenic mice were established, and transverse aortic constriction (TAC) was used to induce pressure overload-induced cardiac hypertrophy. The possible molecular basis of LUZP1 in regulating cardiac hypertrophy was determined by transcriptome analysis. Neonatal rat cardiomyocytes were cultured to elucidate the role and mechanism of LUZP1 in vitro. Results: LUZP1 expression was progressively increased in hypertrophic hearts after TAC surgery. Gain- and loss-of-function methods revealed that cardiac-specific LUZP1 deficiency aggravated, while cardiac-specific LUZP1 overexpression attenuated pressure overload-elicited hypertrophic growth and cardiac dysfunction in vivo and in vitro. Mechanistically, the transcriptome data identified Stat3 pathway as a key downstream target of LUZP1 in regulating pathological cardiac hypertrophy. Cardiac-specific Stat3 deletion abolished the pro-hypertrophic role in LUZP1 cKO mice after TAC surgery. Further findings suggested that LUZP1 elevated the expression of Src homology region 2 domain-containing phosphatase 1 (SHP1) to inactivate Stat3 pathway, and SHP1 silence blocked the anti-hypertrophic effects of LUZP1 in vivo and in vitro. Conclusion: We demonstrate that LUZP1 attenuates pressure overload-induced cardiac hypertrophy through inhibiting Stat3 signaling, and targeting LUZP1 may develop novel approaches to treat pathological cardiac hypertrophy.
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- 2024
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47. Research progress, application and development of high performance 6000 series aluminum alloys for new energy vehicles
- Author
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Yi-Cheng Gao, Bai-Xin Dong, Hong-Yu Yang, Xiao-Yan Yao, Shi-Li Shu, Jie Kang, Jia Meng, Chang-Jie Luo, Cheng-Gang Wang, Kuang Cao, Jian Qiao, Ming Zhu, Feng Qiu, and Qi-Chuan Jiang
- Subjects
Al-Mg-Si alloy ,Alloying ,Microstructure ,Particle enhancement ,Mining engineering. Metallurgy ,TN1-997 - Abstract
For the development of new energy automobile industry and the trend of automobile lightweight have put forward a huge demand for high-strength lightweight materials, so developing high strength aluminum alloys is particularly momentous. As the most widely used aluminum alloy, 6000 series aluminum alloys (Al–Mg–Si alloys) have the advantages such as better mechanical properties, outstanding welding properties, excellent formability and fine processing capability, and therefore have obtained great attention as the structural materials. In addition, the Al–Mg–Si alloys with low density and corrosion resistance not only reduce the total weight of the car, but also extend the service life when subjected to chemical corrosion, which effectively achieve energy saving and emission reduction. This paper summarizes the research progress of 6000 series aluminum alloys, in particular, and reviews the methods of microalloying and particle strengthening, and their effects on the microstructure and properties of the alloy, thus providing a reference for the subsequent development of high-performance aluminum alloys in automobile and aerospace industries.
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- 2024
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48. Supplier selection of complex equipment in a military-civilian collaborative two-tier supply network with uncertain preference: A matching perspective
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Xin Huang, Xiao-yan Qi, Wei-ming Wang, Qiu-xiang Li, and Hui-yan He
- Subjects
Two-stage game ,Complex equipment ,Collaborative development ,Entropy-group-DEMATEL analysis ,Military-civilian integration ,Bonferroni mean operator ,Industrial engineering. Management engineering ,T55.4-60.8 - Abstract
Complex equipment refers to special equipment that differs from general equipment. The collaborative development work of complex equipment in the military-civilian integration context involves numerous suppliers. We consider a two-tier supply network composed of different suppliers that participate in the development work to assemble complex equipment that cooperate with a main-manufacturer regarding spare parts. However, in terms of spare parts, a substitution relationship exists in assembly work for complex equipment. Hence, selecting a suitable supplier from the matching process between suppliers and spare parts under a military-civilian integration background is essential. This study considers three main analyses to obtain a suitable supplier for the development work of complex equipment. First, we construct a two-stage model to acquire the necessary evaluation dimension for subsequent processes. Second, we examine the evaluated attributes for the matching process based on entropy-group-DEMATEL analysis. Third, we perform information aggregation for the uncertain preference information between spare parts and suppliers using a Bonferroni mean operator. Finally, an illustrative example is presented to demonstrate the whole efficiency. Through the aforementioned analysis, we can select a suitable supplier that could participate in complex equipment military-civilian collaborative development work.
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- 2024
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49. Nucleic acid prevalence of zoonotic babesia in humans, animals and questing ticks, a systematic review and meta-analysis
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Yao, Xiao-Yan, Yu, Shao-Qi, Tian, Na, Wang, Fei, Li, Shi-Zhu, and Li, Lan-Hua
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- 2023
50. Delay Update in determinant quantum Monte Carlo
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Sun, Fanjie and Xu, Xiao Yan
- Subjects
Condensed Matter - Strongly Correlated Electrons - Abstract
Determinant quantum Monte Carlo (DQMC) is a widely used unbiased numerical method for simulating strongly correlated electron systems. However, the update process in DQMC is often a bottleneck for its efficiency. To address this issue, we propose a generalized delay update scheme that can handle both onsite and extended interactions. Our delay update scheme can be implemented in both zero-temperature and finite-temperature versions of DQMC. We apply the delay update scheme to various strongly correlated electron models and evaluate its efficiency under different conditions. Our results demonstrate that the proposed delay update scheme significantly improves the efficiency of DQMC simulations, enable it to simulate larger system size., Comment: 12 pages, 7 figures
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- 2023
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