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32 results on '"Wiesel, Ory"'

2. Utility and reproducibility of 3‐dimensional printed models in pre‐operative planning of complex thoracic tumors

Author

George, Elizabeth, Barile, Maria, Tang, Anji, Wiesel, Ory, Coppolino, Antonio, Giannopoulos, Andreas, Mentzer, Steven, Jaklitsch, Michael, Hunsaker, Andetta, and Mitsouras, Dimitrios

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Cancer, Bioengineering, Biomedical Imaging, Good Health and Well Being, Adenocarcinoma, Adult, Aged, Female, Humans, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Male, Models, Anatomic, Printing, Three-Dimensional, Reproducibility of Results, Sarcoma, Thoracic Neoplasms, 3D printing, chest wall invasion, mediastinal invasion, superior sulcus tumor, thoracic oncology, thoracic surgery, Oncology and Carcinogenesis, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Background and objectives3D-printed models are increasingly used for surgical planning. We assessed the utility, accuracy, and reproducibility of 3D printing to assist visualization of complex thoracic tumors for surgical planning.MethodsModels were created from pre-operative images for three patients using a standard radiology 3D workstation. Operating surgeons assessed model utility using the Gillespie scale (1 = inferior to 4 = superior), and accuracy compared to intraoperative findings. Model variability was assessed for one patient for whom two models were created independently. The models were compared subjectively by surgeons and quantitatively based on overlap of depicted tissues, and differences in tumor volume and proximity to tissues.ResultsModels were superior to imaging and 3D visualization for surgical planning (mean score = 3.4), particularly for determining surgical approach (score = 4) and resectability (score = 3.7). Model accuracy was good to excellent. In the two models created for one patient, tissue volumes overlapped by >86.5%, and tumor volume and area of tissues ≤1 mm to the tumor differed by

Published
2017

4. Real-World Clinical Outcomes of Neoadjuvant Platinum-Based Chemotherapy with Nivolumab in Non-Small Cell Lung Cancer.

Author

Shalata, Walid, Daher, Sameh, Maimon Rabinovitch, Natali, Shamai, Sivan, Kian, Waleed, Turgeman, Ilit, Dudnik, Yulia, Kazareen, Olga, Rovitsky, Yulia, Sabo, Edmond, Faber, Dan Levy, Galili, Ronen, Wiesel, Ory, Baranovsky, Konstantin, and Agbarya, Abed

Subjects
NON-small-cell lung carcinoma, IMMUNE checkpoint inhibitors, NEOADJUVANT chemotherapy, TREATMENT effectiveness, LUNG cancer
Abstract

Background: Lung cancer is among the most prevalent and serious forms of cancer, characterized by an allogenic phenotype that presents significant therapeutic challenges. Materials and Methods: We analyzed medical records from January 2022 to August 2023, focusing on individuals aged 18 and older diagnosed with resectable NSCLC who received neoadjuvant chemo-immunotherapy prior to surgical intervention. Results: The cohort comprised 56 patients, predominantly smokers (95%) and male (74%), with 80% presenting the disease at stage III. Of the participants, 44 underwent surgery, with 95% receiving lobar resection. Clinical assessments via PET-CT imaging revealed an 86% rate of response or disease stabilization, while pathological evaluations showed complete and major pathological responses in 61% of cases. Conclusions: This real-world data supports the safety and efficacy of incorporating immune checkpoint inhibitors in the neoadjuvant treatment of NSCLC, followed by surgical resection. [ABSTRACT FROM AUTHOR]

Published
2024
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5. The Potential Benefit of a Novel Urine Biosensor Platform for Lung Cancer Detection in the Decision-Making Process: From the Bench to the Bedside.

Author

Wiesel, Ory, Suharev, Tatiyana, Awad, Alaa, Abzah, Lina, Laser-Azogui, Adi, and Mark Danieli, Michal

Subjects
*LUNG cancer, *PATIENT compliance, *EARLY detection of cancer, *CANCER-related mortality, *VOLATILE organic compounds
Abstract

Background: Lung cancer is the leading cause of cancer-related mortality worldwide. Lung cancer screening and early detection resulted in a decrease in cancer-specific mortality; however, it introduced additional dilemmas and adherence barriers for patients and providers. Methods: Innovations such as biomolecular diagnosis and biosensor-based technology improve the detection and stratification of high-risk patients and might assist in overcoming adherence barriers, hence providing new horizons for better selection of screened populations. Conclusions: In the present manuscript, we discuss some of the dilemmas clinicians are currently facing during the diagnosis and treatment processes. We further highlight the potential benefits of a novel biosensor platform for lung cancer detection during the decision making process surrounding lung cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Extended cervical approach for retrosternal multinodular goiter

Author

Tsur, Nir, primary, Levi, Lirit, additional, Frig, Omry, additional, Koch, Noam, additional, Eshel, Yossi, additional, Bachar, Gideon, additional, Shpitzer, Thomas, additional, Yehuda, Moshe, additional, Pescovitz, Yuri, additional, Wiesel, Ory, additional, Dudkiewicz, Dean, additional, and Mizrachi, Aviram, additional

Published
2024
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15. A multicenter single-arm trial of sintilimab in combination with chemotherapy for neoadjuvant treatment of resectable esophageal cancer (SIN-ICE study)

Author

Duan, Hongtao, primary, Wang, Tianhu, additional, Luo, Zhilin, additional, Wang, Xiaoyuan, additional, Liu, Honggang, additional, Tong, Liping, additional, Dong, Xiaoping, additional, Zhang, Yong, additional, Valmasoni, Michele, additional, Kidane, Biniam, additional, Almhanna, Khaldoun, additional, Wiesel, Ory, additional, Pang, Sainan, additional, Ma, Jianqun, additional, and Yan, Xiaolong, additional

Published
2021
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16. Assessing the development status of intraoperative fluorescence imaging for perfusion assessments, using the IDEAL framework

Author

Ishizawa, Takeaki, primary, McCulloch, Peter, additional, Muehrcke, Derek, additional, Carus, Thomas, additional, Wiesel, Ory, additional, Dapri, Giovanni, additional, Schneider-Koriath, Sylke, additional, Wexner, Steven D, additional, Abu-Gazala, Mahmoud, additional, Boni, Luigi, additional, Cassinotti, Elisa, additional, Sabbagh, Charles, additional, Cahill, Ronan, additional, Ris, Frederic, additional, Carvello, Michele, additional, Spinelli, Antonino, additional, Vibert, Eric, additional, Terasawa, Muga, additional, Takao, Mikiya, additional, Hasegawa, Kiyoshi, additional, Schols, Rutger M, additional, Pruimboom, Tim, additional, Murai, Yasuo, additional, Matano, Fumihiro, additional, Bouvet, Michael, additional, Diana, Michele, additional, Kokudo, Norihiro, additional, Dip, Fernando, additional, White, Kevin, additional, and Rosenthal, Raul J, additional

Published
2021
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17. Assessing the development status of intraoperative fluorescence imaging for perfusion assessments, using the IDEAL framework

Author

Ishizawa, Takeaki, McCulloch, Peter, Muehrcke, Derek, Carus, Thomas, Wiesel, Ory, Dapri, Giovanni, Schneider-Koriath, Sylke, Wexner, Steven S.D., Abu-Gazala, Mahmoud, Boni, Luigi, Cassinotti, Elisa, Sabbagh, Charles, Cahill, Ronan, Ris, Frederic, Carvello, Michele, Spinelli, Antonino, Vibert, Eric, Terasawa, Muga, Takao, Mikiya, Hasegawa, Kiyoshi, Schols, Rutger Merlijn, Pruimboom, Tim, Murai, Yasuo, Matano, Fumihiro, Bouvet, Michael, Diana, Michele, Kokudo, Norihiro, Dip, Fernando, White, Kevin, Rosenthal, Raúl Jacobo, Ishizawa, Takeaki, McCulloch, Peter, Muehrcke, Derek, Carus, Thomas, Wiesel, Ory, Dapri, Giovanni, Schneider-Koriath, Sylke, Wexner, Steven S.D., Abu-Gazala, Mahmoud, Boni, Luigi, Cassinotti, Elisa, Sabbagh, Charles, Cahill, Ronan, Ris, Frederic, Carvello, Michele, Spinelli, Antonino, Vibert, Eric, Terasawa, Muga, Takao, Mikiya, Hasegawa, Kiyoshi, Schols, Rutger Merlijn, Pruimboom, Tim, Murai, Yasuo, Matano, Fumihiro, Bouvet, Michael, Diana, Michele, Kokudo, Norihiro, Dip, Fernando, White, Kevin, and Rosenthal, Raúl Jacobo

Abstract

Intraoperative fluorescence imaging is currently used in a variety of surgical fields for four main purposes: assessing tissue perfusion; identifying/localizing cancer; mapping lymphatic systems; and visualizing anatomy. To establish evidence-based guidance for research and practice, understanding the state of research on fluorescence imaging in different surgical fields is needed. We evaluated the evidence on fluorescence imaging for perfusion assessments using the Idea, Development,Exploration, Assessment, Long Term Study (IDEAL) framework, which was designed for describing the stages of innovation in surgery and other interventional procedures. Narrative literature review with analysis of IDEAL stage of each field of study. All publications on intraoperative fluorescence imaging for perfusion assessments reported in PubMed through 2019 were identified for six surgical procedures: coronary artery bypass grafting (CABG), upper gastrointestinal (GI) surgery, colorectal surgery, solid organ transplantation, reconstructive surgery, and cerebral aneurysm surgery. The IDEAL stage of research evidence was determined for each specialty field using a previously described approach. 196 articles (15 003 cases) were selected for analysis. Current status of research evidence was determined to be IDEAL Stage 2a for upper GI and transplantation surgery, IDEAL 2b for CABG, colorectal and cerebral aneurysm surgery, and IDEAL Stage 3 for reconstructive surgery. Using the technique resulted in a high (up to 50%) rate of revisions among surgical procedures, but its efficacy improving postoperative outcomes has not yet been demonstrated by randomized controlled trials in any discipline. Only one possible adverse reaction to intravenous indocyanine green was reported. Using fluorescence imaging intraoperatively to assess perfusion is feasible and appears useful for surgical decision making across a range of disciplines. Identifying the IDEAL stage of current research knowledge aids in, SCOPUS: ar.j, DecretOANoAutActif, info:eu-repo/semantics/published

Published
2021

31. Esophageal surgery in the 21 st century.

Author

Wiesel O

Abstract

Competing Interests: Conflicts of Interest: The author has completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/atm-20-6642). The series “Innovations and Updates in Esophageal Surgery” was commissioned by the editorial office without any funding or sponsorship. OW served as the unpaid Guest Editor of the series and serves as an unpaid editorial board member of Annals of Translational Medicine from Oct 2019 to Sep 2021. The author has no other conflicts of interest to declare.

Published
2021
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