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1. Longitudinal effects of SARS-CoV-2 breakthrough infection on imprinting of neutralizing antibody responses

Author

Messmann, Helmut, Fuchs, Andre, Ebigbo, Alanna, Römmele, Christoph, Ullrich, Maximilian, Freitag, Marie, Traidl-Hoffmann, Claudia, Goekkaya, Mehmet, Metz, Aline, Holetschek, Corinna, Neumann, Avidan, Hoffmann, Reinhard, Kling, Elisabeth, Pruteanu, Mihail, Wibmer, Thomas, Rost, Susanne, Überla, Klaus, Steininger, Philipp, Wytopil, Monika, Beileke, Stephanie, Müller-Schmucker, Sandra, Korn, Klaus, Hastreiter, Tamara, Fraedrich, Kirsten, Obergfäll, Debora, Neumann, Frank, Kuhn, Claudia, Günther, Katja, Friedrich, Elke, Hoelscher, Michael, Wieser, Andreas, Geldmacher, Christof, Janke, Christian, Plank, Michael, Guggenbühl, Jessica, Reinkemeyer, Christina, Noreña, Ivan, Castelletti, Noemi, Acero, Raquel Rubio, Ahmed, M.I.M., Diepers, Paulina, Eser, Tabea M., Fuchs, Anna, Baranov, Olga, Bauer, Bernadette, Wang, Danni, Paunovic, Ivana, Protzer, Ulrike, Jeske, Samuel D., Christa, Catharina, Tinnefeld, Kathrin, Vu, Martin, Willmann, Annika, Roggendorf, Hedwig, Körber, Nina, Bauer, Tanja, Gleich, Sabine, Wagner, Ralf, Asam, Claudia, Einhauser, Sebastian, Weps, Manuela, Senninger, Antonia, Carnell, George, Heeney, Jonathan Luke, Ebner, Antonia, José de Schultz, Maria, Rajes, Cedric, Al Wafai, Aya, Brenner, David, Sicheneder, Laura, Berr, Melanie, Schütz, Anja, Bauernfeind, Stilla, Hiergeist, Andreas, Gessner, André, Schmidt, Barbara, Niller, Hans-Helmut, Wenzel, Jürgen, Biermeier, Daniela, Lampl, Benedikt, Rothe, Ulrich, Gleißner, Ute, Brückner, Susanne, Treml, Michaela, Schedl, Holger, Biermaier, Beate, Achatz, Markus, Hierhammer, Daniela, Englhardt, Johanna, Scheidl, Werner, Jeyaraman, Sivaji, Schutt, Barbara, Liese, Johannes, Prelog, Martina, Almanzar, Giovanni, Schwägerl, Valeria, Bley, Julia, Vogt, Tim, Kousha, Kimia, Ziegler, Lars, Stein, Astrid, Förg, Franziska, Löw, Johann, Finkenberg, Barbara, Pollak, Dennis, Zamzow, Alexander, Eberbach, Nicole, Balkie, Lara, Kretzschmann, Tanja, Gehrig, Matthias, Bandorf, Matthias, Keck, Kilian, Allmanritter, Jan, Rafique, Shahid, Finster, Mona, Baumgart, Ingo, Heumüller-Klug, Sabine, Koglin, Hans-Jürgen, Gefeller, Olaf, Gall, Christine, Pfahlberg, Annette B., Kaiser, Isabelle, Scheidt, Jörg, Drescher, Johannes, Siebenhaar, Yannic, Wogenstein, Florian, Reinel, Dirk, Weber, Beatrix, Zarzitzky, Fabian, Liebl, Bernhard, Herr, Caroline, Katz, Katharina, Sing, Andreas, Dangel, Alexandra, Peterhoff, David, Asbach, Benedikt, Carnell, George William, and Fuchs, André

Published
2024
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6. Histology as a potential clinical predictor of outcome in advanced non-small-cell lung cancer treated with vinorelbine and mitomycin combination chemotherapy.

Author

Wibmer, Thomas, Berghmans, Thierry, Kropf-Sanchen, Cornelia, Lafitte, Jean-Jacques, Rüdiger, Stefan, Paesmans, Marianne, Blanta, I, Scherpereel, Arnaud, Stoiber, Kathrin M, Rottbauer, Wolfgang, Sculier, Jean-Paul, Schumann, Christian, Wibmer, Thomas, Berghmans, Thierry, Kropf-Sanchen, Cornelia, Lafitte, Jean-Jacques, Rüdiger, Stefan, Paesmans, Marianne, Blanta, I, Scherpereel, Arnaud, Stoiber, Kathrin M, Rottbauer, Wolfgang, Sculier, Jean-Paul, and Schumann, Christian

Abstract

The importance of clinical predictors in the treatment of non-small-cell lung cancer (NSCLC) has increased during the last decade. This retrospective study analyzed the combined patient-level data from two phase II trials that investigated the efficacy and safety of combination chemotherapy with vinorelbine and mitomycin in patients with locally advanced or metastatic NSCLC. The aim of this analysis was to determine if patients' baseline and disease characteristics, including histology, gender, smoking history, and expression of TTF-1, might be potential predictors of outcome., Journal Article, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2013

7. Histology as a potentil clinical prdictor of outcome in advanced non-small cell lung cancer treated with vinorelbine and mitomycin combination chemotherapy.

Author

Wibmer, Thomas, Berghmans, Thierry, Kropf, C, Lafitte, Jean-Jacques, Stoiber, KM, Paesmans, Marianne, Ruediger, S, Scherpereel, Arnaud, Blanta, I, Rottbauer, W, Sculier, Jean-Paul, Schumann, C, Wibmer, Thomas, Berghmans, Thierry, Kropf, C, Lafitte, Jean-Jacques, Stoiber, KM, Paesmans, Marianne, Ruediger, S, Scherpereel, Arnaud, Blanta, I, Rottbauer, W, Sculier, Jean-Paul, and Schumann, C

Abstract

info:eu-repo/semantics/published

Published
2012

9. Effects of Nasal Positive Expiratory Pressure on Dynamic Hyperinflation and 6-Minute Walk Test in Patients With COPD.

Author

Wibmer, Thomas, Rüdiger, Stefan, Heitner, Claudia, Kropf-Sanchen, Cornelia, Blanta, Ioanna, Stoiber, Kathrin M, Rottbauer, Wolfgang, and Schumann, Christian

Subjects
ARTIFICIAL respiration, OBSTRUCTIVE lung diseases, PLETHYSMOGRAPHY, SPIROMETRY, STATISTICAL hypothesis testing, T-test (Statistics), POSITIVE pressure ventilation, DATA analysis software, DESCRIPTIVE statistics
Abstract

INTRODUCTION: Dynamic hyperinflation is an important target in the treatment of COPD. There is increasing evidence that positive expiratory pressure (PEP) could reduce dynamic hyperinflation during exercise. PEP application through a nasal mask and a flow resistance device might have the potential to be used during daily physical activities as an auxiliary strategy of ventilatory assistance. The aim of this study was to determine the effects of nasal PEP on lung volumes during physical exercise in patients with COPD. METHODS: Twenty subjects (mean ± SD age 69.4 ± 6.4 years) with stable mild-to-severe COPD were randomized to undergo physical exercise with nasal PEP breathing, followed by physical exercise with habitual breathing, or vice versa. Physical exercise was induced by a standard 6-min walk test (6MWT) protocol. PEP was applied by means of a silicone nasal mask loaded with a fixed-orifice flow resistor. Body plethysmography was performed immediately pre-exercise and post-exercise. RESULTS: Differences in mean pre- to post-exercise changes in total lung capacity (_0.63 ± 0.80 L, P = .002), functional residual capacity (-0.48 ± 0.86 L, P = .021), residual volume (-0.56± 0.75 L, P = .004), SpO2 (-1.7 ± 3.4%, P = .041), and 6MWT distance (-30.8 ± 30.0 m, P = .001) were ±tatistically significant between the experimental and the control interventions. CONCLUSIONS: The use of flow-dependent expiratory pressure, applied with a nasal mask and a PEP device, might promote significant reduction of dynamic hyperinflation during walking exercise. Further studies are warranted addressing improvements in endurance performance under regular application of nasal PEP during physical activities. [ABSTRACT FROM AUTHOR]

Published
2014
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