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8. Calculated Shoulder to Gauge Ratio of Fatigue Specimens in PWR Environment

Author

Simonovski, Igor, primary, Mclennan, Alec, additional, Mottershead, Kevin, additional, Gill, Peter, additional, Platts, Norman, additional, Bruchhausen, Matthias, additional, Waters, Joshua L., additional, Vankeerberghen, Marc, additional, Moreno, Germán Barrera, additional, Gomez, Sergio Arrieta, additional, and Novotny, Radek, additional

Published
2021
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12. ALCOHOL INDUCES LIVER NEOPLASIA IN A NOVEL ALCOHOL-PREFERRING RAT MODEL

Author

Yip-Schneider, Michele T., Doyle, Courtney J., McKillop, Iain H., Wentz, Sabrina C., Brandon-Warner, Elizabeth, Matos, Jesus M., Sandrasegaran, Kumaresan, Saxena, Romil, Hennig, Matthew E., Wu, Huangbing, Waters, Joshua A., Klein, Patrick J., Froehlich, Janice C., and Schmidt, C. Max

Subjects
Male, Oxidative Stress, Carcinoma, Hepatocellular, Alcohol Drinking, Ethanol, Liver Neoplasms, Models, Animal, Animals, Cytochrome P-450 CYP2E1, Mitogen-Activated Protein Kinases, Article, Rats
Abstract

Alcohol is a significant risk factor for the development of hepatocellular carcinoma (HCC). To date, no rodent model has demonstrated the formation of hepatic neoplasia in the setting of chronic alcohol consumption alone.We investigated whether rats selectively bred for high alcohol preference (P rats), allowed free access to water, or water and 10% (v/v) alcohol, for 6, 12, or 18 months, develop hepatic neoplasia.At necropsy, liver tumor incidence and multiplicity were significantly increased in 18-month alcohol-consuming versus water-consuming P rats. These data were confirmed histologically by glutathione-S-transferase pi-class (GSTp) staining. Phosphorylated mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 (MAPK/ERK) staining was also increased in the sinusoidal lining cells within livers of alcohol-consuming versus water only P rats. In addition, cytochrome p450IIE1 (CYP2E1) mRNA, protein expression/activity, and intrahepatic oxidative stress were significantly increased in alcohol-consuming P rat livers versus water only. In contrast, acetaldehyde dehydrogenase expression decreased in alcohol-consuming versus water only P rats. No significant difference in alcohol dehydrogenase expression was detected.These data demonstrate that chronic alcohol consumption is associated with hepatic neoplasia, MAPK/ERK activation, increased CYP2E1 activity, and intrahepatic oxidative stress in P rats. As these rats are well characterized as a model of alcoholism, these findings identify a novel rodent model of alcohol or "alcoholism"-induced liver neoplasia.

Published
2011

13. Developing elite Neurospora crassa strains for cellulosic ethanol production using fungal breeding.

Author

Lee, Kwangwon, Waters, Joshua, Dwyer, Morgan, Nixon, Andrew, and Biffinger, Justin

Subjects
*NEUROSPORA crassa, *FUNGAL cultures, *CELLULOSIC ethanol, *CELLULASE, *FUNGAL variation, *FERMENTATION, *BREEDING
Abstract

The demand for renewable and sustainable energy has generated considerable interest in the conversion of cellulosic biomass into liquid fuels such as ethanol using a filamentous fungus. While attempts have been made to study cellulose metabolism through the use of knock-out mutants, there have been no systematic effort to characterize natural variation for cellulose metabolism in ecotypes adapted to different habitats. Here, we characterized natural variation in saccharification of cellulose and fermentation in 73 ecotypes and 89 laboratory strains of the model fungus Neurospora crassa. We observed significant variation in both traits among natural and laboratory generated populations, with some elite strains performing better than the reference strain. In the F1 population N345, 15% of the population outperformed both parents with the top performing strain having 10% improvement in ethanol production. These results suggest that natural alleles can be exploited through fungal breeding for developing elite industrial strains for bioethanol production. [ABSTRACT FROM AUTHOR]

Published
2017
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14. 910 Does Preoperative Imaging Accurately Predict Main Duct Involvement in Intraductal Papillary Mucinous Neoplasm

Author

Barron, Morgan R., primary, Waters, Joshua A., additional, Parikh, Janak A., additional, DeWitt, John, additional, Al-Haddad, Mohammad A., additional, Ceppa, Eugene P., additional, House, Michael G., additional, Zyromski, Nicholas J., additional, Nakeeb, Attila, additional, Pitt, Henry A., additional, and Schmidt, C. Max, additional

Published
2013
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15. Mo1457 Self-Expandable Metallic Stents Do Not Impact on the Frequency of Complications Related to Preoperative Biliary Drainage or Subsequent Pancreatoduodenectomy

Author

Leung, Wesley D., primary, Cote, Gregory A., additional, Tan, Damien M., additional, Waters, Joshua A., additional, Schmidt, C. Max, additional, Sherman, Stuart, additional, Lehman, Glen A., additional, Fogel, Evan L., additional, Watkins, James L., additional, McHenry, Lee, additional, and House, Michael G., additional

Published
2012
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19. Complications of Endoscopic Preoperative Biliary Drainage (PBD) for Pancreatic Cancer: A Tertiary Hospital Experience

Author

Tan, Damien M., primary, Singh, Sanjeev, additional, Waters, Joshua A., additional, Sherman, Stuart, additional, McHenry, Lee, additional, Lehman, Glen A., additional, Fogel, Evan L., additional, Schmidt, C. Max, additional, Lillemoe, Keith D., additional, House, Michael G., additional, Watkins, James L., additional, and Cote, Gregory A., additional

Published
2011
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23. Intraductal Papillary Mucinous Neoplasms

Author

Schmidt, C Max, primary, White, Patrick B., additional, Waters, Joshua A., additional, Yiannoutsos, Constantin T., additional, Cummings, Oscar W., additional, Baker, Marshall, additional, Howard, Thomas J., additional, Zyromski, Nicholas J., additional, Nakeeb, Atilla, additional, DeWitt, John M., additional, Akisik, Fatih M., additional, Sherman, Stuart, additional, Pitt, Henry A., additional, and Lillemoe, Keith D., additional

Published
2007
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24. Trousseau Syndrome in a 25-YearOld Woman with Occult Colon Malignancy, Lynch Syndrome, and Chronic Thromboembolic Pulmonary Hypertension.

Author

Matthews, Caleb R., Madison, Mackenzie, Chen Zhang, Waters, Joshua, Garcia, Jose P., and Beckman, Daniel

Abstract

We present a rare case of thrombosis associated with an occult colon malignancy (Trousseau syndrome) in a 25-year-old woman who also presented with previously unidentified Lynch syndrome and acute-on-chronic thromboembolic pulmonary hypertension. Staged treatment included bilateral pulmonary endarterectomy under deep hypothermic circulatory arrest, followed 11 days later by laparoscopic subtotal colectomy and creation of a primary anastomosis. The patient tolerated both procedures well and recovered normal functional status. Final pathologic analysis of the resected colon mass revealed a pT3N0, stage IIA adenocarcinoma; no adjuvant therapy was administered. At her one-year follow-up visit, the patient was cancer-free, remained on lifelong apixaban anticoagulation, and was undergoing routine monitoring and genetic counseling. This case highlights the need for multidisciplinary management of a patient with severe chronic thromboembolic pulmonary hypertension and a concomitant malignancy [ABSTRACT FROM AUTHOR]

Published
2022
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