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Additional file 1: Figure S1. Flowchart of the selection process of eligible participants. Table S1. Sensitivity analysis of some missing variables before and after filling. Table S2. Clinical and demographic characteristics of patients with renal function impairment of different sexes. Figure S2. Subgroup analysis for the risk of eGFR

Additional file 1: Table S1. COVID-19 daily reported cases and response policies by local government. Table S2. Variable definitions and parameter values. Table S3. PHMS-Index calculation. Table S4. Intervention simulation corresponding parameters. Table S5. Parameter estimation of actual spillover rate and spillover threshold. Table S6. Rt and PHMS-Index values at different stages. Table S7. Mean, standard deviation, Person correlation coefficient of Rt and PHSM_Index. Table S8. Simulation of different mask wear rates in 4 cities. Table S9. Simulation of different social distances in 4 cities. Table S10. Simulation of different social distances and mask wear rates in 4 cities. Table S11. Simulation of different isolation ratios in 4 cities. Table S12. Simulation of different combinations of mask wear, social distance rates and isolation rates in 4 cities. Table S13. Spillover risk values at different stages. Fig. S1. Biological invasion theory framework. (a: Date of reporting of the first case; b: The time when the third-generation cases appeared, that is, a + 6 days; c, d: According to the PTA methods, the case time series data of points 0-H are calculated in segments.). Fig. S2. SEIAR model with booster vaccination intervention. Fig. S3. The stock flow diagram of the system dynamic model for COVID-19. (The intervention strategies are represented by causal variables shown in red color. Other causal variables, are shown in parameter tables.). Fig. S4. Geographical distribution of the study area and importation of cases into other Chinese cities from study areas (Study areas include Shanghai, Shenzhen, Nanjing, and Suzhou. The red line shows the direction of spillover.). Fig. S5. Five stages of the epidemic curve based on the theory of biological invasion in Shanghai (Spread: Landscape spread). Fig. S6. Five stages of the epidemic curve based on the theory of biological invasion in Shenzhen (Spread: Landscape spread). Fig. S7. Five stages of the epidemic curve based on the theory of biological invasion in Nanjing (Spread: Landscape spread). Fig. S8. Five stages of the epidemic curve based on the theory of biological invasion in Suzhou (spread: landscape spread). Fig. S9. Simulation of different mask wear rates in 4 cities (a total of 10 mask wear rates were simulated, ranging from 90 to 0%.). Fig. S10. Simulation of different social distances in 4 cities (a total of 10 social distances were simulated, ranging from 90 to 0%.). Fig. S11. Simulation of different isolation ratios in 4 cities (a total of 26 segregation ratios were modelled, ranging from 80 to 10%.). Fig. S12. Simulation of different combinations of mask wear and social distance rates in 4 cities (a total of 56 possible real-world combinations of masks + social distance measures are simulated.). Fig. S13. Simulation of comprehensive interventions in 4 cities (a total of 100 possible real- world integrated interventions are simulated.). Fig. S14. Map of spillover city top 30 ranking of each city.

Background: Atrial fibrillation (AF) is one of the most common cardiac arrhythmias and can lead to heart failure(HF), stroke, pulmonary embolism(PE) and other complications, seriously affecting people's quality of life and health.Western medicine is limited in the treatment of AF, while Traditional Chinese Medicine(TCM) has unique advantages, such as low side effects, low toxicity, long effect duration and high compliance.Huatan Dingji Decoction(HTDJ) is commonly used in the treatment of AF in our hospital, and its clinical efficacy is confirmed, but a comprehensive evaluation of the clinical efficacy is currently lacking. Method: This study adopts a randomized double-blind, single-simulated, placebo-controlled research method. Participants were randomly assigned in a 1:1 ratio through a centrally controlled, computer-generated, simple randomization schedule. Participants would take the medicine for one month and the curative effect would be evaluated. Subsequently, the participants would not take TCM and only receive western medicine treatment. They would be followed up for another 8 weeks, and a clinical evaluation would be conducted.The evaluation includes the frequency of palpitation, cumulative attack time, increase and decrease rate of western medicine, TCM symptoms, clinical quality of life, clinical endpoint events and safety. Cases are derived from outpatient and inpatient with AF in the Cardiology Department of Longhua Hospital. Evaluations would be conducted at baseline and at week 4 and 12 after randomization.Discussion:In this study, the efficacy and safety of HTDJ plus western medicine in the treatment of AF(palpitation of Qi deficiency-caused phlegm stagnation) were evaluated, so as to provide medicine evidence of short-term and medium-term clinical efficacy for the treatment of AF with integrated traditional and western medicine, and lay a foundation for further clinical development and application.Trial registration: The trial has been registered on March 5,2020 at Chinese Clinical Trial Registry (www.chictr.org.cn; ID:ChiCTR2000030517).Trial registration: This study was registered on May 15,2019 at ClinicalTrials.gov with the identifier number NCT03952676.

A molecule complex exhibiting reversible on–off switching between spin crossover and single-molecule magnet behaviours via a single-crystal-to-single-crystal transformation is reported., The on–off switching of spin-crossover (SCO) and single-molecule magnetism (SMM) remains highly attractive, especially if it involves dynamic crystal-to-crystal transformation. Herein we report the first molecule, a mononuclear cobalt(ii) complex, that exhibits on–off switching between SCO and SMM reversibly during crystal-to-crystal transformation. Subtle structural transformation triggered by a simple dehydration–rehydration process induces significant geometrical changes of the CoII center and modification of the supramolecular interactions and switches its colour and magnetic properties (dark red/SCO-on/SMM-off ↔ orange/SCO-off/SMM-on). This work suggests that modification of the weak supramolecular interactions could be very effective in achieving switchable materials involving both SCO and SMM properties.