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1,208 results on '"Wang, Xiao-Dong"'

6. Secondary bile acids improve risk prediction for non‐invasive identification of mild liver fibrosis in nonalcoholic fatty liver disease

Author

Liu, A‐Na, Xu, Cui‐Fang, Liu, Ya‐Ru, Sun, Dan‐Qin, Jiang, Ling, Tang, Liang‐Jie, Zhu, Pei‐Wu, Chen, Sui‐Dan, Liu, Wen‐Yue, Wang, Xiao‐Dong, Targher, Giovanni, Byrne, Christopher D, Wong, Vincent Wai‐Sun, Fu, Junfen, Su, Ming‐Ming, Loomba, Rohit, Zheng, Ming‐Hua, and Ni, Yan

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Digestive Diseases, Chronic Liver Disease and Cirrhosis, Liver Disease, Good Health and Well Being, Adult, Male, Humans, Female, Non-alcoholic Fatty Liver Disease, Bile Acids and Salts, Liver Cirrhosis, Inflammation, Biomarkers, Obesity, Liver, liver fibrosis, nonalcoholic fatty liver disease, risk prediction, secondary bile acids, Pharmacology and Pharmaceutical Sciences, Gastroenterology & Hepatology, Clinical sciences, Pharmacology and pharmaceutical sciences
Abstract

BackgroundDysregulated bile acid (BA) metabolism has been linked to steatosis, inflammation, and fibrosis in nonalcoholic fatty liver disease (NAFLD).AimTo determine whether circulating BA levels accurately stage liver fibrosis in NAFLD.MethodsWe recruited 550 Chinese adults with biopsy-proven NAFLD and varying levels of fibrosis. Ultra-performance liquid chromatography coupled with tandem mass spectrometry was performed to quantify 38 serum BAs.ResultsCompared to those without fibrosis, patients with mild fibrosis (stage F1) had significantly higher levels of secondary BAs, and increased diastolic blood pressure (DBP), alanine aminotransferase (ALT), body mass index, and waist circumstance (WC). The combination of serum BAs with WC, DBP, ALT, or Homeostatic Model Assessment for Insulin Resistance performed well in identifying mild fibrosis, in men and women, and in those with/without obesity, with AUROCs 0.80, 0.88, 0.75 and 0.78 in the training set (n = 385), and 0.69, 0.80, 0.61 and 0.69 in the testing set (n = 165), respectively. In comparison, the combination of BAs and clinical/biochemical biomarkers performed less well in identifying significant fibrosis (F2-4). In women and in non-obese subjects, AUROCs were 0.75 and 0.71 in the training set, 0.65 and 0.66 in the validation set, respectively. However, these AUROCs were higher than those observed for the fibrosis-4 index, NAFLD fibrosis score, and Hepamet fibrosis score.ConclusionsSecondary BA levels were significantly increased in NAFLD, especially in those with mild fibrosis. The combination of serum BAs and clinical/biochemical biomarkers for identifying mild fibrosis merits further assessment.

Published
2023

7. Galactic Cosmic Rays at Mars and Venus: Temporal Variations from Hours to Decades Measured as the Background Signal of Onboard Micro-Channel Plates

Author

Futaana, Yoshifumi, Shimoyama, Manabu, Wieser, Martin, Karlsson, Stefan, Andersson, Herman, Nilsson, Hans, Wang, Xiao-Dong, Fedorov, Andrey, Andre, Nicolas, Holmström, Mats, and Barabash, Stas

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Space Physics
Abstract

A Micro-Channel Plate (MCP) is a widely used component for counting particles in space. Using the background counts of MCPs on Mars Express and Venus Express orbiters operated over 17 years and 8 years, respectively, we investigate the galactic cosmic ray (GCR) characteristics in the inner solar system. The MCP background counts at Mars and Venus on a solar cycle time scale exhibit clear anti-correlation to the sunspot number. We conclude that the measured MCP background contain the GCR information. The GCR characteristics measured using the MCP background at Mars show features that are consistent with the ground-based measurement in solar cycle 24. The time lag between the sunspot number and the MCP background at Mars is found ~9 months. The shorter-term background data recorded along the orbits (with a time scale of several hours) also show evident depletion of the background counts due to the absorption of the GCR particles by the planets. Thanks to the visible planetary size change along an orbit, the GCR contribution to the MCP background can be separated from the internal contribution due to the \b{eta}-decay. Our statistical analysis of the GCR absorption signatures at Mars implies that the effective absorption size of Mars for the GCR particles have a >100 km larger radius than the solid Martian body., Comment: Submitted to ApJ (2022-03-19)

Published
2022
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28. aMAP Score and Its Combination With Liver Stiffness Measurement Accurately Assess Liver Fibrosis in Chronic Hepatitis B Patients

Author

Fan, Rong, Li, Guanlin, Yu, Ning, Chang, Xiujuan, Arshad, Tamoore, Liu, Wen-Yue, Chen, Yan, Wong, Grace Lai-Hung, Jiang, Yiyue, Liang, Xieer, Chen, Yongpeng, Jin, Xiao-Zhi, Dong, Zheng, Leung, Howard Ho-Wai, Wang, Xiao-Dong, Zeng, Zhen, Yip, Terry Cheuk-Fung, Xie, Qing, Tan, Deming, You, Shaoli, Ji, Dong, Zhao, Jun, Sanyal, Arun J., Sun, Jian, Zheng, Ming-Hua, Wong, Vincent Wai-Sun, Yang, Yongping, and Hou, Jinlin

Published
2023
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31. Heavy concrete shielding properties for carbon therapy

Author

Wang, Jin-Long, Lu, Jiade J, Ding, Da-Jun, Jiang, Wen-Hua, Li, Ya-Dong, Qiu, Rui, Zhang, Hui, Wang, Xiao-Zhong, Ruan, Huo-Sheng, Teng, Yan-Bing, Wu, Xiao-Guang, Zheng, Yun, Zhao, Zi-Hao, Liao, Kai-Zhong, Mai, Huan-Cheng, Wang, Xiao-Dong, Peng, Ke, Wang, Wei, Tang, Zhan, Yu, Zhao-Yan, Wu, Zhen, Song, Hong-Hu, Wei, Shuo-Yang, Mao, Sen-Lin, Xu, Jun, Tao, Jing, Zhang, Min-Qiang, Xue, Xi-Qiang, and Wang, Ming

Published
2023
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40. Muon Tomography imaging improvement using optimized scattering tracks data based on Maximum Likelihood Method

Author

Wang, Xiao-Dong, Ye, Kai-Xuan, Wang, Yi, Li, Yu-Lei, Wei, Xie, Luo, Ling-Yi, and Chen, Guo-Xiang

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

Point of colsest Approche algorithm (PoCA) based on the formalism of muon radiogra- phy using Multiple Coulomb scattering (MCS) as information source is previously used to obtain the reconstruction image of high Z material. The low accuracy of reconstruction image is caused by two factors: the flux of natural muon and the assumption of single scattering in PoCA algo- rithm. In this paper, the maximum likelihood method based on the characteristics of Gaussian-like distribution of muon tracks by MCS is used to predict the optimal track of outgoing muon. The receiver operating characteristic (ROC) and the localization ROC (LROC) are used as two analysis methods to evaluate the quality of reconstruction image. From the results of simulation, the perfect discrimination of longitudinal materials could be well achieved by maximum likelihood algorithm and the discriminate ratio that is predicted by the maximum likelihood method is about 15% higher than that of predicted by PoCA algorithm method. It is seen that the maximum likelihood method can greatly improve the accuracy of reconstruction image., Comment: 12 pages,11 figures. arXiv admin note: substantial text overlap with arXiv:1608.01160

Published
2018

46. Solar X-ray and EUV imager on board the FY-3E satellite

Author

Chen, Bo, Zhang, Xiao-Xin, He, Ling-Ping, Song, Ke-Fei, Liu, Shi-Jie, Ding, Guang-Xing, Dun, Jin-Ping, Li, Jia-Wei, Li, Zhao-Hui, Guo, Quan-Feng, Wang, Hai-Feng, Wang, Xiao-Dong, Wang, Yun-Qi, Zhang, Hong-Ji, Zhang, Guang, Han, Zhen-Wei, Dai, Shuang, Zhang, Pei-Jie, Sun, Liang, Liu, Yang, Wang, Peng, Wu, Kun, Tao, Chen, Mao, Shi-Lei, Mei, Gui, Yang, Liang, Chen, Li-Heng, Han, Chun-Yang, Huang, Bin, Liu, Yang, Ren, Shuai, Zhou, Peng, Wei, Ze-Xi, Zhang, Xiao-Xue, Zhang, Yue, Zheng, Xin, Wang, Yang, Chen, Ya, Xie, Jing-Jiang, He, Fei, Song, Qiao, Zong, Wei-Guo, Hu, Xiu-Qing, Zhang, Peng, Wang, Jing-Song, and Yang, Zhong-Dong

Published
2022
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